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General Information
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 15930286 | 2005 | Cell line : CACO2, LoVo, HCT116, SW48 Source : - Sample Type : CRC tumor and normal tissue No. of Sample : 15 Stage : - | Immunoblotting,FISH,Immunocytochemistry | Up-regulation | - | CENP-H plays an important role in the aneuploidy frequently observed in colorectal cancers. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | Centromere and kinetochore proteins play a critical role in centromere structure, kinetochore formation, and sister chromatid separation. The protein encoded by this gene colocalizes with inner kinetochore plate proteins CENP-A and CENP-C in both interphase and metaphase. It localizes outside of centromeric heterochromatin, where CENP-B is localized, and inside the kinetochore corona, where CENP-E is localized during prometaphase. It is thought that this protein can bind to itself, as well as to CENP-A, CENP-B or CENP-C. Multimers of the protein localize constitutively to the inner kinetochore plate and play an important role in the organization and function of the active centromere-kinetochore complex. [provided by RefSeq, Jul 2008] |
| Chromosome | 5 |
| Location | 5p15.2 |
| Start | 68485375 |
| End | 68506184 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 20810 |
| OMIM ID | 605607 |
| HGNC ID | HGNC:17268 |
| Unigene ID | Hs.631967 |
| Ensembl ID | ENSG00000153044 |
| PharmGKB ID | PA26402 |
Protein Information
| Protein ID | NP_075060.1 |
|---|---|
| Protein Name | centromere protein H |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 247 |
| Uniprot ID | Q96D96 |
| Ensembl Protein ID | ENSP00000242607 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 16 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam05837 | 136-241 | CENP-H |
| cl09387 | 136-241 | CENP-H superfamily |
| PHA02562 | 42-208 | 46 |
| COG1196 | 37-207 | Smc |
| COG1196 | 37-194 | Smc |
Ontology Information
| HPRD ID | 10455 |
|---|---|
| Molecular Class | DNA binding protein |
| Molecular Function | Methyltransferase activity (GO:0008168) |
| Biological Process | Metabolism (GO:0008152); Energy pathways (GO:0006091) |
Drug Information
No matching records could be found.