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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 25120833 | 2014 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | Immunohistochemistry, FISH | Up-regulation | - | Tissue microarray was performed from sections of 106 cases colorectal carcinomas. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Specificity protein transcription factors, "Zinc fingers, C2H2-type" |
| Description | This gene belongs to a family of Sp1 related genes that encode transcription factors that regulate transcription by binding to consensus GC- and GT-box regulatory elements in target genes. This protein contains a zinc finger DNA-binding domain and several transactivation domains, and has been reported to function as a bifunctional transcription factor that either stimulates or represses the transcription of numerous genes. Transcript variants encoding different isoforms have been described for this gene, and one has been reported to initiate translation from a non-AUG (AUA) start codon. Additional isoforms, resulting from the use of alternate downstream translation initiation sites, have also been noted. A related pseudogene has been identified on chromosome 13. [provided by RefSeq, Feb 2010] |
| Chromosome | 2 |
| Location | 2q31 |
| Start | 174771187 |
| End | 174830430 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 59244 |
| OMIM ID | 601804 |
| HGNC ID | HGNC:11208 |
| Unigene ID | Hs.531587 |
| Ensembl ID | ENSG00000172845 |
| PharmGKB ID | PA36045 |
mRNA Information
| mRNA ID | ?NM_001017371.4 |
|---|---|
| Exon | join(1..538,1150..1298,1829..1942,9471..10830, 46918..47110,52437..52633,55446..59244) | mRNA Sequence | Download Select all |
| Length | 6350 |
Protein Information
| Protein ID | NP_001017371.3 |
|---|---|
| Protein Name | Sp3 transcription factor |
| Molecular Wt. (Da) | 81854 |
| Protein Sequence | Download Select all |
| Length | 781 |
| Uniprot ID | Q96J94 |
| Ensembl Protein ID | ENSP00000245255 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| K | Sumoylation | 483 |
| K | Sumoylation | 52 |
| K | Sumoylation | 483 |
| K | Sumoylation | 52 |
| K | Sumoylation | 619 |
| K | Sumoylation | 551 |
| S | Phosphorylation | 73 |
| S | Phosphorylation | 563 |
| S | Phosphorylation | 566 |
| S | Phosphorylation | 495 |
| S | Phosphorylation | 498 |
| S | Phosphorylation | 646 |
| S | Phosphorylation | 578 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 1869 | E2F1 | 1806 | NP_005216.1 | in vitro;in vivo | 10547281 |
| 2033 | EP300 | 4078 | NP_001420.2 | in vitro | 12071960 |
| 3065 | HDAC1 | 3143 | NP_004955.2 | in vitro;in vivo | 12176973 |
| 5925 | RB1 | 1574 | NP_000312.2 | in vivo | 7732011 |
| 6667 | SP1 | 1796 | NP_612482.2 | in vivo | 9329821 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam13465 | 667-690 | zf-H2C2_2 |
| cl22375 | 667-690 | zf-H2C2_2 superfamily |
| pfam13465 | 637-664 | zf-H2C2_2 |
| cl22375 | 637-664 | zf-H2C2_2 superfamily |
| pfam00096 | 681-703 | zf-C2H2 |
| cl23491 | 681-703 | zf-C2H2 superfamily |
| pfam00096 | 651-675 | zf-C2H2 |
| cl23491 | 651-675 | zf-C2H2 superfamily |
| smart00355 | 681-703 | ZnF_C2H2 |
| cl18194 | 681-703 | ZnF_C2H2 superfamily |
| pfam13894 | 681-703 | zf-C2H2_4 |
| cl20498 | 681-703 | zf-C2H2_4 superfamily |
| smart00355 | 651-675 | ZnF_C2H2 |
| cl18194 | 651-675 | ZnF_C2H2 superfamily |
| pfam13894 | 651-675 | zf-C2H2_4 |
| cl20498 | 651-675 | zf-C2H2_4 superfamily |
| COG5048 | 636-718 | COG5048 |
Ontology Information
| HPRD ID | 5491 |
|---|---|
| Molecular Class | Transcription factor |
| Molecular Function | Receptor signaling complex scaffold activity (GO:0030159) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.