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General Information
- Evidence
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 25010701 | 2014 | Cell line : Caco2 Source : Ume University Hospital, Sweden. Sample Type : CRC tumor and normal tissue No. of Sample : 441 Stage : - | Immunohistochemistry,RT-PCR,Western blotting,Digital droplet PCR | Up-regulation | - | SOX2 expression is partly regulated by BRAF signalling, and an increased SOX2 expression may promote CRC metastasis. |
| 25868860 | 2015 | Cell line : Lovo, SW620, HT29, SW480, HCT116, LS174T , HEK 293 Source : Nanfang Hospital, Shanghai Cell Bank of Type Culture Collection. Sample Type : CRC tumor and normal tissue No. of Sample : 100 Stage : - | Plate colony formation, cell invasion assays,Self-renewal assay,real time RT-PCR,Luciferase assay,Chromatin immunoprecipitation assay,Immunofluorescence and immunoblotting | Up-regulation | - | SOX2 expression were observed in CRC cell lines and tissues. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | SRY (sex determining region Y)-boxes |
| Description | This intronless gene encodes a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The product of this gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. Mutations in this gene have been associated with optic nerve hypoplasia and with syndromic microphthalmia, a severe form of structural eye malformation. This gene lies within an intron of another gene called SOX2 overlapping transcript (SOX2OT). [provided by RefSeq, Jul 2008] |
| Chromosome | 3 |
| Location | 3q26.3-q27 |
| Start | 181429712 |
| End | 181432224 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 2513 |
| OMIM ID | 184429 |
| HGNC ID | HGNC:11195 |
| Unigene ID | Hs.518438 |
| Ensembl ID | - |
| PharmGKB ID | PA36032 |
Protein Information
| Protein ID | NP_003097.1 |
|---|---|
| Protein Name | SRY (sex determining region Y)-box 2 |
| Molecular Wt. (Da) | 47132 |
| Protein Sequence | Download Select all |
| Length | 317 |
| Uniprot ID | P49137 |
| Ensembl Protein ID | ENSP00000294981 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 249 |
| S | Phosphorylation | 250 |
| S | Phosphorylation | 251 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 2516 | NR5A1 | 1702 | NP_004950.2 | in vitro | 12732652 |
| 5460 | POU5F1 | 1252 | NP_002692.2 | in vitro | 12923055 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Hippo signaling pathway | hsa04390 |
| Signaling pathways regulating pluripotency of stem cells | hsa04550 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd01388 | 40-111 | SOX-TCF_HMG-box |
| cl00082 | 40-111 | HMG-box superfamily |
| pfam00505 | 41-109 | HMG_box |
| smart00398 | 40-109 | HMG |
| pfam12336 | 110-200 | SOXp |
| cl13733 | 110-200 | SOXp superfamily |
| cd00084 | 41-106 | HMG-box |
| cd01389 | 40-115 | MATA_HMG-box |
| cd01390 | 42-104 | HMGB-UBF_HMG-box |
| pfam09011 | 38-109 | HMG_box_2 |
| PTZ00199 | 35-108 | PTZ00199 |
| COG5648 | 35-109 | NHP6B |
Ontology Information
| HPRD ID | 10409 |
|---|---|
| Molecular Class | Transcription factor |
| Molecular Function | Molecular function unknown (GO:0005554) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.