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General Information
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 18311777 | 2008 | Cell line : HT29 Source : - Sample Type : CRC tumor and normal tissues No. of Sample : 56 Stage : - | real-time PCR, Bisulfite sequencing | Methylation | - | BMP3 silencing as an early and frequent event in colorectal tumors progressing via the serrated and traditional pathways. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Bone morphogenetic proteins |
| Description | BMP3 belongs to the transforming growth factor-beta (TGFB) superfamily. Bone morphogenic protein, also known as osteogenin, induces bone formation. [provided by RefSeq, Jul 2008] |
| Chromosome | 4 |
| Location | 4q21 |
| Start | 81952119 |
| End | 81978685 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 26567 |
| OMIM ID | 112263 |
| HGNC ID | HGNC:1070 |
| Unigene ID | Hs.387411 |
| Ensembl ID | ENSG00000152785 |
| PharmGKB ID | PA25380 |
mRNA Information
| mRNA ID | XM_006714291.2 |
|---|---|
| Exon | join(1..979,15117..15928,22724..24603) | mRNA Sequence | Download Select all |
| Length | 3671 |
Protein Information
| Protein ID | XP_006714354.1 |
|---|---|
| Protein Name | bone morphogenetic protein 3 |
| Molecular Wt. (Da) | 49499 |
| Protein Sequence | Download Select all |
| Length | 439 |
| Uniprot ID | P39900 |
| Ensembl Protein ID | ENSP00000458585 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 1282 | COL4A1 | 359 | NP_001836.2 | in vitro | 2211625 |
| 1284 | COL4A2 | 355 | NP_001837.2 | in vitro | 2211625 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| smart00204 | 370-472 | TGFB |
| cl02510 | 370-472 | TGF_beta superfamily |
| pfam00019 | 367-472 | TGF_beta |
| PHA02913 | 370-471 | PHA02913 |
| pfam00688 | 23-238 | TGFb_propeptide |
| cl02928 | 23-238 | TGFb_propeptide superfamily |
Ontology Information
| HPRD ID | 2522 |
|---|---|
| Molecular Class | Ligand |
| Molecular Function | Metallopeptidase activity (GO:0008237) |
| Biological Process | Protein metabolism (GO:0019538) |
Drug Information
No matching records could be found.