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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
SPTAN1 6709 spectrin, alpha, non-erythrocytic 1  9- 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
24456667   2014Cell line : HCT116, SW480, LoVo

Source : -

Sample Type : Fresh and paraffin embedded colon cancer tissue

No. of Sample : 12

Stage : -

Transient transfection,Western blotting,Coimmunoprecipitation,Immunohistochemistry,Migration assayDown-regulation- SPTAN1 levels decreased in concordance with MLH1 reduction and impaired cellular mobility in MLH1 deficient colon cancer cells.


Gene Details



NC_000009.11 (131314837..131395944)

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Gene Type protein coding
Gene Family EF-hand domain containing
Description Spectrins are a family of filamentous cytoskeletal proteins that function as essential scaffold proteins that stabilize the plasma membrane and organize intracellular organelles. Spectrins are composed of alpha and beta dimers that associate to form tetramers linked in a head-to-head arrangement. This gene encodes an alpha spectrin that is specifically expressed in nonerythrocytic cells. The encoded protein has been implicated in other cellular functions including DNA repair and cell cycle regulation. Mutations in this gene are the cause of early infantile epileptic encephalopathy-5. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Sep 2010]  
Chromosome 9
Location 9q34.11
Start 131314837  
End 131395944  
Strand +  
Gene Sequence

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Length 81108  
OMIM ID 182810   
HGNC ID HGNC:11273   
Unigene ID Hs.372331   
Ensembl ID ENSG00000197694   
PharmGKB ID PA36102   

mRNA Information


mRNA ID ?NM_001130438.2
Exon join(1..139,14181..14420,16215..16340,22118..22258, 22642..22788,24266..24399,24572..24716,24795..24949, 25553..25688,27080..27181,28365..28502,29225..29335, 29922..29999,30137..30292,30520..30724,31231..31412, 31725..31968,32164..32286,33191..33408,35049..35141, 36252..36386,38920..39068,40426..40485,41618..41816, 45843..45947,46406..46429,47523..47558,50986..51033, 51769..51860,52477..52621,52739..52920,55047..55146, 55295..55492,55573..55719,56317..56420,56565..56727, 57094..57108,59157..59288,59552..59689,60824..60928, 63075..63283,65083..65203,65430..65551,66314..66446, 68601..68699,71771..71930,72546..72622,73212..73421, 73834..74130,74829..74941,75368..75385,77764..77818, 79570..79766,79874..79927,80015..80161  
mRNA Sequence

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Length 7907  



CDS Information


   
Location143..7576
CDS Sequence

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CCDS ID CCDS48036.1



Protein Information


      
Protein IDNP_001123910.1
Protein Namespectrin, alpha, non-erythrocytic 1
Molecular Wt. (Da)74194
Protein Sequence

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Length 2472  
Uniprot IDQ01151
Ensembl Protein ID ENSP00000368450  



Post-translational Modification Information (Source : HPRD)


Residue Type site
YPhosphorylation1073
SPhosphorylation1323
YPhosphorylation1176
YDephosphorylation1176
YProteolytic Cleavage1176
YPhosphorylation2423;-
SPhosphorylation1217
KAcetylation2052
KAcetylation2421
KAcetylation1519
KAcetylation637
KAcetylation613
KAcetylation779
KAcetylation592
KAcetylation2426
KAcetylation1022
SPhosphorylation1031
SPhosphorylation1041
SPhosphorylation2138
SPhosphorylation2139
TPhosphorylation196
YPhosphorylation766
SPhosphorylation1029
YPhosphorylation644
TPhosphorylation667
SPhosphorylation783
SPhosphorylation940
YPhosphorylation978
SPhosphorylation982
SPhosphorylation999
SPhosphorylation1190
YPhosphorylation1411
SPhosphorylation1413
SPhosphorylation1647
SPhosphorylation1075

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                                                                                                                                                                 
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
60ACTB32NP_001092.1in vivo9209005   
836CASP32799NP_004337.2in vitro9811849   
1495CTNNA1285NP_001894.2in vitro;in vivo11069925   
1674DES514NP_001918.3in vitro2939097   
2035EPB41558AAD42222.1in vivo12049649   
2038EPB421517NP_000110.2in vitro12049649   
2072ERCC4594NP_005227.1in vitro11401546   
2596GAP431198NP_001123536.1in vivo10521589   
4747NEFL1206NP_006149.2in vitro19   026   663   121   319   
5579PRKCB1499NP_002729.2in vivo8163551   
6711SPTBN11683NP_003119.2in vitro;in vivo12820899   
10078TSSC410357NP_005697.2yeast 2-hybrid16169070   
26136TES5833NP_056456.1in vivo;yeast 2-hybrid15656790   
53635PTOV117929NP_059128.2yeast 2-hybrid16169070   
57062DDX245860NP_065147.1yeast 2-hybrid16169070   


Pathway Information


      
Pathway Name Pathway ID
Tight junction hsa04530


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd00176679-890  SPEC
cl02488679-890  SPEC superfamily
cd00176150-361  SPEC
cl02488150-361  SPEC superfamily
cd001761765-1974  SPEC
cl024881765-1974  SPEC superfamily
cd001761234-1445  SPEC
cl024881234-1445  SPEC superfamily
cd001761446-1658  SPEC
cl024881446-1658  SPEC superfamily
cd00176468-678  SPEC
cl02488468-678  SPEC superfamily
cd001761092-1339  SPEC
cl024881092-1339  SPEC superfamily
cd00176362-572  SPEC
cl02488362-572  SPEC superfamily
cd001761871-2082  SPEC
cl024881871-2082  SPEC superfamily
cd11808971-1023  SH3_Alpha_Spectrin
cl17036971-1023  SH3 superfamily
cd001761978-2196  SPEC
cl024881978-2196  SPEC superfamily
cd0017612-148  SPEC
cl0248812-148  SPEC superfamily
cd001762096-2312  SPEC
cl024882096-2312  SPEC superfamily
cd000512327-2395  EFh
cl083022327-2395  EFh superfamily
cd00176256-467  SPEC
cd00176785-975  SPEC
cd001761659-1870  SPEC
cd0017645-254  SPEC
cd00176574-784  SPEC
cd001761340-1550  SPEC
cd001761553-1764  SPEC
pfam00435784-888  Spectrin
pfam004351764-1868  Spectrin
smart00150787-887  SPEC
pfam004351233-1337  Spectrin
pfam00435678-782  Spectrin
pfam00435258-359  Spectrin
smart00150153-251  SPEC
pfam00435149-251  Spectrin
smart001501236-1335  SPEC
smart001501767-1867  SPEC
smart00150258-358  SPEC
pfam00435468-571  Spectrin
smart00150681-780  SPEC
pfam004351658-1762  Spectrin
cl024881658-1762  SPEC superfamily
pfam004351445-1549  Spectrin
pfam004351870-1974  Spectrin
smart001501448-1547  SPEC
pfam0043544-147  Spectrin
pfam00435574-676  Spectrin
pfam00435361-465  Spectrin
pfam004351978-2081  Spectrin
smart001501873-1973  SPEC
smart00150470-569  SPEC
smart00150576-674  SPEC
smart001501661-1761  SPEC
pfam004351339-1438  Spectrin
smart0015049-145  SPEC
smart00150364-464  SPEC
smart001501342-1442  SPEC
cd00176891-1233  SPEC
smart001501554-1655  SPEC
pfam004351553-1656  Spectrin
smart001501980-2079  SPEC
smart00326968-1022  SH3
smart001501096-1229  SPEC
cd00174974-1020  SH3
pfam004351094-1229  Spectrin
pfam00018974-1018  SH3_1
pfam00435890-971  Spectrin
cl02488890-971  SPEC superfamily
cd11805971-1023  SH3_GRB2_like_C
pfam004352092-2194  Spectrin
pfam004352205-2310  Spectrin
pfam14604974-1022  SH3_9
smart00150893-971  SPEC
cd11845971-1020  SH3_Src_like
cd11888972-1020  SH3_ARHGAP9_like
cd11812972-1021  SH3_AHI-1
cd11833974-1023  SH3_Stac_1
cd11809971-1021  SH3_srGAP
cd11772974-1021  SH3_OSTF1
cd11775970-1022  SH3_Sla1p_3
cd11956973-1021  SH3_srGAP4
cd11842972-1022  SH3_Ysc84p_like
cd11769972-1023  SH3_CSK
cd11996972-1022  SH3_Intersectin2_5
cd11768971-1023  SH3_Tec_like
cd11786974-1022  SH3_SH3RF_1
cd11964972-1021  SH3_STAM1
cd11800972-1023  SH3_DNMBP_C2_like
cd11840972-1022  SH3_Intersectin_5
cd11849974-1022  SH3_SPIN90
cd11856974-1023  SH3_p47phox_like
cd11773971-1020  SH3_Sla1p_1
cd11908971-1021  SH3_ITK
cd11995972-1022  SH3_Intersectin1_5
cd11828971-1022  SH3_ARHGEF9_like
cd12046971-1022  SH3_p67phox_C
cd11782974-1022  SH3_Sorbs_2
cd11928974-1022  SH3_SH3RF3_1
cd11875974-1022  SH3_CD2AP-like_3
cd11824973-1023  SH3_PSTPIP1
cd12142975-1021  SH3_D21-like
cd11803974-1021  SH3_Endophilin_A
cd11953971-1017  SH3_ASPP2
cd11920974-1024  SH3_Sorbs2_1
smart001502096-2194  SPEC
cd11841972-1022  SH3_SH3YL1_like
cd11823974-1021  SH3_Nostrin
cd12007973-1025  SH3_Yes
cd11873972-1023  SH3_CD2AP-like_1
cd11985973-1023  SH3_Stac2_C
cd11781974-1021  SH3_Sorbs_1
cd12009972-1021  SH3_Blk
cd11869974-1022  SH3_p40phox
cd11951972-1021  SH3_GRAP_C
cd11975974-1022  SH3_ARHGEF9
cd11858974-1022  SH3_Myosin-I_fungi
cd11877971-1022  SH3_PIX
cd11765971-1021  SH3_Nck_1
cd11804974-1021  SH3_GRB2_like_N
cd11974974-1022  SH3_ASEF2
cd12006971-1021  SH3_Fyn_Yrk
cd12141974-1023  SH3_DNMBP_C2
pfam07653974-1023  SH3_2
cd11978971-1023  SH3_VAV3_2
cd11954971-1017  SH3_ASPP1
cd11955973-1021  SH3_srGAP1-3
cd12057975-1024  SH3_CIN85_3
cd11963972-1021  SH3_STAM2
cd11820972-1023  SH3_STAM
cd11946973-1022  SH3_GRB2_N
cd11764971-1017  SH3_Eps8
cd11830973-1023  SH3_VAV_2
cd11774972-1021  SH3_Sla1p_2
cd11949972-1022  SH3_GRB2_C
cd11911974-1022  SH3_CIP4-like
cd12008973-1021  SH3_Src
cd11878974-1020  SH3_Bem1p_1
cd12143974-1020  SH3_ARHGAP9
cd12002974-1024  SH3_NEDD9
cd12074971-1021  SH3_Tks5_1
cd11763971-1021  SH3_SNX9_like
cd11806972-1021  SH3_PRMT2
cd12070976-1024  SH3_ARHGAP12
cd11948973-1022  SH3_GRAP_N
cd11927974-1022  SH3_SH3RF1_1
cd12015977-1023  SH3_Tks_1
cd11960974-1022  SH3_Abp1_eu
cd12003970-1024  SH3_EFS
cd11952972-1020  SH3_iASPP
cd11906972-1021  SH3_BTK
cd11921976-1024  SH3_Vinexin_1
cd12001971-1024  SH3_BCAR1
cd11950972-1022  SH3_GRAP2_C
cd11973974-1022  SH3_ASEF
cd11758970-1023  SH3_CRK_N
cd11897974-1022  SH3_SNX18
cd11807972-1017  SH3_ASPP
cd11817972-1020  SH3_Eve1_4
cd12076970-1023  SH3_Tks4_2
cd11826972-1021  SH3_Abi
cd11992973-1022  SH3_Intersectin2_3
cd11844974-1022  SH3_CAS
cd12058974-1021  SH3_MLK4
cd11912974-1022  SH3_Bzz1_1
cd12021974-1022  SH3_p47phox_1
cd12004971-1025  SH3_Lyn
cd11959974-1022  SH3_Cortactin
cd12000971-1018  SH3_CASS4
cd11969972-1024  SH3_PLCgamma2
cd12011973-1024  SH3_SLAP2
cd11864974-1022  SH3_PEX13_eumet
cd11851971-1023  SH3_RIM-BP
cd11770971-1023  SH3_Nephrocystin
cd11762971-1021  SH3_FCHSD_2
cd11905970-1021  SH3_Tec
cd11929974-1022  SH3_SH3RF2_1
cd12073973-1022  SH3_HS1
cd11976974-1023  SH3_VAV1_2
cd11941972-1021  SH3_ARHGEF37_C2
cd11848974-1024  SH3_SLAP-like
cd11977973-1023  SH3_VAV2_2
cd11838974-1023  SH3_Intersectin_3
cd11843972-1021  SH3_PACSIN
cd11827974-1023  SH3_MyoIe_If_like
smart000542327-2355  EFh
cl233472327-2355  EFh superfamily
cd11961972-1022  SH3_Abp1_fungi_C2
cd11876974-1021  SH3_MLK
cd12059974-1021  SH3_MLK1-3
cd11757972-1022  SH3_SH3BP4
cd11870972-1022  SH3_p67phox-like_C
cd11991973-1022  SH3_Intersectin1_3
cd12052976-1023  SH3_CIN85_1
cd12061971-1024  SH3_betaPIX
pfam134052327-2356  EF-hand_6
cl236342327-2356  EF-hand_6 superfamily
cd11825972-1023  SH3_PLCgamma
cd11957972-1021  SH3_RUSC2
cd12056969-1021  SH3_CD2AP_3
cd11986973-1021  SH3_Stac3_1
cd11818974-1020  SH3_Eve1_5
cd11923973-1022  SH3_Sorbs2_2
cd11821972-1020  SH3_ASAP
cd11895971-1024  SH3_FCHSD1_2
cd11907972-1021  SH3_TXK
cd11947974-1021  SH3_GRAP2_N
cd11850971-1021  SH3_Abl
cd12054975-1024  SH3_CD2AP_2
cd11855974-1021  SH3_Sho1p
cd11894972-1022  SH3_FCHSD2_2
cd12016976-1023  SH3_Tks_2
cd11836974-1023  SH3_Intersectin_1
pfam000362327-2355  EF-hand_1
cl234892327-2355  EF-hand_1 superfamily
cd12060971-1024  SH3_alphaPIX
cd11958972-1020  SH3_RUSC1
cd11766972-1023  SH3_Nck_2
cd12047972-1021  SH3_Noxa1_C
cd11919974-1024  SH3_Sorbs1_1
smart001502208-2309  SPEC
cd11813974-1022  SH3_SGSM3
cd12069971-1022  SH3_ARHGAP27
cd12075971-1018  SH3_Tks4_1
cd11999972-1021  SH3_PACSIN_like
cd12024971-1022  SH3_NoxO1_2
cd11819974-1022  SH3_Cortactin_like
cd11816973-1021  SH3_Eve1_3
pfam08239981-1022  SH3_3
pfam087262402-2471  EFhand_Ca_insen
pfam134992333-2395  EF-hand_7
COG51262310-2434  FRQ1
PTZ001842320-2469  PTZ00184
TIGR021689-689  SMC_prok_B
COG1196120-888  Smc
PTZ001832318-2414  PTZ00183
pfam12128159-697  DUF3584
TIGR02168607-1433  SMC_prok_B
TIGR02169610-1336  SMC_prok_A
TIGR021681019-1724  SMC_prok_B
COG43721134-1351  COG4372
COG51262307-2401  FRQ1
PTZ001842321-2398  PTZ00184
PRK02224175-561  PRK02224
PRK10246614-902  PRK10246
COG30961095-1407  MukB
COG0419122-693  SbcC
TIGR02168197-985  SMC_prok_B
TIGR021691029-1325  SMC_prok_A
PRK011561688-2019  PRK01156
TIGR02168865-1611  SMC_prok_B
COG11961627-2286  Smc
COG1196187-571  Smc
COG1196118-457  Smc


Ontology Information


   
HPRD ID5146
Molecular ClassCytoskeletal protein
Molecular FunctionTranscription regulator activity (GO:0030528)
Biological ProcessRegulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO