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General Information
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 25227796 | 2014 | Cell line : - Source : Songklanagarind Hospital . Sample Type : Formalin-fixed paraffin embedded CRC tissue samples No. of Sample : 85 Stage : TNM Stage I-IV | Methylation specific PCR,immunohistochemistry | Hypermethylation | - | CpG island methylation of BMP6 is found in high frequency in CRC and this epigenetic event is associated with suppressed protein expression in the tumor tissue |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Bone morphogenetic proteins, "Endogenous ligands" |
| Description | The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. Based on its expression early in embryogenesis, the BMP encoded by this gene has a proposed role in early development. In addition, the fact that this BMP is closely related to BMP5 and BMP7 has lead to speculation of possible bone inductive activity. [provided by RefSeq, Jul 2008] |
| Chromosome | 6 |
| Location | 6p24-p23 |
| Start | 7727011 |
| End | 7881972 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 154962 |
| OMIM ID | 112266 |
| HGNC ID | HGNC:1073 |
| Unigene ID | Hs.285671 |
| Ensembl ID | ENSG00000153162 |
| PharmGKB ID | PA25383 |
mRNA Information
| mRNA ID | NM_001718.4 |
|---|---|
| Exon | join(1..842,118363..118555,134674..134822,135524..135721, 152297..152373,153214..153324,153417..154951) | mRNA Sequence | Download Select all |
| Length | 3105 |
Protein Information
| Protein ID | NP_001709.1 |
|---|---|
| Protein Name | bone morphogenetic protein 6 |
| Molecular Wt. (Da) | 54561 |
| Protein Sequence | Download Select all |
| Length | 513 |
| Uniprot ID | P45452 |
| Ensembl Protein ID | ENSP00000260302 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 92 | ACVR2A | 25 | NP_001607.1 | in vivo | 10504300 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Hippo signaling pathway | hsa04390 |
| Ovarian steroidogenesis | hsa04913 |
| TGF-beta signaling pathway | hsa04350 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| smart00204 | 412-513 | TGFB |
| cl02510 | 412-513 | TGF_beta superfamily |
| pfam00019 | 412-513 | TGF_beta |
| pfam00688 | 66-362 | TGFb_propeptide |
| cl02928 | 66-362 | TGFb_propeptide superfamily |
| PHA02913 | 404-512 | PHA02913 |
| pfam15252 | 82-199 | DUF4589 |
Ontology Information
| HPRD ID | 3775 |
|---|---|
| Molecular Class | Ligand |
| Molecular Function | Metallopeptidase activity (GO:0008237) |
| Biological Process | Protein metabolism (GO:0019538) |
Drug Information
No matching records could be found.