Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| SNCG | 6623 | synuclein, gamma (breast cancer-specific protein 1) | 10 | BCSG1, SR, persyn |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 10546834 | 1999 | Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : 217 Stage : - | - | Up-regulation | - | BCSG1 overexpressed in the resistant�colorectal�tumor cell line. |
| 22736138 | 2012 | Cell line : - Source : Tissue Bank and Department of Pathology, Peking University School of Oncology Sample Type : Serum and tissue sample No. of Sample : 32 serum samplesCRC and 17 formalin-fixed paraffin-embedded tumor tissue sections Stage : - | Immunohistochemistry | Up-regulation | - | SNCG may be used as a predictive biomarker for colorectal liver metastases and is an important prognostic factor in patients with liver metastasis from colorectal cancer. High expression of SNCG is present in the tumor tissue in patients with liver metastasis from colorectal cancer. |
| 18586385 | 2008 | Cell line : Colorectal and fibrosarcoma cell lines Source : - Sample Type : - No. of Sample : - Stage : - | ELISA,Western blotting,Immunoprecipitation,RT-PCR,Immunocytochemistry | Up-regulation | - | Elevated serum SNCG and overexpressed SNCG in tumor tissue from CRC patients suggest SNCG is a potential biomarker for CRC. Immunohistochemical results showed that SNCG was highly expressed in tumor cells of CRC patients, but was undetectable in the adjacent normal epithelium. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | |
| Description | This gene encodes a member of the synuclein family of proteins which are believed to be involved in the pathogenesis of neurodegenerative diseases. Mutations in this gene have also been associated with breast tumor development. |
| Chromosome | 10 |
| Location | 10q23.2-q2 |
| Start | 86958531 |
| End | 86963260 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 4730 |
| OMIM ID | 602998 |
| HGNC ID | HGNC:11141 |
| Unigene ID | Hs.349470 |
| Ensembl ID | ENSG00000173267 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_003087.2 |
|---|---|
| Exon | join(1..288,1103..1144,1471..1598,4074..4145,4435..4730) | mRNA Sequence | Download Select all |
| Length | 855 |
CDS Information
| Location | join(168..288,1103..1144,1471..1598,4074..4145,4435..4455) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS7380.1 |
Protein Information
| Protein ID | NP_003078.2 |
|---|---|
| Protein Name | synuclein, gamma (breast cancer-specific protein 1) |
| Molecular Wt. (Da) | 13200 |
| Protein Sequence | Download Select all |
| Length | 127 |
| Uniprot ID | P47928 |
| Ensembl Protein ID | ENSP00000367972 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 124 |
| S | Phosphorylation | 51 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 701 | BUB1B | 4176 | NP_001202.4 | in vitro;in vivo;yeast 2-hybrid | 14576821 |
| 5594 | MAPK1 | 1496 | NP_002736.3 | in vivo | 12121974 |
| 5595 | MAPK3 | 3479 | NP_002737.2 | in vivo | 12121974 |
| 5599 | MAPK8 | 3100 | NP_620637.1 | in vivo | 12121974 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam01387 | 1-112 | Synuclein |
| cl03193 | 1-112 | Synuclein superfamily |
Ontology Information
| HPRD ID | 974 |
|---|---|
| Molecular Class | Chaperone |
| Molecular Function | Cytokine activity (GO:0005125) |
| Biological Process | Immune response (GO:0006955) |
Drug Information
No matching records could be found.