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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
BNIP3 664 BCL2/adenovirus E1B 19kDa interacting protein 3  10Nip3 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
19956881   2010Cell line : -

Source : -

Sample Type : CRC tumor and normal tissues

No. of Sample : 27

Stage : -

PCR, Methylation specific PCRMethylation-BNIP3 gene methylation is a possible marker predicting a poor response to the S-1/CPT-11 combined therapy in colorectal cancer.


Gene Details



NC_000010.10 (133781204..133795435, complement)

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Gene Type protein coding
Gene Family -
Description This gene is encodes a mitochondrial protein that contains a BH3 domain and acts as a pro-apoptotic factor. The encoded protein interacts with anti-apoptotic proteins, including the E1B 19 kDa protein and Bcl2. This gene is silenced in tumors by DNA methylation. [provided by RefSeq, Dec 2014]  
Chromosome 10
Location 10q26.3
Start 133781204  
End 133795435  
Strand -  
Gene Sequence

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Length 14232  
OMIM ID 603293   
HGNC ID HGNC:1084   
Unigene ID Hs.144873   
Ensembl ID ENSG00000176171   
PharmGKB ID PA25394   

mRNA Information


mRNA ID XM_006717914.2
Exon complement(<12034..12387)  
mRNA Sequence

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Length 1651  



CDS Information


   
Location216..1325
CDS Sequence

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CCDS ID -



Protein Information


      
Protein IDXP_006717977.1
Protein NameBCL2/adenovirus E1B 19kDa interacting protein 3
Molecular Wt. (Da)42210
Protein Sequence

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Length 369  
Uniprot IDP43246
Ensembl Protein ID ENSP00000233146  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation86
SPhosphorylation93
TPhosphorylation140
TPhosphorylation142
TPhosphorylation148
SPhosphorylation149

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                          
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
596BCL21045NP_000624.2in vitro;in vivo;yeast 2-hybrid10625696   
598BCL2L12497NP_612815.1in vitro;in vivo;yeast 2-hybrid10625696   
665BNIP3L7288NP_004322.1yeast 2-hybrid16189514   
961CD473017NP_001768.1in vitro;in vivo;yeast 2-hybrid12690108   
4686NCBP12717NP_002477.1yeast 2-hybrid7478990   
8834TMEM1112680NP_003867.1yeast 2-hybrid16189514   


Pathway Information


            
Pathway Name Pathway ID
FoxO signaling pathway hsa04068
Legionellosis hsa05134


Structure Information


No matching records could be found.

Domain Information




ID Location Description
pfam065531-192  BNIP3
cl058571-192  BNIP3 superfamily


Ontology Information


   
HPRD ID2931
Molecular ClassUnclassified
Molecular FunctionDNA repair protein (GO:0003685)
Biological ProcessRegulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO