Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| SKP2 | 6502 | S-phase kinase-associated protein 2, E3 ubiquitin protein ligase | 5 | FBXL1, FBL1, p45 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 24336114 | 2013 | Cell line : - Source : - Sample Type : Nude mouse No. of Sample : - Stage : - | MTT assay,Flow Cytometry, western blotting, TUNEL staining | Up-regulation | - | Skp2 regulates colorectal cancer cell growth by inhibiting the expression of cell cycle regulator p27 and p16. |
| 24913024 | 2014 | Cell line : SW620 Source : - Sample Type : - No. of Sample : - Stage : - | real time RT-PCR and western blotting | Up-regulation | - | Skp2 may enable the early diagnosis of colon cancer and provide new insights into molecular targets for cancer therapy. |
| 26114183 | 2015 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | - | Up-regulation | - | Alterations in the Skp2, Cks1 and CDKN1B (p27) expression have major effects on colorectal carcinogenesis and may serve as an important and independent prognostic marker. Skp2 may be a promising therapeutic target for colorectal cancer, and development of Skp2 inhibitors would have a great impact on colorectal cancer therapy. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | F-boxes / Leucine-rich repeats |
| Description | This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class; in addition to an F-box, this protein contains 10 tandem leucine-rich repeats. This protein is an essential element of the cyclin A-CDK2 S-phase kinase. It specifically recognizes phosphorylated cyclin-dependent kinase inhibitor 1B (CDKN1B, also referred to as p27 or KIP1) predominantly in S phase and interacts with S-phase kinase-associated protein 1 (SKP1 or p19). In addition, this gene is established as a protooncogene causally involved in the pathogenesis of lymphomas. Alternative splicing of this gene generates three transcript variants encoding different isoforms. [provided by RefSeq, Jul 2011] |
| Chromosome | 5 |
| Location | 5p13 |
| Start | 36152091 |
| End | 36184143 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 32053 |
| OMIM ID | 601436 |
| HGNC ID | HGNC:10901 |
| Unigene ID | Hs.23348 |
| Ensembl ID | ENSG00000145604 |
| PharmGKB ID | PA35801 |
mRNA Information
| mRNA ID | ?NM_001243120.1 |
|---|---|
| Exon | join(1..282,783..1054,11657..11768,14531..14674, 16325..16459,18356..18454,19615..19745,24977..25028, 25197..25304,40633..40800) | mRNA Sequence | Download Select all |
| Length | 1503 |
Protein Information
| Protein ID | NP_001230049.1 |
|---|---|
| Protein Name | S-phase kinase-associated protein 2, E3 ubiquitin protein ligase |
| Molecular Wt. (Da) | 70194 |
| Protein Sequence | Download Select all |
| Length | 424 |
| Uniprot ID | O43684 |
| Ensembl Protein ID | ENSP00000357851 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 64;- |
| S | Phosphorylation | 64;- |
| S | Phosphorylation | 48 |
| S | Phosphorylation | 48 |
| S | Phosphorylation | 57 |
| S | Phosphorylation | 57 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 890 | CCNA2 | 453 | NP_001228.1 | in vivo | 9858587 |
| 898 | CCNE1 | 455 | NP_001229.1 | in vitro;in vivo | 11237742 |
| 997 | CDC34 | 306 | NP_004350.1 | in vivo | 9430629 |
| 1017 | CDK2 | 310 | NP_001789.2 | in vivo | 10386600 |
| 1027 | CDKN1B | 2867 | NP_004055.1 | in vitro;in vivo | 105 599 161 252 917 000 000 000 |
| 1028 | CDKN1C | 2913 | NP_000067.1 | in vitro;in vivo | 12925736 |
| 1163 | CKS1B | 299 | NP_001817.1 | in vitro;in vivo | 1 123 158 512 813 040 000 000 000 000 000 000 000 000 |
| 1869 | E2F1 | 1806 | NP_005216.1 | in vitro;in vivo | 10559858 |
| 4605 | MYBL2 | 3247 | NP_002457.1 | in vivo | 10871850 |
| 5925 | RB1 | 1574 | NP_000312.2 | in vitro;in vivo | 15469821 |
| 6500 | SKP1 | 3255 | NP_733779.1 | in vitro;in vivo;yeast 2-hybrid | 9 827 542 943 062 910 000 000 000 000 000 000 000 000 000 000 |
| 6929 | TCF3 | 918 | NP_003191.1 | in vivo | 14592976 |
| 7314 | UBB | 6771 | NP_061828.1 | in vitro | 15070733 |
| 7465 | WEE1 | 1907 | NP_003381.1 | in vivo | 15070733 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Cell cycle | hsa04110 |
| Epstein-Barr virus infection | hsa05169 |
| FoxO signaling pathway | hsa04068 |
| Herpes simplex infection | hsa05168 |
| Pathways in cancer | hsa05200 |
| Small cell lung cancer | hsa05222 |
| Ubiquitin mediated proteolysis | hsa04120 |
| Viral carcinogenesis | hsa05203 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam12937 | 97-143 | F-box-like |
| cl02535 | 97-143 | F-box superfamily |
| smart00256 | 100-140 | FBOX |
| pfam00646 | 96-142 | F-box |
| cd09293 | 193-345 | AMN1 |
| cl23706 | 193-345 | AMN1 superfamily |
Ontology Information
| HPRD ID | 5895 |
|---|---|
| Molecular Class | Ubiquitin proteasome system protein |
| Molecular Function | ATPase activity (GO:0016887) |
| Biological Process | Metabolism (GO:0008152); Energy pathways (GO:0006091) |
Drug Information
No matching records could be found.