Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| SP4 | 6671 | Sp4 transcription factor | 7 | SPR-1, HF1B, MGC130008, MGC130009 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 15883203 | 2005 | Cell line : SW-480 ,RKO, HT-29,DLD Source : - Sample Type : - No. of Sample : - Stage : - | - | Degradation | - | Results suggest that the antiangiogenic activity of COX-2 inhibitors in colon cancer cells is linked to activation of proteasome-dependent degradation of Sp1 and Sp4 proteins. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Specificity protein transcription factors, "Zinc fingers, C2H2-type" |
| Description | - |
| Chromosome | 7 |
| Location | 7p15 |
| Start | 21467689 |
| End | 21554440 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 86752 |
| OMIM ID | 600540 |
| HGNC ID | HGNC:11209 |
| Unigene ID | Hs.88013 |
| Ensembl ID | ENSG00000105866 |
| PharmGKB ID | PA36046 |
mRNA Information
| mRNA ID | ?NM_003112.3 |
|---|---|
| Exon | join(1..188,607..722,1219..2773,49009..49237,53854..54053, 82952..86474) | mRNA Sequence | Download Select all |
| Length | 5811 |
Protein Information
| Protein ID | NP_003103.2 |
|---|---|
| Protein Name | Sp4 transcription factor |
| Molecular Wt. (Da) | 18023 |
| Protein Sequence | Download Select all |
| Length | 784 |
| Uniprot ID | Q9Y653 |
| Ensembl Protein ID | ENSP00000373465 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 691 |
| S | Phosphorylation | 136 |
| T | Phosphorylation | 138 |
| S | Phosphorylation | 767 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 1869 | E2F1 | 1806 | NP_005216.1 | in vitro;in vivo | 10547281 |
| 6667 | SP1 | 1796 | NP_612482.2 | in vitro | 7559627 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam13465 | 693-716 | zf-H2C2_2 |
| cl22375 | 693-716 | zf-H2C2_2 superfamily |
| pfam13465 | 663-690 | zf-H2C2_2 |
| cl22375 | 663-690 | zf-H2C2_2 superfamily |
| pfam00096 | 707-729 | zf-C2H2 |
| cl23491 | 707-729 | zf-C2H2 superfamily |
| pfam00096 | 677-701 | zf-C2H2 |
| cl23491 | 677-701 | zf-C2H2 superfamily |
| pfam13894 | 707-729 | zf-C2H2_4 |
| cl20498 | 707-729 | zf-C2H2_4 superfamily |
| smart00355 | 707-729 | ZnF_C2H2 |
| cl18194 | 707-729 | ZnF_C2H2 superfamily |
| smart00355 | 677-701 | ZnF_C2H2 |
| cl18194 | 677-701 | ZnF_C2H2 superfamily |
| COG4049 | 699-736 | COG4049 |
| cl20182 | 699-736 | COG4049 superfamily |
| pfam13894 | 677-701 | zf-C2H2_4 |
| cl20498 | 677-701 | zf-C2H2_4 superfamily |
| COG5048 | 662-733 | COG5048 |
| pfam09606 | 363-612 | Med15 |
Ontology Information
| HPRD ID | 5170 |
|---|---|
| Molecular Class | Transcription factor |
| Molecular Function | Molecular function unknown (GO:0005554) |
| Biological Process | Immune response (GO:0006955) |
Drug Information
No matching records could be found.