Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| SNAI2 | 6591 | snail family zinc finger 2 | 8 | SLUGH1, SNAIL2 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 25249558 | 2014 | Cell line : SW620 ,DLD1,HCT116 Source : - Sample Type : - No. of Sample : - Stage : - | miR145 luciferase promoter assay,invasion and migration assay. | Up-regulation | 2-fold | SNAI2:miR145 pathway may represent a novel clinical therapeutic target in colorectal cancer and may serve as a response predictor to chemoradiation therapy. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Snail homologs, "Zinc fingers, C2H2-type" |
| Description | This gene encodes a member of the Snail family of C2H2-type zinc finger transcription factors. The encoded protein acts as a transcriptional repressor that binds to E-box motifs and is also likely to repress E-cadherin transcription in breast carcinoma. This protein is involved in epithelial-mesenchymal transitions and has antiapoptotic activity. Mutations in this gene may be associated with sporatic cases of neural tube defects. [provided by RefSeq, Jul 2008] |
| Chromosome | 8 |
| Location | 8q11.21 |
| Start | 49830236 |
| End | 49833999 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 3764 |
| OMIM ID | 602150 |
| HGNC ID | HGNC:11094 |
| Unigene ID | Hs.360174 |
| Ensembl ID | ENSG00000019549 |
| PharmGKB ID | PA35945 |
mRNA Information
| mRNA ID | ?NM_003068.4 |
|---|---|
| Exon | join(1..254,1000..1545,2453..3764) | mRNA Sequence | Download Select all |
| Length | 2112 |
Protein Information
| Protein ID | NP_003059.1 |
|---|---|
| Protein Name | snail family zinc finger 2 |
| Molecular Wt. (Da) | 113727 |
| Protein Sequence | Download Select all |
| Length | 268 |
| Uniprot ID | O95970 |
| Ensembl Protein ID | ENSP00000360467 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Adherens junction | hsa04520 |
| Hippo signaling pathway | hsa04390 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam13465 | 200-223 | zf-H2C2_2 |
| cl22375 | 200-223 | zf-H2C2_2 superfamily |
| pfam13465 | 227-252 | zf-H2C2_2 |
| cl22375 | 227-252 | zf-H2C2_2 superfamily |
| COG5189 | 101-182 | SFP1 |
| COG5048 | 182-258 | COG5048 |
Ontology Information
| HPRD ID | 5332 |
|---|---|
| Molecular Class | Transcription factor |
| Molecular Function | Acyltransferase activity (GO:0008415) |
| Biological Process | Metabolism (GO:0008152); Energy pathways (GO:0006091) |
Drug Information
No matching records could be found.