Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| BNIP3 | 664 | BCL2/adenovirus E1B 19kDa interacting protein 3  | 10 | Nip3  |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 19956881    | 2010 | Cell line : - Source : - Sample Type : CRC tumor and normal tissues No. of Sample : 27 Stage : - | PCR, Methylation specific PCR | Methylation | - | BNIP3 gene methylation is a possible marker predicting a poor response to the S-1/CPT-11 combined therapy in colorectal cancer. |
Gene Details

| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene is encodes a mitochondrial protein that contains a BH3 domain and acts as a pro-apoptotic factor. The encoded protein interacts with anti-apoptotic proteins, including the E1B 19 kDa protein and Bcl2. This gene is silenced in tumors by DNA methylation. [provided by RefSeq, Dec 2014]   |
| Chromosome | 10 |
| Location | 10q26.3 |
| Start | 133781204   |
| End | 133795435   |
| Strand | -   |
| Gene Sequence |    Download   Select all |
| Length | 14232   |
| OMIM ID | 603293    |
| HGNC ID | HGNC:1084    |
| Unigene ID | Hs.144873    |
| Ensembl ID | ENSG00000176171    |
| PharmGKB ID | PA25394    |
mRNA Information
| mRNA ID | XM_006717914.2 |
|---|---|
| Exon | complement(<12034..12387)   | mRNA Sequence |    Download   Select all |
| Length | 1651   |
CDS Information
| Location | 216..1325 |
|---|---|
| CDS Sequence |    Download   Select all |
| CCDS ID | - |    
Protein Information
| Protein ID | XP_006717977.1 |
|---|---|
| Protein Name | BCL2/adenovirus E1B 19kDa interacting protein 3 |
| Molecular Wt. (Da) | 42210 |
| Protein Sequence |    Download   Select all |
| Length | 369   |
| Uniprot ID | P43246 |    
| Ensembl Protein ID | ENSP00000233146   |    
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 86 |
| S | Phosphorylation | 93 |
| T | Phosphorylation | 140 |
| T | Phosphorylation | 142 |
| T | Phosphorylation | 148 |
| S | Phosphorylation | 149 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING)      View   
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 596 |    BCL2 |    1045 |    NP_000624.2 |    in vitro;in vivo;yeast 2-hybrid |    10625696    |
| 598 |    BCL2L1 |    2497 |    NP_612815.1 |    in vitro;in vivo;yeast 2-hybrid |    10625696    |
| 665 |    BNIP3L |    7288 |    NP_004322.1 |    yeast 2-hybrid |    16189514    |
| 961 |    CD47 |    3017 |    NP_001768.1 |    in vitro;in vivo;yeast 2-hybrid |    12690108    |
| 4686 |    NCBP1 |    2717 |    NP_002477.1 |    yeast 2-hybrid |    7478990    |
| 8834 |    TMEM11 |    12680 |    NP_003867.1 |    yeast 2-hybrid |    16189514    |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| FoxO signaling pathway |    hsa04068 |    
| Legionellosis |    hsa05134 |    
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam06553 | 1-192  | BNIP3 |
| cl05857 | 1-192  | BNIP3 superfamily |
Ontology Information
| HPRD ID | 2931 |    
|---|---|
| Molecular Class | Unclassified |
| Molecular Function | DNA repair protein (GO:0003685) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219)   |
Drug Information
No matching records could be found.
External Links
| ArrayExpress | GO |    
|---|---|
| ICGC | GO |    
| Cancer3D | GO |    
| COSMIC | GO |    
| NCG | GO |    
| TSGene | GO |    
| Tumor Gene Family of Databases | GO |    
| CCDB | GO |    
| G2SBC | GO |    
| Osteosarcoma Database | GO |    
| RCDB | GO |    
