Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| BMX | 660 | BMX non-receptor tyrosine kinase | X | ETK, PSCTK3 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
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- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 24709422 | 2014 | Cell line : HCT116, DLD 1 Source : ATCC Sample Type : - No. of Sample : - Stage : - | Western Blotting,RNA Interference,real time RT-PCR | Unknown | - | BMX is an antiapoptotic downstream effector of PI3K, independent of AKT. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Pleckstrin homology (PH) domain containing, "SH2 domain containing" |
| Description | This gene encodes a non-receptor tyrosine kinase belonging to the Tec kinase family. The protein contains a PH-like domain, which mediates membrane targeting by binding to phosphatidylinositol 3,4,5-triphosphate (PIP3), and a SH2 domain that binds to tyrosine-phosphorylated proteins and functions in signal transduction. The protein is implicated in several signal transduction pathways including the Stat pathway, and regulates differentiation and tumorigenicity of several types of cancer cells. Multiple alternatively spliced variants, encoding the same protein, have been identified.[provided by RefSeq, Sep 2009] |
| Chromosome | X |
| Location | Xp22.2 |
| Start | 15482356 |
| End | 15574652 |
| Strand | + |
| Gene Sequence |