Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| SMYD3 | 64754 | SET and MYND domain containing 3 | 1 | KMT3E; ZMYND1; ZNFN3A1; bA74P14.1 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 21531130 | 2011 | Cell line : - Source : Japanees patients Sample Type : CRC tumor and normal tissue No. of Sample : 113 Stage : - | Peptide Nucleic Acid (PNA)-clamp real-time-PCR TaqMan assay, Gene expression profiles. | Up-regulation | - | - |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Zinc fingers, MYND-type, Chromatin-modifying enzymes / K-methyltransferases |
| Description | This gene encodes a histone methyltransferase which functions in RNA polymerase II complexes by an interaction with a specific RNA helicase. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011] |
| Chromosome | 1 |
| Location | 1q44 |
| Start | 245749340 |
| End | 246507342 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 758003 |
| OMIM ID | 608783 |
| HGNC ID | HGNC:15513 |
| Unigene ID | Hs.567571 |
| Ensembl ID | ENSG00000185420 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_001167740.1 |
|---|---|
| Exon | join(1..289,152249..152312,171869..171976,176806..176863, 180006..180142,577406..577473,579310..579412, 591703..591813,643457..643544,648673..648847, 743194..743302,757679..758003) | mRNA Sequence | Download Select all |
| Length | 1641 |
CDS Information
| Location | join(126..289,152249..152312,171869..171976, 176806..176863,180006..180142,577406..577473, 579310..579412,643457..643544,648673..648847, 743194..743302,757679..757780) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | - |
Protein Information
| Protein ID | NP_001161212.1 |
|---|---|
| Protein Name | SET and MYND domain containing 3 |
| Molecular Wt. (Da) | 48966 |
| Protein Sequence | Download Select all |
| Length | 428 |
| Uniprot ID | O00358 |
| Ensembl Protein ID | ENSP00000364265 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
| EC | 2.1.1.43 |
|---|---|
| Name | histone-lysine N-methyltransferase protein methylase III protein methylase 3 protein (lysine) methyltransferase protein methyltransferase II protein-lysine N-methyltransferase histone H1-specific S-adenosylmethionine:protein-lysine N-methyltransferase S-adenosyl-L-methionine:histone-L-lysine 6-N-methyltransferase |
| Class | Transferases; Transferring one-carbon groups; Methyltransferases |
| Sysname | S-adenosyl-L-methionine:histone-L-lysine N6-methyltransferase |
| Substrate | S-adenosyl-L-methionine [CPD:C00019]; histone L-lysine |
| Product | S-adenosyl-L-homocysteine [CPD:C00021]; histone N6-methyl-L-lysine |
| Reaction (IUBMB) |  |
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 3320 | HSP90AA1 | 777 | NP_001017963.2 | in vitro;in vivo | 15235609 |
| 5089 | PBX2 | 8890 | NP_002577.2 | yeast 2-hybrid | 14667819 |
| 5440 | POLR2K | 5826 | NP_005025.1 | in vitro;in vivo | 15235609 |
| 9931 | HELZ | 10452 | NP_055692.2 | in vitro;in vivo | 15235609 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam01753 | 49-87 | zf-MYND |
| cl20224 | 49-87 | zf-MYND superfamily |
| pfam00856 | 147-239 | SET |
| cl02566 | 147-239 | SET superfamily |
| smart00317 | 148-239 | SET |
| COG2940 | 202-270 | SET |
Ontology Information
| HPRD ID | 1901 |
|---|---|
| Molecular Class | Enzyme: Methyltransferase |
| Molecular Function | Transcription factor activity (GO:0003700) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
No matching records could be found.