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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
SPP1 6696 secreted phosphoprotein 1  4BSPI, ETA-1 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
23251004   2013Cell line : -

Source : Beijing Cancer Hospital and Institute (Beijing, China)

Sample Type : -

No. of Sample : -

Stage : -

real time RT-PCR, Immunohistochemistry, tissue microarrays, immunofluorescence and Western blotting Up-regulation-OPN-CD44 interaction is important for colorectal cancer progression and could serve as a potential therapeutic target for the treatment of colorectal cancer.


Gene Details



Chromosome 4 - NC_000004.12 (87975650..87983411)

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Gene Type protein coding
Gene Family Endogenous ligands
Description The protein encoded by this gene is involved in the attachment of osteoclasts to the mineralized bone matrix. The encoded protein is secreted and binds hydroxyapatite with high affinity. The osteoclast vitronectin receptor is found in the cell membrane and may be involved in the binding to this protein. This protein is also a cytokine that upregulates expression of interferon-gamma and interleukin-12. Several transcript variants encoding different isoforms have been found for this gene.  
Chromosome 4
Location 4q22.1
Start 87975650  
End 87983411  
Strand +  
Gene Sequence

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Length 7762  
OMIM ID 166490   
HGNC ID HGNC:11255   
Unigene ID Hs.313   
Ensembl ID ENSG00000118785   
PharmGKB ID -   

mRNA Information


mRNA ID NM_001251830.1
Exon join(1..151,1233..1300,1410..1448,2013..2201,4397..4477, 4744..4785,5826..6149,6843..7762)  
mRNA Sequence

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Length 1616  



CDS Information


   
Location join(1247..1300,1410..1448,4397..4477,4744..4785, 5826..6149,6843..7247)
CDS Sequence

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CCDS ID CCDS43250.1



Protein Information


      
Protein IDNP_001238759.1
Protein Namesecreted phosphoprotein 1
Molecular Wt. (Da)37114
Protein Sequence

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Length 327  
Uniprot IDP50213
Ensembl Protein ID ENSP00000299518  



Post-translational Modification Information (Source : HPRD)


Residue Type site
RProteolytic Cleavage154
SDephosphorylation148
SPhosphorylation148
GProteolytic Cleavage152
DProteolytic Cleavage196
SPhosphorylation148
SPhosphorylation148
SPhosphorylation148
GProteolytic Cleavage152
AProteolytic Cleavage187
DProteolytic Cleavage196
RProteolytic Cleavage154
SPhosphorylation296
SPhosphorylation310
SPhosphorylation283
SPhosphorylation205
SPhosphorylation219
SPhosphorylation192
SPhosphorylation201
SPhosphorylation215
SPhosphorylation188
SPhosphorylation294
SPhosphorylation308
SPhosphorylation281
SPhosphorylation297
SPhosphorylation311
SPhosphorylation284
SPhosphorylation289
SPhosphorylation303
SPhosphorylation276
SPhosphorylation62
TPhosphorylation171
SPhosphorylation177
SPhosphorylation181
TPhosphorylation185
SPhosphorylation191
SPhosphorylation195
TPhosphorylation158
SPhosphorylation164
SPhosphorylation168
SPhosphorylation210
SPhosphorylation214
SPhosphorylation220
SPhosphorylation224
SPhosphorylation228
SPhosphorylation234
SPhosphorylation197
SPhosphorylation201
SPhosphorylation207
SPhosphorylation240
SPhosphorylation249
SPhosphorylation253
SPhosphorylation254
SPhosphorylation263
SPhosphorylation267
SPhosphorylation227
SPhosphorylation236
SPhosphorylation240
SPhosphorylation256
SPhosphorylation261
SPhosphorylation266
SPhosphorylation270
SPhosphorylation275
SPhosphorylation280
SPhosphorylation243
SPhosphorylation248
SPhosphorylation253
SPhosphorylation24
SPhosphorylation24
SPhosphorylation63
SPhosphorylation244
SPhosphorylation258
SPhosphorylation231
YPhosphorylation211
TPhosphorylation223
YPhosphorylation225
TPhosphorylation237
YPhosphorylation198
TPhosphorylation210
TPhosphorylation213
TPhosphorylation227
TPhosphorylation200

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                                                                       
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
960CD44115NP_000601.3in vitro1   065   730   112   377   940   
3488IGFBP5901NP_000590.1in vivo10698186   
3678ITGA5627NP_002196.2in vitro7592829   
3688ITGB1628NP_391987.1in vitro;in vivo10593924   
6449SGTA4568NP_003012.1yeast 2-hybrid16189514   
9260PDLIM710436NP_005442.2yeast 2-hybrid16189514   
55324ABCF312404NP_060828.2yeast 2-hybrid16169070   
56259CTNNBL110850NP_110517.2yeast 2-hybrid16189514   
56893UBQLN45670NP_064516.2yeast 2-hybrid16713569   


Pathway Information


                        
Pathway Name Pathway ID
ECM-receptor interaction hsa04512
Focal adhesion hsa04510
PI3K-Akt signaling pathway hsa04151
Toll-like receptor signaling pathway hsa04620


Structure Information


No matching records could be found.

Domain Information




ID Location Description
pfam0086520-314  Osteopontin
cl0242520-314  Osteopontin superfamily
smart0001717-314  OSTEO


Ontology Information


   
HPRD ID957
Molecular ClassAdhesion molecule
Molecular FunctionCytokine activity (GO:0005125)
Biological ProcessImmune response (GO:0006955)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO