Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| SNCA | 6622 | synuclein, alpha (non A4 component of amyloid precursor) | 4 | NACP, PD1, alpha-synuclein |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 25802477 | 2015 | Cell line : - Source : - Sample Type : Tissue and Stool sample No. of Sample : 89 DNA tissue samples (normal/cancer) and corresponding stool samples and 30 healthy stool samples Stage : - | methylation-specific PCR | Methylation | - | SNCA and FBN1 were significantly hypermethylated in CRC patients in tissue samples. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Parkinson disease |
| Description | Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Alternatively spliced transcripts encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2016] |
| Chromosome | 4 |
| Location | 4q21.3-q22 |
| Start | 90645250 |
| End | 90759447 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 114198 |
| OMIM ID | 163890 |
| HGNC ID | HGNC:11138 |
| Unigene ID | Hs.21374 |
| Ensembl ID | ENSG00000145335 |
| PharmGKB ID | PA35986 |
mRNA Information
| mRNA ID | ?NM_000345.3 |
|---|---|
| Exon | join(19..63,2623..2768,10131..10172,15927..16069, 109038..109121,111655..114216) | mRNA Sequence | Download Select all |
| Length | 3022 |
Protein Information
| Protein ID | NP_000336.1 |
|---|---|
| Protein Name | synuclein, alpha (non A4 component of amyloid precursor) |
| Molecular Wt. (Da) | 152334 |
| Protein Sequence | Download Select all |
| Length | 140 |
| Uniprot ID | O95395 |
| Ensembl Protein ID | ENSP00000379377 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 87 |
| S | Phosphorylation | 87 |
| S | Phosphorylation | 129 |
| S | Phosphorylation | 129 |
| S | Phosphorylation | 129 |
| Y | Phosphorylation | 125 |
| Y | Phosphorylation | 125 |
| Y | Phosphorylation | 125 |
| Y | Phosphorylation | 125 |
| Y | Phosphorylation | 133 |
| Y | Phosphorylation | 136 |
| Y | Phosphorylation | 108 |
| S | Phosphorylation | 129 |
| S | Phosphorylation | 129 |
| Y | Phosphorylation | 125 |
| S | Phosphorylation | 9 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 351 | APP | 100 | NP_000475.1 | in vitro | 9163350 |
| 801 | CALM1 | 241 | NP_008819.1 | in vitro | 12358748 |
| 4131 | MAP1B | 1139 | NP_005900.2 | in vitro;in vivo | 10764738 |
| 4137 | MAPT | 1142 | NP_001116538.1 | in vitro;in vivo | 10464279 |
| 4514 | MT-CO3 | 2471 | AAP90927.1 | in vitro;yeast 2-hybrid | 12059041 |
| 6531 | SLC6A3 | 543 | NP_001035.1 | in vivo;yeast 2-hybrid | 1 267 253 811 292 650 |
| 7314 | UBB | 6771 | NP_061828.1 | in vivo | 11603807 |
| 54205 | CYCS | 479 | NP_061820.1 | in vitro;in vivo | 10506125 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Alzheimer's disease | hsa05010 |
| Parkinson's disease | hsa05012 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam01387 | 1-132 | Synuclein |
| cl03193 | 1-132 | Synuclein superfamily |
Ontology Information
| HPRD ID | 11882 |
|---|---|
| Molecular Class | Chaperone |
| Molecular Function | Protein serine/threonine kinase activity (GO:0004674) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.