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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
SLC22A3 6581 solute carrier family 22 (organic cation transporter), member 3  6OCT3, EMT 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
18710896   2008Cell line : SW480, HCT116, HT29, Lovo.

Source : Japanese patients

Sample Type : -

No. of Sample : 6

Stage : -

Real time PCR,Cancer Profiling Array,Cytotoxicity Assay,TransfectionUp-regulation9.7 foldThe level of hOCT3 mRNA in the colon was 9.7-fold higher in cancerous than in normal tissues in six Japanese patients (P = 0.0247).


Gene Details



NC_000006.11 (160769405..160873613)

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Gene Type protein coding
Gene Family Solute carriers
Description Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein. [provided by RefSeq, Jul 2008]  
Chromosome 6
Location 6q25.3
Start 160769405  
End 160873613  
Strand +  
Gene Sequence

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Length 104209  
OMIM ID 604842   
HGNC ID HGNC:10967   
Unigene ID Hs.567337   
Ensembl ID ENSG00000146477   
PharmGKB ID PA330   

mRNA Information


mRNA ID ?NM_021977.3
Exon join(1..476,49607..49710,58669..58823,60381..60549, 62357..62474,88408..88505,88625..88839,94389..94497, 95258..95370,99347..99446,102624..104207)  
mRNA Sequence

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Length 3245  



CDS Information


   
Location48..1718
CDS Sequence

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CCDS ID CCDS5277.1



Protein Information


      
Protein IDNP_068812.1
Protein Namesolute carrier family 22 (organic cation transporter), member 3
Molecular Wt. (Da)0
Protein Sequence

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Length 556  
Uniprot IDQ9NR30
Ensembl Protein ID ENSP00000346120  



Post-translational Modification Information (Source : HPRD)


No matching records could be found.

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

No matching records from HPRD source could be found.

Pathway Information


      
Pathway Name Pathway ID
Choline metabolism in cancer hsa05231


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd06174149-518  MFS
cl21472149-518  MFS superfamily
cd06174145-289  MFS
cd06174350-518  MFS
TIGR00880173-269  2_A_01_02
TIGR0089812-528  2A0119
TIGR00879156-528  SP
pfam00083159-527  Sugar_tr
TIGR00895133-487  2A0115
pfam07690159-485  MFS_1
TIGR01299160-525  synapt_SV2
TIGR00891140-509  2A0112
PRK10077138-535  xylE
TIGR00887156-527  2A0109
TIGR00881140-267  2A0104
PRK11551163-470  PRK11551
TIGR00893163-516  2A0114
TIGR00710163-291  efflux_Bcr_CflA
COG2814159-286  AraJ
COG0477151-445  ProP


Ontology Information


   
HPRD ID5216
Molecular ClassTransport/cargo protein
Molecular FunctionMolecular function unknown (GO:0005554)
Biological ProcessBiological_process unknown (GO:0000004)  



SNP Information


View SNP Geneview Report   

Drug Information


Uniprot ID DrugBank ID Name Type
O75751DB00122CholineSmallMoleculeDrug
O75751DB00182AmphetamineSmallMoleculeDrug
O75751DB00184NicotineSmallMoleculeDrug
O75751DB00331MetforminSmallMoleculeDrug
O75751DB00368NorepinephrineSmallMoleculeDrug
O75751DB00396ProgesteroneSmallMoleculeDrug
O75751DB00457PrazosinSmallMoleculeDrug
O75751DB00458ImipramineSmallMoleculeDrug
O75751DB00501CimetidineSmallMoleculeDrug
O75751DB00526OxaliplatinSmallMoleculeDrug
O75751DB00536GuanidineSmallMoleculeDrug
O75751DB00541VincristineSmallMoleculeDrug
O75751DB00575ClonidineSmallMoleculeDrug
O75751DB00624TestosteroneSmallMoleculeDrug
O75751DB00667Histamine PhosphateSmallMoleculeDrug
O75751DB00709LamivudineSmallMoleculeDrug
O75751DB00718Adefovir DipivoxilSmallMoleculeDrug
O75751DB00762IrinotecanSmallMoleculeDrug
O75751DB00783EstradiolSmallMoleculeDrug
O75751DB00925PhenoxybenzamineSmallMoleculeDrug
O75751DB00988DopamineSmallMoleculeDrug
O75751DB01035ProcainamideSmallMoleculeDrug
O75751DB01042MelphalanSmallMoleculeDrug
O75751DB01151DesipramineSmallMoleculeDrug
O75751DB01394ColchicineSmallMoleculeDrug
O75751DB01577MethamphetamineSmallMoleculeDrug

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO