Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| SPP1 | 6696 | secreted phosphoprotein 1  | 4 | BSPI, ETA-1  |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 23251004    | 2013 | Cell line : - Source : Beijing Cancer Hospital and Institute (Beijing, China) Sample Type : - No. of Sample : - Stage : - | real time RT-PCR, Immunohistochemistry, tissue microarrays, immunofluorescence and Western blotting | Up-regulation | - | OPN-CD44 interaction is important for colorectal cancer progression and could serve as a potential therapeutic target for the treatment of colorectal cancer. |
Gene Details

| Gene Type | protein coding |
|---|---|
| Gene Family | Endogenous ligands |
| Description | The protein encoded by this gene is involved in the attachment of osteoclasts to the mineralized bone matrix. The encoded protein is secreted and binds hydroxyapatite with high affinity. The osteoclast vitronectin receptor is found in the cell membrane and may be involved in the binding to this protein. This protein is also a cytokine that upregulates expression of interferon-gamma and interleukin-12. Several transcript variants encoding different isoforms have been found for this gene.   |
| Chromosome | 4 |
| Location | 4q22.1 |
| Start | 87975650   |
| End | 87983411   |
| Strand | +   |
| Gene Sequence |    Download   Select all |
| Length | 7762   |
| OMIM ID | 166490    |
| HGNC ID | HGNC:11255    |
| Unigene ID | Hs.313    |
| Ensembl ID | ENSG00000118785    |
| PharmGKB ID | -    |
mRNA Information
| mRNA ID | NM_001251830.1 |
|---|---|
| Exon | join(1..151,1233..1300,1410..1448,2013..2201,4397..4477, 4744..4785,5826..6149,6843..7762)   | mRNA Sequence |    Download   Select all |
| Length | 1616   |
CDS Information
| Location | join(1247..1300,1410..1448,4397..4477,4744..4785, 5826..6149,6843..7247) |
|---|---|
| CDS Sequence |    Download   Select all |
| CCDS ID | CCDS43250.1 |    
Protein Information
| Protein ID | NP_001238759.1 |
|---|---|
| Protein Name | secreted phosphoprotein 1 |
| Molecular Wt. (Da) | 37114 |
| Protein Sequence |    Download   Select all |
| Length | 327   |
| Uniprot ID | P50213 |    
| Ensembl Protein ID | ENSP00000299518   |    
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| R | Proteolytic Cleavage | 154 |
| S | Dephosphorylation | 148 |
| S | Phosphorylation | 148 |
| G | Proteolytic Cleavage | 152 |
| D | Proteolytic Cleavage | 196 |
| S | Phosphorylation | 148 |
| S | Phosphorylation | 148 |
| S | Phosphorylation | 148 |
| G | Proteolytic Cleavage | 152 |
| A | Proteolytic Cleavage | 187 |
| D | Proteolytic Cleavage | 196 |
| R | Proteolytic Cleavage | 154 |
| S | Phosphorylation | 296 |
| S | Phosphorylation | 310 |
| S | Phosphorylation | 283 |
| S | Phosphorylation | 205 |
| S | Phosphorylation | 219 |
| S | Phosphorylation | 192 |
| S | Phosphorylation | 201 |
| S | Phosphorylation | 215 |
| S | Phosphorylation | 188 |
| S | Phosphorylation | 294 |
| S | Phosphorylation | 308 |
| S | Phosphorylation | 281 |
| S | Phosphorylation | 297 |
| S | Phosphorylation | 311 |
| S | Phosphorylation | 284 |
| S | Phosphorylation | 289 |
| S | Phosphorylation | 303 |
| S | Phosphorylation | 276 |
| S | Phosphorylation | 62 |
| T | Phosphorylation | 171 |
| S | Phosphorylation | 177 |
| S | Phosphorylation | 181 |
| T | Phosphorylation | 185 |
| S | Phosphorylation | 191 |
| S | Phosphorylation | 195 |
| T | Phosphorylation | 158 |
| S | Phosphorylation | 164 |
| S | Phosphorylation | 168 |
| S | Phosphorylation | 210 |
| S | Phosphorylation | 214 |
| S | Phosphorylation | 220 |
| S | Phosphorylation | 224 |
| S | Phosphorylation | 228 |
| S | Phosphorylation | 234 |
| S | Phosphorylation | 197 |
| S | Phosphorylation | 201 |
| S | Phosphorylation | 207 |
| S | Phosphorylation | 240 |
| S | Phosphorylation | 249 |
| S | Phosphorylation | 253 |
| S | Phosphorylation | 254 |
| S | Phosphorylation | 263 |
| S | Phosphorylation | 267 |
| S | Phosphorylation | 227 |
| S | Phosphorylation | 236 |
| S | Phosphorylation | 240 |
| S | Phosphorylation | 256 |
| S | Phosphorylation | 261 |
| S | Phosphorylation | 266 |
| S | Phosphorylation | 270 |
| S | Phosphorylation | 275 |
| S | Phosphorylation | 280 |
| S | Phosphorylation | 243 |
| S | Phosphorylation | 248 |
| S | Phosphorylation | 253 |
| S | Phosphorylation | 24 |
| S | Phosphorylation | 24 |
| S | Phosphorylation | 63 |
| S | Phosphorylation | 244 |
| S | Phosphorylation | 258 |
| S | Phosphorylation | 231 |
| Y | Phosphorylation | 211 |
| T | Phosphorylation | 223 |
| Y | Phosphorylation | 225 |
| T | Phosphorylation | 237 |
| Y | Phosphorylation | 198 |
| T | Phosphorylation | 210 |
| T | Phosphorylation | 213 |
| T | Phosphorylation | 227 |
| T | Phosphorylation | 200 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING)      View   
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 960 |    CD44 |    115 |    NP_000601.3 |    in vitro |    1   065   730   112   377   940    |
| 3488 |    IGFBP5 |    901 |    NP_000590.1 |    in vivo |    10698186    |
| 3678 |    ITGA5 |    627 |    NP_002196.2 |    in vitro |    7592829    |
| 3688 |    ITGB1 |    628 |    NP_391987.1 |    in vitro;in vivo |    10593924    |
| 6449 |    SGTA |    4568 |    NP_003012.1 |    yeast 2-hybrid |    16189514    |
| 9260 |    PDLIM7 |    10436 |    NP_005442.2 |    yeast 2-hybrid |    16189514    |
| 55324 |    ABCF3 |    12404 |    NP_060828.2 |    yeast 2-hybrid |    16169070    |
| 56259 |    CTNNBL1 |    10850 |    NP_110517.2 |    yeast 2-hybrid |    16189514    |
| 56893 |    UBQLN4 |    5670 |    NP_064516.2 |    yeast 2-hybrid |    16713569    |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| ECM-receptor interaction |    hsa04512 |    
| Focal adhesion |    hsa04510 |    
| PI3K-Akt signaling pathway |    hsa04151 |    
| Toll-like receptor signaling pathway |    hsa04620 |    
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam00865 | 20-314  | Osteopontin |
| cl02425 | 20-314  | Osteopontin superfamily |
| smart00017 | 17-314  | OSTEO |
Ontology Information
| HPRD ID | 957 |    
|---|---|
| Molecular Class | Adhesion molecule |
| Molecular Function | Cytokine activity (GO:0005125) |
| Biological Process | Immune response (GO:0006955)   |
Drug Information
No matching records could be found.
External Links
| ArrayExpress | GO |    
|---|---|
| ICGC | GO |    
| Cancer3D | GO |    
| COSMIC | GO |    
| NCG | GO |    
| TSGene | GO |    
| Tumor Gene Family of Databases | GO |    
| CCDB | GO |    
| G2SBC | GO |    
| Osteosarcoma Database | GO |    
| RCDB | GO |    
