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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
SOS1 6654 son of sevenless homolog 1 (Drosophila)  2HGF, GF1 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
23756862   2013Cell line : -

Source : -

Sample Type : -

No. of Sample : -

Stage : -

 Immunohistochemistry,Tissue microarrayUnknown--


Gene Details



NC_000002.11 (39208690..39347686, complement)

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Gene Type protein coding
Gene Family Rho guanine nucleotide exchange factors, "Pleckstrin homology (PH) domain containing"
Description This gene encodes a protein that is a guanine nucleotide exchange factor for RAS proteins, membrane proteins that bind guanine nucleotides and participate in signal transduction pathways. GTP binding activates and GTP hydrolysis inactivates RAS proteins. The product of this gene may regulate RAS proteins by facilitating the exchange of GTP for GDP. Mutations in this gene are associated with gingival fibromatosis 1 and Noonan syndrome type 4. [provided by RefSeq, Jul 2008]  
Chromosome 2
Location 2p21
Start 39208690  
End 39347686  
Strand -  
Gene Sequence

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Length 138997  
OMIM ID 182530   
HGNC ID HGNC:11187   
Unigene ID Hs.709893   
Ensembl ID ENSG00000115904   
PharmGKB ID PA36024   

mRNA Information


mRNA ID ?NM_005633.3
Exon join(4282..4409,56992..57117,65941..66072,67879..68043, 69922..70131,73458..73601,89245..89355,89435..89533, 100608..100735,101520..102175,109899..109980, 110756..110878,111182..111285,112397..112619, 114042..114161,117552..117714,118216..118333, 127320..127492,127707..127823,129358..129622, 135431..135475,137154..137272,138430..143196)  
mRNA Sequence

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Length 8331  



CDS Information


   
Location 42..4043
CDS Sequence

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CCDS ID CCDS1802.1



Protein Information


      
Protein IDNP_005624.2
Protein Nameson of sevenless homolog 1 (Drosophila)
Molecular Wt. (Da)34179
Protein Sequence

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Length 1333  
Uniprot IDQ12904
Ensembl Protein ID ENSP00000350699  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation1082
SPhosphorylation1210
SPhosphorylation1167
SPhosphorylation1193
SPhosphorylation1178
SPhosphorylation1132
SPhosphorylation1197
SPhosphorylation1134
SPhosphorylation1137
SPhosphorylation1078
SPhosphorylation1275

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                                                                                                                                                                                                                             
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
274BIN13150NP_647593.1in vitro9182529   
529ATP6V1E1163NP_001687.1in vitro;in vivo11560919   
1398CRK1267NP_058431.2in vitro;in vivo8810325   
1956EGFR579NP_005219.2in vivo9447973   
2059EPS82563NP_004438.3in vitro10499589   
2064ERBB21281NP_004439.2in vitro;in vivo11173924   
2260FGFR1634NP_000595.1in vivo9480847   
2534FYN655NP_002028.1in vitro9856337   
2885GRB2150NP_002077.1in vitro;in vivo84   935   798   479   541   100   000   000   000   000   000   000   000   000   000   
3055HCK796NP_002101.2in vitro12029088   
4582MUC11152P15941in vivo112   788   687   664   271   
5296PIK3R24404NP_005018.1in vitro;in vivo9651378   
5335PLCG11398NP_002651.2in vitro10913276   
6237RRAS1299NP_006261.1in vivo11560935   
7462LAT29304NP_071323.1in vitro12486104   
7535ZAP701495NP_001070.2in vitro;in vivo7629168   
10048RANBP94835NP_005484.2in vitro12147692   
54869EPS8L113276NP_573441.2in vitro14565974   
64787EPS8L210940BAB15180.1in vitro14565974   


Pathway Information


                                                                                                                                                                                                            
Pathway Name Pathway ID
Acute myeloid leukemia hsa05221
Alcoholism hsa05034
B cell receptor signaling pathway hsa04662
Chemokine signaling pathway hsa04062
Choline metabolism in cancer hsa05231
Chronic myeloid leukemia hsa05220
Dorso-ventral axis formation hsa04320
Endometrial cancer hsa05213
ErbB signaling pathway hsa04012
Estrogen signaling pathway hsa04915
Fc epsilon RI signaling pathway hsa04664
Focal adhesion hsa04510
FoxO signaling pathway hsa04068
Gap junction hsa04540
Glioma hsa05214
GnRH signaling pathway hsa04912
Hepatitis C hsa05160
Insulin signaling pathway hsa04910
Jak-STAT signaling pathway hsa04630
MAPK signaling pathway hsa04010
MicroRNAs in cancer hsa05206
Natural killer cell mediated cytotoxicity hsa04650
Neurotrophin signaling pathway hsa04722
Non-small cell lung cancer hsa05223
Pathways in cancer hsa05200
Phospholipase D signaling pathway hsa04072
PI3K-Akt signaling pathway hsa04151
Prolactin signaling pathway hsa04917
Prostate cancer hsa05215
Proteoglycans in cancer hsa05205
Ras signaling pathway hsa04014
Regulation of actin cytoskeleton hsa04810
Renal cell carcinoma hsa05211
T cell receptor signaling pathway hsa04660


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd00155776-1015  RasGEF
cl02485776-1015  RasGEF superfamily
cd01261439-545  PH_SOS
cl17171439-545  PH-like superfamily
cd00160201-388  RhoGEF
cl02571201-388  RhoGEF superfamily
cd06224605-739  REM
cl02520605-739  REM superfamily
smart00147776-1020  RasGEF
pfam00617777-963  RasGEF
smart00229597-741  RasGEFN
smart00325204-389  RhoGEF
pfam00618600-717  RasGEF_N
cd01224419-542  PH_Collybistin_ASEF
pfam00621213-383  RhoGEF
smart00233444-546  PH
pfam00169445-546  PH
pfam0012597-169  Histone
cl0007497-169  H2A superfamily
cd13243411-538  PH_PLEKHG1_G2_G3
cd00821446-541  PH
COG526284-177  HTA1
smart0041497-176  H2A
cd13389443-541  PH1_FGD5_FGD6
cd01218444-541  PH_Phafin2-like
cd0007497-177  H2A
cd13328447-541  PH1_FDG_family
PLN0015497-172  PLN00154
cd13388452-541  PH1_FGD1-4_like
cd01223455-541  PH_Vav
cd13239457-548  PH_Obscurin
cd13246424-545  PH_Scd1
cd01226444-541  PH_RalBD_exo84
cd01257448-545  PH_IRS
cd13387444-538  PH1_FGD3
cd13240458-541  PH1_Kalirin_Trio_like
cd13309512-541  PH_SKIP
cd15791444-541  PH1_FDG4
cd01220443-541  PH1_FARP1-like
PTZ004491018-1319  PTZ00449
PTZ0001797-172  PTZ00017
PLN0015397-172  PLN00153
PLN0015697-172  PLN00156
PHA032471017-1325  PHA03247
PLN0015797-172  PLN00157
PHA032471018-1307  PHA03247


Ontology Information


   
HPRD ID5288
Molecular ClassGuanine nucleotide exchange factor
Molecular FunctionProtein serine/threonine kinase activity (GO:0004674)
Biological ProcessCell communication (GO:0007154); Signal transduction (GO:0007165)  



SNP Information


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Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO