CoReCG

Search results:

General Information

Gene_Symbol	Gene_ID	Gene_Name	Chromosome	Alias
BMI1	648	BMI1 polycomb ring finger oncogene	10	PCGF4; RNF51; FLVI2/BMI1

Evidence
Gene
mRNA
CDS
Protein
PTM
Enzyme
PPi
Pathway
Structural
Domain
Ontology
SNP
Drug
External Links

Evidence Information

Pubmed ID	Year	Sample Information	Techniques	Mechanism	Fold Change	Remark
14732230	2004	Cell line : - Source : Department of Surgery Eulji Hospital Sample Type : CRC tumor and Normal tissue No. of Sample : 46 Stage : -	RT-PCR, Immunohistochemistry	Up-regulation	-	The level of Bmi-1 mRNA in the carcinoma tissues was significantly higher than those of the adjacent non-neoplastic colonic mucosal tissues. Bmi-1 might play a role in the development and progression of colorectal carcinoma through the mechanism of cell cycle Regulation.
25054051	2014	Cell line : - Source : Department of Surgery, Queen Mary Hospital, The University of Hong Kong Sample Type : CRC tumor and Normal tissue No. of Sample : 45 Stage : TNM Stage IV	real time RT-PCR	Up-regulation	-	Plasma Bmi1 mRNA levels may serve as a non-invasive biomarker for monitoring occult metastasis and predicting the development of distant metastasis.

Gene Details

Chromosome: 10; NC_000010.10 (22610139..22620414)
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Gene Type	protein coding
Gene Family	RING-type (C3HC4) zinc fingers, Polycomb group ring fingers
Description	-
Chromosome	10
Location	10p11.23
Start	22321210
End	22331485
Strand	+
Gene Sequence	>gi\|568815588:22321210-22331485 Homo sapiens chromosome 10, GRCh38.p2 Primary Assembly ACAGCAACTATGAAATAATCGTAGTATGAGAGGCAGAGATCGGGGCGAGACAATGGGGATGTGGGCGCGG GAGCCCCGTTCCGGCTTAGCAGCACCTCCCAGCCCCGCAGAATAAAACCGATCGCGCCCCCTCCGCGCGC GCCCTCCCCCGAGTGCGGAGCGGGAGGAGGCGGCGGCGGCCGAGGAGGAGGAGGAGGAGGCCCCGGAGGA GGAGGCGTTGGAGGTCGAGGCGGAGGCGGAGGAGGAGGAGGCCGAGGCGCCGGAGGAGGCCGAGGCGCCG GAGCAGGAGGAGGCCGGCCGGAGGCGGCATGAGACGAGCGTGGCGGCCGCGGCTGCTCGGGGCCGCGCTG GTTGCCCATTGACAGCGGCGTCTGCAGCTCGCTTCAAGATGGCCGCTTGGCTCGCATTCATTTTCTGCTG AACGACTTTTAACTTTCATTGTCTTTTCCGCCCGCTTCGATCGCCTCGCGCCGGCTGCTCTTTCCGGGTA CGTAGGAGGCGAGGCGCCCCCGGGACGGGGCTGGGGGCCGGCGGGGGCCGCGCGGGGCTCGGGGCGGCCG CGGGTGGAAGGGGAGCCCCCCCCGCGCCCCGGCCGCGCCGCCGGGAGGGCGCTGACAGCGTGGGCGCCCG GCCCCGCGCCCCGCGCCGCCCGCCCCGCGCCTGCCGGCCCCGCGCGCCGCCCTCCCCGCGCCCGCGAGCG CGCGCCCGCCGCCGCCCGCCGACTCCCGCGGCGCCGGGACCGACCCGCAGCCCGCGCCGCGCCGCCGCCG CCAGCAGGGCTCGGCGCCGCTCCAGCCGCCGCCGCCCGCTCAGCCCCGGCGCGCCGCGCGCGGCCCCACG TTTTAGTTCCCCGCTCCCCCGGGCGCCCCTCCGCACCCTCGCGACGCACATGGCCCCCGAGAGGAGTACT GGTATTTCCAGCCTCGGCGGCTCTCCCGGCCGCAGCGCCCTTTGTTGAGAGGTAGATTTGGATGAAACGG GGACGGGTTCCTGAAATCGGGAGCTGCTTGGGTCAAGTGGCTTCCCTCCTCTCCCGAAGAAAGGGCTCTG GAGGGGCTCCAGCAGCCAGAGAACGCCCCCATTTTATAGGGACGGGTTGCGTGGGGGGCGGCCATCCCGC CAAGGTGGGTGTTAGGCTGGAGAGAGCCCCGACGAAAATGTTATTAACTTAAGTTGGGGGGACACTTGTC TGAGATTGGATGGCTGGTAAGATGGCGGTTCCCAGTTGTTTCCAAGGTCTCCTGCATTTGTGTTTAAAAT GCTGAAGTTTTCAAGGTGGTGTGTGTTGGGAGTCTTGGATAAGTGCTCTGAACATCGCTTGGGAGGTGCT CCCTGGGAAGTGGGCATTTCAAATTTGGAGCTTTTTGTGGAGTGAAGATGGTGACTGGACGTTAGCTTTG CTGGAGGCTTGCTTTCTCACTACTTCTTTTTCTCCTTTTTCTTTTTTCCCCTTTTGGAGACTGCAACTTT TCTCTCGACTTCTACTAAAGGATGCACTCAGCATCATGACTCCAGTCCACTATCTTTTACAGGTTTTGCT AAATGTCAGCATAGGTCATTTGGCAAAGGGATGCTTTAGAAAAGAGCACTAAAAAGTTGATTGCATATGT TTACGCAGTCACTTGGGCTTGACAGTGATATGGCATGATCTTTTTCCCAGAGATTTACAGTTAATAATTG GAAGTAAACAAGTAGAGAGACTTTGATCATTACCACTTGCAATAAAAGGATTTAGTGGGCTTAGTGGTCA CGGTTCAATATATGAAAGAGAAGCATGTATTAACCCCTTCCCTTAATGTGGGCAAAATTCCGAGCATATT TATCCAAATGCAAGTGTAGGTTGGTGGTGTGTACAACGTTATGAGTAGTTCAACCTATATTTTATAGGAA CCTTAACTCCCATGTTCTGGAAACACATTATAAGCTACACTAAACAGTTGATATTTAAGGATGCAAATTA TTGACAGTATATAACAAGTTATGAGACTCTATATGTTAACATTTGAGTTTTAAGTAGACCGATCAGAAAT CCCTGGGATTGATTTTATAAACAAAATTATAAGTTTTTAGATTTGAGTTAATTCCATACATCTACCCCAA AGTGTAGTCAGAAGTGTTTGAAATAACCTACTTGTGTGAGTCTTATGCCTAGTAAAATATCTTTAAAGCC ATATACAAGTCACTTTGTATGCATGTATACACATAAAGCTTTTGTAAGAAAATTAAGCATTTAATTGTAC ATGATAAATCCATTAATACTCTATCACTAACTTCTTGGATGTATGTTAAGTGTGCAGATAGGCTTTCTCC CCAGGAGTCAAATTAACCCCAACTTTACCCATGCTTATGTTGGGCTGTGAACCCCAACTGGGGCTATGGA GTTCATTTGCATTTCTTAGATTGCAGTAGGCAAGCTGATGGTTAACATAAGAACTTGCTTCTGTTTTCCT TCATTTTGACATTCCTGGTGTTAGGCCTCCACCTAAAAACTGACAGCCCCAACTGAGTGTGTTACAATGG CAAGTTTTAACGGTTGAGTATTTTTACCATGATATGTTTGGTGCATTTTTGTTTGCTTAACTGGCAGTTT CTGGGTTGGAACCTGGAAGGTTTTCACTTCTGAGGTGGAAGAGATTGTTTCTCAAATCTTATCAAGCACG TCAAACACTTTGGAAGTCTTCATTAGGTTGCCACTACTTTCAAAGGGCATAAAAACATAACTGATTTTTA TATAAGTAACAGTGGTATTTATTAGCATTATAAATGGTCACAGGATTGTGGCCAAATTCTTCTGAACTGA GGTAGAGGAATTGTGTGAATTAAGACTTAAGATGAATTTGAAAGACTTTTGGTCAAGTACATGTGACTTA AATGCTCAAAGCCAACCGGTAGATAACCCTCCACTGAGGTTTGATTGTTCTCCTTGTTAATACTTGTCTT TGTGTGGTGTTGGTTTTCTGCAAGCTAGAGGAGAAATAAAGGCAGCTATTTTTATTGGAGCCCCTTCATG AACTTCGTGATCGGTGGTTTTTTAGTGCAGTATGCTTTCACAGGCAAACAGAAATATCAGCTTGCTATCT TTCTAGGAAAGATCCTGTGGTTTCACAAGGAGAATTTTCTTTAAGCACCAAGAAGGCTGTTCTTTAATTT ACCAAGTATAATTTGATTTAAATATTGCTACTCTTTAGGGTCATTGCTCTACCTACAACTCCTCCGTGCC CCGCTTAGATTTATGTTAATATGTTGACAATATTCTCCAAAACAAGTAATCCAGAGATAACTGAGGAGTC AGTCACACAAGAAGTTTTCTGGTAGAGGTCGCCAGTTGCCACTGTGGTCACTTTCATAAGAGAGGCTTTG TTTTGTTTTTTACCATTTTCTAGAGGTTAGCTCTTAATTTCAGCCATTGAGCTGTGTTGATTGGTGTTTC CCTTTACTGCATTAATACACCTTAGGAATTAAAACCGCAGGTATATCTTACTGCAAGTTTCAAAAGGTCC TGGATTTCCATTCAAGGAAGATTTGAGAATGTACTTCAGTGAGGTCTGGAAGCTTAGTCTTATATCAGGT TCTGAAATGAATGAAGAAGGGGGGTTGAAGTTTATTTTTCAAGAATACTACACGAAGTATTTGACTTCCC TGACTGTCGGCTGGTGTATTGTTGCTGACAGTTCCCCATTGTGACTTTCCTGTAATAGAGGTATCTGTTG GGAATATCATTTCATCGTATGGGGGGTTTTACATTTGTTTTTCTCTCCTGTCGCTGCTTTGGGTTGACAA GCTGTTGATTTAGCGTTGGAAATGGGCTGGTCACATGGTTCTGTACATATTGTCACTATTGTACCGATTA AAGTACTTTTTCTTGCCCCCAGCATAGTTTGTCCAAATAAAACACTGGGCTTTGCCCTCTCCTCTTCTTG TAAAACAGATTTCAGTTTTCAGCCTTTCCAAAACTTTGTATCGCTCATTTAATCTACAGGAGAGCGTCAC ATTAGAGAAGGAAGTTTTAAAGAGGTTCGGTTCAATAAACATCTCTGCAATTTGAGCCCTGACGGTTTCG GGCTAAGTGCACAGTTGGCAATTCTCAAAAAATCCCTTCGTGAAATTTCTGACCGAGTGATTGCAGACAG GACAGACCGAGAGAGTCGAGATCTGAAACCAGCTCTGCGCACCAAGTCGACGTGAAAAGAGGCCCCCGGA GTGTCCGAAATGGCCGGGAGTGCGGTTTGCATTTTCCTTTCGCGGGCGCTGCCGCAGGCTCCGGGGTCCC CGCCGCCCAGGACTGGGTCCCTGGTCCCCGATCCCCGCTCCCCGCTCCCCAGCGCTGTGGCCTCGTGGGG CTGCCCCGCCCCCCCGGCGTCGCCGCACCCACCCCGCCCCCGCGCCGGCCCCGCCCCCGCGGCGCGCCGC CCCTCCCCCGCCCGCCCGCCCGCCCGCCGCCCCGCACGCCCGCCGAGGCTCGGGGCTCGGGCCGGGCTCC GCGCGGAGTTGCAGCGGTGGCCGGATGCCAAGTGTAAGTGTAAGTTGCTATGGAAACCCCGACCGAGGCG AGTTCCGAATCCGGAGCGAGACGGAGCCCCGGGCGCCGCCGGATCCGCCCCTCGCATCCCGGCCCCCGGG CGTCCGCCGCGCTCAGGCCCCGGCCCAGGCCGACTGGAGGTGCTCCTCCTGCGGCCCCAGCACCCGGCTC CGGAAATGCCAGGGATGCAGGGAGGGCAGAATTGTTTTCCCTGCGCGTCGCGTAAAAACGTGCCAGGTTC TGCTTGCTGGAACCGTCTAAAACAACCGGAACCCCGGATTTTCACTTGCAGATTCTTGAGGAAGTTTTAT AATAAATTCGGAGACCTGGAACAAGCCCTAGTGGTTGGTAAATATCCGCGGGGATTGTGTGGCGTCTGCA GCAGCCTTGGGGCTGCTGGGCTGGAGGACAAATGGAAGAAAGAGACCCTAATACGCTCAGCTCCCAGCCC CCACCCCAGACTTTCTTCTACCTACAGGAATGATCTGAGAGACCAGAAGTAATGTTAGTTGGATCCTTTT GCATCAGTTTGGTAGAACTGATTCCGATCTGATGAGTAAATTCCTTCTGTAGAAACGTTAGGACAGCCCA GCTGTACAGTGTTAAATGAGTTTTATAAATTCAGTGTTTCAGGGTTTGTGATTACTAGATGATCTCCATT CTTGTTCTGTGAATTATGGCCATTATTTCTGTGTCTTGCAGGATTTTTTATCAAGCAGAAATGCATCGAA CAACGAGAATCAAGATCACTGAGCTAAATCCCCACCTGATGTGTGTGCTTTGTGGAGGGTACTTCATTGA TGCCACAACCATAATAGAATGTCTACATTCCTGTAAGTACCGAGCTTTAGCTCTCTTTTGTATCATGCGT ATTTCACAGTTCGACCTGGAATTTGAAAACTGTTAATGATTCCTGCAATCTGTGGAAATGTTGGTACAAA GTGGTGAAGGCATTTTCTTCTCTTGCATCTAATGACTTTTTGTTAATATGTATTGATTGTATTACAAGCA TGCAATATATGTGTTCTCAGGATATGAATTAGCTTATTTAGTTGGAAATGCCTTTCACCATCTTGTTTTC TACTAGTTCTGGGTTTCTAACACCAATGATTTATCCACTCATTTCTAAACATAAAAAAACTTCACATGTT CTACTTCTAGTCTGTAAAACGTGTATTGTTCGTTACCTGGAGACCAGCAAGTATTGTCCTATTTGTGATG TCCAAGTTCACAAGACCAGACCACTACTGAATATAAGGTAGGAAACTGTTGAAATTCCTTGTTTGTAATT ATTATTGGAGTTGTATAATTTACTGAAGGCAACCCTCTTTATTTCTTCACAGAAAATTTACTCTTGAATA CATAACTAATATGTGTGTGCTTTGTGGAGGGTAGCCGTTTAATTTCTTGCCATATTAATGGTGACCAAGT TTAGACAAAGTTTAGTAGTATTCAAGTGATTTTAAGATTTTTTTTTCCTAACTGTCCTTTAAAAACTGAG TTAGTTCACCTTTTTTGCATTGCTTTATGGACTTCATGACAGGCAGGAATAAATATTTAAAAGGGCTTCC ATTCCTCTTTATTCCCTATTCATATTAGCTAGTTTAGTAACTTGAAAGGCACACTTCTTTTGACAGAGCA AATGTGAAGAATTTATTAGTGAATATAAAATATTTTTCTACTGATTTAAAAAGTGCTATATACAGAGAAC TTTTATTCTCATAGTTTTTATCTTATCAATAATAGTTATAGACAGCATCACAATCAAGTAAAATATTATA GCACAAAAGAAGACTATAGAAACTTATGAACATTTTTAGTTCTTGCCATCTGAATTCATAGTTTTCTATT TTAATTATTTTTCAGGTCAGATAAAACTCTCCAAGATATTGTATACAAATTAGTTCCAGGGCTTTTCAAA AGTGAGTAACTTGCTTAGAAAATGAATTTAAAGAGATTATTCATTAGTTCTTTGTGTTATGCCAAATGTT TACATCTTTTTTCCCCATTCAGATGAAATGAAGAGAAGAAGGGATTTTTATGCAGCTCATCCTTCTGCTG ATGGTAAACCTTTTAGGGGAGGGAAGACATTTTATATGGGGGGAGAGCTTATCTAGGAATTAAAATGTAT TAAAATTGACTTTACCACTTCCATCCTCTTATATATAAAATTTATTAGGCATCTGATTTTTAAAAATTAC ATTTCACTATATCGTTATAGCTGCCAATGGCTCTAATGAAGATAGAGGAGAGGTTGCAGATGAAGATAAG AGAATTATAACTGATGATGAGATAATAAGCTTATCCATTGAATTCTTTGACCAGAACAGGTAAAATCTTT AGGCAATTTATTTTATGCTAATGTTTTATTAGATTGTTTCACTAATAAATTTTCTCTTTATTAGATTGGA TCGGAAAGTAAACAAAGACAAAGAGAAATCTAAGGAGGAGGTATGTTTCATGTTACAAAAACATATAGAA GAAACATTGTTTGGAATCCAGATTTTATCAGGGATTGTGTTGCCCTTTAGAATATTAGGCTGTTAAATAG AAGAAAATGGTCATGTTTAATGTTTAAGAAAGGTCTACATGTGATATTTAATAATTAGAATTTATTTTAT ATATGATTGTTAGTCTTACAAAATATTTTAAGTAGTTCACAGTTAATACTTTGGTATGCTTGAAGATTAT ATTAGGAATCTGTTCATTTAGTATTTGTAATGATAGTAAACTCAGAGTGTAATTAGTTGAGAGGTTGGTC ACCTCCAATTTTGTTTGATACTAGTATCTTTTATATTCAAGCAATCAAATTGAAACTTTCTTCATATCTT AAAGTAACTGAAAAAGTTACTTTTCTAAATGTACTTTTAGGTGAATGATAAAAGATACTTACGATGCCCA GCAGCAATGACTGTGATGCACTTAAGAAAGTTTCTCAGAAGTAAAATGGACATACCTAATACTTTCCAGG TATCTACTTTTATATTCTTCTTGCATTTTACATAGATTTTACAATTTTAATTACATTTTTCACTTTGGAT TTTGAACCCAAAAAAGCAATAGAAAAAAAATGTGAAGTTAGTGCTAAAGTTGAAATTTATCTTAAAACAT TTGGTATACATTCTCTTTTATGCTATGAAAACAAATCCCTTAACACTCTCTAGAAATAATTTTTTCTCAT TTGAAGTTTCAGGAGTCTTTCTTTGTTAAAATGTTTGGAGAATATGTTTCTTAAAGCACTTTTGGATTAT ATTTAAATGACAAAAAATGTACATTTACCTTTGTTCTTTTATTACTTAATAAAAATATTTTTCACTAGAT TGATGTCATGTATGAGGAGGAACCTTTAAAGGATTATTATACACTAATGGATATTGCCTACATTTATACC TGGAGAAGGGTAAGTAGCATATCTGTTGTTAGATTATGATGGTAAACTATATTTAAAGAATTAAGAGTAA TTTTTTTCCTTTTAACTTTGTAGAATGGTCCACTTCCATTGAAATACAGAGTTCGACCTACTTGTAAAAG AATGAAGATCAGTCACCAGAGAGATGGACTGACAAATGCTGGAGAACTGGAAAGTGACTCTGGGAGTGAC AAGGCCAACAGCCCAGCAGGAGGTATTCCCTCCACCTCTTCTTGTTTGCCTAGCCCCAGTACTCCAGTGC AGTCTCCTCATCCACAGTTTCCTCACATTTCCAGTACTATGAATGGAACCAGCAACAGCCCCAGCGGTAA CCACCAATCTTCTTTTGCCAATAGACCTCGAAAATCATCAGTAAATGGGTCATCAGCAACTTCTTCTGGT TGATACCTGAGACTGTTAAGGAAAAAAATTTTAAACCCCTGATTTATATAGATATCTTCATGCCATTACA GCTTTCTAGATGCTAATACATGTGACTATCGTCCAATTTGCTTTCTTTTGTAGTGACATTAAATTTGGCT ATAAAAGATGGACTACATGTGATACTCCTATGGACGTTAATTGAAAAGAAAGATTGTTGTTATAAAGAAT TGGTTTCTTGGAAAGCAGGCAAGACTTTTTCTCTGTGTTAGGAAAGATGGGAAATGGTTTCTGTAACCAT TGTTTGGATTTGGAAGTACTCTGCAGTGGACATAAGCATTGGGCCATAGTTTGTTAATCTCAACTAACGC CTACATTACATTCTCCTTGATCGTTCTTGTTATTACGCTGTTTTGTGAACCTGTAGAAAACAAGTGCTTT TTATCTTGAAATTCAACCAACGGAAAGAATATGCATAGAATAATGCATTCTATGTAGCCATGTCACTGTG AATAACGATTTCTTGCATATTTAGCCATTTTGATTCCTGTTTGATTTATACTTCTCTGTTGCTACGCAAA ACCGATCAAAGAAAAGTGAACTTCAGTTTTACAATCTGTATGCCTAAAAGCGGGTACTACCGTTTATTTT ACTGACTTGTTTAAATGATTCGCTTTTGTAAGAATCAGATGGCATTATGCTTGTTGTACAATGCCATATT GGTATATGACATAACAGGAAACAGTATTGTATGATATATTTATAAATGCTATAAAGAAATATTGTGTTTC ATGCATTCAGAAATGATTGTTAAAATTCTCCCAACTGGTTCGACCTTTGCAGATACCCATAACCTATGTT GAGCCTTGCTTACCAGCAAAGAATATTTTTAATGTGGATATCTAATTCTAAAGTCTGTTCCATTAGAAGC AATTGGCACATCTTTCTATACTTTATATACTTTTCTCCAGTAATACATGTTTACTTTAAAGATTGTTGCA GTGAAGAAAAACCTTTAACTGAGAAATATGGAAACCGTCTTAATTTTCCATTGGCTATGATGGAATTAAT ATTGTATTTTAAAAATGCATATTGATCACTATAATTCTAAAACAATTTTTTAAATAAACCAGCAGGTTGC TAAAAGAAGGCATTTTATCTAAAGTTATTTTAATAGGTGGTATAGCAGTAATTTTAAATTTAAGAGTTGC TTTTACAGTTAACAATGGAATATGCCTTCTCTGCTATGTCTGAAAATAGAAGCTATTTATTATGAGCTTC TACAGGTATTTTTAAATAGAGCAAGCATGTTGAATTTAAAATATGAATAACCCCACCCAACAATTTTCAG TTTATTTTTTGCTTTGGTCGAACTTGGTGTGTGTTCATCACCCATCAGTTATTTGTGAGGGTGTTTATTC TATATGAATATTGTTTCATGTTTGTATGGGAAAATTGTAGCTAAACATTTCATTGTCCCCAGTCTGCAAA AGAAGCACAATTCTATTGCTTTGTCTTGCTTATAGTCATTAAATCATTACTTTTACATATATTGCTGTTA CTTCTGCTTTCTTTAAAAATATAGTAAAGGATGTTTTATGAAGTCACAAGATACATATATTTTTATTTTG ACCTAAATTTGTACAGTCCCATTGTAAGTGTTGTTTCTAATTATAGATGTAAAATGAAATTTCATTTGTA ATTGGAAAAAATCCAATAAAAAGGATATTCATTTAGAAAATAGCTAAGATCTTTAATAAAAATTTGATAT GAAAAGCACAATGTGCAGAAGTTATGGAAAACCTATAGAGGATTACAACAGGTAAACGTTAAAGAGAATA CATTGCTGACTTATAGTGATGTGGCTAAGAAGTACATGCTTTGTTGTAAAATTGCTTGAAAGCCCATTGA AAGATGTATCTGTTTATTTACAGTCTTTGAAGTAAAAGTTACCAATGTTTGCCAAT Download Select all
Length	10276
OMIM ID	164831
HGNC ID	HGNC:1066
Unigene ID	Hs.380403
Ensembl ID	ENSG00000168283
PharmGKB ID	PA25376

mRNA Information

mRNA ID	NM_001204062.1
Exon	join(<5222..5352,5681..5777,6386..6441,6533..6583, 6741..6849,6925..6970,7391..7489,7839..7919,8004..10276)
mRNA Sequence	>648 GTGGTGTGCGTGTCGAAGGTCACGGCGCGCTCACAATGGAGCTCTCGGAGTCTGTGCAGAAAGG CTTCCAGATGCTGGCGGATCCCCGCTCCTTCGACTCCAACGCCTTCACGCTTCTCCTCCGGGCG GCATTCCAGAGTCTGCTGGACGCCCAGGCGGACGAGGCCGTGTTAGATCATCCAGACTTGAAAC ATATCGACCCAGTGGTTTTAAAACATTGTCATGCAGCAGCTGCAACTTACATACTAGAGGCAGG AAAGCACCGAGCTGACAAGTCAACTCTAAGCACTTATCTAGAAGACTGTAAATTTGACAGAGAG CGAATAGAACTGTTTTGCACGGAATATCAGAATAATAAGAATTCCCTAGAAATCCTACTGGGAA GAACACTGATTCCCCATCCTATCCAGAGATTAGTTTTAGTTGCAGCATGGAACAATTACAGGAT TTTTTATCAAGCAGAAATGCATCGAACAACGAGAATCAAGATCACTGAGCTAAATCCCCACCTG ATGTGTGTGCTTTGTGGAGGGTACTTCATTGATGCCACAACCATAATAGAATGTCTACATTCCT TCTGTAAAACGTGTATTGTTCGTTACCTGGAGACCAGCAAGTATTGTCCTATTTGTGATGTCCA AGTTCACAAGACCAGACCACTACTGAATATAAGGTCAGATAAAACTCTCCAAGATATTGTATAC AAATTAGTTCCAGGGCTTTTCAAAAATGAAATGAAGAGAAGAAGGGATTTTTATGCAGCTCATC CTTCTGCTGATGCTGCCAATGGCTCTAATGAAGATAGAGGAGAGGTTGCAGATGAAGATAAGAG AATTATAACTGATGATGAGATAATAAGCTTATCCATTGAATTCTTTGACCAGAACAGATTGGAT CGGAAAGTAAACAAAGACAAAGAGAAATCTAAGGAGGAGGTGAATGATAAAAGATACTTACGAT GCCCAGCAGCAATGACTGTGATGCACTTAAGAAAGTTTCTCAGAAGTAAAATGGACATACCTAA TACTTTCCAGATTGATGTCATGTATGAGGAGGAACCTTTAAAGGATTATTATACACTAATGGAT ATTGCCTACATTTATACCTGGAGAAGGAATGGTCCACTTCCATTGAAATACAGAGTTCGACCTA CTTGTAAAAGAATGAAGATCAGTCACCAGAGAGATGGACTGACAAATGCTGGAGAACTGGAAAG TGACTCTGGGAGTGACAAGGCCAACAGCCCAGCAGGAGGTATTCCCTCCACCTCTTCTTGTTTG CCTAGCCCCAGTACTCCAGTGCAGTCTCCTCATCCACAGTTTCCTCACATTTCCAGTACTATGA ATGGAACCAGCAACAGCCCCAGCGGTAACCACCAATCTTCTTTTGCCAATAGACCTCGAAAATC ATCAGTAAATGGGTCATCAGCAACTTCTTCTGGTTGATACCTGAGACTGTTAAGGAAAAAAATT TTAAACCCCTGATTTATATAGATATCTTCATGCCATTACAGCTTTCTAGATGCTAATACATGTG ACTATCGTCCAATTTGCTTTCTTTTGTAGTGACATTAAATTTGGCTATAAAAGATGGACTACAT GTGATACTCCTATGGACGTTAATTGAAAAGAAAGATTGTTGTTATAAAGAATTGGTTTCTTGGA AAGCAGGCAAGACTTTTTCTCTGTGTTAGGAAAGATGGGAAATGGTTTCTGTAACCATTGTTTG GATTTGGAAGTACTCTGCAGTGGACATAAGCATTGGGCCATAGTTTGTTAATCTCAACTAACGC CTACATTACATTCTCCTTGATCGTTCTTGTTATTACGCTGTTTTGTGAACCTGTAGAAAACAAG TGCTTTTTATCTTGAAATTCAACCAACGGAAAGAATATGCATAGAATAATGCATTCTATGTAGC CATGTCACTGTGAATAACGATTTCTTGCATATTTAGCCATTTTGATTCCTGTTTGATTTATACT TCTCTGTTGCTACGCAAAACCGATCAAAGAAAAGTGAACTTCAGTTTTACAATCTGTATGCCTA AAAGCGGGTACTACCGTTTATTTTACTGACTTGTTTAAATGATTCGCTTTTGTAAGAATCAGAT GGCATTATGCTTGTTGTACAATGCCATATTGGTATATGACATAACAGGAAACAGTATTGTATGA TATATTTATAAATGCTATAAAGAAATATTGTGTTTCATGCATTCAGAAATGATTGTTAAAATTC TCCCAACTGGTTCGACCTTTGCAGATACCCATAACCTATGTTGAGCCTTGCTTACCAGCAAAGA ATATTTTTAATGTGGATATCTAATTCTAAAGTCTGTTCCATTAGAAGCAATTGGCACATCTTTC TATACTTTATATACTTTTCTCCAGTAATACATGTTTACTTTAAAGATTGTTGCAGTGAAGAAAA ACCTTTAACTGAGAAATATGGAAACCGTCTTAATTTTCCATTGGCTATGATGGAATTAATATTG TATTTTAAAAATGCATATTGATCACTATAATTCTAAAACAATTTTTTAAATAAACCAGCAGGTT GCTAAAAGAAGGCATTTTATCTAAAGTTATTTTAATAGGTGGTATAGCAGTAATTTTAAATTTA AGAGTTGCTTTTACAGTTAACAATGGAATATGCCTTCTCTGCTATGTCTGAAAATAGAAGCTAT TTATTATGAGCTTCTACAGGTATTTTTAAATAGAGCAAGCATGTTGAATTTAAAATATGAATAA CCCCACCCAACAATTTTCAGTTTATTTTTTGCTTTGGTCGAACTTGGTGTGTGTTCATCACCCA TCAGTTATTTGTGAGGGTGTTTATTCTATATGAATATTGTTTCATGTTTGTATGGGAAAATTGT AGCTAAACATTTCATTGTCCCCAGTCTGCAAAAGAAGCACAATTCTATTGCTTTGTCTTGCTTA TAGTCATTAAATCATTACTTTTACATATATTGCTGTTACTTCTGCTTTCTTTAAAAATATAGTA AAGGATGTTTTATGAAGTCACAAGATACATATATTTTTATTTTGACCTAAATTTGTACAGTCCC ATTGTAAGTGTTGTTTCTAATTATAGATGTAAAATGAAATTTCATTTGTAATTGGAAAAAATCC AATAAAAAGGATATTCATTTAGAAAATAGCTAAGATCTTTAATAAAAATTTGATATGAAAAGCA CAATGTGCAGAAGTTATGGAAAACCTATAGAGGATTACAACAGGTAAACGTTAAAGAGAATACA TTGCTGACTTATAGTGATGTGGCTAAGAAGTACATGCTTTGTTGTAAAATTGCTTGAAAGCCCA TTGAAAGATGTATCTGTTTATTTACAGTCTTTGAAGTAAAAGTTACCAATGTTTGCCAAT Download Select all
Length	3388

CDS Information

Location	join(<5222..5352,5681..5777,6386..6441,6533..6583, 6741..6849,6925..6970,7391..7489,7839..7919,8004..8333)
CDS Sequence	>gi\|323276615:36-1445 Homo sapiens COMMD3-BMI1 readthrough (COMMD3-BMI1), mRNA ATGGAGCTCTCGGAGTCTGTGCAGAAAGGCTTCCAGATGCTGGCGGATCCCCGCTCCTTCGACTCCAACG CCTTCACGCTTCTCCTCCGGGCGGCATTCCAGAGTCTGCTGGACGCCCAGGCGGACGAGGCCGTGTTAGA TCATCCAGACTTGAAACATATCGACCCAGTGGTTTTAAAACATTGTCATGCAGCAGCTGCAACTTACATA CTAGAGGCAGGAAAGCACCGAGCTGACAAGTCAACTCTAAGCACTTATCTAGAAGACTGTAAATTTGACA GAGAGCGAATAGAACTGTTTTGCACGGAATATCAGAATAATAAGAATTCCCTAGAAATCCTACTGGGAAG AACACTGATTCCCCATCCTATCCAGAGATTAGTTTTAGTTGCAGCATGGAACAATTACAGGATTTTTTAT CAAGCAGAAATGCATCGAACAACGAGAATCAAGATCACTGAGCTAAATCCCCACCTGATGTGTGTGCTTT GTGGAGGGTACTTCATTGATGCCACAACCATAATAGAATGTCTACATTCCTTCTGTAAAACGTGTATTGT TCGTTACCTGGAGACCAGCAAGTATTGTCCTATTTGTGATGTCCAAGTTCACAAGACCAGACCACTACTG AATATAAGGTCAGATAAAACTCTCCAAGATATTGTATACAAATTAGTTCCAGGGCTTTTCAAAAATGAAA TGAAGAGAAGAAGGGATTTTTATGCAGCTCATCCTTCTGCTGATGCTGCCAATGGCTCTAATGAAGATAG AGGAGAGGTTGCAGATGAAGATAAGAGAATTATAACTGATGATGAGATAATAAGCTTATCCATTGAATTC TTTGACCAGAACAGATTGGATCGGAAAGTAAACAAAGACAAAGAGAAATCTAAGGAGGAGGTGAATGATA AAAGATACTTACGATGCCCAGCAGCAATGACTGTGATGCACTTAAGAAAGTTTCTCAGAAGTAAAATGGA CATACCTAATACTTTCCAGATTGATGTCATGTATGAGGAGGAACCTTTAAAGGATTATTATACACTAATG GATATTGCCTACATTTATACCTGGAGAAGGAATGGTCCACTTCCATTGAAATACAGAGTTCGACCTACTT GTAAAAGAATGAAGATCAGTCACCAGAGAGATGGACTGACAAATGCTGGAGAACTGGAAAGTGACTCTGG GAGTGACAAGGCCAACAGCCCAGCAGGAGGTATTCCCTCCACCTCTTCTTGTTTGCCTAGCCCCAGTACT CCAGTGCAGTCTCCTCATCCACAGTTTCCTCACATTTCCAGTACTATGAATGGAACCAGCAACAGCCCCA GCGGTAACCACCAATCTTCTTTTGCCAATAGACCTCGAAAATCATCAGTAAATGGGTCATCAGCAACTTC TTCTGGTTGA Download Select all
CCDS ID	CCDS59213.1

Protein Information

Protein ID	NP_001190991.1
Protein Name	BMI1 polycomb ring finger oncogene
Molecular Wt. (Da)	53163
Protein Sequence	>648 MELSESVQKGFQMLADPRSFDSNAFTLLLRAAFQSLLDAQADEAVLDHPDLKHIDPVVLKHCHA AAATYILEAGKHRADKSTLSTYLEDCKFDRERIELFCTEYQNNKNSLEILLGRTLIPHPIQRLV LVAAWNNYRIFYQAEMHRTTRIKITELNPHLMCVLCGGYFIDATTIIECLHSFCKTCIVRYLET SKYCPICDVQVHKTRPLLNIRSDKTLQDIVYKLVPGLFKNEMKRRRDFYAAHPSADAANGSNED RGEVADEDKRIITDDEIISLSIEFFDQNRLDRKVNKDKEKSKEEVNDKRYLRCPAAMTVMHLRK FLRSKMDIPNTFQIDVMYEEEPLKDYYTLMDIAYIYTWRRNGPLPLKYRVRPTCKRMKISHQRD GLTNAGELESDSGSDKANSPAGGIPSTSSCLPSPSTPVQSPHPQFPHISSTMNGTSNSPSGNHQ SSFANRPRKSSVNGSSATSSG Download Select all
Length	469
Uniprot ID	P16050
Ensembl Protein ID	ENSP00000293761

Post-translational Modification Information (Source : HPRD)

Residue	Type	site
S	Phosphorylation	251;-
S	Phosphorylation	253;-
S	Phosphorylation	255;-

Enzyme Information

EC	6.3.2.19
Name	ubiquitin---protein ligase ubiquitin-activating enzyme
Class	Ligases; Forming carbon-nitrogen bonds; Acid-D-amino-acid ligases (peptide synthases)
Sysname	ubiquitin:protein-lysine N-ligase (AMP-forming)
Substrate	ATP [CPD:C00002]; ubiquitin [CPD:C00496]; protein lysine
Product	AMP [CPD:C00020]; diphosphate [CPD:C00013]; protein N-ubiquityllysine
Reaction (IUBMB)

PPi Information

(Click to view network : Source STRING) View

Interactant Gene ID (Source: HPRD)	Gene Symbol	HPRD ID	Ref Seq ID	Technique	References
4297	MLL	1162	NP_005924.2	in vitro;in vivo	12829790
5764	PTN	1199	NP_002816.1	yeast 2-hybrid	16169070
10989	IMMT	2658	NP_006830.2	yeast 2-hybrid	16169070
55791	C1orf103	17975	NP_060842.3	yeast 2-hybrid	16169070
57562	KIAA1377	17212	NP_065853.2	yeast 2-hybrid	16169070

Pathway Information

Pathway Name	Pathway ID
MicroRNAs in cancer	hsa05206
Signaling pathways regulating pluripotency of stem cells	hsa04550
Transcriptional misregulation in cancer	hsa05202

Structure Information

No matching records could be found.

Domain Information

ID	Location	Description
cd00162	17-56	RING
cl17238	17-56	RING superfamily
pfam00097	18-56	zf-C3HC4
pfam13923	18-56	zf-C3HC4_2
smart00184	18-56	RING
pfam13639	17-56	zf-RING_2
pfam13920	17-63	zf-C3HC4_3
COG5432	4-168	RAD18
TIGR00599	8-180	rad18
COG5222	Aug-56	COG5222
PRK10803	224-281	PRK10803
pfam12678	33-56	zf-rbx1

Ontology Information

HPRD ID	1067
Molecular Class	DNA binding protein
Molecular Function	Catalytic activity (GO:0003824)
Biological Process	Metabolism (GO:0008152); Energy pathways (GO:0006091)

SNP Information

View SNP Geneview Report

Drug Information

No matching records could be found.

External Links

ArrayExpress GO
ICGC GO
Cancer3D GO
COSMIC GO
NCG GO
TSGene GO
Tumor Gene Family of Databases GO
CCDB GO
G2SBC GO
Osteosarcoma Database GO
RCDB GO

ArrayExpress	GO
ICGC	GO
Cancer3D	GO
COSMIC	GO
NCG	GO
TSGene	GO
Tumor Gene Family of Databases	GO
CCDB	GO
G2SBC	GO
Osteosarcoma Database	GO
RCDB	GO

Mechanism	Up-regulation
Biomarker	-
Drug Target	-
Biological Process	Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism