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General Information
- Evidence
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 17919499 | 2007 | Cell line : DLD 1, SW 480, HT 29, HCT 116 Source : ATCC Sample Type : Mouse model No. of Sample : - Stage : - | Immunoblotting, MTT Assay, Immunoblotting, Annexin V and 7-Amino-Actinomycin D Assays and luciferas | Down-regulation | - | Statins induce apoptosis in CRC cells through induction of BMP2. Statin therapy may only be effective in SMAD4-expressing CRCs and may have adverse effects in SMAD4-negative tumors. |
| 22923219 | 2012 | Cell line : - Source : - Sample Type : - No. of Sample : 20 colorectal juvenile polyps and 15 colorectal polyps of hamartomatous polyposis obtained from children, and 20 colorectal adenomas and 20 colorectal adenocarcinomas obtained from adults Stage : - | Immunohistochemical streptavidin-peroxidase (SP) method. | Down-regulation | - | The expression levels of TLR3, TLR4 and BMP2 were significantly different among the colorectal juvenile polyp, hamartomatous polyposis, adenoma and adenocarcinoma groups. |
| 21551187 | 2011 | Cell line : - Source : - Sample Type : Mouse model No. of Sample : - Stage : - | Methylation-specific PCR, bisulphite sequencing, immunoblotting, reverse transcription PCR. | Methylation | - | Statins act as DNMT inhibitors, demethylating the BMP2 promoter, activating BMP signalling, inducing differentiation of CRC cells, and reducing 'stemness'. BMP2 is silenced by promoter hypermethylation in cell lines with the hypermethylator phenotype and in primary tumours. |
| 21387313 | 2012 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | - | Polymorhpism | - | Genetic variation in BMPR1A, BMPR1B, BMPR2, BMP2 BMP2 (5 tagSNPs) and BMP4 was associated with risk of developing colon cancer. |
| 21761138 | 2012 | Cell line : - Source : - Sample Type : Population-based case-control studies No. of Sample : colon cancer 1,574 cases, 1,970 controls; rectal cancer 791 cases, 999 controls Stage : - | - | Polymorhpism | - | - |
| 23161572 | 2012 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | Genotyping, Meta-analysis | Polymorhpism | - | 14q22.2 (rs4444235 and rs1957636) and 20p12.3 (rs961253 and rs4813802) are located close to BMP4 and BMP2, respectively. |
| 18756288 | 2008 | Cell line : - Source : Southern European cohorts Sample Type : - No. of Sample : 2028 CRC cases and 4273 controls Stage : - | - | Unknown | - | Upregulation of RUNX3 by BMP reduces c-Myc expression. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Bone morphogenetic proteins |
| Description | The protein encoded by this gene belongs to the transforming growth factor-beta (TGFB) superfamily. The encoded protein acts as a disulfide-linked homodimer and induces bone and cartilage formation. [provided by RefSeq, Jul 2008] |
| Chromosome | 20 |
| Location | 20p12 |
| Start | 6767694 |
| End | 6780263 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 12570 |
| OMIM ID | 112261 |
| HGNC ID | HGNC:1069 |
| Unigene ID | Hs.73853 |
| Ensembl ID | ENSG00000125845 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | XM_011529323.1 |
|---|---|
| Exon | join(1..1182,10552..12570) | mRNA Sequence | Download Select all |
| Length | 3150 |
CDS Information
| Location | join(2434..2779,10552..11396) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS13099.1 |
Protein Information
| Protein ID | NP_001191.1 |
|---|---|
| Protein Name | Bone morphogenetic protein 2 |
| Molecular Wt. (Da) | 42482 |
| Protein Sequence | Download Select all |
| Length | 396 |
| Uniprot ID | O95076 |
| Ensembl Protein ID | ENSP00000358807 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| N | Glycosylation | 200 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 90 | ACVR1 | 21 | NP_001096.1 | in vivo | 8006002 |
| 93 | ACVR2B | 4106 | NP_001097.2 | in vitro | 15064755 |
| 429 | ASCL1 | 11 | NP_004307.2 | in vitro | 9197246 |
| 8646 | CHRD | 4592 | NP_003732.2 | in vitro | 15064755 |
| 26585 | GREM1 | 7048 | NP_037504.1 | in vitro | 15064755 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Basal cell carcinoma | hsa05217 |
| Cytokine-cytokine receptor interaction | hsa04060 |
| Hedgehog signaling pathway | hsa04340 |
| Hippo signaling pathway | hsa04390 |
| Pathways in cancer | hsa05200 |
| Signaling pathways regulating pluripotency of stem cells | hsa04550 |
| TGF-beta signaling pathway | hsa04350 |
Structure Information
| PDB ID | 1ES7 |
|---|---|
| Resolution | 2.9 |
| Method | X-RAY DIFFRACTION |
| Chains | A,C |
| Molecule | BONE MORPHOGENETIC PROTEIN-2 |
| Model | View |
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam00688 | 42-267 | TGFb_propeptide |
| cl02928 | 42-267 | TGFb_propeptide superfamily |
| smart00204 | 296-396 | TGFB |
| cl02510 | 296-396 | TGF_beta superfamily |
| pfam00019 | 295-396 | TGF_beta |
| PHA02913 | 292-395 | PHA02913 |
Ontology Information
| HPRD ID | 16190 |
|---|---|
| Molecular Class | Ligand |
| Molecular Function | Transcription regulator activity (GO:0030528) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
No matching records could be found.