CoReCG

Search results:

General Information

Gene_Symbol	Gene_ID	Gene_Name	Chromosome	Alias
BRCA1	672	breast cancer 1, early onset	17	RNF53, BRCC1, PPP1R53

Evidence
Gene
mRNA
CDS
Protein
PTM
Enzyme
PPi
Pathway
Structural
Domain
Ontology
SNP
Drug
External Links

Evidence Information

Pubmed ID	Year	Sample Information	Techniques	Mechanism	Fold Change	Remark
23496813	2013	Cell line : - Source : Chinese patients Sample Type : - No. of Sample : 120 Stage : -	real time RT-PCR	Down-regulation	-	ERCC1 and BRCA1 mRNA expression levels correlate inversely to CRC metastasis.Down-expression of ERCC1 and BRCA1 was significantly associated with LNM (P < 0.001), advanced TNM stage (P < 0.001), and decreased 5-year overall survival rate
24292448	2014	Cell line : - Source : Canada, United States, Europe Sample Type : CRC tumor and population based case control study No. of Sample : 21 CRC cases, 7015 women with a BRCA mutatant CRC case Stage : -	Meta analysis	Mutation	-	The risk of colorectal cancer is increased in female carriers of BRCA1 mutations below the age of 50 years but not in women with BRCA2 mutations or in older women.
25195694	2015	Cell line : - Source : - Sample Type : - No. of Sample : - Stage : -	-	Mutation	-	A recent prospective study of 7015 women with a BRCA1 or BRCA2 mutation identified significant fivefold increased risk of colorectal cancer among BRCA1 mutation carriers younger than 50 years

Gene Details

NC_000017.10 (41196312..41277500, complement)
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Gene Type	protein coding
Gene Family	RING-type (C3HC4) zinc fingers, "Serine/threonine phosphatases / Protein phosphatase 1, regulatory subunits"
Description	This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified. [provided by RefSeq, May 2009]
Chromosome	17
Location	17q21.31
Start	41196312
End	41277500
Strand	-
Gene Sequence	>gi\|568815581:c43125483-43044295 Homo sapiens chromosome 17, GRCh38.p2 Primary Assembly GTACCTTGATTTCGTATTCTGAGAGGCTGCTGCTTAGCGGTAGCCCCTTGGTTTCCGTGGCAACGGAAAA GCGCGGGAATTACAGATAAATTAAAACTGCGACTGCGCGGCGTGAGCTCGCTGAGACTTCCTGGACGGGG GACAGGCTGTGGGGTTTCTCAGATAACTGGGCCCCTGCGCTCAGGAGGCCTTCACCCTCTGCTCTGGGTA AAGGTAGTAGAGTCCCGGGAAAGGGACAGGGGGCCCAAGTGATGCTCTGGGGTACTGGCGTGGGAGAGTG GATTTCCGAAGCTGACAGATGGGTATTCTTTGACGGGGGGTAGGGGCGGAACCTGAGAGGCGTAAGGCGT TGTGAACCCTGGGGAGGGGGGCAGTTTGTAGGTCGCGAGGGAAGCGCTGAGGATCAGGAAGGGGGCACTG AGTGTCCGTGGGGGAATCCTCGTGATAGGAACTGGAATATGCCTTGAGGGGGACACTATGTCTTTAAAAA CGTCGGCTGGTCATGAGGTCAGGAGTTCCAGACCAGCCTGACCAACGTGGTGAAACTCCGTCTCTACTAA AAATACAAAAATTAGCCGGGCGTGGTGCCGCTCCAGCTACTCAGGAGGCTGAGGCAGGAGAATCGCTAGA ACCCGGGAGGCGGAGGTTGCAGTGAGCCGAGATCGCGCCATTGCACTCCAGCCTGGGCGACAGAGCGAGA CTGTCTCAAAACAAAACAAAACAAAACAAAACAAAAAACACCGGCTGGTATGTATGAGAGGATGGGACCT TGTGGAAGAAGAGGTGCCAGGAATATGTCTGGGAAGGGGAGGAGACAGGATTTTGTGGGAGGGAGAACTT AAGAACTGGATCCATTTGCGCCATTGAGAAAGCGCAAGAGGGAAGTAGAGGAGCGTCAGTAGTAACAGAT GCTGCCGGCAGGGATGTGCTTGAGGAGGATCCAGAGATGAGAGCAGGTCACTGGGAAAGGTTAGGGGCGG GGAGGCCTTGATTGGTGTTGGTTTGGTCGTTGTTGATTTTGGTTTTATGCAAGAAAAAGAAAACAACCAG AAACATTGGAGAAAGCTAAGGCTACCACCACCTACCCGGTCAGTCACTCCTCTGTAGCTTTCTCTTTCTT GGAGAAAGGAAAAGACCCAAGGGGTTGGCAGCAATATGTGAAAAAATTCAGAATTTATGTTGTCTAATTA CAAAAAGCAACTTCTAGAATCTTTAAAAATAAAGGACGTTGTCATTAGTTCTTTGGTTTGTATTATTCTA AAACCTTCCAAATCTTAAATTTACTTTATTTTAAAATGATAAAATGAAGTTGTCATTTTATAAACCTTTT AAAAAGATATATATATATGTTTTTCTAATGTGTTAAAGTTCATTGGAACAGAAAGAAATGGATTTATCTG CTCTTCGCGTTGAAGAAGTACAAAATGTCATTAATGCTATGCAGAAAATCTTAGAGTGTCCCATCTGGTA AGTCAGCACAAGAGTGTATTAATTTGGGATTCCTATGATTATCTCCTATGCAAATGAACAGAATTGACCT TACATACTAGGGAAGAAAAGACATGTCTAGTAAGATTAGGCTATTGTAATTGCTGATTTTCTTAACTGAA GAACTTTAAAAATATAGAAAATGATTCCTTGTTCTCCATCCACTCTGCCTCTCCCACTCCTCTCCTTTTC AACACAAATCCTGTGGTCCGGGAAAGACAGGGACTCTGTCTTGATTGGTTCTGCACTGGGGCAGGAATCT AGTTTAGATTAACTGGCATTTTGGCTTTTCTTCCAGCTCTAAAACAAGCTCCATCACTTGAAATGGCAAA ATAAAATCATGGATGAGGCCGAGGGCGGTGGCTTATGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGTG GTAGGATCACGAGGTCAGGAGATCGAGACCATCCTGGCCAACATGGTGAAACCCCCTCTCCACTAAAAAT ACAAAAATTAGCTGGGCGTAGTGGCATGTGCCTGTAATCCCAGCTACTCAGGAGGCTGAGGCAGGAGAAT CACTTGAACCAGGAGGCAGATGTTGCTGTGAGCCAATATGGCACCACTGAACTCCAGCGACAGAGCTAAA CTCCATCTCAAAAAAAAAAAAAAAAAAAAAAAAACATGGATGATCGGTGTCGTTGAGAGGATAGGTATTT GGAAGAACCTTTGTTTGAAACTGGCTCTGTACATACAATGAAATTACATACTTATTTACATACAATGAAA TGCAGAGGTTTTTTTTTTATATAGGATCTCTGTCGAGAGGCTGGAGTGCAGTGGTGCTATCACAGCTCAC TGCAGCCTCAACCTCGTCAGGCTCAAGCAATCCTCCCACCTCAGCCTCCAGAGTAGCAGGGACGATAGGT GTGCACCACCATGCCCAGCTAATTTTTGTATTTTTTTTTCTTTTTTTGAGATGGAGTCTTGCTCTGTTGC CCAGGCTGGAGTGCAGTGGCGCGATCTCAGCTCACTGCAAACTCTGCCTCCCGGGTTCATGCCATTCTTC TGCCTGAGCCTCCTGAATAGCTGGGACTACAAGCACCCACTACCACGCCCGGCTAATTTTTTGTATTTTT TTTTCTTTTTTAGTAGAGGCGGGATTTCACCGTGTTAGCCAGGATAGTCTTGATCTCCTGACCTTGTGAT CCACCCGCCTGGGCCTCCCAAAGTGCTAGGATTACAGGCATAAGCCACTGCGTCCAGCCATTCTTGTATT TTTCTGTTGTAGAGATAGGGTTTTGCTATGTTGGCCATGCTGGTCTCAAACTCCTGACCTCAAGTGATCT ACCCTCCCTTGGCCTCTCAAGGTGCTGGGATTACAGGCCTGAGCCATTGCACCCAGCCATGGTCTAAAAA TCTTGATTGAAATACCACCTTTTCATTTCCAGACACCCCTATTTAAAATTACCACACCCCCAGCACACAC TTTATCTTCTATTCCTGCTGCTTCTCCATAACACTGATTACTAGCTGACATTCTATGTAATGTATCCATT TTTTATCTCTAGTCCCACAGAATGTAAACTCCAGGATGGGATTTTTGTTTTGTTTACATACATCTGTATG TTCAGTAGTTAGAACGGTACTTGGGACCTAGTTGCCACTCAATAAACATTTGTCAAATAAATAATAAACT AAACTAAATTAGTTCTTTAATTTTTTTAAATATGGTGATGGTTAGTAGTGAGTAACATTCAAAAAATAAG TTGAAAAGTTGTACCATTGCCTCTTACCCACAATAAAAAAGGGTAAATTCTTTTCTGCTTTATGAAAGTT GTTTTTCATATTTGAAGTCAAGTTAATCAGATTAAGGAAAATGTATGTTGTGTTTTCAGAGCGATACAAG ATTTATAAATAACCATCCTCTCCCTTGCCCTTCAACATTATAGCTAAACAAAAATAAGAGGAAAACAGGA TTCACAATTTATCAATTTATTGAAAATCAGAGCCAGAGAAGCAGGAAATGACATTGTAGGAAAAAACTGC TTTTGAAAAAGCACAAAACTTACTCATGACAATCAGTGATCAGGAAAATCCTCAATAGTGTGGCATTTGG ATACATTTATGTTTCATTTCCATGGGAGAGAGTCATAAAAATAGGATGTTCTTTCTCATTCTGGCAAATT AAACCATCAATTAAAAACTCAGATACATAAAAATTAAAGATGTAAGAATGAAAATGCTAAATTGTTATTT TCAATCAACTATTATGTTTTCTAGCTTTTCATTGCTTTTTTCTGTTTCCTGTTAAGATTAATTTCTTTTT TTTTTTTTTTTTTTTTTTTTGAGACAGACTTTGGCTCTTGTTGCCCAGGCTGGAGTGCAGTGGCACAATC TCGGCTCACTACAACCTCCACCTCCCGGGTTCAAGCAATTCTGCTGCCTCAGCCTCCGGAGTACCTGGGA TTGCAGGCATGTGCCATCACACCAGCTAATTTTGTATTTTTAGTAGAGACAGGGTTTCTCCATATTGGTC AGGTTGGTCTCGAACTCCTGACCTCAGGTGATCCTCCTGCCTTGGCCTCCGAAAGTGCTGGGATTACAGG CGTGAGCCACCGCTCCCAGACTTTTTGTTTTGTTTTGTTTTGTTTTTTTGAGACACGGTCTCGCTCTGCT GCCTAGGCTGGAGTGCAGTGGCACGATCTTGGCTCACTGCCAGCTCCGCCTCCCGGGTTCAGGCCATTCT CCTGCCTCAGCCTCCCGAGTAGCTGGGACTACAGGCGCCCACCACTATGCCCGGCTAATTTTTTGTATTT TTAGTAGAGACGGGGTTTCACCATGTTAGCCAAGATGGTCTCGATCTCCTGACCTTGTGATCCACCCGCC TCAGCCTTCCAAAGTGCTGGGATTACAGTCCTGAGCCACTGCGCCCGGCCTGGACCTTTTTTTTTCGGGG TGGGGGGTTGGAGTCTGGCTCTGTCGCCCAGGCTGGAGTGCAGTGGCGCCATCTTGGCTCACTGCAACCT CCGCCTGCCAGGTTCAAGTTCAAGCGCTTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGATTATAGGCGCA CGCCACCGTGGCCGGCTAATTTTGTATTTTTAGTAGAGATAGGGTTTCATCACGTTGGTCAGGCTGGTCT TGAAGTCCTGATCTCGTGATCCACCCGCCTCGGCCTTCCAAAGTGCTGGCGTGAGCCACTGCGCCTGGCT TAAGATTAATTTTTGTTTGTTTTGTTTTTGAGACGGAGTCTCGCTCTTTCACCCAGGCCGGAGTGCAGTG GCGCCATCTCGGCTCACTGCAAGCTCCGCCTCCCGGGTTCACGCCATTCTCCTGCCTCGGCCCCCCAAGT AGCTGGGACTACAGGCGTCCACCACCACGCCCGGCTAATTTTTTGTATTTTTAGTAGAGACGGGGTTTCA CCGTGTTAGCCAGGATGGTCTCCACTTCCTGACCTCGTGATCCGCCCACCTCGGCCTCCCAAAGTGCTGG GATTACAGGCGTGAGCCACCGCGCCCGGCCTTAAGATTAATTTTTATGGTGTTTTACATTCATTTGTATG GAAAGTTCTAGGATAGGGATCATATTTCACTTCCTTTTAATATAGTACAGTATAGCACAATTTGCAGTTA TGTCTTAATATGTGATCAGGAATGATCATGACTGGAAACAGTGTTATTTGTGGTAGCTATAGGGTAGGTA AGGTTTTCAGCCTGTTTTAGGTTTCTTGAACTAAAATTCCTTCTGCTGTCTTCTAAGTCAATATTGGCAG CTATTTCTGACAATTGGTAGTTCTTTGTAACTTTTTACCTATGACTATAACATTTTTGACTTTCAGAAGA ATTTGCTAAAATGTGTTCCCCGGTGGGTTGTTGTTTTTCAACCTAAACCTAGCTGCTTTTTCCAGTCACT TATCCGTATTGGAAGCTCAAAATGCAAATATACAGTAGGCCTAAAATATTGCCTGGTTTGAAAAGTGTTT AAAATATTTGAATCATTTTTATAGTAAACATTTACTCTCATCAGGACCTAGAAGGGGAACATTTTAATTT TTTTTCTTTTCCCTTTTCACAGTCTTCCTTCAACATTCATTACCTTTTTACATATCGGAGTTTTCATCTG TTCAAAGTTTGTGTTTACAGTGTGTTTATATAGTTTAGATTATAATTACCATACTGAAATATAATTGTTT CAGAATTGAGTCAGTGGTGAGAATGAAAGCCATCTGGTATGATAACTGAATCCAATTTTTCTTTTACGGA GAATTTCTTTGAAATGTAGCTTATCTCAGAAATAGGGATTTAGTAACCAATCAGAGTTTTCTTTGTCAAG GTTGTTTTTCTTTTTAAAGTCACATTTGGTCCCAGTAATAATACCAATGTTGGTACAAGTTATCTCAGGT TGTGAAGCATTTTTCCCAAGTCATCTCAGGTTGTGAAGCATTTTCCCAAGTAGCATTTAATTTTATTCTT GCAATAGCCCAAGGAGTCTGGCAGGGTGAATGGCAAGAGAAGGAAACAGGTTCAGGTAGAGTGGTTAGCC CAAGGTGGCTCTGCTTATATACACAACTGGTAGTAGAAACCCAGCCTCCTGACTTAGTTCATTGTTTTTC TTTTCACTGCCCTGTGCTATGTCAAAAACCCCATGATTACAAGAGTTGTATTACAACCCTTCACAATAAG GTTACTGTCCACAAGCTTTTCTTGTGATCCTTTTCTTTTTTTTTTTTCTTTTTTTGAGATGGATTCTCTG TCACCCAGGCTGGCCCGCCTTGGCCTCCCAAAATGCTGGGATTACAGCGTGAGCCACCGCACCTGGCCCT TGTGATCCTTTTCTAAAAAGTTAAATATTTAAGGAAAAAACCACATTCTTGTCACACTGCCAGGTTAGTC GTTCTTTGATATCTTGCCTGGACTTTATCCAAAAAATCCGTTTCAAAAATTCACATTTAGAGCTAAGTGT AGTGGCTCACGCCTGTAATCCCGGTCGAGGCAGATGGATCACTTGAGGTCAGGACTTCAAGACCAGCCTG GGCAATATGGTGAAACCCCTTCCCTACCAAAAATACAAAAAAATTAGCCGGGTGTGGCAGCACGCGCCTG TAGTCCCAGCTACTTGGAATGCTGAGGCACAAGAATCACTTCAATCCGAGAGGCAGAGGTTGCAGTGAGC CAAGACCACACCACTGCACTCCAGCCTGAGCAGCAGAGTGAGTGAGACTCCATCTCCAAAAAAAAAAAAA AAGGTTCACATTCAGAAGAAAGCTAAAGGCCGGGTATAGTAGCTCACACCTGTAATCCCAGCACTTTGGG AAGCCGAAGCAGGAAGATTGCTTGATGCCAGGCATTCAAGACCAGCATGGGCATCATAGTGAGATCCTGT CTCTACAAAAATTAATTAACATTAAAAATTAAAAAGATGGCTGGCATGGTGGCTCACTCCTGTAATCCCA GTACTTTGGGAGGCCAAGGCATGGTGGTGCATGCCTTTAGTCCCAGCTACTCGGGAGGCTGAGGCAGGAG AATCACTTGAATTCAGGAGGCGGAGGTTACAGAGAGCCGAGATGGTGCCACTGCACTCCAGCCTGGGCGA CAGAACGAGACTCTGTCTGAAAAAAAAAAAGAAAATTAAAAAGACCAGAATAAAGCTAAAGATTTAAAAT AGCCTATAGGTTCCTACCAGAAGTTACCAGCTACCTCTCTGATAGTCTTTCCCTACAATATCCTCCTGGA TTATTACATTTTAGCACCTTGACCTATCTGATGTCCTGCATACACAGGCATGGTCCTGCTCAGGGTTTGC CTTCTCTGCTCCCTCTTTCTTGGAATGCTCTTCCCCTAATTGTTGCATAGTGTGTTTCTTTACATTATTA AGCTATCCTCTAGTCTCACCTCAGTGAAACCTTTCCTGACTCCCCCCATGTACATCTCACCCCCACATAG ATATTGAACTACCTGTTTCCCCTTACCCTGCTTAATTTTTCTCTTTAATGCACTTATTCCCATGTATTCT TTAATTCCGTATCAACTGTCTACCACACTAGAATATGAGCTCTATGAGAGCAGGCTTTATTTTGTAAACT GCTACATTTCTATCTCCTAGAATAGTACTTGAATATAGTAGTAGATACTTAATAAACACTTGTTATATTA GTATAATAAATGAACTAATCTCAGGAATGCCTTGGTTTTGTGGATAGACAGGTAGGGATGGGAACTTGGG TGATGTATTTTCTGAAGTTTTTATTTTTAAGCTTATTATTATTTTGAGATGGAGTCCAGCTCTGTCGCCC AGGTTGGAGTACAGTGGCGCGATCTTGGCTCACTGCAACGTGCACTTCCCCGGTTCAAGCGATTCTCCTG CCTTAGCCTCCCAAGTAGCTGGGATTACAGGCGCATGCCACCATGCCCAGTTAGTTTTGGTATTTTTAGT AGAGACAGCGTTTCACTGTGTTGGCCAGGCTGGTCTCGAAATCCTGACCTCATGATCCGCCCGCCTCGGC CTCCCAAGTGCTGGGATTACAAGCATGAGCCCCCGTGTCTGGCCTTATTTTCTTTTTTTTGAGACAGAGT CTTCCTCTGTCACCTAGGCTGGAGTGCAGTGGCACGATATTGGCTCACTCTGCAACCTCCACCTCCAGGA TTCAAGTGATCCTTCTACCTTAGTCTCCAAAGTAGCTGAGACCACAGGCATGCGCCACCACGCCCGGCTA ATTTTTGTATTTTTAGCGTAGACAGGGTTTCACCATATTGTCCAGGATGATCTGGAACTCCTGAGCTCAG GTGATCCACCCACCTCAGCCTCCCAAAGTGCTAGGATTACAGGCATGAGGCACCATGCCCGGCCTTAAGC TTATCATTTTCTAAATTTCCTTTAGTGAGTACTTATTACACTGTTTTTACAAAGTAATCACAAACCAAAC ATCATGCCTCTTCTGAAGTGATCTAATAAGAGTACACAGTACCATCTGTAAAGTGTTCTTGCCAGAAAGT TGAACCTGAATGATTAAGCCTGTAAGTCTAGTTTATAGGAAATAAGGCTAGAGGAACAAGTTAAACCTCA CCATAGGGTTATACAATCAGCAAAATCCAGAATGGGGGAAACTCCACAGGTCAAATGACCTAATTTTAAA AATAAATGACAAGGGAGAAAAAGTAAGAGACACCTATAGATCAGAAGACACTTGGGGCTGGGCATGGTGG CTCACACCTGTAATCCCAGCACTTTGGGAGGCCAAGGCAGGCGGATCACCTGAGGTCAGGAGTTCAAGAC CAGCCGGCCAACATGGTGAAACCCCAACTCTACTAAAAATACGAAAAATCAGCCGGGCGTGGTGGCGCAC GCCTGTAGTTCCAACTACCTGGGAGGCTGAGGCAGGAGAATCACTTGAACTTGGGAGGCAGAGGTTGCAG TGAGCCGAGATCGCACCATTGCATGCCAGTCTGGGCTACAAAAGCAAAACCCCATCTCAAAAAAAAGAAG ACACTTGGGTTTGGGTGTGTTGGCTCATGCCTGTAAACCCCGTGCTGGGAGGATTGCTTGAGCCCAGGAG TTCAAGGCTGCAGTGAGGTATGTTTGCACCACTGCACTCCAGCCTAGGTGACAGAGTGTGACCTTATCTT AAAAGTAATAATAATTAAAATAATCTGGGGTAGGGGTGGATATGGGTGAAACAGCTTGGCCATGAGTTGA TGGTTGTTGGACCAGGGTGATGGTCCATATAGTTCATTTTATTATTTTATTTACTTGAAATTTTGAAATA CTTGAAATTTTCCATATTAAGTTAAAAAGGCATTTACAGTAAACAAAAAAAAGTTCTAGGAAGGAATTCA AAAGAAATATAAGCAGAAAATTTTGTCTTTATGGAGCTTAAAGATGAGATGTGCACCCACAGTGATAGTG CAGAAAAATATATCACTGGAAATGAATTCGTACGAACTATTATCAACTAATCTTTTAAATGCTGATGATA GTATAGAGTATTGAAGGGATCAATATAATTCTGTTTTGATATCTGAAAGCTCACTGAAGGTAAGGATCGT ATTCTCTGCTGTATTCTCAGTTCCTGACACAGCAGACATTTAATAAATATTGAACGAACTTGAGGCCTTA TGTTGACTCAGTCATAACAGCTCAAAGTTGAACTTATTCACTAAGAATAGCTTTATTTTTAAATAAATTA TTGAGCCTCATTTATTTTCTTTTTCTCCCCCCCTACCCTGCTAGTCTGGAGTTGATCAAGGAACCTGTCT CCACAAAGTGTGACCACATATTTTGCAAGTAAGTTTGAATGTGTTATGTGGCTCCATTATTAGCTTTTGT TTTTGTCCTTCATAACCCAGGAAACACCTAACTTTATAGAAGCTTTACTTTCTTCAATTAAGTGAGAACG AAAAATCCAACTCCATTTCATTCTTTCTCAGAGAGTATATAGTTATCAAAAGTTGGTTGTAATCATAGTT CCTGGTAAAGTTTTGACATATATTATCTTTTTTTTTTTTTTTGAGACAAAGTCTCGCTCTGTCGCCCAGG CTGGAGTGCAGTGGCATGATCTTGGCTCACTGCAACCTCCGCCCCCCGAGTTCAAGCGATTCTTCTACCT CAGCCTCCCAGGTAGCTGGGACTACAGGCACCCGCCACCATGCTTGGCTAATTTTTGTACTTTTAGTAGA GATAAGGTTTCACCATATTGGCCAGGCTGGTCTCGAACTCCTGACCTTGTGATCCACCTGCCTCGGCCTC CCAAAGTTCTGGGATTACAGGCGTGAGCCACCACACCCGACTGACATATATTATCTATTAGGATGTAACA TCATTTTGAACAGTGTTTTGTATTTTTTGTGTCCATCAGTGAAAGCAAACTGCAAGCAGTTTTGAAATAA GCACATTGTGTTTGAGCCTTCCCAGTTTCTCCTTTCTGTTCATTTCTGCATATCCTTATGCATTCCCCCT TCTAAGGGTCAGTGTTTGCCCGCTTTGTAATCATTGTGAAGACAGGAAAGGACCTGATACCAGTTTCTAT TTAGGCCAAAATTCATTTATAGCAGTGATTCAAGTTATATTTACGTATTTGATGATCTTGTCTTTTGAAA TGAAAATGTTTGTTTCTTAATAAAAGAATTTCAGAAAAAGTAGAGTAGGTAATTTAGTAGAACAAGTGGG CTTTCTCCTTTTCTTTATGTTAAGCTATGGCTCACATCTTACCTTAAATGTCAACTAATTTGTTTTTAAG TATTTATGTACCTGGTACATAACCTGGTACCAGGTACAAACTATGTACTTGGTAAAAAGTTTATTAGCAC AAAAAGGTATATGATGCAAAGTATACTTCCCTCTTACCCTACAACCCCTGCCTCCCTGTTCCCTCCCCAG ACAACCACAATGATCAATTTCTTATGTATCCTTTGAGGAATTTTTAAATTCCAGAGTTCTTAACTTGGGG TTTATGAATAGTCTTTATGAATTTCCTAGAATTATATTTAAATTGTATTCAAAACTATGGCCATGTACAT TTTTCTGGGAAGATAGTCCATAATTTTCATCTGAGTGAGCTAAGATCATGCCACTGCATTCCAGCCTGGG CGACAAGAGGGAGACTCAAAAAAAAAAAAAAAAGTCCCAGTATTTACTACAGAGAGCTAAAGATTAACCT TTAAAGCCCTGGGGCTTTCAATTTATCTGGATGAGAATCTTTCTGGAATGAACTGTATGTTTTCTTGTCA GCTTGAGTAACAAATGCTGAACATACTATACTATTATTACAGGGACTCAAGGGCCCAGTGTGGTAGCTCC TGCCCATAACCCCAGCACTTTGGGAGGCCAAGGCAGGAAGATCACTTAAGGCCAGGAGTTCGAAGCTGTA GTGAGCTATGATCACACCACTGCACTCCAGCCTAGATGACAGAGTGAGACCCTGTCTTTTTTTTTTTTTG AGATGGTGTTTCACTCTATTGCCCAGGCTGGAGTGCAGTGGTGTGATCTCGGCTCACTGCAACCTCCACC TCCTGGGTTCAAGCGATTCTCCTGCCTCAGCCTCTTGAGTAGCTGGGATTACAGGCATCTGCCACCACAC CCAGCTAATTTTTGTATTTTTAGTCGAGACAGGGTTTTCACCATGTTGGCCAGGCTGCTCTCAAACTCCT GACTTCAGCTACCTTGGCCTTAAAAAGTGTTGGGATTACAGGTGTAAGCCACCGCGCCTGGCTGACCCTG TCTCTTAACAAAAAAAGAGAGATTAAGTTATGAATATAGTTGCTTTGAGAACTTGTGGAAGAAGGAAATT ATAGGCTTATAGGCAGAGATAATAATACGAGCAAATGTACAAATAAAAGAAAATAGAGGACGGGCGCGGT GGCTCACGCCTATAATACCAGCACTTTGGGAGGTCGAGGTGGGCGGATCACGAGGTCAGGAAATTAAGAC CATCCTGGCCAAAATGGCGAAACACTGTCTCTACTAAAACACACAAAAAACTAGCCTGGCATGGTGGCAC GTACCTGTAGTCCCAGCTACTTGGTAGGCTGCGGCAGGGGTATCACTTGAACCTGGGAGGCAGAGGTTGC CCTGAGCCGAGATCATGCCAATGCACTCCAGCCTGACAACAGAGTGAGACTCTGTCTGAAAAAAAAGAAA AGAAAAGAAAATACATCCAGGAAAAATAAGCTAACTTTGCATATGTGTATAGGAGTTGTGTTAGAAAAGG AAGAAGCCCTCAAAGATGGGAAGCCATTTGCAAGAAAGAGAAGGTCCAAGAGGAGGCAGAAGGGATTGGA AATAGAAAAAGGATGTAAGAAAGAGTTGATTATTACTCATAAACAGTAATGAAGGAAAAGGAGAGTAATT CTACAGGAAGATGCTGAGGTGCTTTGAGCCCAGTGAAGTTGGAGGTAAAGACAGCTGTTGAGGCCGGGCA CGGTGGCTCACGCCTCTAATCCTAGCACTTTTGGAGCCCAAGGCAGGTGGATCACCTGAGGTCAGGAGCT CAAGACCAGCCTGACCAACATAGAGAAACCCCATCTCTACTAAAAATACAAAATTAGACGGGCGTGGAGG CGCATGCCTGTAATCCCAGTTACTTGGGAGGCTGAGGCAGGAGAATCACTTGAACCTGGGAGGCGGAGGT TGCAGTGAGCCGAGATTGCGCCATTGCACTCCAGCCTGGGCGACAAGAGTGAAAACTGTCTCAAAAAAAA AAAACAACAAAAAACAGCTGTTGAGATTGAGAGGATTAGAGTTGGCAACTGGAGAAGAGTGAGAAGCTTG GTTTCAAGCTTGTGATAGTCAGGATTGTGATAGTCAGGAAAGAACCAGTCATAAAGATATATGTGTGTGT ATACATATAAATATGTTATATATATGTGTGTGTGTGACACATATATATTTTTGTTTGTTTCTTTGAGACA GTGTCTCCCTCTGACACCCAGGCTGGAGTTCAGTGGTGTGATCATAGTTCACTTTTACCTTGCAATCTGG GTTCAAGCAATCTCTCATCTCAGCCCCTCAAGTAGCTAGGACTACAGGTACATGGCATTTGCCCAGCTAA TTTTTAAGTTTCTTGTAGAGATGGGCCAGCCATATTTTAAATTGTGTTTTGAATGTTATATTAGAATTAA AAGTCCAAAGCCGGGTGTGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGTGGGCGGATC ACGAGGTCAGGAGTTCGAGACCAGCCTGGCCAATATGGTAACACCATCTCTACTAAAAATACAAAAATTA GCTGGGTATGGGGGCACATGCCTGTAGTCCCAGCTACTCAGGAGGCTGAGGCAGAGGAACCTCTTGAACC CAGGAGGCAGAGGCTGCAGTGAGTTGAGATCGTGCCACTGTACTCTAGCCTGGGCGACAGAGCAAGATTC CGTCTCAAAAAAAAAAAAAGTCCAGTATAATGCCCATGTGATAGATCGACTTTTTCATGAAATCTCTTCT GTAATATCAATATAATCTGAATAACACTTTGATCTATATGATGAGAAAGCTGGGAGCCTGGGAGCGATAC CCCCATGCTTTTGTTGTATTAATTGTATTTTCTACGGATAAACTCTAATTGCTAAAAATAAAACAACTTT ATTGACCCAAGCAAGCCTAAAGTTCTGAAATCTTTTTTTTATTTTTGTTTGTTTGTTTGTTTGTTTTTGT TTGTTTTGTTTTGAGACGGAGTCTCGCTCTGTCGCCCAGGCTGGAGTGCGGTGGTGCAGTCTCGGCTCAC TGCAAGCTCCACCTCCCGGGTTCACACCATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGACTACAGACG CCTGCCACCACGCCCAGCTAATTTTTTTGTATTTTTAGTAGAGAAAGGGTTTCACCGTGTTAGCCAGGAT GGTCTCGATCTCCTGACCTCGTGATCTGCCCGCCTTGGCCTCCCTAAGTTCTGGGATTACAAGTGTGAGC CACCACGCCCGGCTGTTTTTTTTTGTTTTGTTTTGAGACGGAGTCTCACTGTGTTGCCCAGACTGGAGTG CAGTGGCATGATCTCAGCTCACTGCCACCTCCATCTCCTGGGTTCAAGCAAATCTCCTGCCTCAGCCTCC CGAGTAGCTGGGACTACAGGCATGTGCCACCACACCTGGCTAATTTTTGTATTTTTAGTAGAGACGGGGT TTCACTATGTTGGCCAGGCTGGTCCAAAACTCCTGACCTCAGGTGATCTGCTCGCCTTGGCCTCCCACAG TGCCAGGATTACAGGCATGAGCCACCTTGCCCAGCCAGTTCTGAAATCTTTTATGAAGCCTATAAAAAAA GATAATAATACCAATCTAGAAAATATTTCTTAAGGCAGTCATGCATTAGTTTGAACTTTCCAAACAAAAA AATGCAATGTGTAATACTTTTTTTTTTTTTTTTGAGATGGAGTCTTGTTCTGTTGCCCAGGCTGGAGTGC AGTGGTACAATCTCGGCTCACTGCAGCCTCTGCCTCTCTGGTTCAAGTGATTCTCCTGCCTCAGCCTCCC AAGTAGCTGGGATTACAGGCGTGCACCACCATGCATGGCTAATTTTTGTATTTTTAGTAGAGACAGGGTT TCACCATGTTGACAAGGCTGATCTCGAACTCCTGACCTCAGGTGATCCGCCCACCTCAGCCTCCCAAAGT GCTGAGATTACAGGCATTAGCCACCACGCCCAGCCTTTTATTTTAGTAGAGACCATGTTTCACCATGTTG ACCAAGCTGGTCTTGAGCTGACCTCAAGTGATCCGCCCACCTCCACCTCCCAAAATGGTGGGATTATAGG CATGAGCCACCGCACCCAGCCTGTAATACTTTTTTGAAGATCTAGAACCACATTGTTCAAAGAGATAGAA TGTGAGCAATAAATGTAACTTAAATTTTTCAACAGCTACTTTTTTTTTTTTTTTTTGAGACAGGGTCTTA CTCTGTTGTCCCAGCTGGAGTACAGTGGTGCGATCATGAGGCTTACTGTTGCCTTGACCTCCTAGGCTCA AGCGATCCTATCACCTCAGTCTCCCAAGTAGCTGGGACTGTAAGTGCACACCACCATATCCAGCTAAATT TTGTGTTTTCTGTAGAGACGGGGTTTCGCCATGTTTCCCAGGCTGGTCTTGAACTTTGGGCTTAACCCGT CTGCCCACCTAGGCATCCCAAAGTGCTAGGATTACAGGTGTGAGTCATCATGCCTGGCCAGTATTTTAGT TAGCTCTGTCTTTTCAAGTCATATACAAGTTCATTTTCTTTTAAGTTTAGTTAACAACCTTTATACATGT ATTCTTTTTCTAGCATAAAGAAAGATTCGAGGCCGGGTGCGGTGGCTCACGCCTGTAATCCCAGCACTTT GGGAGGCTGAGATGGGCACATCACGAGGTCAGGAGATCGAGACCATCCTGGCTAACATGGTGAAACCCCG CCTCTACTAAAATTACAAAAAGTTAGCCAGGCGTGGTAGCGGGCACCTGTAGTCCCAGCTACTCAGGAGG CTGAGGCAGGAGAATGGCGTGAACCCAGGAGGCAGAGCTTGCAGTGAGCAGAGATTGTGCCACTGCACTC CAGCCTGAGAGACAGAGCGAGACTCCGTCTAAAAAAAAAAAAAAAGATTCGAATCCTTATCTTGGTTGAT TTTTGCGTATCTAGTTCCACTGAATTATTTATATAATTGTATAGACTACAGCACGAGACAGCTTAGCTTG TCACTCTACTGTACTATATTCTGCAGTACTATCATAAGGGAATTTCCTCCCTACCCCTGCTCTGAATTGT TCAATTGTACTATTTGCTGGAGTAATGCTTGATGCCTTCTTGATCCATTATACTAGAGTATATGTAGTAT TTGTAGATTCTGAAGGAGTGGGAGCCTCTATTCTGAGTTTTAAAGGTACTTATGTACAGTGGAGGTAGCT TTTTGACAGCCTCATCTTCCAAACTATAGAGTCATTGTTTTGTTGAGTGCAATATGGTACTTGAAGCATC TATATCGGCGAAGAAGGACCCAAGTCTCCTTGACCTTACCTACCTACATTCACTTTCTCTGGTAGGAAGA TTGTGGGTGCCTCTCTCCAGACTTAGTTTCCATGTCAAAAAAGAAAAAAGGAAGATTGTGGGCTTTGCTA CAATCCAATTCTGGATCCAATATAACCTTCATTGCTTAATTACTGTGTGATCTGGGACAAGCCTCTACTC TATAAAAATGAAGATAAGGCCAGGCTTGATGGCTCATGCCTGTAATCCCAGCACGTTGGGATGCCAAGGC AGGAGGATCACTTGAGGTCAGGAGTTCGAGACCAGACTGGGCAATATAGTGAAACCACATCTGTACAAAA ATAAAGATAGAAAGTAGCCCAGCGCAATGGCTCACACCTGTAATCCCAGCACTTTGGGAGGCTGAAGCAG GCGATCACTTGAGGTCGGGAGTTCAAGACTGTAGACAGATAGATAGGTAGGTAGATAGATAGAGATATAG ATATAGTTGGGGTTTTTTTGTTTTGTTTTGTTTTGTTTTTGAGATGGAGTTTCGCTCTTGTTGCCCAGGC TGGAGTGCAATGGCGCGATCTCAGTTTACTGCAACCTCCGCCTCCCGGGTTCAAGAGATTCTCCTGCCTC AGCCTCCTGAGTAGCCAGGATTACAGGCATATGCCACCATGCCCGGCTAATTTTTGTATTTTTAGTAGAG ACAGGGTTTCTCCGTGTTGGTCAGGCTGGTCTTGAACTCCTGACCTCTCCCAAAGTGTTGGGATTACAGG CGTGAGCCACCGCTCCTGGCCTTTTTTTTTTTTTTTTTTTTTTTTTTGAGACAGAGTCTTCCTCTGTTGC CCAGGGTGGAGTGCAGTGGCACTCTTCTCAGCTCATTGCAACCTCTGCCATCCTGGGTTCCAGTGATTCT CATGCCTCAGCCTCCCAAGTAGCTGGGACTCAGGCGTGTGCCCACCACGCCTGGCTAATTTTGTTGTATT TTTAGTAGAGACAGGGTTTCACCATGTTAGCCAGGCTGGTCTCAAACTCCAGGCCTCAAGTGATCTGCCT GCCTCAGCCTCCTGGGATTGCAGACATGAGCCACTGCACCCGGCCAAGAGAGGGTAATAAATGTTAAATT ACCTGGCTAGTAAAAAATATTCTCTAAGTGTCTTTTCTCACAATTCCCAATGCCTTTTTTTTTTTTTTGG CACAATCTCACTCTGTTGCCCAGGCTGGAATGCAATGGTGCAATATTGGCTCACTGTAACCCCCGCCTCA CAGGTTCAACTTATTCTCATGCCTCAGCCTCCCGAGTAACTGGGACTACAGTGCACCACCACCACACCCA GCTAATTTTTGAATATTTAGTAGAGACAGGGTTTCACCATGTTGGCCAGGCTGGTCTTGAACTCCTGGCC TCAAGTGATTCACCCACCCCGCAAGTGCTGGGATTACAGGTGTGGACCACCGTGCACAGCCCTAGTGACT TTTTTTTTAGCCCCTTAATCTTTTCTTTCCTGGGTCTCTTCATTGTCAGTGTCTGCTATTTACTCCCTAC CTAGTCACCCCCTTCACCAGTATATTATGTCCTTTATGTTTTATTTTGCAGGATCTTATTTTGCTTTTCT ATTGAATCCCCTCCATCTAGAATAGTACTAGACATAGTAAATATTGGTTGTATGAGTGAATCGCTGCTTT TAATTATCATCACCATTGCTCTCTCTACTTCTGGTCTATGATCCACTTTGAGTTAACTTTTGTTATTTGG TGTGAGATAGGAGTATAATTTCATTCTTTTACATGTGGTTATACTTTTGTCTCAACACTGTTTGTTAAAA ACACAAAAAGTATTATTTTCCCATTTAATCATCTTTGGCCTGGGCACGGTGGCTCATGCCTGTAATCCCA GCACTCTGGAAGGCCAAGGCAGATGGATCAATTTGAGGCCAGGAGTTCAAGACTAGCCAACATGGTGAAA CTAAAAATACAAAAAATTAGCTGGGTATGGTGGTGCATGTCTGTAATCCCAGCTACTCGGGAGGCTGAGG CACGAGAATTGCTTGAGCCTAGGAGGTGGAGGTTGTAGTGAGCTGAGATTGTGTCACTACCCTCCAGCCT GGGTGATAGAGTGAGTCTGTCTCAAAAAAAAAAAAAAAAAATTAAGAAAATAAAAATCGTCGGCCAGGCA TGGTGGCTCACACCTGTAATCCCAGCACTTTGGGAGGCAGAGGCGGGCAGATCACGAGGTCAGGAGATGG AGACCATCCTGGCTAACATGGTGAAACCCCGTCTCTACTAAAAATAAAAAAATTAGCCGGGCATGGTGCT GGGCGCCTGTAGTCCCAGCTGCTCGGGAGGCTGAGGCAGGAGAATGGCGTGAACCCAGGAGGTGGAGCTT GCAGTGAGCCGAGATCGTGCCACTGCACTCCAGCCTGGGAGACAGAGCGAGACTCCGTCTCAAAAAAAAA AAAAAAAAAAATTGTCTTGGTATTTATTATTGTTGAAAATCGCTTGATCACAGATGTATGTATGAGTTTA TTTCTGTACTGTCAATTCCATTTTATTGATGTATGTGTCTATTCTTATGCTATTACCACACTTTCTTGAT TACTATAGCTTTGTGGTGAGGTGTTGAGATTTTAAACTAATTATAAGCATCTTACATGAACTACTTACCG TTTATATTTGATTATGCAGCATGAAATAATTATGAATATATCATTAAATATGCCATATTAACTTTTATTA AGTTTTATGTGATCATAACAGTAAGCCATATGCATGTAAGTTCAGTTTTCATAGATCATTGCTTATGTAG TTTAGGTTTTTGCTTATGCAGCATCCAAAAACAATTAGGAAACTATTGCTTGTAATTCACCTGCCATTAC TTTTTAAATGGCTCTTAAGGGCAGTTGTGAGATTATCTTTTCATGGCTATTTGCCTTTTGAGTATTCTTT CTACAAAAGGAAGTAAATTAAATTGTTCTTTCTTTCTTTATAATTTATAGATTTTGCATGCTGAAACTTC TCAACCAGAAGAAAGGGCCTTCACAGTGTCCTTTATGTAAGAATGATATAACCAAAAGGTATATAATTTG GTAATGATGCTAGGTTGGAAGCAACCACAGTAGGAAAAAGTAGAAATTATTTAATAACATAGCGTTCCTA TAAAACCATTCATCAGAAAAATTTATAAAAGAGTTTTTAGCACACAGTAAATTATTTCCAAAGTTATTTT CCTGAAAGTTTTATGGGACATCTGCCTTATACAGGTATTAGAAACTTACTGCCTTTCTCTAATGCTTCTA GTGTAAAAACTTGCAGACTTATGTAAAGTAGGGCTGTATCGCCGTGCCCCCATTGTCTGTTAATCTTGTT TTTATATTTTTGATTGTGTTTCCTTTTCTTTTTTTTTTTTTTTTTAAGACAGGGTCCTGCTCTGTCACTG AGGCTGGAGTGCAGTGGCGTGATCTCGGCTCACTGTAGCCTCTGTCTCCCAGCCTCTTCCTGCCTTAGCC TCCCAAATAGCTGGGACTACAGGCACACGCTACCATGCCCGGCCAATTTTTGTATTTTTTGTAGAGATGA GGTTTTACCATGTTGCCCAGGCTGGTAACTCCTGAGCTCAGGTGATCTGCCCACCTCGGCCTCCCAAAGT GCTGGGGTTCACAGGTGTGTGTTTATTTCTATCTAATTATTTACACAAACACAATGTATTTATATATTGT GTATCTCTTCTGCTACAATGTAAATTCTATGAGAGTAGTAATTTTGTCTGTCTCAACACTGTTTTTCCTA AGTTTGGTACATAGTAGGCACTCAGATGCTTAAAGGAATGAATGAATTGTGCTTTAATTCCACTTTACTA AACCCAAATCTCCCTTTGGACATTGTTATCTATGTGTTTTCAAAGAAGTATAATCATAATTTGACAGAAA TCCTTGAGAGGCAGAACTAAGTGAGGGATTGGGCAGGGTTCAGATGTTAAGAACAGTAAGCTCAGCAGGG TGTGATTGCTCATGCCTATAACCCTAGCACTCTAGGAGGCTGAGGTGGGATGATTGCTTGAGGCCAGGAG TTTGAAATCAGCCTGGGCAACATAGTGAGACCCCATCACTACCAACAAAATAAATAAATAAATGTACATG GTGGCATATGCCCATAGTCCTAGCTACTTGGGAGGCTATAGTGGGAGGATAGCTTGAGTACAGAAGTCTG AGGCTGCAGTGAGCTATGATTGTGGCACTGCATGCTAGCCTGGGCAATAGAGCAAGACCCTGTCTCTAAA TTAAACAAAAAAAAAAGTACTCTAGTTTTCTATGCAATGCATTATATCTGCTGTGGATTTAGGGCAGTAT TATATCAGATAATTTTAGGCATTTGGTAGGCTTAAATGAATGACAAAAAGTTACTAAATCACTGCCATCA CACGGTTTATACAGATGTCAATGATGTATTGATTATAGAGGTTTTCTACTGTTGCTGCATCTTATTTTTA TTTGTTTACATGTCTTTTCTTATTTTAGTGTCCTTAAAAGGTTGATAATCACTTGCTGAGTGTGTTTCTC AAACAATTTAATTTCAGGAGCCTACAAGAAAGTACGAGATTTAGTCAACTTGTTGAAGAGCTATTGAAAA TCATTTGTGCTTTTCAGCTTGACACAGGTTTGGAGTGTAAGTGTTGAATATCCCAAGAATGACACTCAAG TGCTGTCCATGAAAACTCAGGAAGTTTGCACAATTACTTTCTATGACGTGGTGATAAGACCTTTTAGTCT AGGTTAATTTTAGTTCTGTATCTGTAATCTATTTTTAAAAAATTACTCCCACTGGTCTCACACCTTATTT TATCAATCGTAAGGTGCACATTTTTCACATCTTAACATCTCTGAAATTGGGAACATTTTACTATTGAGGG TGTGTCATTTGTTTAATTTGTGTGCTTTCTTTCTTAGTGATACAGAAAATAATAGTGCAACTTACATTGT TGGTGTCTTAGCTTTAGTGAAATACAGTATTGATAGGCAAATTTCTTAGTGTTAAGGTAGAAAACAAGGA CTCTAAATAACTTTGATGGTCTGTGTATTTGTTTTTGTTTCCTAGGAGTAAAATTTCCAGTTGATTTTTT AAAATTTGATTTTTAAAAAAAATCACAGGTAACCTTAATGCATTGTCTTAACACAACAAAGAGCATACAT AGGGTTTCTCTTGGTTTCTTTGATTATAATTCATACATTTTTCTCTAACTGCAAACATAATGTTTTCCCT TGTATTTTACAGATGCAAACAGCTATAATTTTGCAAAAAAGGAAAATAACTCTCCTGAACATCTAAAAGA TGAAGTTTCTATCATCCAAAGTATGGGCTACAGAAACCGTGCCAAAAGACTTCTACAGAGTGAACCCGAA AATCCTTCCTTGGTAAAACCATTTGTTTTCTTCTTCTTCTTCTTCTTCTTTTCTTTTTTTTTTCTTTTTT TTTTTTGAGATGGAGTCTTGCTCTGTGGCCCAGGCTAGAAGCAGTCCTCCTGCCTTAGCCCCCTTAGTAG CTGGGATTACAGGCACGCGCCACCATGCCAGGCTAATTTTTGTATTTTTAGTAGAGACGGGGTTTCATCA TGTTGGCCAGGCTGGTCTCGAACTCCTAACCTCAGGTGATCCACCCACCTCGGCTCCCCAAATTGCTGGG ATTACAGGTGTGAGCCACTGTGCCCGGCCGGTAAAACCATTTTCATTTATTCTGGCAACATCTCTTTATT GAGCATTGTGAATATGTTAGTGAATGTGCTAGATGCTCATAGATTTATATAAAAAGTTAGTGAAGAAGGA AAGATGGTATATTAAGTGGTTAGACAAGTGTTCTAATCAGTTAGAGTTCAGAGAAGGTCAGGGTACCTGA TATAATCAAGAGAGAGACCTTACAGCCAGGTGAGGTGAATGTACCTATAATCCCAGCTACTTAGGAGGCT GAAATGGGAGGATCACTTGAGTCCAGGTTTGAGACCAGCCCAGGCAACATAGCAAGATCCCCATCAGATA CACCAAAAAGACAGATTTCTTTTTTTTTTTTTTTTTTGAGACAGAGTCTCGCTCTGTCGCCCAGGCTGGA GCGCAGTGACACGATGTCAGCTCACTGCAACCTCCGCCTCCCAGGTTCAAGTGATTCTCCTGCCTCAGCC TCCTGAGTAGTTGGGACTACAGGGGTACGACACCAGACCTGGCTAATTTTTGTAATTTTAGTAGAGTCGG GGTTTCACCATATTGGTCAGGCTGGTCTCGAACTCCTGACCTCAGGTGATCCACCCTCCTTGGCCTCCCA GAGTGCTGGGATTACAGGCGTGAGCCACCAAGCCCGGCCAAAAAAGAGAGCTCTTATAGGCCCTTCCTTG CTTTGGAGCTTTATCTGCTCTGTGATGCTTATCTAAAATAGCCATAAGGTCACTGATATTTTTAAGCATT TGGAAATTACTTCAGCTGGGTGCCATGGCTCATGCCTATAATCCCAACCCTTTGGGAGGCTGAGGTAGGA GGTCCTTTGAGCCCAGCTTGGGCAACACAGTGAGACACTGTCTCTGCAATTAAAAAAAAAAAAAAGTAGC TGGGTGCCGTGGCTCACGCCTGTAATTCCAGCACTAGGAGGCTTGAGGATTGCCTGAGCTCAGGAGTTCA AGACCAGTTTGGGCAACATAGCAAGTCCTTGTCTATATTAAAAGTTTTTTTAAATTATCTGGGCATGGTG GTGTGTGCCTGTAGTCCCAGCTACTTGGGAAGCTGAGACAGAAGGATCACTTGAGTCCAGGAGATGTAGA CTACAGTGAGCTATGATCACTCCACTGCACTTCAGCGTGGGCGGCAAAGCAAGATCTAGTTGCAAAAAAA AAAAGAACTGGCTGGGTGCGGCGGCTAACACCTGCAATCCCAGCACCTTGGGAGGCTGAGGCCAGTGGAT CATGAGGTCAGGAGATTGAGACCACCCTGGCCAACATGGTGAAACCCGGTCTCTACTAAAAATACAAAAA TTAGCTGGGTGTGGTGGCACGTGCCTGTAATCCCAGCTACTCCAGAGGCTGAGGATGGAGAATCACTTGA ACCTGAGAGTCGGAGGTTGCAGTGAGCCGAGATTGCGCCACTGCACTCCAGCCTGGCGACAGAGCGAGAC TCCGTCTCAAAAAAAAAAAAAAAAAAGCTTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGTCAAGT GGATCACGAGGTGTGGAGATCAAGACTATCCTGGCTCACATGGTGAAAGCCCGTCTCTACTAAAAACACA GAAAAATTAGCTGAGCGTGATGGCGGACTCCTGTAGTCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATA GCATGAACCCGGGAGGTGGAGCTTGCAGTGAGCCGAGATCCCGCCACTGCGATCCAGCCTGGGCGACAGA GTGAGACTCTGTCTCAAAAAAAAAACAAAAAAACTTAGCTGGGCGTGGTGGTATGCACCTGTGGTCCTAG CTACTTGGGAGGCTGAGGCTGGAGCATTGCTTTAACATAGAGAGTCAAGGCTGCAGTTGAGCTATGACTG TGCCACTGGACTCCAGCGCAGGTGACTGAGACCCTATCTTTTAAAAAAAGGGAAAATTACTTGAACTTAA AAGGTGTAATTGTTAAAGAAAATGTAGTGATTTGCTCTGTTGTTACTTATATGTGCATGAATGATGGAGA TCTTAAAAAGTAATCATTCTGGGGCTGGGCGTAGTAGCTTGCACCTGTAATCCCAGCACTTCGGGAGGCT GAGGCAGGCAGATAATTTGAGGTCAGGAGTTTGAGACCAGCCTGGCCAACATGGTGAAACCCATCTCTAC TAAAAATACAAAAATTAGCTGGGTGTGGTGGCACGTACCTGTAATCCCAGCTACTCGGGAGGCGGAGGCA CAAGAATTGCTTGAACCTAGGACGCGGAGGTTGCAGCGAGCCAAGATCGCGCCACTGCACTCCAGCCTGG GCCGTAGAGTGAGACTCTGTCTCAAAAAAGAAAAAAAAGTAATTGTTCTAGCTGGGCGCAGTGGCTCTTG CCTGTAATCCCAGCACTTTGGGAGGCCAAGGCGGGTGGATCTCGAGTCCTAGAGTTCAAGACCAGCCTAG GCAATGTGGTGAAACCCCATCGCTACAAAAAATACAAAAATTAGCCAGGCATGGTGGCGTGCGCATGTAG TCCCAGCTCCTTGGGAGGCTGAGGTGGGAGGATCACTTGAACCCAGGAGACAGAGGTTGCAGTGAACCGA GATCACGCCACCACGCTCCAGCCTGGGCAACAGAACAAGACTCTGTCTAAAAAAATACAAATAAAATAAA AGTAGTTCTCACAGTACCAGCATTCATTTTTCAAAAGATATAGAGCTAAAAAGGAAGGAAAAAAAAAGTA ATGTTGGGCTTTTAAATACTCGTTCCTATACTAAATGTTCTTAGGAGTGCTGGGGTTTTATTGTCATCAT TTATCCTTTTTAAAAATGTTATTGGCCAGGCACGGTGGCTCATGGCTGTAATCCCAGCACTTTGGGAGGC CGAGGCAGGCAGATCACCTGAGGTCAGGAGTGTGAGACCAGCCTGGCCAACATGGCGAAACCTGTCTCTA CTAAAAATACAAAAATTAACTAGGCGTGGTGGTGTACGCCTGTAGTCCCAGCTACTCGGGAGGCTGAGGC AGGAGAATCAACTGAACCAGGGAGGTGGAGGTTGCAGTGTGCCGAGATCACGCCACTGCACTCTAGCCTG GCAACAGAGCAAGATTCTGTCTCAAAAAAAAAAAACATATATACACATATATCCCAAAGTGCTGGGATTA CATATATATATATATATATATATATTATATATATATATATATATATGTTATATATATGTTATATATATAT AACATATATATATGTTATATATATGTTATATATATATAATATATATATGTTATATATATGTTATATATAT ATATACACACACACACACATATATATGTATATATATATACACACACACACACAAATTAGCCAGGCATAGT TGCACACGCTTGTAGACCCAGCTACTCAGGAGGCTGAGGCAGGAGAATCTCTTGAACTTAGGAGGCGGAG GTTGCAGTGAGCTGAGATTGCGCCACTGCACTCCAGCCTGGGTGACAGAGCAGGACTCTGTACACCCCCC AAAACAAAAAAAAAAGTTATCAGATGTGATTGGAATGTATATCAAGTATCAGCTTCAAAATATGCTATAT TAATACTTCAAAAATTACACAAATAATACATAATCAGGTTTGAAAAATTTAAGACAACAGAAAAAAAAAT TCAAATCACACATATCCCACACATTTTATTATTACTACTACTATTATTTTGTAGAGACTGGGTCTCACTC TGTTGCTTATGCTGGTCTTGAACTCCTGGCCTCAAGCAGTCCTGCTCCAGCCTCCCAAAGTGCTGGGATT ATAGGCATGAGCTACCGCTCCCAGCCCCAGACATTTTAGTGTGTAAATTCCTGGGCATTTTTTCCAGGCA TCATACATGTTAGCTGACTGATGATGGTCAATTTATTTTGTCCATGGTGTCAAGTTTCTCTTCAGGAGGA AAAGCACAGAACTGGCCAACAATTGCTTGACTGTTCTTTACCATACTGTTTAGCAGGAAACCAGTCTCAG TGTCCAACTCTCTAACCTTGGAACTGTGAGAACTCTGAGGACAAAGCAGCGGATACAACCTCAAAAGACG TCTGTCTACATTGAATTGGGTAAGGGTCTCAGGTTTTTTAAGTATTTAATAATAATTGCTGGATTCCTTA TCTTATAGTTTTGCCAAAAATCTTGGTCATAATTTGTATTTGTGGTAGGCAGCTTTGGGAAGTGAATTTT ATGAGCCCTATGGTGAGTTATAAAAAATGTAAAAGACGCAGTTCCCACCTTGAAGAATCTTACTTTAAAA AGGGAGCAAAAGAGGCCAGGCATGGTGGCTCACACCTGTAATCCCAGCACTTTGGGAGGCCAAAGTGGGT GGATCACCTGAGGTCGGGAGTTCGAGACCAGCCTAGCCAACATGGAGAAACTCTGTCTGTACCAAAAAAT AAAAAATTAGCCAGGTGTGGTGGCACATAACTGTAATCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATC ACTTGAACCCGGGAGGTGGAGGTTGCGGTGAACCGAGATCGCACCATTGCACTCCAGCCTGGGCAAAAAT AGCGAAACTCCATCTAAAAAAAAAAAAGAGAGCAAAAGAAAGAATATCTGGTTTTAAATATGTGTAAATA TGTTTTGGAAAGATGGAGAGTAGCAATAAGAAAAAACATGATGGATTGCTACAGTATTTAGTTCCAAGAT AAATTGTACTAGATGAGGAAGCCTTTTAAGAAGAGCTGAATTGCCAGGCGCAGTGGCTCACGCCTGTAAT CCCAGCACTTTGGGAGGCCGAGGTGGGCGGATCACCTGAGGTCGGGAGTTCAAGACCAGCCTGACCAACA TGGAGAAACCCCATCTCTACTAAAAAAAAAAAAAAAAAAATTAGCCGGGGTGGTGGCTTATGCCTGTAAT CCCAGCTACTCAGGAGGCTGAGGCAGGAGAATCGCTTGAACCCAGGAAGCAGAGGTTGCAGTGAGCCAAG ATCGCACCATTGCACTCCAGCCTAGGCAACAAGAGTGAAACTCCATCTCAAAAAAAAAAAAAAAGAGCTG AATCTTGGCTGGGCAGGATGGCTCGTGCCTGTAATCCTAACGCTTTGGAAGACCGAGGCAGAAGGATTGG TTGAGTCCACGAGTTTAAGACCAGCCTGGCCAACATAGGGGAACCCTGTCTCTATTTTTAAAATAATAAT ACATTTTTGGCCGGTGCGGTGGCTCATGCCTGTAATCCCAATACTTTGGGAGGCTGAGGCAGGTAGATCA CCTGAGGTCAGAGTTCGAGACCAGCCTGGATAACCTGGTGAAACCCCTCTTTACTAAAAATACAAAAAAA AAAAAAAATTAGCTGGGTGTGGTAGCACATGCTTGTAATCCCAGCTACTTGGGAGGCTGAGGCAGGAGAA TCGCTTGAACCAGGGAGGCGGAGGTTACAATGAGCCAACACTACACCACTGCACTCCAGCCTGGGCAATA GAGTGAGACTGCATCTCAAAAAAATAATAATTTTTAAAAATAATAAATTTTTTTAAGCTTATAAAAAGAA AAGTTGAGGCCAGCATAGTAGCTCACATCTGTAATCTCAGCAGTGGCAGAGGATTGCTTGAAGCCAGGAG TTTGAGACCAGCCTGGGCAACATAGCAAGACCTCATCTCTACAAAAAAATTTCTTTTTTAAATTAGCTGG GTGTGGTGGTGTGCATCTGTAGTCCCAGCTACTCAGGAGGCAGAGGTGAGTGGATACATTGAACCCAGGA GTTTGAGGCTGTAGTGAGCTATGATCATGCCACTGCACTCCAACCTGGGTGACAGAGCAAGACCTCCAAA AAAAAAAAAAAAAGAGCTGCTGAGCTCAGAATTCAAACTGGGCTCTCAAATTGGATTTTCTTTTAGAATA TATTTATAATTAAAAAGGATAGCCATCTTTTGAGCTCCCAGGCACCACCATCTATTTATCATAACACTTA CTGTTTTCCCCCCTTATGATCATAAATTCCTAGACAACAGGCATTGTAAAAATAGTTATAGTAGTTGATA TTTAGGAGCACTTAACTATATTCCAGGCACTATTGTGCTTTTCTTGTATAACTCATTAGATGCTTGTCAG ACCTCTGAGATTGTTCCTATTATACTTATTTTACAGATGAGAAAATTAAGGCACAGAGAAGTTATGAAAT TTTTCCAAGGTATTAAACCTAGTAAGTGGCTGAGCCATGATTCAAACCTAGGAAGTTAGATGTCAGAGCC TGTGCTTTTTTTTTGTTTTTGTTTTTGTTTTCAGTAGAAACGGGGGTCTCACTTTGTTGGCCAGGCTGGT CTTGAACTCCTAACCTCAAATAATCCACCCATCTCGGCCTCCTCAAGTGCTGGGATTACAGGTGAGAGCC ACTGTGCCTGGCGAAGCCCATGCCTTTAACCACTTCTCTGTATTACATACTAGCTTAACTAGCATTGTAC CTGCCACAGTAGATGCTCAGTAAATATTTCTAGTTGAATATCTGTTTTTCAACAAGTACATTTTTTTAAC CCTTTTAATTAAGAAAACTTTTATTGATTTATTTTTTGGGGGGAAATTTTTTAGGATCTGATTCTTCTGA AGATACCGTTAATAAGGCAACTTATTGCAGGTGAGTCAAAGAGAACCTTTGTCTATGAAGCTGGTATTTT CCTATTTAGTTAATATTAAGGATTGATGTTTCTCTCTTTTTAAAAATATTTTAACTTTTATTTTAGGTTC AGGGATGTATGTGCAGTTTGTTATATAGGTAAACACACGACTTGGGATTTGGTGTATAGATTTTTTTCAT CATCCGGGTACTAAGCATACCCCACAGTTTTTTGTTTGCTTTCTTTCTGAATTTCTCCCTCTTCCCACCT TCCTCCCTCAAGTAGGCTGGTGTTTCTCCAGACTAGAATCATGGTATTGGAAGAAACCTTAGAGATCATC TAGTTTAGTTCTCTCATTTTATAGTGGAGGAAATACCCTTTTTGTTTGTTGGATTTAGTTATTAGCACTG TCCAAAGGAATTTAGGATAACAGTAGAACTCTGCACATGCTTGCTTCTAGCAGATTGTTCTCTAAGTTCC TCATATACAGTAATATTGACACAGCAGTAATTGTGACTGATGAAAATGTTCAAGGACTTCATTTTCAACT CTTTCTTTCCTCTGTTCCTTATTTCCACATATCTCTCAAGCTTTGTCTGTATGTTATATAATAAACTACA AGCAACCCCAACTATGTTACCTACCTTCCTTAGGAATTATTGCTTGACCCAGGTTTTTTTTTTTTTTTTT TTGGAGACGGGGTCTTGCCCTGTTGCCAGGATGGAGTGTAGTGGCGCCATCTCGGCTCACTGCAATCTCC AACTCCCTGGTTCAAGCGATTCTCCTGTCTCAATCTCACGAGTAGCTGGGACTACAGGTATACACCACCA CGCCCGGTTAATTGACCATTCCATTTCTTTCTTTCTCTCTTTTTTTTTTTTTTTTTTGAGACAGAGTCTT GCTCTGTTGCCCAGGCTGGAGTACAGAGGTGTGATCTCACCTCTCCGCAACGTCTGCCTCCCAGGTTGAA GCCATACTCCTGCCTCAGCCTCTCTAGTAGCTGGGACTACAGGCGCGCGCCACCACACCCGGCTAATTTT TGTATTTTTAGTAGAGATGGGGTTTCACCATGTTGGCCAGGCTGGTCTTGAACTCATGACCTCAAGTGGT CCACCCGCCTCAGCCTCCCAAAGTGCTGGAATTACAGGCTTGAGCCACCGTGCCCAGCAACCATTTCATT TCAACTAGAAGTTTCTAAAGGAGAGAGCAGCTTTCACTAACTAAATAAGATTGGTCAGCTTTCTGTAATC GAAAGAGCTAAAATGTTTGATCTTGGTCATTTGACAGTTCTGCATACATGTAACTAGTGTTTCTTATTAG GACTCTGTCTTTTCCCTATAGTGTGGGAGATCAAGAATTGTTACAAATCACCCCTCAAGGAACCAGGGAT GAAATCAGTTTGGATTCTGCAAAAAAGGGTAATGGCAAAGTTTGCCAACTTAACAGGCACTGAAAAGAGA GTGGGTAGATACAGTACTGTAATTAGATTATTCTGAAGACCATTTGGGACCTTTACAACCCACAAAATCT CTTGGCAGAGTTAGAGTATCATTCTCTGTCAAATGTCGTGGTATGGTCTGATAGATTTAAATGGTACTAG ACTAATGTACCTATAATAAGACCTTCTGTAACTGATTGTTGCCCTTTCGTTTTTTTTTTTGTTTGTTTGT TTGTTTTTTTTTGAGATGGGGTCTCACTCTGTTGCCCAGGCTGGAGTGCAGTGATGCAATCTTGGCTCAC TGCAACCTCCACCTCCAAGGCTCAAGCTATCCTCCCACTTCAGCCTCCTGAGTAGCTGGGACTACAGGCG CATGCCACCACACCCGGTTAATTTTTTGTGGTTTTATAGAGATGGGGTTTCACCATGTTACCGAGGCTGG TCTCAAACTCCTGGACTCAAGCAGTCTGCCCACTTCAGCCTCCCAAAGTGCTGCAGTTACAGGCTTGAGC CACTGTGCCTGGCCTGCCCTTTACTTTTAATTGGTGTATTTGTGTTTCATCTTTTACCTACTGGTTTTTA AATATAGGGAGTGGTAAGTCTGTAGATAGAACAGAGTATTAAGTAGACTTAATGGCCAGTAATCTTTAGA GTACATCAGAACCAGTTTTCTGATGGCCAATCTGCTTTTAATTCACTCTTAGACGTTAGAGAAATAGGTG TGGTTTCTGCATAGGGAAAATTCTGAAATTAAAAATTTAATGGATCCTAAGTGGAAATAATCTAGGTAAA TAGGAATTAAATGAAAGAGTATGAGCTACATCTTCAGTATACTTGGTAGTTTATGAGGTTAGTTTCTCTA ATATAGCCAGTTGGTTGATTTCCACCTCCAAGGTGTATGAAGTATGTATTTTTTTAATGACAATTCAGTT TTTGAGTACCTTGTTATTTTTGTATATTTTCAGCTGCTTGTGAATTTTCTGAGACGGATGTAACAAATAC TGAACATCATCAACCCAGTAATAATGATTTGAACACCACTGAGAAGCGTGCAGCTGAGAGGCATCCAGAA AAGTATCAGGGTAGTTCTGTTTCAAACTTGCATGTGGAGCCATGTGGCACAAATACTCATGCCAGCTCAT TACAGCATGAGAACAGCAGTTTATTACTCACTAAAGACAGAATGAATGTAGAAAAGGCTGAATTCTGTAA TAAAAGCAAACAGCCTGGCTTAGCAAGGAGCCAACATAACAGATGGGCTGGAAGTAAGGAAACATGTAAT GATAGGCGGACTCCCAGCACAGAAAAAAAGGTAGATCTGAATGCTGATCCCCTGTGTGAGAGAAAAGAAT GGAATAAGCAGAAACTGCCATGCTCAGAGAATCCTAGAGATACTGAAGATGTTCCTTGGATAACACTAAA TAGCAGCATTCAGAAAGTTAATGAGTGGTTTTCCAGAAGTGATGAACTGTTAGGTTCTGATGACTCACAT GATGGGGAGTCTGAATCAAATGCCAAAGTAGCTGATGTATTGGACGTTCTAAATGAGGTAGATGAATATT CTGGTTCTTCAGAGAAAATAGACTTACTGGCCAGTGATCCTCATGAGGCTTTAATATGTAAAAGTGAAAG AGTTCACTCCAAATCAGTAGAGAGTAATATTGAAGACAAAATATTTGGGAAAACCTATCGGAAGAAGGCA AGCCTCCCCAACTTAAGCCATGTAACTGAAAATCTAATTATAGGAGCATTTGTTACTGAGCCACAGATAA TACAAGAGCGTCCCCTCACAAATAAATTAAAGCGTAAAAGGAGACCTACATCAGGCCTTCATCCTGAGGA TTTTATCAAGAAAGCAGATTTGGCAGTTCAAAAGACTCCTGAAATGATAAATCAGGGAACTAACCAAACG GAGCAGAATGGTCAAGTGATGAATATTACTAATAGTGGTCATGAGAATAAAACAAAAGGTGATTCTATTC AGAATGAGAAAAATCCTAACCCAATAGAATCACTCGAAAAAGAATCTGCTTTCAAAACGAAAGCTGAACC TATAAGCAGCAGTATAAGCAATATGGAACTCGAATTAAATATCCACAATTCAAAAGCACCTAAAAAGAAT AGGCTGAGGAGGAAGTCTTCTACCAGGCATATTCATGCGCTTGAACTAGTAGTCAGTAGAAATCTAAGCC CACCTAATTGTACTGAATTGCAAATTGATAGTTGTTCTAGCAGTGAAGAGATAAAGAAAAAAAAGTACAA CCAAATGCCAGTCAGGCACAGCAGAAACCTACAACTCATGGAAGGTAAAGAACCTGCAACTGGAGCCAAG AAGAGTAACAAGCCAAATGAACAGACAAGTAAAAGACATGACAGCGATACTTTCCCAGAGCTGAAGTTAA CAAATGCACCTGGTTCTTTTACTAAGTGTTCAAATACCAGTGAACTTAAAGAATTTGTCAATCCTAGCCT TCCAAGAGAAGAAAAAGAAGAGAAACTAGAAACAGTTAAAGTGTCTAATAATGCTGAAGACCCCAAAGAT CTCATGTTAAGTGGAGAAAGGGTTTTGCAAACTGAAAGATCTGTAGAGAGTAGCAGTATTTCATTGGTAC CTGGTACTGATTATGGCACTCAGGAAAGTATCTCGTTACTGGAAGTTAGCACTCTAGGGAAGGCAAAAAC AGAACCAAATAAATGTGTGAGTCAGTGTGCAGCATTTGAAAACCCCAAGGGACTAATTCATGGTTGTTCC AAAGATAATAGAAATGACACAGAAGGCTTTAAGTATCCATTGGGACATGAAGTTAACCACAGTCGGGAAA CAAGCATAGAAATGGAAGAAAGTGAACTTGATGCTCAGTATTTGCAGAATACATTCAAGGTTTCAAAGCG CCAGTCATTTGCTCCGTTTTCAAATCCAGGAAATGCAGAAGAGGAATGTGCAACATTCTCTGCCCACTCT GGGTCCTTAAAGAAACAAAGTCCAAAAGTCACTTTTGAATGTGAACAAAAGGAAGAAAATCAAGGAAAGA ATGAGTCTAATATCAAGCCTGTACAGACAGTTAATATCACTGCAGGCTTTCCTGTGGTTGGTCAGAAAGA TAAGCCAGTTGATAATGCCAAATGTAGTATCAAAGGAGGCTCTAGGTTTTGTCTATCATCTCAGTTCAGA GGCAACGAAACTGGACTCATTACTCCAAATAAACATGGACTTTTACAAAACCCATATCGTATACCACCAC TTTTTCCCATCAAGTCATTTGTTAAAACTAAATGTAAGAAAAATCTGCTAGAGGAAAACTTTGAGGAACA TTCAATGTCACCTGAAAGAGAAATGGGAAATGAGAACATTCCAAGTACAGTGAGCACAATTAGCCGTAAT AACATTAGAGAAAATGTTTTTAAAGAAGCCAGCTCAAGCAATATTAATGAAGTAGGTTCCAGTACTAATG AAGTGGGCTCCAGTATTAATGAAATAGGTTCCAGTGATGAAAACATTCAAGCAGAACTAGGTAGAAACAG AGGGCCAAAATTGAATGCTATGCTTAGATTAGGGGTTTTGCAACCTGAGGTCTATAAACAAAGTCTTCCT GGAAGTAATTGTAAGCATCCTGAAATAAAAAAGCAAGAATATGAAGAAGTAGTTCAGACTGTTAATACAG ATTTCTCTCCATATCTGATTTCAGATAACTTAGAACAGCCTATGGGAAGTAGTCATGCATCTCAGGTTTG TTCTGAGACACCTGATGACCTGTTAGATGATGGTGAAATAAAGGAAGATACTAGTTTTGCTGAAAATGAC ATTAAGGAAAGTTCTGCTGTTTTTAGCAAAAGCGTCCAGAAAGGAGAGCTTAGCAGGAGTCCTAGCCCTT TCACCCATACACATTTGGCTCAGGGTTACCGAAGAGGGGCCAAGAAATTAGAGTCCTCAGAAGAGAACTT ATCTAGTGAGGATGAAGAGCTTCCCTGCTTCCAACACTTGTTATTTGGTAAAGTAAACAATATACCTTCT CAGTCTACTAGGCATAGCACCGTTGCTACCGAGTGTCTGTCTAAGAACACAGAGGAGAATTTATTATCAT TGAAGAATAGCTTAAATGACTGCAGTAACCAGGTAATATTGGCAAAGGCATCTCAGGAACATCACCTTAG TGAGGAAACAAAATGTTCTGCTAGCTTGTTTTCTTCACAGTGCAGTGAATTGGAAGACTTGACTGCAAAT ACAAACACCCAGGATCCTTTCTTGATTGGTTCTTCCAAACAAATGAGGCATCAGTCTGAAAGCCAGGGAG TTGGTCTGAGTGACAAGGAATTGGTTTCAGATGATGAAGAAAGAGGAACGGGCTTGGAAGAAAATAATCA AGAAGAGCAAAGCATGGATTCAAACTTAGGTATTGGAACCAGGTTTTTGTGTTTGCCCCAGTCTATTTAT AGAAGTGAGCTAAATGTTTATGCTTTTGGGGAGCACATTTTACAAATTTCCAAGTATAGTTAAAGGAACT GCTTCTTAAACTTGAAACATGTTCCTCCTAAGGTGCTTTTCATAGAAAAAAGTCCTTCACACAGCTAGGA CGTCATCTTTGACTGAATGAGCTTTAACATCCTAATTACTGGTGGACTTACTTCTGGTTTCATTTTATAA AAGCAAATCCAGGTGTCCCAAAGCAAGGAATTTAATCATTTTGTGTGACATGAAAGTAAATCCAGTCCTG CCAATGAGAAGAAAAAGACACAGCAAGTTGCAGCGTTTATAGTCTGCTTTTACATCTGAACCTCTGTTTT TGTTATTTAAGGTGAAGCAGCATCTGGGTGTGAGAGTGAAACAAGCGTCTCTGAAGACTGCTCAGGGCTA TCCTCTCAGAGTGACATTTTAACCACTCAGGTAAAAAGCGTGTGTGTGTGTGCACATGCGTGTGTGTGGT GTCCTTTGCATTCAGTAGTATGTATCCCACATTCTTAGGTTTGCTGACATCATCTCTTTGAATTAATGGC ACAATTGTTTGTGGTTCATTGTCTCCTTAAATTAGACTGTAAGCACCTTGATGGAACTCATACTACCTTT TATTTCACACACACGCACACGCGCACACACAGCCTACACATACACTGCCTAGCTCATTGTAGCATACTAA ATACTGATTTTAATGAATAAGCTAAACCTTCGAAACCCATTTGCTAATCCCAGCACTTTGGGAGGCCAAG GTGGGTGGATCACCTCAGGTCAGAAGTTTGAGACCAGCCTGGCCAACATGGTGAAACCCCACATCTACTA AAAATACAAAAATTAGCTGGGCGTGGTGGCCAATGCCTTGTAATCCCAGCTATTCTGGAGGCTGAGACAG GAGAATCGCCTGAACCTGGGAGGCGGAGGTTGCACTGAGCTGGGATTGTACCACTGCACTCCAGCCTGGG TGACAAAGTGAGACTCCATCTCAAAAACAAACAAACAAAAACACATCATTTCCCCTATAGCAAAAACATG ACGGCACTTACTGTATCAAGAGAGGTGAGAAAAAGGAGCCACAGCAGGATGATTCAAGGGACTCTGCATA GCTCCATTTTAAGAATATGCCTACTGCAGGTCAGAGAAGGTAAGCAAACTGCCTAAGGCCACACAGCCAG GTACAGAACTCTCACCAATATTATTGCCAGCAATCGCAATTTTGGTGTTTATTCTTGGTACCAAGTTGGA GACTATAGGGTTCTCTTCCTAATAGAGACCATCTAGCCTTTCACTGTTTTGTGGATACTTCTTTCTCTTC TTCTTTTTTTTTTTCCCTTTTAAAATCTAGTTATTTTTTTCTTTTTGGTTTCTTTGACACAGGGTCTCTT ACTCTGTTACCCAGGCTGGAATGGAGTAGTGCAGTCATGGTTCACTGTAGCTTTGACTTCCTGGGCTCAA GCGATCCTCCTACCTCAGCTTCCCGAGTAGCTGGGACCACAGGCGCCCACCAACACCTCCAGCTAATTTT TAAGTTTTTACTAGAGACAACATCTCACTATGTTGCCCAGGCTGGTCTCAAAATCCTGGGCTCAAGTGAT CCCACCTCAGCCTCCCAAAATGCTGGGATTACAGGTGTGTGCAACCACGCCTGGCCTATTTTTTTTTTAA TTGCTCATAAATCATCTTTTTTCTTTAAAAAAAAGAAAGATGGGAGGCTAAAGCAGGAGAATCACTTGAA CCCAGGAGGCGGAGGTTGCAGTGAGCTGAGATCATGCTGCTGCTCTCCAGCCTGGGCAACAAGAGTGAAA CTCCATCTCAAAAAAAAAAAAAAAGAAAGTACACAATTTTACTTTCTGGACCTAATGGTCAAGGCCAATA ATTTGGTCACCTATGAAATAAATAAAAGCTTTACCATATATATGACCATTTGATAATGTAATATGAAATG TTTATGTACTAAAGGCAGAATAGTCTAGAAAAAACATTCTGTATCACAACGTCTAAAAATGAATATCATC TTCATCATAGAACCAGGCTCTTTCTCCTAATTTTTTTTTTTGAGATGGAGTTTTGCTCTGTCACCCAGGC TGGAATGCAGTGGCACAATTTTGGCTCACTGCAACCTTCAGCTCCCAGGTTCAGGATCAAGTGATTTTCG TGCTTCAGCCTTCTAAGTAGCTGGGATTACAGGTGACTGCCACCACACCCAGCTCATTTTTTTGTATTTT TTTAGTAGAGAGAGGGTTTCACCATGTTGGCCAGGCTCGTCTCGAACTCCTGACCTCAAATAATCCACCC GTCTCAGCCTCCCAAAGTGCTGAGATTACAGGCGTGAGCCACCAGGCCTGGCCTCCTAATTTTTATTTGT AGAAGTGGCACCAAAATTTTCCAAGTTCTCATGCAAAAATTCAGGCTCATCTCAGTTTATTTTTTTCATT TATTTATCTCCCACTAAATTGACAACTTCTAATAATTAGGTTGGTTCTTTGTATTCCCAGCACAGGGTTC TATGCAGAATACACACACAGCAGTTGCTGGCAATAATATTGGTGAGAGTTCTGTACTGGGCTATGTGATC TTAGACAGTTTGCTTATGTTCTCTGACCTGCCGTAGGCACATTCTTAAAATGAAGCTGTTCAGACCCCCT CGATTCATCCTGCTGTGGCTTCTTTTTCCCACCTAAATCTTAAATACCCTTTTAGCTGCTAGTAAGTGAA TGATGTTTTTTTATGAACTTTCTGAAGTCAGATTAGATGAAGTTGAGAAAAGCCTGATATTCTTATAAAG TTATATATGTGCATCATAGAAAACTTAGAAAATACAGATAAACAAAAATCATCCATGGACGAACCTTGAA GACATTGTGTTAACTGAAATAAACCGGACACCAAAGGACACATGTTATATGCTTCCACTTATATGAGATA CCTAGAATAGTTACATTTGGTTACTCTGGGTACATTGCCTATAGATAAGCCTTGCTCCACAAGGAGCAGT TAAAAAAAAAAAAAAGATAAATTCATAGGATGGAAGGTAGAATAGTGGTTACTAGGGACTTGGGGAGGGG GAAATGGGGAGTTACTGTTTGATGAGTGCAGATTTCAGTTTGGGATGATGAAAAAGTTCTGGAGATAGAT AGTGGCAATGGTAACACAACAGTGTGAAAATAATGCCACTGAACTGTACACTTAAAATGATTAAAATGAT AAGTTAATTGTAATTTGTGTTATCCAGAAATGGTTAGCAATTTATTGGTGTATATTCTTTTAGTATTCCT GTGTGTGCACAGGGGTGCTTGTATATACTTTATCTTTAAAATATATCCAGGAAGCTAGGCACAGTGGCTT ACACCTGTAATCCCAGCACTTTGGGAGGGTGAGGCAGGAAGATTGCCTGAGCCCCGGAGGTCAAGGCTGC AGTGAGTTGTGATCACGCTACTGCACTCTGTTCTGGGCAACCCCTGTCTGGGAAAAAAAAAAAAATTAGT GAGGCTTAGTGGTGCACACCTGTAGTCTCAGCTACTTGAGTGGCTGGGGTAGGATTGCTTGATCCCAGCA AGTTGAGGCCGTGGTGAGCCATGATGGTGCCACTGCACTCCATCCTGGGTGATATGGTGAGACCCTGTCT CAAAAACAAGAAATCCAGATAATTCTGTGCATTATAATCTAGCTTTTACTGGATCATTAAAATTCTTTTT TCTTTTTTTTTTTTTTTTTCTGAGATGGAGTTTCACTCTTGTTGCCCAGGCTGGAGTGCAGTGGTGTGAC CTTGGCTCACCGCATCCTCTGCCTCCCGGGTTCATGCGATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGG ATTACAGGCATGTGCCACCATGCCCAGCTAACTTTGTATTTTTAGTAGAGACAGGGTTTCTCCATGTTGA CCAGGCTGGTCTCAAACTCCTGGCCTCAAGTGATCCACCCACCTCGGCCTCCCAAAGTGCTGGGGTTACA GGCGTGAGCCACCGCACTCAGCCTGGGTCGTTAAAATTCTTAAGTGACTTCATTTTTAATTACTATATGG GATTCTATCTTTCCAGTGTATCATGATTTATTTGACCTATTGCTGAATGTTGGAGGTTTCAGGGTAAGAG GCACAGTTTGCTATTATGTACATCACTATAGTGGCATCCTGATAGCTAAATATTTGCCTACATCCCTGAT TATTTCCTTAGTCTAAATTACTGGGACTAGGATTTTGGTGTTTGATACATGTTACTAAATTGTTTTTTAG AAAGATTAAACCAGTTTATGCTCTTCCAGCCCCTGTGGTATATGATAGTTCCCATTTTCCTGTACCTTGC CAACACTGGGTGATATCCAGTTTTAAAATCTAAATCTTGCATTGCTATGAGAACTACAATTAGAGAAGGC TTATCTTCTACTGCCCATTCTCTGTACAGAGCAAATCCCTCTAGACCTGAAGCCCCTTGGAGTTGTCAAG AAACCTTTGAGATGACTCCCCACTCTGTATCTGAGCTGTCACCAGTATTCTCCACTTCTTCAGGATTGCC ATGGCAACTAAATTGATGAAAAGATTTAGGAGGCCTTTTCTCTCTTTGCAATTCCTATGATCCTTTTTGA ATGTGGGTTTGGGACTCTGTCAATATACCCATCATCTAATTCTGTCCATTGTGTTTTAAAGTTTAAGGTT GCAATTTCTGATTACATCTGCCTTAGCCATACTGTATTATATTTGACATTCAATATACAATGTCCTTGTT TTTCTGTATTTCTAATCTTATTCCCAGAGATGTGTCTATTTGTTCAGGATTCATTTTGCAACGTGTTTTT ACTAAGCATCTACCCAAAACCGTTGAAGTCAGATTTCAGGCTGTCTTACGTCTAAAGTAGCACAGGCAGG AAAAACTATTGAAGTGGGATTTTTTTTTCCCTTTTTGTACTGAACCGAGAAAAAGTATATAGATGATAGA GAATTCCTAATTTGGTATCATTGATATCTGGGTTTTTGTTTGTTTTTACAGAAGACTGATTAACTATACT TATTTATTAATTTATCTTCTCATTAATAAACACTTGCTGAGTGCTTACTGTCTGCTAGGCATTAGGGAGA CAAATATGATTAAGGGAAGCTTCCTCCTATCAAGGTCATGTGTTCCATTTGGGTATACTAATGCATTAGC AATGTAAATCAAGTAGTGAGAGATCATCTGTTCCCGATAGGAGATGGATTATTGGTGGGGACTTCTGTGT GTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTATGTATGTGATAAAATAAATATAGGAAATGTTAATT ATAGATTCTAAGTAGTAGATATATAAACACTCATTGCAAAGTTGCTTCAAGTTTTCTGTATATTTGAAAA TATTCACAACATGTCGACAAAACTAGCATGATAAAGCCACTATTTGTGCTAAGACTTCAGCTTGTATCTG GATTAGGCTTATTATGTAGTAGTAGGAACATTAGAAATAGTTTTAACTCATTAAATACACATGTTTTATG GGAAGGTTTTATATATATATTTATATGTAATGAATGTGAACAAACAAGGGTCAGATATACACTCTGCTTC CCTCCAGACCAGTTCCGGCTGCTCTGCTGCACATTTCAGGAGTCTTATTAGAATTAGCCACATTCTGCCC ACTTGCCCTTACTTCTCATATTTCACAACTCCTCCTGGTGGGGACTTAAGGAGACATTCAAACTAGGCCT TGAAAGATGAGAATTTTTCCAAGTGGAAAAAGAGGAGTGGCAGCAAGTAAGGTAAAGGTACAGAGTCATG GAATTCCCAGGAAACGTAAAGTTGTCATGTGTTATAGGAAAACAACTTGTGTGAGGGGTGTTGGGAGAAA TGAGAGATAATACCAGGGTATAAAGGGCCTTTTGAATGCTATGTTGAGGAATTTTATCCTAATGGCAGTA ATGACTAACAATTATATAGTGTTCAAAAAGTATAAATCAGCAGTGGTATACCACTAAGGGTTTTTTTCTT TTCTTTTTTTTTTTGAGACAGAGTTTTGCTCTGTTGCCCAGGCTGGAGTGCCGTGGCACGATCTCAGCTC ACTGCACTTCCGCCACCTGGGTTCAAGTGATTCTTCTGCCTCAGCCAGTGTTTCACTGTGATGGCCAGGA TGGAGCACTAAGGGTCTTTATGGAAGAAAAAGACATGATAAACAAGGCTTTTAGGGAACTTCTACAGTAA TGTAGCTGTATTAAAAGTAGAGATCAGAGCAGCATAGTAGAAGTAGAAGGCTAGAGCTAATTGAAGGAGC ACTTCAGAATTAGAATCAAGAAGTCTTAGAAACCTATTGGTTTTATTCTCCCTAATGTATTTGGCCACTT ACCTGCTGGGGAATTTGTCTAAGTTATAAAAAATAATTCCTTTGGGAAACCCAAAGGAAAGTTATCTATT AATAATTACCCCACTACTTTTTCTGATTTATGTAATGGCCACGTAGAGGTTAGATGTGATGGTTGTGACA GTAGTGACTAATACAGCCTGTGAAGCATTTTGGTCAGATATCTATGTGCTTTCATTCCAGGTTGACTGAG GCAAGACTTTGGCTAGGGTTTGATCAGTGATGTAACTACTCACGAGTACCACGTGGTGGCAATGGCATTG CTGCAGACCTTGGCAGCAAAGCAGTGTTAGAGTAGCAGTAGAAACCTTTGTGAAGCTAGGAATACATTTT CTGGTCATAAAAACCTCCTGAAAATTGTGAACTCAGTGTAGCAGGAGAAAGAAGATGGCTTGTTTTTAGT AAAGGGCAAAGTCATTTTTAAGGATCAGAAGAAGAAACGGAGAGTGAAACAATGTGTTCCTGCCCTACTC CCCCACTGGACTTTTTGGCAACCATTGCTGTTCCTTCTAAAAGTGATTTTTAAACATGTATATTTTGAAG CCAGGCACAGTGACTCACGTCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGGCAGATCACCTGAGGTC AGGAGTTCAAGACCAGCCTGGCCAACATGGTGAAACCCCGTCTCTACTAAAAATACAAAAATTAGGCCAG GTGTGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGGAGGATCATGTGGTCAGGAGA TCCAGACCATCCTGGCTAACACGGTGAAACACCATTTCTACTAAAAATACAAAAAATTAGCTGGGCATGG TGGCGGGCGCCTGTAATCCCAGCTACTCAGGAGGCTGAAGCAGAAGAATGGCTTGAACCTGGGAGGCGGA GCTTGCAGTGAACCAAGATTGCGCCACTGCACTCCAGCCTGGGCAACAAAGTGAGACTCCGTCTCAAAAA AAAAAAAAAAAATTAGTCGGGCATGGTAACAGGTGCCTGTAATCCCAGCTACTTGAGAGGCTGAGGCAGG GAGAATTGCTTGAACCAGGTAGGCGGAGGTTGCAGTGAGCCAAGATCGCACCACTGCACTCCAGCCTGGG GCAACAGAGCAAGACTGTCTCAAAAAAAATAAATAAATAAAATAAATTCTTAAGAAGGATATTTTGGAAA ACTCCTTACATACCTAAATTCTTTGTTTATCAAATACTTGGACTTAGCACACTCTTCTTTGAAATGGACC AATAAACAACAGGAGCCCATAAGCAAAAAGAACTCATTATTTTAAAAACAGTAACTATCCTTACAGGCTT TCTCAGGGCTCTTTCTGTTGGATCCTTCCCTCTCACAGGTCCTTGCTAATGATCTCTAGGTGGACACATT CTAGATGAGATGTCCCTGTCTAGAATGGCAGCACCATGAGGGCTATATCCTCAGTACTAGGACAGCGCCT GGTGCTTAATAGATAGTAAATAGTTGTCTAATTAACTGAGCAAACAGATAGATTCATGAATTAGCTTTTT GCTTTTTCTGTTAGAAACTAAAGGTTCAGGTCAGGCACAATGGCGCATGTCTCTAATCCCAGCACTTTGG GAGGCCGAGGCGGGCTGATCACTTGAGGTCAGGAGTTCAAGACCAGCCTGGCCAACATAGTAAAACCCTG TTTCTACAAAAATTACCAAAATTAGCCGGGCGTCTTGGCAAGCACCTGTAATGCCAGCTACTTGAGAGGC TGAGGTGGGAGAATCGCTTGAACCTGGGAGGAAGAGGTTGCAGTGAGCCGAGATGGTGCCAACCTGGGTG ACAGAGGGAGACTTAAAAAAAAAAAGAAAGAAAGAAAGAAAAGAAACTAAAGGTTCAAAGAATCCCAGAA AAGGAAGAGTCCTCACAAGCCAGTAATCTAGGCAGGATTACTGATAGTATTTTTATATTTGTTGTATTTT TATAAAATGCCATAGATAGAGGGCTTTTTTCAACATTACATCAGTCTAAAAATCACACATTTTTATATGA ACTAACCTAAATGTCTGATGAATCTCACAACACCAAGTCTTTGAAATGTGCCCATATAAATAAAATGTTA ACAGATTCATGCTAATTTTAAATATCGATAGTGTTTAAATGCCTTAATTATTTTTTCACTCCCTAGCTTT AAAAGAAAATAACCAACTTCAAAAGGACATCACAATAACATCAAGTCTATTTGGGGGAATTTGAGGATTT TTTCCCTCACTAACATCATTTGGAAATAATTTCATGGGCATTAATTGCATGAATGTGGTTAGATTAAAAG GTGTTCAGCTAGAACTTGTAGTTCCATACTAGGTGATTTCAATTCCTGTGCTAAAATTAATTTGTATGAT ATATTTTCATTTAATGGAAAGCTTCTCAAAGTATTTCATTTTCTTGGTGCCATTTATCGTTTTTGAAGCA GAGGGATACCATGCAACATAACCTGATAAAGCTCCAGCAGGAAATGGCTGAACTAGAAGCTGTGTTAGAA CAGCATGGGAGCCAGCCTTCTAACAGCTACCCTTCCATCATAAGTGACTCTTCTGCCCTTGAGGACCTGC GAAATCCAGAACAAAGCACATCAGAAAAAGGTGTGTATTGTTGGCCAAACACTGATATCTTAAGCAAAAT TCTTTCCTTCCCCTTTATCTCCTTCTGAAGAGTAAGGACCTAGCTCCAACATTTTATGATCCTTGCTCAG CACATGGGTAATTATGGAGCCTTGGTTCTTGTCCCTGCTCACAACTAATATACCAGTCAGAGGGACCCAA GGCAGTCATTCATGTTGTCATCTGAGTACCTACAACAAGTAGATGCTATGGGGAGCCCATGGAAGATACA TGGTATACAACATAGCTCTTGCTCTATTGGAAGCTAAGTGGAATGGGAGAAATTGGTGACAGGCAACCCC ATAATTTCAGAAAGCTATGAAAAAGTACTCAGACATATTCCTTATAACACTGGTGTCACATCACAAAGAC CTATTTAATGTGCTTCTGATTTATAGGGAGAGACATCCTATACTTCAGGAACTGCACTTTGATCCACAGA AAGCCTAGTGATGTAGAGCTCCTGTTAGTTCAAAAGGAAAAGAAAAGAACAACACAGAAAGCCTAATTAT GCAATAGAGTCAAGTGCTTTATAGCAATGTTACAGTTATCAAAAAAAATCCAGATGGACCTCTGAGAGGA TGCCATTGGAGTAACCAGGCAGATGCAGTTGATCAGAGCTGACTTCCTATAAGAAGTGAGCACTGAGCTG AGGAATAATGGCATAAATGAAGGAAAGTGAGATGGAAATTTGAGTTTTTAATTGGAAAGACAATACATCA GGCAGATTTTTAAATAGGGGCAAACAAACAGACACATAGGAGATGCTAGGCATGGGGTCCCCACTAGGAT GCTGCTTAGAAACATGCAGGGGTGGTGAGTACTCCCAAAGTACACTTCATTCCTAGCTCAGTGATTCTTA TCTGAGTGTTAAAGTTCCTTCTTCAGCACCCCGTTCCACAGTCCAACTGGGAACTTTAAGACCTTTCTTG GAGTCTTTCTAGGAACTCAAGTCTGCTACTTATACAGAACAGTGGCTTTGGTCCCCAGTTGTGCCTTGCA GTATTTTTGTGTTCAGGAAGAAACAGTAGCTCTTGGATAAAGAAGCTAGCTAGAAACTCTGTTGCTATGG CAGTGCTTCAAAATGTATTTCCTTAAATGCTTTCTTTGTAACTATCTTCATTTAGTTCATCTCTCAGATA ATGAGAGATCAGAGTCCCATCCCCAGTATAATACTCTTCTTTAGGGTACTTTCACCATCTTCAGTCTAAA CACAGACTAGACTTTCAATTATAATGTGTAAGATTTAAAATGTTATTATTGTGTGACTTTGAATATCTGT GTAAATCTACTATCTCCTCTTTGGTATATACGTGTGTTTATTTTTTTCTGGAGATCTGTAACTGAAATGC TTAATTTCTGAATTGTTTTGGATATCACAACTTAATACCAACATAAGTTTTGAGCCTTTTTCTCCCTAAA TCTGGTGTGAGTCTAACTGAAACTCAAATGAACTTTTTAAAAATAATTTTTTCTTTTCTTTAATTTTTTT TTTAAGTAGAGACAGGGACGCACTGTTAACTAGGCTGGTCTTGAACTCCTGATCTTGAGCCATCCTCCCC GACCTGAGCCTCACCTTATAGAGAGGGTCTTGCTCTGTTGCCCAAGCTGGAGGGCAGTGGCATAATCACA GCTCACTGCAGCCTCTCGACCTCCTCAAGCGATCCTCCTGCCTTAGCCTCCCAAGTAGCTGGGACTATAG GCGTCCACCACCATACCCAGCTAATTTTTTTTTTTATTTTTTGTAGAGACAAGGTCTCCCTATGTTGCCC AAGTTGGTCTCAAACTCCTGGACTCAAGCAGTCCTCTCACCTCAGCCTCCCAAAGTGCTGGGGTTACAGG TGTGAGCCATGGCACCTGGCCAGAACTTCTAGTAAAAAGAATATTGTTGCCGGGTACGGTGGCTCACGCC TGTAACCCCAGCACTTTGGGAGGCCAAGGCAGGCGAATCACCTGAGGTCGGGAGCTCGAGACCAGCCTGA CCAACATGGAGAAACCACATCTCTACTAAAACTACAAAAAATTAGCCGGGCGTGGTGGCACATGCCTGTA ATCCCACCTACTTGGGAGCTACGGTGCCTGGCCTAGTTTATTATTTCTTAATATCTGTTGTCTTCCAGTG TCTTCCTTAATTCTTCACAATACCCTGTACAATGCTTAGCACACAGTGGGCAGTCTGTAAGTTTATTAAA TGTTTGGTGTGGCCCATACTTCCTATCCACAAAGAATGTAACATGTTAAGACATCTAGATGAGGGAATGA TTTAAGAGGAACTACAATAATATTCTGAAACTTGGACTCTGGATCTCTGCATTTAGACTTTCCTAAACCA GCCAGCAAGTAGATCATCATGTCACAAGGCTTAGGTTGGGCTTGCTGTTCAGAGAATGAATTAAGGATTA AGGAGAAAAAAAAGCAGAAAGGTTTTGCTCTGTTTTTCAGGTTCTATTGAGTTGTTAACTTCTAACAAGT TATCTTATTTGCTTCATTGCATGAGGCCCATTGTAGTAAGAAGAGGAATTTATATGCTAAATGTTCTGGT GATAGAATGACTTTTCTTTTTTTTTACAGTCCAAAGGTCTTTTTTTTTTTTTTTTAACACCTATTATGCC ATGAATTCATAGGGAATAGGTTCCAGCTGCTCAGGCTCCTTCCCATTGGTTCTCACAAAGTGTGCTTCTC TGGGTGGAGCAGGCTGGTGCTTCAGTTGAACCCACGTACCTTTCTCTTTGGCTTCTTTCTTTTTCTGATC ATTTTCCTTCACGCGTTTCAGGAAGCTGTCTTGGCTCTTAGAGTGTTTAATGTGCTCAATACGCACATTA ATTCTCTTGGCAAGAATCTTGCCCTTAACTTGTTTACAGCGATGCCAACAGCATGCTGGGTCACGTTGTA GACTTTTCCAGTTTTGCCATGGTAACACTTGTGGGGCATTCCTTTTTGAACAGTACCCGTTCCCTTGATG TCTACAATTTCACCTTTCTTACAGATTCGCATATACATGGCCAAAGGAACAACTCCATGTTTTCTAAAAG GCCTAGAGAACATATATCAGGTGCCTCTCCTCTTTCCCTTTGTGTTCGTCATTTTGGCAAATTACTGAAA GATGGTGGTTCTGGCCAAAAGGAGGAATGACTTTTTAATAGCTGTGTTTGTATCTGAGCCTTCCCTCTGC CTTTCATTTTTTTTGTTTTGTTTTGTTTTGTTTTTGTTTGAGATGAAGTTTCACTTTTGTTGCCCAGGCT GGAGTGCAATGGTGTGATTTCGGCTCATTACAATGTCCGCCTCAGCCTCCTGGGTAGCTGGGATTACAGG CACCCGCCACCACGCCCAGCTAATTTTTGTATTTTTAGTAGAGACAGGGTTTCACCATGTTGGCCGGGCT GGTCTCAAACTCCTGACCTCAGGTGATCTGTCCACCTCGGCCTCTCAAAGTGCTGGGATTGTAGGCGTGA GCCACATCACCTGGCCACTTTTTTAACTCTTTCCAATGGTTAATTCCGTTTGATATGGTTCCTTGGAACT TGCACATTACCCTTTATCAATTATCACCCTGTATTGGGGGTGGGGAGGATGATACCTCTCTTCATAGTTA GATCCTACTTACTTTCAACAGAGTTCTTAACAATCCTAGAAACTCACAGGTCCAGAAAAGACAAGCATAA AGGAAACTATAAATAATGCATTTGAAGACTAACTCAGGAAATCAATGATTATTTCCCCCCAGGCTACCCA GTGTCTTAAAAAAACAGTTTAATTAATACAATCTTTTGTTTCAATTTTCTACCTATATTTATGGCTTTTA GCTTTTCTAATAAAAGCTCAAAATGAATTACAGTCATCAGTGACTTTTTAATGAATAGAAGACTTTTGCA ATTTTTAACTATTTGTTTTTACTTATTAAATATTTCCGCCTTGGCCAGGCATGGTGGCTCACGCCTATAA TCCCAGCACTGTGAGATGCCAAGGCAGGAGGATCACTTGAGTTTAAGAGTTCTAGACCAGGCTGGGTATG GTGGCTCATGCCTATAATCCCAGCACTTTGTGAGGCCAAGGTTGGCGGATCACCTGAGGTCAGGAGTTTA AGACCAGCCTGGCCAACATGGTAAAACCCCATCTCTACAAAAAATACAAAAATTAGCCAAGGGGTGGTGG TGGGCACCTATAATCCCATCTTCTTGGGAGGCTAAGGCAGGAGAATCGCTTGAACCTGGAGGCAGAGGTT GCAGTGAGCCGAGATCATGCCACTGTATTCCAGCCTGGGTAACAGAGCAAGACTCTGTCTCAAAAAAAAA AAAAAGTTTGAAACCAGCCTGGTCAACACAGCAAGACACCCATCTCGTTGAAAAATAACGGTCGGGCGCA GTGGCTCACGCCTGTAATCCCATCACTTTGGGAGGCCGAGGCAGGCAGATCACCTGAGGTCGGGAGTTCG AGACCAGCGTGACCAACATGGAGAAACCCCATCTCTACTAAAAATACAAAATTAGTTGGGCGAGGTGGTG CATACCTGTAATCCCAACTACTTGGGAGGCTGAGGCAGGAGAACAGCTTGAACCTGGGAGGCAGAGAGGT TGTGGTGAGCCAAGATCATGCCATTGCACTGCAGCCTGGGCAACAAGAGCAAACTCCATCTCAAAAAAAA TAAATAAATAAAAATAAATAAATAAGTACTTCTGCCTTTAAGCCACTTCCTAGAAGGCAGTGGCACAAAG TGATACATTTGGAGGAGTAAATATATTACAAAATGAATTAGGCTGGGCGCAGTGGCTCATGTCTGTAATC CCCGCACTTTGGGAGGCCAAGGCGGGTGGATCACTTGAGGTCAGGAGTTCGAGACTAGCCTGATCAACAG GGTAAAATCCCATCTCTACTAAAAATACCAAAAAAACTAGCTGGGCGTGGTGGCAGGCACCTGTAATGTC AGCTACTAGGAAGGCTGAGGCAGGAGAATCGCTTGAACCCAGGAGGTGGAGGTTGCAGTGAGCCAAGATT GCACCATTGCACTTCAGCTTGGGCAACAGAGTGAGACTCCGTCTCAAAAAAAAAAAAAGAACTAACATGC CAGAACTTTGCCTTCAGTATGTTTTGTGATTTTTCCCTTCTTGTGCCATTTCATCATTAGTTCCATGTAT TATTTAAGATTTCTTATCAACCAGCACCTTGGGATTTTTTTGTGTATGTGTTGGTTTAGGGGGTTTATTT GTTTTTTTCTTTTTTTTCGGTAATTGAAAATGTGAAGCAAAATGTCACCTGTTTTTTCTTTCATGTCTGA CACTCATGTCTTGTTTACCCCCGACATGCAGAAGCTGAAATCCCCATTTCATACAGTCTTCAATGTGGAG GCAGTAGGGATGGAGAAAATAATGTACTTTGTGCTCTCCGGTACTCTTTCTTTCCTATTGTCTGAGGGGA TTTGGGCATAATTTATTTTGCTGCAGAGATAAAAATTTGTTATATATATTTTTTATCATTCAGGGCCAAG GAATATAGATTTTTTTTTTCAGCCTTGTCTCAGCTGGGTGTCTTTATTTACTCTGTCTTAAAGTGTTCCT TTTATTATCATTATTATTTTTTAATCATTGAATTCCATTTGGTGCTAGCATCTGTCTGTTGCATTGCTTG TGTTTATAAAATTCTGCCTGATATACTTGTTTAAAAACCAATTTGTGTATCATAGATTGATGCTTTTGAA AAAAATCAGTATTCTAACCTGAATTATCACTATCAGAACAAAGCAGTAAAGTAGATTTGTTTTCTCATTC CATTTAAAGCAGTATTAACTTCACAGAAAAGTAGTGAATACCCTATAAGCCAGAATCCAGAAGGCCTTTC TGCTGACAAGTTTGAGGTGTCTGCAGATAGTTCTACCAGTAAAAATAAAGAACCAGGAGTGGAAAGGTAA GAAACATCAATGTAAAGATGCTGTGGTATCTGACATCTTTATTTATATTGAACTCTGATTGTTAATTTTT TTCACCATACTTTCTCCAGTTTTTTGCATACAGGCATTTATACACTTTTATTGCTCTAGGATACTTCTTT TGTTTAATCCTATATAGGTTTTTTGAACCTATAACATAAGCTACAACATGAGAAATGTGCGGTTAGATAG ATATGTCCCTTCTGAAGGTCAGAAAAAAATATAATGGAGGTAAAACCTGAACAAGCTTGGAAACTGATGG TAGACTTCTTCAAGGCAGCCCTTGCCCTAATTAAAATTCTTGTCTTTCTAGAAAAAGTCTAGCTGTTGAT TTACCACAGAAAATAATAATAATAATTACTATTATTATTATTTTTTGAGACAGGGTCGCCCTGTGTCACC TAGATTGCAGTGGTGCAGTCATGGCTCACTGCATCCTCCGTTTTTCAGGCTCAAGCAATCCTCCCACCTT AGCCTCCTGAGTAGCTGGGTCCACAAGCATGCGCCACCCACACCCACTAAGTTTTTGTATTTTTGGTAGA GATGGAGTTTTACCTTGTTGCCCAGGCTGGTCTCAAATTCCTGGACTCAAGTAGTCCGCCCGCCTTGCCC TCCCAAAGCCAGAAAACATTTAGAATATCTTTCAGAGATGTGTATTTACACCACTATTAACACAGGGCTG TATAGCAGTCCAGTACTGGACTATGTAGTCCAGTACTATTCTTTTCCTTACTGGAGGGCCAGGCGTGGTG GCAGGTGCCTGTAATCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATTGCTTGAACCTGGGAGGCAGAGG TTGCAGTGAGCTGGGACCGTGCCATTGCACTCCAGCCTGGGCGACAGAGCAAGACTCCGTCTCAAAACAA AAAAAAAAAGAGAGAGAGAGCAGTAATTCAGGTCTCACCCATCTTCAATCCAGGGGGCCTAGCCTTAGTA TTTGACCCATAGTAAGCACCCAATAATTGTTTAAATTAATTAACCTCTGAGGCCCTTTAAATCTGTTGAT AAGTATCTTATTTTGCAAAGTCCTAAGCACTTGGAAGAGCAGAGGAACTATTTACTGGGTGTGTATGCTT TTCTAACAATATTTTATAGCTGGCTTTTGTTTTTAGAATGAATTTGAACATTGAAAAGGCAGGCAATAGG GATGATTCTGTGAATTCTGCTAAAACTGAGTAGAAAGAATGAGTGTAGAGATGTCGACATTGATCAACTT TCTATCTTCATAAGAGATCTGATTCTAACATATCCATTTAGACTCAAGTAGAATATTGTGTATAGAGTGA GTGGCAGTGAGTAATTTGGTAAAAATTTGCTGACCTGCTTTTATTCTTTCCTCCTTTCTTTCTTCCTTTC CTTCCTTCCTTCCTTCCGTCCTTTCCTTTCCTTTCCCTCCCTTCCTTCCTTCTTTCCTTCTTTCTTTCCT TTCTTTCCTTTCTTCCTTTCTTTCCTTCCTCCCTTCCTTTTCTTTTCTTTCTTTCCTTTCCTTTTCTTTC CTTTCTTTCCTTTCCTTTCTTTCTTGACAGAGTCTTGCTCTGTCACTCAGGCTGGAGTGCAGTGGCGTGA TCTCGGCTCACTGCAACCTCTGTCTCCCAGGTTCAAGCAATTTTCCTGCCTCAGCCTCCCGAGTAGCTGA GATTACAGGCGCCAGCCACCACACCCAGCTACTGACCTGCTTTTAAACAGCTGGGAGATATGGTGCCTCA GACCAACCCAACCCCATGTTATATGTCAACCCTGACATATTGGCAGGCAACATGAATCCAGACTTCTAGG CTGTCTTGCGGGCTCTTTTTTGCCAGTCATTTCTGATCTCTCTGACATGAGCTGTTTCATTTATGCTTTG GCTGCCCAGCAAGTATGATTTGTCCTTTCACAATTGGTGGCGATGGTTTTCTCCTTCCATTTATCTTTCT AGGTCATCCCCTTCTAAATGCCCATCATTAGATGATAGGTGGTACATGCACAGTTGCTCTGGGAGTCTTC AGAATAGAAACTACCCATCTCAAGAGGAGCTCATTAAGGTTGTTGATGTGGAGGAGCAACAGCTGGAAGA GTCTGGGCCACACGATTTGACGGAAACATCTTACTTGCCAAGGCAAGATCTAGGTAATATTTCATCTGCT GTATTGGAACAAACACTTTGATTTTACTCTGAATCCTACATAAAGATATTCTGGTTAACCAACTTTTAGA TGTACTAGTCTATCATGGACACTTTTGTTATACTTAATTAAGCCCACTTTAGAAAAATAGCTCAAGTGTT AATCAAGGTTTACTTGAAAATTATTGAAACTGTTAATCCATCTATATTTTAATTAATGGTTTAACTAATG ATTTTGAGGATGAGGGAGTCTTGGTGTACTCTAAATGTATTATTTCAGGCCAGGCATAGTGGCTCACGCC TGTAATCCCAGTACTCCAGGAGGCCGAGGCAGGTGGATCAGCTGAGGTCAGGAGTTCAAGACCTGTCTGG CCAACATGGTGAAACCCTGTCTCTACTAAAAATACAAAAAAATTAACTGGGTGTGCTAGTGCATGCCCGT AATCCTAGCTACTCTGGAGGCTGAGGCAGCAGAATCACTTGAACCCGGGAGGCGGAGGTTGCGGTGAGCC AAGATCACACCACTGCACTCCAGTCTGGGTGACAGAGCAAGACTCCATCTCAAAAAATATATATATATAT ATATACACACATATATTTTATTTCAACTGTTAGACAAGAGTCCAAAGGCCAAAGAATAAAGTTTTAGGCC AGTCCTTTATTAGAAAATGAGTCAAATCCCAAAGCAAGTTTTTTTTATGAGTTAATGAATATAAATGACT ACATATTTTATGCCTTAAAAATCACTTTTAATGAATGGTGTTTTATGGCTTGTAAATCAGAGTTTTAATC AGTAAAGAAAGTTTTTAATCCTCAAAAACACGTTATCATAAAAGACACTGTTTGGCATCAAATGTGGTAT TTGGCCATGTTCATTAGGGTCATTTTAGGAATCTCATACATTCTACTTAGCTATGCTTAATTCCTGATAC CATGGCATTTTCTGAAATGTTTCAAGGATGACATCTCTGCTGTTTTTAATTTGGTAATGATATCTGCTGA TTTATTAAGTGAAAAAAGTAATGGTGTCATTACCTTGGATGAAGAAACAAAAATAAAGCATTTGCCACAT TTTTCAACTTTTTTTTCCTTTCTTACAAAATTGCTATAAGCTCATTGCCCCCAAATTGGACAATATAGGG AATAAAAAAGATAATTTGGGGTGGGGTTAGACACGGGTCTTGTTATGTTGCCGAGGCTGGTCTCTAACTC CTGGCCTCATGCAATCTTCCTACCTTGGCCTCCCAAAGTGCTGGGATTATAGGTGTGAGCCACTTCACCA AGCTGAGATGCCACCTCTTAAAAGATAAAATAAGGACAGATTACAGCCACTGCTCATGCCTGTAATCTCA GTACTTTGGGAGGCCAAGGTGGGAGAATTGCTCGAGGCCAAGAGTTCAAGACCAGCCTGGGCAATGTAGC GAGACCTGATCTCTATAAAAAGTAAAAAAAAAAAAAAACTAGCTGGGGCCAGGCGTGGTGGGTGGCTTAC GCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGGCAGATCACCTGAGGGCAGGAGTTCAGGACCAACC TGACCAATATGGAGAAACCCTGTCTCTACTAAAAATACAAAATTAGCCAGGCTTGGTGGCTTATGCCTGT AGTCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATCGCTTGAACCTGGGAGGCAGAGGTTTCAGTGAGCT GAGATCGCGCCATTGCACTCTAGCCTGGGCAACAAGAATGAAACTCCATCTCAAAAAAAAAAAAAATCAG CTGGAAGGTGGCAAACACCTGTGGTCCCAGCTACTCAGGAGGCTGAGACAGGAAGATCACTTGAGTCCAG GAGGTCAAGGCTGCAGGTGAGCCATGTTTGTGCCACTGCACTGCAGCCTGGATGACAGACCGAGACCCTT CTCAAAAAAAAAAATATTACCCGTACTCTTTTTTGAGACGGAGTTTCACTCTTGTTGCCCAGGCTGGAGT GCAATGGCGCAATCTCGGCTCAGCGCAACCTCCGCCTCCTGGGTTCGAGCGATTCTCCTGCTTCAGCCTC CCCAGTAGCTGGGATTACAGGCATGCACCACCACGCCCGGCTAATTTTTTGTATTTTTAGTAGAGACAGG GTTTCTCCATGTTGGTCAGACTGGTCTCGACCTCTTGACCTCAGGTGATCCGCCCACCTTGGCCTCCCAA AGTGCTGGGATTACAGGCCTGAGCCACCGCACCCGGCCTGTACTCTTATTCTTTAATAATAAAATATTTC TGTGTTTCTTTAGTCATTTTACATAAACTTTTATTTATTTATTTATTTTTATTTATTTATTTTTTTGAGA CGGAGTCTCGCTCTGTTGCCCAGGCTGGAATGCAATGGCTCAATCTCAGCTCACTGCAAGCTCTGCCTCC CGGGTACACGCCATTCCCCTGCCTCAGCCTCCCTAGTAGCCGGGACTACAGGCGCCCGCCACCACGCCCA GCTAATTTTTTTTTTTGTATTTTCAGTAGAGACAGGGTTTCACTGTGTTAGCCAGGATGGTCTTGATCTC CTGACCTCGTGATCCACCCGTCTCGGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACCGTGCTCGG CCCATAAACTTTTATTTTTAAAATAATGTCATGATAAATAATATTGCTTAGGTGTCTTTAATATATTAGT AACATTTCTGTTTTATTGTACATCAACATTTATATTCAAATTAATGGGTGAAGAGTACTCCATTGGACTA GGTATATCGTAATTTAATCTCCTATTATTGGACAACTACATTGTTTCTAAAATTATACTATTCCTATGAC TAAACCTTTGCATATATCTTTTATCTCCCTAGGATATATTTCTAAAACTAGCATTGTTGACTGAAAGTGT AAATACGTGTTAAGGTGTTTGCTACATAATGCCATATTTCCTTTTTAGGAAACTAAGCTACTTTGGATTT CCACCAACACTGTATTCATGTACCCATTTTTCTCTTAACCTAACTTTATTGGTCTTTTTAATTCTTAACA GAGACCAGAACTTTGTAATTCAACATTCATCGTTGTGTAAATTAAACTTCTCCCATTCCTTTCAGAGGGA ACCCCTTACCTGGAATCTGGAATCAGCCTCTTCTCTGATGACCCTGAATCTGATCCTTCTGAAGACAGAG CCCCAGAGTCAGCTCGTGTTGGCAACATACCATCTTCAACCTCTGCATTGAAAGTTCCCCAATTGAAAGT TGCAGAATCTGCCCAGAGTCCAGCTGCTGCTCATACTACTGATACTGCTGGGTATAATGCAATGGAAGAA AGTGTGAGCAGGGAGAAGCCAGAATTGACAGCTTCAACAGAAAGGGTCAACAAAAGAATGTCCATGGTGG TGTCTGGCCTGACCCCAGAAGAATTTGTGAGTGTATCCATATGTATCTCCCTAATGACTAAGACTTAACA ACATTCTGGAAAGAGTTTTATGTAGGTATTGTCAATTAATAACCTAGAGGAAGAAATCTAGAAAACAATC ACAGTTCTGTGTAATTTAATTTCGATTACTAATTTCTGAAAATTTAGATCTAGATAAAGCTATAGTGTGG ATTATTTTATGTATATTTACTTGAGAAAATAATTATTAAATATTAGTGGAAAAGCTATACTTTGGGTATG ATATAGGACTTTCGAATTGGAATTTTCCTTTCTATCTGTAAAAGCAAGTAGGTATAGTTTTATTCCCCAG AAGGCATCTTTTTCTCCCCCTTGTCTCACATGGGTGAATTTACCAGCATATTTAACTAAATTCAGACTGG TTCCAAATGTACTGCCAGATAGTAGCATTTCTCTAGTGTTTGTTTTCATCCTGGCTTGTAAGAATGCCCT GCCACTTCTGCCCTGCAATATCCCTTGCTATTAGGATTTTGGCATCACCTTGGGTCCTTAATGCCAGAAA TGGGAATTGCTTCATACTGTGGAAAAATACCCATTAAAATATTAAGACCAGTAAAACCTCGTTTCTGCTT GGGCTATTTGTGGATTTCAGACATCCTGAGAAGTTTACCACCCCTGTAATTAATTGTCATTGTCATCACT TCATAATAAAAATAATTGCATGGCCGGGCATGGTGGCTCAAGCCTGTAATCCCAGCACTTTGGGAGGCTG AGGTGGTCAGATCACCTAAGGTCAGGAGATCAAGACCAGCCTGACCAACATGAAGAAACCCCATCTTTAC TAAAAATACACAATTAGCCGGGCGTGGTGGCGCATGCCTATAATCCCAGCTACTCAGGAGGCTGAGGCAG GAGAATTGCTTGAACCCGGGAGGCGGAGGTTGCGGTGAGCCGAGATTGCACCATTGCACTCCAGCCTGGG CAACAAGAGCGAAACTCTGTCTCAATAATAAGAAGAAGAATTGCGTGAATATTTCTTTAAAACTATGATG AGATAACATACCAGATTATCAAATGGATTCAGTAGTGGGTGTGCCATTTATTGCACACTGAGAGATGACC AAGTCATTCTGAAATATCTTTATTAATATATCCTTCCTAGGATTTTTCATCCTAACTTCTCCATAGGTAG TTACTTAGCATAACATCTCTGTGGCCAGATGTATCCCACTACTAAAAGGGCAAAGTAAGCTGTGGCTGCC CTGGTAGATACAATGAGTAAGTGCACAGTGATGGCTATAAATGTTTTCATCTCATAATCCCATGTCCAGA CCAGCAATTTGCTCTGAAAGCTCTTACCTGTGTCTGTTTCAATGGCTCTTGATCACTTGCCTGCACGTCC AGAATTCCTTATTTATTCATTGAAAATTAGCGTTCTTTATCCCTTTGTTTTGCAAGTTCAGCTTTTTAGA GATGGCTAAAATGGTCTAATCTTTCTTGGCAAAGGCAATTCTGAGCTGCAGATTAGACTACAAGTGGCTT GGGTACATGTTGTCTTTAAACAAGCGAAGAGGAAAACTTTGAGCTCTATTCAGACTTGGTGAAGTGTGGT AAATTTATGATGAAAGCTACTGACTGTATTACACATGATTAATTCTGAAGCCCATATTAAGATGATCTTT TCAGCAGTTCAGCATTGCTCTTCTAACTGAACAGTTTCAAGGCTGGGATTTCAGCAATTAATCAGTTCAG AATTGCTAATGATCCTGGCGGAGGGTGGTAGCAAAAGGGGGAGGATGTCATTAGCTTCTCTAGCCTGCCT TTTTTCAGTGCCCTGTGGCAGTATGGAGTGAGGCAACATGAAAGAAAGATGGCCTGACCTTCATGGCAGT ATTGTGCAACACGTAAATACTGGTGTGAGTGGCTGTGGCTATGGCTAGTAAATGATGGCCCTTGGTAAAC AAAGTTATTTATCAGACAATACCTACCAGCTAGGTCAACTGTGCCCATAATTGATCTGGTTAATTTCTTT TGCTGCCTATTGATTTTTATTTGGTTGATAGATAATAGCTAGAGGACTCTAAATTTCTTTGGGGAAGAAC ATGAACCCCTTCTAAGCCTTCTTACGAGAGAATTGATCGCTTTTGCACTGACCTTTAGTAACATCCTGAT TTCAGTGTTTTGTAACTATCAGAGGGTTGAGTCTTGGTTTTAAGCCATGTATATCTGTAGCATAACTTTC TGTGTAGGCTAGTTACCTCTCAGCTTATAAAGTGTAGGCTGATAAATTTATAGTACAGTAGAGTGTCACT ATGCAAAGAAACGATCTTAGGGAATCGAATGATATCTGCTATTAAAGCAAAATTAATATATATTTTTTCT TTTTACTTTTTTTTTTTTTTAAAGACATGAAATCTCACTGTATTGCCCAGGCTGGTCTTGGTCTCAGACT CTTGAGCTCAAGCAGTCCTCCCACCTCAGCTTCCCAAAGTGCTGGGATTATAGGCATGAGCTGCCGTGTC TGGCCCAGTATATATTTTTTAAGTTTTAAGTTTTGTGGTACGTAGTAGGTTTATAATATTATTTTGAATC CTTAGTTGTAATTTTATGTCTGCTGATGTGTACATAATTTTTATTAAACTATTTATTTGAGACTTCAGGT ATCTTTTTTTTTTTTTTGAGACGGAGTCTCGCACTCTCGCCCAGGCTAGAGTGCAGTGGCGCCATCTCGG CTTACTGCAAGCTCTGCTTCCTGGGTTCACGCCATTCTCCTGCCTCAGCCTCCTGAGTAGCTGAGACTAC AGGTGCCCGCCACCACGCCTGGCTAATTTTTTGTATTTTTAGTAGAGACAGGGTTTCACCGTGTTAGCCA GGATGGTCTCGATCTCCTGACCTTGTGATCTGCCCGCCTCAGCCTCCCAAAGTGCTGAGATTACAGGCGT GAGCCACCGCGCCCAGCCGAGACTTCAGGTGTCTTAGAATTTTTTAAATGTACCCTTTCTGAGAAAAACA GAGACTTAAAGCTAGGATAACTGGTATTCTATTTTTTTTTTTTTTTTTTTTTTACCTCCAGCCTGGGTGA CAGAGCAAGACTCTGTCTAAAAAAAAAAAAAAAAAAATTCACTTTAAATAGTTCCAGGACACGTGTAGAA CGTGCAGGATTGCTACATAGGTAAACATATGCCATGGTGGAATAACTAGTATTCTGAGCTGTGTGCTAGA GGTAACTCATGATAATGGAATATTTGATTTAATTTCAGATGCTCGTGTACAAGTTTGCCAGAAAACACCA CATCACTTTAACTAATCTAATTACTGAAGAGACTACTCATGTTGTTATGAAAACAGGTATACCAAGAACC TTTACAGAATACCTTGCATCTGCTGCATAAAACCACATGAGGCGAGGCACGGTGGCGCATGCCTGTAATC GCAGCACTTTGGGAGGCCGAGGCGGGCAGATCACGAGATTAGGAGATCGAGACCATCCTGGCCAGCATGG TGAAACCCCGTCTCTACTAAAAAATAAAAAAATTAGCTGGGTGTGGTCGCGTGCGCCTGTAGTCCCAGCT ACTCGTGAGGCTGAGGCAGGAGAATCACTTGAACCGGGGAGATGGAGGTTGCAGTGAGCCGAGATCATGC CACTGCATTCCAGCCTGGCGACAGAGCAAGGCTCCGTCTCAAAAAAAAAAAAAAAAAACGTGAAAAAATA AGAATATTTGTTGAGCATAGCATGGATGATAGTCTTCTAATAGTCAATCAATTACTTTATGAAAGACAAA TAATAGTTTTGCTGCTTCCTTACCTCCTTTTGTTTTGGGTTAAGATTTGGAGTGTGGGCCAGGCACGGTG GCTCACACCTGTAATCTCAGCACTTTGGGAGGCCGAGGCGGGTGGATCACCTGAGGTCAGGAGTTCGAGA CCAGCCTGGCCAACGTGTTGAAACCCCGTCTCTACTAAAAATATAAAAATTAGGTGGGCGTGGTGGCAGG CACCTGTAATCCCAGCTACTCAGGAGGCTGAGGCAGCAGAATCGCTTGAACCCAGGAGGTGGAGGTTGCA GTGACCCAAGATCGCACCATTGCACTCCAGCCTGGGGACAAGAGCGAGATTCTTGTCTCAAAAAAAAAAA AAAAAAAAAAAGGTTTGGAGGGTGGTGAGCTGAGATAGTCAACTATTAACTCCTATCTACCTGCTGGGAC TACACTGGTGAGGTGGAGCCTAAGTCCTAAAACAACAAGTGAGGCAGCTGGACGCGGTGGCTCGCATCAG TAATCCCAGCACTTTGGGAGCCTGAGGCGGGCAGATCACAAGGTCAGGAGTTCGAGACCAGCCTGGCCAA TATGGTAAAACCCAGTCTCTACTAAAAATACATAAATTGGCTGGGCGTGGTGGTGTGCACCTGTAATCCC AGCTACTTGGGAGGCTGACACAGAAGAATTGCTTGAACTCTGGAGGCTGAGGTTGCAGTCAGCTGAGATC CTGCCACTGCACTCCAGCCTGGCGACAGAGTGAGACTCTGTCTCAACAACAACAAAAGAAAGAACAAGTG AGGCAAAACCTGGAGACCCCAGCTTCATGTAACACCTAGTTTGAGTATTGTTGAGAGTTTTTCAGGAAAA AAGTCTGATAACAGCTCCGAGATAGTCTTAACATATGAAAAAGCAAAAAAGGGAGGAGACAGATCATTTG TCCTATACCTTTCTCTTTTAAGGTTTTAATTATAACTTGTGTAATACAGGAGACCTCTGGGTGTTTTTAG TTGACTATAAACTAAATCTGAGTACACATTTCAGGGCTGCTAAAAATGCTTATTTGAAACTGGGCCGTAT TAACACAAGCAGAGGCTCTGGAGCAAGTGAAGTACAGATCCAGAGCCCCACTGTATTCTCCAATGGAGTG ATTGCCTGAAAGATGATGTCAGTTTTAAGCACCGTGCTTGGTTTTTAACATGGTCACTGACAAATTGGAG AGTGTTTATCCAGAGGTAGATGGTAAAGATACATAAAAGTAACTTGAAATACTGTCTTTTGAAGAAGAAA TGAGAAGATTTAAGGAAATAAGACACTGTCTTCAAGTATCTGAAGAACCGTTACCCGGAAGAGAACTGTT ATCTGGAACAGGATTAAGACTCACTCATGGGGCTCCAGAAAGCAGACGAGTGCATGGAGGACGCAGAAGA TGCAGATTGTGTGGCTCAACTCTAAAATCTTTCTAACAAAATTAGTTCTCTGGATGTGTTCCAGTTCACT TGATGATGATTCTTTTGTTTTTGTTTTTGTTTTTGAGGTGTAGTTTTTCACTCTTGTTGCCCAGGCTGCT GGAGTGCAATGGCACGATCTTGGCTTGCTGCAACCTCCCCCTCCCGGGTTCAAGCGATTCTCCTGCCTCA GCCTCCCGAGTAGCTGGGATTACAGGAATGCACCACCATACCTAATTTTGTATTTTTAGTAGAGACAGGG TTTTTCCATGTCAGTCAGGCTGGTCTTGGACTCCCGACCTCAGGTGATCCACCTACCTCGGCCTCCCAAA GTGCTGGGATTACAGGTGTGAGCCATCGCGCCTAGCCTATGATGATTCTTTTCACAGAGATACAGGCACT TAAGGAGAGGATCTAAACCCCTTGGACACATTGCCGTTGAACTTCTAAGATCTTAGGTTTCCACTTACTC ATGAAAATTATACCACAGGGTCAGAGGGTAGTGTTCATTGGAGCCAGGTGCCAGAACAAGTTATTACAAA CTACTATTTTAGAGAAAAATGTCATTAAAGTTTAAGATACCTTAAGCTATAGGTTTGCATCAAAGTTAAT GAAAGGTAAAAAGATGCCAAGCGTGGTGGCTCAGGCCTGTAATCCCAGCGCTTTGGGGGGCCAAGGCGGG CAGATCACGAGGTCAGGAGATCGAGACCATCCTGGCTAACACGGTGAAACCCCATCTCTAGTAAAAATAC AAAAAATTAGCCGGGCATGGTGGCGGGCATCTGTAGTCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATG GCATGAACCCAGGAGGCAGAGCTTGCCGTGAGCTGAGATCCAGCCACTGCACTCCAGCCTGGCTGACAGA GCAAGACTGCATCTCAAAAAAAAAAAAAAAAAAAAATGCAAATCAAATCTAAAGTAGTTCAGTCTTTAAA CTCAAAGCCAATACATTTGCTTTGAACTACAAATGAACTGAAGTTTTTAAGTGTAATAAATGTTACTAAA TCGGCTTTTGTAGCAGTTAAACAAAAAACTTCAAAAATTGTAAGGATTCTGTGAGGGAGCATGGCTGCTG CTGCTGCTGCTGCTTGCAGATAGCCTGCTGTGTTTAGGATTTAGTTAAATACATTTCTCCTGTTTAAAAC TAAATGGTCTTTCCTTAGTTTGCTTAGTTCTTCAGAAGGGCCTTTGAAACACTGGGAAATAAACAAGTGA TTCTTTAGCTACTGCTTTCTGAAATACTTATATAAAAGCTCTGCACTGTATTCTCCCATCCCTCTCAGGG GAATATTAGAGGGTTAGGACTCCCCAGGTAGACATTCTAGGGGTGAAAATTTGTCATTACATTGACATTT CAGATTTAGGTTTTCAACAATACTGTTTTCTTCTTTCACATATTGCCATCTAGTAATATAGATGTTCTCC GTCCACATTAATCAAAACTATTGACATGGATAATTCCTAATTCCTTGAACACTATAATGGAGATCTATAG CTAGCCTTGGCGTCTAGAAGATGGGTGTTGAGAAGAGGGAGTGGACAGATATTTCCTCTGGTCTTAACTT CATATCAGCCTCCCCTAGACTTCCAAATATCCATACCTGCTGGTTATAATTAGTGGTGTTTTCAGCCTCT GATTCTGTCACCAGGGGTTTTAGAATCATAAATCCAGATTGATCTTGGGAGTGTAAAAAACTGAGGCTCT TTAGCTTCTTAGGACAGCACTTCCTGATTTTGTTTTCAACTTCTAATCCTTTGAGTGTTTTTCATTCTGC AGATGCTGAGTTTGTGTGTGAACGGACACTGAAATATTTTCTAGGAATTGCGGGAGGAAAATGGGTAGTT AGCTATTTCTGTAAGTATAATACTATTTCTCCCCTCCTCCCTTTAACACCTCAGAATTGCATTTTTACAC CTAACGTTTAACACCTAAGGTTTTTGCTGATGCTGAGTCTGAGTTACCAAAAGGTCTTTAATTGTAATAC TAAACTACTTTTATCTTTAATATCACTTTGTTCAGATAAGCTGGTGATGCTGGGAAAATGGGTCTCTTTT ATAACTAATAGGACCTAATCTGCTCCTAGCAATGTTAGCATATGAGCTAGGGATTTATTTAATAGTCGGC AGGAATCCATGTGCAGCAGGCAAACTTATAATGTTTAAATTAAACATCAACTCTGTCTCCAGAAGGAAAC TGCTGCTACAAGCCTTATTAAAGGGCTGTGGCTTTAGAGGGAAGGACCTCTCCTCTGTCATTCTTCCTGT GCTCTTTTGTGAATCGCTGACCTCTCTATCTCCGTGAAAAGAGCACGTTCTTCTGCTGTATGTAACCTGT CTTTTCTATGATCTCTTTAGGGGTGACCCAGTCTATTAAAGAAAGAAAAATGCTGAATGAGGTAAGTACT TGATGTTACAAACTAACCAGAGATATTCATTCAGTCATATAGTTAAAAATGTATTTGCTTCCTTCCATCA ATGCACCACTTTCCTTAACAATGCACAAATTTTCCATGATAATGAGGATCATCAAGAATTATGCAGGCCT GCACTGTGGCTCATACCTATAATCCCAGCGCTTTGGGAGGCTGAGGCGCTTGGATCACCTGATGTCGGGA GTTCAAGACCAGCCTGACCAACATGGAGAAACCCCGTTTCTACTAAAAATACAAAATTAGCCGGGCTTGG TGGCACTTGCCTGTAATTCCAGCTACTCGGGAGGCTGAGGCAGGAGAATCACTTGAACCTGGGAGGCGGG GGTTGCAGTGAGCTGAGATCGCATCATTGCACTCTAACCTGGGCAACAAGAGCAAAACTCCATCAAAAGA AAAAAAAAATCGGGTGCAGTGGCTCATGCCTGTAATCCTAACACTGTGGGAGGCCAAGACAGGCAGATTG CCTGAGCTCAGGAGTTCGAGATCAGCCTGGGCAACATGGTGAAACCCTGTCTCTACTAAAATACAAAAAA TTACTCAGCGTGGTGGCATGCGCCTTTAGTTCCAGCTACTCAGGAGGCTGAGGCAGGAGAATCTCTTGAA CCCGGGAGGTGGAGGTTGCAATGAGCCAAGATCGTGCCACTGCACTCCAACCTGGCAACAGAGCGAGACT CCGTCTTAAAAAAAAAAAAAATTTTGCAGCGCAAACCAGGATATCCTCTGTTCTCATTTGTTCTAGATTT CAAAAGAAACAGTCCTTTCTTTGGGGAAAAGAGAAAGGAAAAGGAGTTTTATAAAAGGAAAGAAAAGATT CATAAGAACAAGAAGTGGGCCCACTTGCATATACCTTTGTAGAAAACTGTTCACTGTTGTTGAAGAAAAG CTCTTCATATTAATATGCAGTCCAGATGCAGTGGCTCACACTTATAATCTCAGCCCTTTGGGAGGCTGAG ACAGGAAGATTACTTGAGGCCAGGAGTTTGAAACCAGCCTGGGCAACATAGTGAGACTCTGTCTCCACAA AATTTTTTTTTAATTAGCCGGGCATGGCAGTGTGCTTCTGTAGTCTTAGCTACTGAGGAAGCTAAGCCAG AAGAATCACTTGAGCCCAGGAGTTCAAGGCTGCAGTGAGCTATGATCATACCATTGCACTCTTGCACTTG CACAGAGCAAGACCCTGTCTCTTAAAAAAAAAAAAGTGTGTGTGTGCATATGCATATATACATATATATA CATGCAAATGTATCTGTTTATAATTCAGATTGCTTCAAAAAGATGTTGCACTTTATGATACTGAGAACAG TGAGAAGTAAATAAGATAGAGTGTAGGAGGAGGAATAATTTCAGAACAGCCATCTGAGAACTTCTGTGAC AACAGATCAGGCAAAATGAAATGTGAAAGTAATTTTATAGGCCAGGCGTGGTGGCTCATGCCTATAATCC CAGCACTTTGAGTGGCCAAGGCAGGTGGATCACTTGAGGTCAGGAGTTCGAGACCAGCCTGGTCAACATG GTGAAACCTTGTCTCTACTAAAAACACAAAAAAATTAGTCGAGCGTGGTGGCATGTGCCTGTAATCCTAG CTGCTGGGGAGGCTGAGGCAGGAGAATCACTTGAACCCGGGAGGCGGAGGTTGCAGTGAGCCTAGATTGC ACCACTGCACTCCAGCCTGTGAGACAGAATGAGACCCTGTCTTAAAAAAAAAAAAAAAGTAATTTTATAA ACTATTGTGCACAATTCGATGTATTCATAATTAATTAAATGATTATTTTTGTTGGTTTTAACTTTTATTC AGTGGCTATTTATTGGGAGCCTACTGTGTTCTGGGCACTAGGAATGCAACAGTAAATAAGACTAACTAAG TCCCTGGTAGGATTCAGGTTCTGTCGAGGGGAGATACACAATAAAGATGAATTTAAGATAACAATAAATG CTATGGAGAAATATACAGAACAGTGGAATAGTATTAGCTGTCAAAGGTTGTTGATTACTTTCGTTTAAGG AGGCCAGGGAAAGCCTTTCTGAAAAAATTGAGCTGAGACCTAAATAACAAGAAATAATTGTCCTTGAAAA ATGAAGGGAATGCATCTTATAGGCAGAGGAATAGCAAACATAAAGGTCTTGAGGTAATAATGAGTGTGGT TTTTTGATTTCTGTATTTTGGTTTTTTTGAGATGGTGTCTCCCTCTATCCCCCAGGCTGGAGTGCAGTGG CACAATCTTGGCTCACTGCAAACTCTGTCTCCTGGGTTCAAGCAATTCTCCTGCCTTGGCCTCCTGAGTA GCTGGTATTACAGGCACGCGTGCTACCACACCCGACTAGTTTTTATTTTTAGTAGAGATGGGGTTTTACC ACGTTGGTCAGGCTGGTCTCAAACTCCTGAACTCAAGTGATCCAACCACCTCAACCTCCCAAAGTGCTGG GATCACAGGTGTGAGCCACTGTGCCCGGCCAGAGCTTGGTTTATTTTTTAAAAGATAGGCCAATGTTGGT CGTGTGTGGTGGCTCGTGCCTATAATCCCAGCACTTTGGGAAGCCAAGGCAGGCAAATCACTTGAGGTCA GGAGTTCGAGACCAGCCTGGCCAACATGGTGAAACCCCATCTCTACTAAAAATACAAAAAACTAGCATGG TGTGGTGGTGTGTGCCTGTAATCCCAGTGCCTGTAATCCCAGCTACTCCAGAGGCTGAGGCAGGAGAATC ACTTGAACCGAAAGGTAGGAGTTACAGTGAGCCAAGATCGCATCACTGCACTCCAGCCTGAACGACAGAG CAAGACTCCTGTCTCAAGAAATAATAATGATAAAAGGTTCGGGCACAGTGGCTCACACCTGTAATTCCAG CACTCTAGGAGGCCGAGGCAGGCAGATCCCCTGAGGTCAGGAGTTTGAGACCAGCCTGGCCAACGTGGCA AAACCCCATCTCTACTAAAAAATGCAAAAATTAGCTGGGCACGGCTGGGTGTGGTGGCTCATTCCTGTAA TCCCAGCACTTTGGGAGGTCAAGGCGGACAGATCACTGAGGTAGAAACCCTGTCTCTACTAAAAATACAA AAATTTGCCCAGCGTGGTGGCGCGTGCCTCTAATCCCAGCTACACGGGAGGCTGAGACAAGAGAATCACT TCATCAACCCGGGAGGTGGAGGTTGTGGTGAGCTGAGATCGCACCATTGCACTCCAGCCTGGGCAACAAG AGTGAAACTCCATCTCAAAAACAAAAAAAAATTAGCTGGGAATGGTGGCATGTGCCTGTAATCACAGCTA CTTGGGAGGCTGGGGCAGGAGAATCGCTTGAACCCAGGAGGCGGAGATTGCAGTGAGCTGAGATTGCGCC ACTGCACTCCAGGCTGGGCGAAAGAGCAAGACTCCGTCTCAAAAATAATAATAATAATAATAATAGGCCA GTGTAGCTGGAGTAATTTGCAAATTATGTGTGGAGGCAGAGATTACACAAGGAATGGGAGAAGGTCATAG ATGAGGGCCAGATCACATAGTATTTGGTGGTAAGGAATTCAGATTTTATCCTTGTGGTAATTGGTGGTGT GGAGATGGTTAAAAACAAGGTTGGTTTGGGATGGGTTTGAAGAGAGGACTTGCTAATGGATTAAATTTGG AGGATAAGGTAAAGAGAAATTGAAGGAGTGACACTTGGGTTTTGGCTTGAACAATAGATCTTGTTAGTAA TATTAAATTAGATGAAGAAGGCATGGTAGGGAATATGGGGGAGTGGGAAAGGCAGGAAGCAGGAATGGAA CCAGGAACTCTGTTTTAGATGTGAGAATTTGTTGTTGTTGTTGTTGTTGTTGTTGTTGTTGTTGTTGTTG TTGTGACAGCATCTCGTTCTGTTGCCCAGGCTAGAGTGCATGGAGTGCGGTAGCACGATCTCAGCTCACT CCAACCTCCGCCTCCCGGTTCAAGTGATTTTCCTGCCTCAGCCTCCCGAGTAGCTGGGATTACAGGCACC TGCCACAATGCCTGGCTAATACTTGTATTTTTAGTAGAGATGGGGTTTTACCATGTTGGCCAGGCTGGTC TTAAACTCCTGACCTCAGGTAATCCACCCACCTCGGCCTCCCAAAGTGCTGGGATTGCAGGTGTGAGCCA CTGTGCCCGGCCAGATGCATGAATTTTGAGATGTATACTAGACTTCTGGATAGAGAAGTTAAGTAGGCAG TTGGACACATTGTATGAAGCTCAGGGGTACAAGGAGGACTATGAACATGGGAGTCTTCTGACAAATTTAT CACTAGACTCCTCATTCAAGTAACTAGGAAATGTCAGATATTCTTCCCCTAGTAATAGCCAGTGGTTATA CTCTTGCCTTTAGTTTTCTTCACAATACTCTTGGCAACACATAAGGCCTTCCCTACAATCTGAGTTTCAG TCAGAATTGTTTCTGAGCGTTCTTCCTCAAATTTCTCCCCAGTCTCATTATTCTTTATTCTCATGTCCAT GACCAGTCATAATAGTAATTATGAAAAACCTCTAACTTTCTTTAGTGCATTGAATGTATATTTTATCATT TTGGTTGTGTTAACTGTAAATCTCTCAGTGGAAATCTGAAAAGCCTTTATTTCCTTAGATGATAATATAC AATTGATTTAGGAGATAGGGAATTTTTCAGTTACCTTTATAACAGCACAGTATTAGCAGTCTAATCTAAA TGCTAAGTGAATGTTTTGAGAGGAGATAGATGTTGAAAATTAAAATACATTAAGTCCCAGTGAGGTGAAA AGCCGATTGTTAAGTTCTGCACACAAAAGATTTGCTTCAGTGAATTGATTTCAACAGCTGAGATCCTAGT CATTTCACCTGGTCTACCAAAAAGAATGATTTTACTTGCTTTTGGTCAAATCTCTGCCCAGCAATTCTTT TTCTTTCTTTCTTTTTTTTGTTTTATGTGTGTGTGTGTGTGTGTTTTTTTTTAGCAGAGTCTCACTTTGT CACCCAGGCGGGAGTGTGGTGGTATGATCACAGTTCACTGCAGCCTCCAACTCCTGGGCTCAAGTGATCC TCCAGCTTCAGCTTTTCAAGAAATTGGGACTGCAGGCACATGCAACTATGCCTGGCTGAGGTTTTATGTA TCTTTTTTCTAGAGAAGGGGTCTCACTGTGTTGCCCAGCTGGGTCTCCAGCTCCTGGTCTCAAGCTGTCC TCCTGCCTCAGCCTCCCAAAGTGCCAAAGTGCTAGGGTTATAGGTGTGAGCCATTGGTGCCCAGCTACTG CCTGCCTGGCAATTCTGAATGCCTTAAATTTTTTTTTTTTTTTTTTTTTTTTTTGAGACAGAGTTTCACT CTGTCACCCAGGCTGGAGTGCAGTGGCATGATCGTGGCTCACAGCAACCTCTGCCTCCTGGATTCCAGCA ATTCTCATGCCTCAGCTTCCCGAGTAGCTGGGACTACAGGTGCATGCCACCACGCCCAGCTAATTTTTGG TTTTTTTGTTTGTTTGTTTGTTTGTTTTGAGACGGAGTCTCGCTCAGTTGCCCAGGCTGGAGTGCAGTGG CGTGATCTCCGCTCACTGCAAGCTCCGCCTCCCGGGTTCACGCCATTCTCCTGCCTCAGCCTCCCGAGTA GCTGGGACTACAGGCGCCTGCCACTACACCCGGCTAATTTTTTTGTATTTTAAGTAGAGACGGGGTTTCA CCGTGTTAGCCAGGATGGTCTCGATCTCCTGACCTCGTGATCCGCCTGTCTCGGCCTCCCAAAGTCCTGG GATTACAGGCGTGAGCCACCACACCCGGCCTAATTTTTTTTTTTTTAATTTTATTTTTAATTTTTTGAGA TGCGAGATGGAGTCTCGCTCTGTTACCCAGGCTGGAGTGCAGTGGCACCATCTCAGCTCACTGCAACCTC CACCTCCTGCATTCAAAAGATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGATTACAGGTGCCTGCCACC ACGCCCAACTAATTTTTTGTATTTTTAGTAGAGATGAGGTTTCACCATGTTGGTCAGACTGGTGTCGAAC TCCTGACCTCAAGTGATCTGCCTGCCTCAGTCTCCCAAAGTGCTAGGATTACAGGGGTGAGCCACTGCGC CTGGCCTGAATGCCTTAAATATGACGTGTCTGCTCCACTTCCATTGAAGGAAGCTTCTCTTTCTCTTATC CTGATGGGTTGTGTTTGGTTTCTTTCAGCATGATTTTGAAGTCAGAGGAGATGTGGTCAATGGAAGAAAC CACCAAGGTCCAAAGCGAGCAAGAGAATCCCAGGACAGAAAGGTAAAGCTCCCTCCCTCAAGTTGACAAA AATCTCACCCCACCACTCTGTATTCCACTCCCCTTTGCAGAGATGGGCCGCTTCATTTTGTAAGACTTAT TACATACATACACAGTGCTAGATACTTTCACACAGGTTCTTTTTTCACTCTTCCATCCCAACCACATAAA TAAGTATTGTCTCTACTTTATGAATGATAAAACTAAGAGATTTAGAGAGGCTGTGTAATTTGGATTCCCG TCTCGGGTTCAGATCTTAGCTGATAAGTGGAAGAGCTGGGACTTTAAGCAGATGAGAATCTAAAGACTTT GCTCTTTTCACTTCACTGGGGTGTCTTTCTCTCTCTCTCTCTTGCTCTCTCTCTCTCTTTTTTTTTTTCC CAAGACGGAGTCTCACTCCATTGCCCAGGCCAGAGTGCAGTGGTGCGATCTCAGCTCACTGAAAACTCAT CTTGCCCAGGCTGGTCTTGAACCCCTGACCTTGTGATCCTCCCGCCTTGGCCTCCCCAAGTGCTGGGATA GGCGTGAGCCACCGTGCCCAGCCAATAATAGCTAAAATTTATATAATGTTCACTGGGCCAGGCACAGCGG CTCGTTCCTGTTATCCCAGCACTTTGGGAAGCTGAGGCAGGCAGATCGCTTGAGCCAAGGAGTTCGATAC CAGCCTGGGCAACATGGCAAAACCCCATCTCTACCAAAAAAAATATACAAAAATTAGCCAGGCGTGGTGG CATGTACTTGTAGTTCCAGCTACTCGGAAGGCTGAGTTGAGAGTATCTCTTGAGCCCAAGAAGAGGGGAC TACAGTGAACGGAGATTGCGCCACTGCACTCCAGCCTAGACGACAGACAGAAGATCTCAAAAGAAAAAAA AAAAAAAAAGATCACTTTATGCTGGGACTGCTCTAAAGGCCCAACCATGTTTTAACTAATTAACAATTTT ATGACAACTCTATGAGCTATGTACTGTAATTATGCCTATATTACAGATGTGAAAATTGAGGCTCAGAGAG GTTGAATAAGTTGCTCAAAGTCACACAGGTAATAAGTGATGGAACTAGAAGTTGAACTCAGGAAGTCTAG CTCCAAGTCTAAATTCTTTGTTAATTTATTTTTCGGGCCAGAGTCTTACTCTGTCACCCAGGCTGGAGTG CAGTGCCACTATCTCTGCTCACTGCAACCTTCACCTCCCAAGTTCAAACCTTGTTCAATTCTTGTGCCTT GGCCTCCCAAGTGGCTAGGATTACAGGCATGTGCCACAACAACTAGCTAATTTTTTGTCTGATTCTGTTG GCCAGTCTGGAGTGCAGTGGCGCAATCTCAGCTCACTGCAGTCTCCAGCTCCCAGGTTCAAGTGATTCTC GTGCCTTAGCCTCCCAAATAGCTGGGATTACAGGCACGTGCCACCACACCGAGATAGTTTTTTGTATTTT TAATAGAAACAAGGTTTCAACATGTTGGCCAGGCTGGTCTCAAATTCCAGACCTCAGATCATCTGCCCGC CTCAGGCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACTGCACCCGGCCTTAATTTTTATATTTTTAT TAGAGATGGGGTTTTGCCATGTTGGCCAGGCTGGCCTTGATCTCCTGGCCTCCAGTGATCCACCCGCCTT GGCTTCCCAAAGTGCTGGGATTACAAGCATGAGCCACTGCACCCGGCCTCCAATTCTAAACTCTTAACAA CAATACTATAGTTTCTTGAAAAGTTGTTGAAGGCTTCACGGAGGGAAAAAAAATGGAGCATTCTAACAAC TTTGCAGATGAGACCCAAGAAGACTCAATGACTTTCTCCTGATCATATTGTAGCAGATGACTTAGCCAGA ACTCTGACTTCCTCACAGGGAGAAAGTCTGCAAGATTTCACACTTACCTGTCAGGCCTGAGCTGGCTGCT TTCTCAGCTCCCTAAGTGCTATGTTCCCAGTCTGCTTTTCTTCCTTTTTCAAGTGTGCACTACCAGGCAT TTCAGAACATCCCAGGCTGGTCGCGGTGGCTCACACCTGTGATCCCAGCACTTTGGGAGCCCAAGGCGGG TGGATCACCTGAGGTCAGGAGTTCGAGACCAGCCTGGCCAACATGGTGAAACCCCATCTCTACTAAAAAT ACAAAAGTTAACTGGGCGTGGTGGTAGGCACCTGTAATCCTAGCTCAGGATTACTCGGGAGGCTGAGGCT AGAGAATCGGTTGAACCCAGGAGGCGGAGGTTGCAGTGAGCCAAGATTGCGCCACTGCACTCTAGCCTGG GGACAAGAGGGAGACTTCATCTCAAAAAAAAAAAAAAAATCCCAGCTGGGCACAGCGGCTCACTTCTGTA ATCCCAGCACTTTAGGAGGCCAAGGCAGGAGGATCACTTGAGCCCAGGAGTTCAAGACTAGCCTGGGCAA CATAGTAAGACCCTGTCTCTACAAAAAAATTTAAAAATTAATTGGGTGTCGTAGCACACTCTTGTATTCC CAGCTACTCAGGAGGCTGAGGTGAGAAGAATGCTTGAGTCTGGGAGGTCGAGGCTGCAGTGAGCCATGAT GGTGCTACTGCACTCCAGCCTGGCCAACATTGTGAGACCTTGTCTCAAAACAAAACAAAACATCCTTCTA CTGAGCACTTTCTGTCCCTTTATAGAAACTTAAGAGGGAACCAGTAGAGGTAATTTCCTAAGGAAAACTG CTTTGGGACATGATCACAAATGAAGCCTGGAGTTTTGAACTGCTGAGGTCAGCCTGTTTTTACCTTCTGA GCCTATCAAGTAATTGTTCCAGATGCCAAGAAAAGCTGCTGGCCTTATTTCTGCTTCTGCCTTTACCACA GGGGAGCGCCATGTGAGCCAGTCCTCTGTTTTTCCTCCACTGTATGCTAGGCAGTATTAGCACCAGATTC TTCCCCTCTTTAAAAAGAAATTCTAGTGCTTTGGATTTTTTCCTCCATGCAGAATAGCAATGATGGAAAG TATGTGGTCAAAGTAATGACATTCTGAAAATACTAAATGTCACCATAGTATTTTTCTCTGGAAGAGAAAT GTATATGTAGAGGTGAAACTTCAAATTTCTTTTTTTTTTTTTTTAAGACGAAGCTTTGCTCTTCTTGCCC AGGCTGAAGTACAATGGCGTGATCTTGGCTCACCGCAATCTCTGCCTCCAGGGTTCAAGTGATTCTCCTG CCTCAGCCTCCTAAGTAGCTAGGATTACAGGCATGTGCCACCACGCCCAGCTGATTTTGTATTTTTAGTA GAGATGGGGTTTCTCCATGTTGGTCACGCTGGTCTTGAACTCCCGACCCCAAGTGATCCACCCACCTCGG CCTCCCAAAGTGCTAGGATTACAGGCCACCGCGCCCGGCCTGAAACTTCAAATTTCTTTTTTTTTTTGAG ACAGAGTCTCGCTATGTCACCCAGGCTGGAGTGCAGTGGCGCCGTCTCGGCTCACTACCAGCTCCACTCC ACCTCCTGGGTTCACACCATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGACTACAGGTGCCCGCCACCA TGCCCAGCTAATTTTTTGTATTTTTAGTAGAGACGGGTTTTCACTGTGTTAGACGGGATGGTCTCCATCT CTTGACCTCGTGATCCGCCTGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACTACGCCAA GCCCGAAACTTCAAATTTCTTATCTCATAACTAGGCATCCTCATCACTGAGTGTTAGCCTGGATATAAAC ATTCCTAATCTTTTGTACTTTTCATGTCAGCATTTGGCTCCACTTGGCTGCCTGGGGAGAACTTCTAGCA TTATGAGCATGCAGGTCCTATCAACAGGTTGGGGGTGCGGTTTATTCATACAGGTAGTGAGAGTGGCACA GATGGATGCTGTCCCTTAAAACAAACAGACTTGTCTTTGGGAGCCTGAGGCGGGTGGATCATGAGGTCAG GAGTTCAAGACCAGCCTGGCCAACATAGTGAAACCCCGTTTCTACTAAAAATACAAAAAATTAGCCGGGT GTGGTGGTGTGCACCTGTAATCCCAGCTACTAGGGAGGCTGAGGCAGGAGAATCACTTGAACCCAGGAGG TGGAGGTTGCAGTGAGCCGAGATGGCACCATTGCACTCCAGCCCAGGCGACAGTGCAAGACTGCGTCTCA AAAAAAAAAAAAAAACACACAGACTTGTCCTACTGCCATTTCTTTTCACTCTGGCGGTAAAGTAAGAGAG TGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTTTCTGTCCGTCTGTCTGTCAAGGGGGA GGGTGACCACTTTCTAAAAGGCCATCCGTGTATTTTTAGCTTCCTGATTTTTTTCTCTATCGCAGTCTCT TTGAAGCCAGGTGAATTTTAGGCCTTGGCAATTTTCTTTTTATTGCAATGGGAAGGTCAAGACACTGAGA GTCACCCAAAACATATCCATCCAAAATGATACAATTTTAGGGTTTATTTTTAAGTGATACCCAAGTTATT TGCTAAGAACCTATGCCAGTGTGTTTATGAGAATTTGCACTGTCCCACACTGTTGCCACCAGCCACATGG GACTGTTTAAATTTAAATTTTACAAATTAGCCAGTCATGGTGGTGTGCACTTGTAGTCCCAGCTACTTAG GAGGCTGAGGCAAGAGGATTGCTTGAGCCCAGAAGTTCAATACTGCAGCAAGCTATGATCGTGCCACTGT ACTCCAGCCTGAGTGACAGAATGAGACCTCATCTCTTCAAAAAAAAAGAAAAAAATTAAAATATGAAGTT TAGTTCTTCATTCACCCTAACCACATCTCCAGTGCTCAATAACTATATGTGACTCATGGCTACCTTATTA GCATAGATATAGAACATTGTGACTATCACAGAAAGTTGTTTTGAACAGTGTTGCCAAGCCCTGTAAGTGG AAGAGGCAGTGCAGTGTGATCTGTGTCTTCAGGAAACCAGGTAGTCAGACTAGTTCAATGAGGAGAGGCA GAACCTGGCTTCACTTCTAGATTAAAAACTGCTTAGGTGGCCTAAAGATACAATGGCCATTCTCAGAGTA GTGAGAAGGAAGGAACAGATGTTTAGGGGGCTAGAAGAAAGTCAGAGAGGGCCGGGCGCAGTGGCTTATG CCTGTAATCCCAGCACTTTGGAAGGCCAAGACAGGCAGATCACGAGGTCAGGAGTTCGAGACCAGCCTGA CCAACATGGTGAAACCCTGTCTCTACTAAAAATACAAAAATTAGCCGGGCGTGGTGGTGCGCGCCTGTAA TCCCAGCTACTCAGGAGGCTAAGGCAGGAGAATCGCTTGAACCCTGGAGGCAGAGGTTGCAGTGAGCCCA GATCGCACCACTACGCTCCAGCCTAGGTGACAGAGAGAGACTCCGTCTCAAAAAAAAAAAAAAAAGTCAG AGGAGACAAGGAGCATGTACACCTAAAATCAACATAGACCCCTCTGTTGATGGGGTCATAGTGAGTACTT GAGGTACCAAGTCTGGATAAACATCAAACTTCAGCCAATAACTTTGAGTTTCTAGCCATCCAAGCCTCTT ATTAAACATACAGAAGGACCTTTTTTCCCTTGCATCTAACAAGTTAAAGCACCTGCAGAGATCATTAGGG AGGAGCCTTGGCCTGATTGGTGACAAAAGTGAGATGCTCAGTCCTTGAATGACAAAGAATGCCTGTAGAG TGCAGGTCAACTACATATGCACTTCAAGAAGATCTTCTGAAATCCAGTAGTGTTCTGGACATTGGACTGC TTGTCCCTGGGAAGTAGCAGCAGAAATCATCAGGTGGTGAACAGAAGAAAAAGAAAAGCTCTTCCTTTTT GAAAGTCTGTTTTTTGAATAAAAGCCAATATTCTTTTATAACTAGATTTTCCTTCTCTCCATTCCCCTGT CCCTCTCTCTTCCTCTCTTCTTCCAGATCTTCAGGGGGCTAGAAATCTGTTGCTATGGGCCCTTCACCAA CATGCCCACAGGTAAGAGCCTGGGAGAACCCCAGAGTTCCAGCACCAGCCTTTGTCTTACATAGTGGAGT ATTATAAGCAAGATCCCACGATGGGGGTTCCTCAGATTGCTGAAATGTTCTAGAGGCTATTCTATTTCTC TACCACTCTCCAAACAAAACAGCACCTAAATGTTATCCTATGGCAAAAAAAAACTATACCTTGTCCCCCT TCTCAAGAGCATGAAGGTGGTTAATAGTTAGGATTCAGTATGTTATGTGTTCAGATGGCGTTGAGCTGCT GTTAGTGCCAACATGTTAGTGAGAAAATATCTTTGGATAGGTAAAAATCAAGGAGGAGTTCTCCTCTTCC TAAACCATCTTAATTTACTTACATAGAAGAAAGCACAGCAGCTGGCCCACCACGGACGGGCCCAGAGCAG GGGAAGATTCTCGGTGAACATTTCTTTTTTTTTTTCTTTTTTTTTGAGGTCGAGTCTCTGTTGCCCAGGC CAGAGTGCAATGGCGCGATCTCGGCTCACTGCAACCTCCACCTCCCGGGTTCAAGTGATTCTCCTGCCTC AGCCTCCCAAATAGCTGAGACTACAGGCGTGTGCCACCACGCCCGACTAATTTTTTGTATTTTTTTTTTA GTAGAGACGGGGTTTCACCGTGTTAGCCAATATGGTCCCGATCTCCTGACCTCGTGATCCACCCGCCTCA GCCTCCCAAAGTGCTAGGATTACAGGCATGAGCCACTGTGCCCAGCCCTCTCCATGAACATTTTCTAATT AAACTTGACACTTAATACAATGTTATGCTTAGGACTGCTATAAAGCTTACCTCTGGAGTTGCGCAGCACA AAGGCCTTGGTGTGTGTATAAATTTGGTTTGTTCTTTTCACAGCAAAAGCTACCCACCTTTGCCTCCTGT GCCTGCTTCTGCCCAGGGACTTAGGTCCTCTTACACCTTAGAGAAAGGCCTTAGCATCTGGTCACAGGCA GATGAGTGACAGCAAGAAAACCTGGCTGCAATGTAATTTTGTTTCCATCCTCTTTATTAGTTATCAATTG GATTTTTATGAAATTTCCAAGTTCCACTCAAGGATTTCTCAGTGTTTTTTTACTTTGGTATAGTGGAAAC CAGGGTTGCCAGAAAGTATTATTTTGGGGGTGAGTTAGTCAACCTTCGTTCAGTCAGACAGACAGGAGCA CCTCAGCAATTCCCAGAAACGGGCTGATGGGAAAGAGCAACATACATGAATGTCTTGAAGAACACAGCCA ACAGAGCCCATTGGGCAGTTCTGATTTTCCAGGTACACAGCATCTCCACAGTCTCTTCTGATTTTTATTC CCCTGAGTATATGGATTCCAGCTCAGCATGTAGCCTTTCCCTGCTGAGTCTCTAACCAGGATAACATGTA TTTTTTTGACTGGATGAATTATCTTCCCATCTCTTGACATTTACAGTAATTACCACCAAGTATGGTATTT TCAGTGGCCGTGATTATCAGTTACCAACACAGAATTAGGATGAAGGGAGGAAGGGAGGGAAGGAAGGTGG GTGTTTTTTCACACAGTGTCTTAGCCAGCAATTTAGCAAATTAATGGAAATTAGATCTTTGATTTTTTTT TCTTTCAAGCATTTTATTTGAGAGACTATCAAACCTTATACCAAGTGGCCTTATGGAGACTGATAACCAG AGTACATGGCATATCAGTGGCAAATTGACTTAAAATCCATACCCCTACTATTTTAAGACCATTGTCCTTT GGAGCAGAGAGACAGACTCTCCCATTGAGAGGTCTTGCTATAAGCCTTCATCCGGAGAGTGTAGGGTAGA GGGCCTGGGTTAAGTATGCAGATTACTGCAGTGATTTTACATCTAAATGTCCATTTTAGATCAACTGGAA TGGATGGTACAGCTGTGTGGTGCTTCTGTGGTGAAGGAGCTTTCATCATTCACCCTTGGCACAGTAAGTA TTGGGTGCCCTGTCAGAGAGGGAGGACACAATATTCTCTCCTGTGAGCAAGACTGGCACCTGTCAGTCCC TATGGATGCCCCTACTGTAGCCTCAGAAGTCTTCTCTGCCCACATACCTGTGCCAAAAGACTCCATCTGT AAGGGATGGGTAAGGATTTGAGAACTGCACATATTAAATATACTGAGGGAAGACTTTTTCCCTCTAACTC TTTTTCCCATATGTCCCTCCCCCTCCTCTCTGTGACTGCCCCAGCATACTGTGTTTCAACAAATCATCAA GAAATGATGGGCTGGAGGCTGGGCATGGTGGCTCATGTCTGTAATCCCAGCACTTTGGGAGGCCGAGGCA GGTGGATCACTTGTCAGGAGTTTGAGACCAGCCTGGCCAACATGGTGAAACCCCATCTGTACTAAAAAAA AAAAAACAAAAAGTAGCCAGGCCTGGTGGAGCATGCCTGTAATGCCAGCTATTTGGGAAGTTGAGGTGTG AGCATCGCTTGAACGTGGGAGGCAGAGGTTGCAGTGAGCCAAGATTGCACCACTGCACTCCAGACTGGGT GACAGAGTGAGACTTTGTCTAAAAAAAAAAAAAAAGAGAGAGAGAGAAAAGCTAGGTGCGGTGGCTCACG CCTGTAATCCCAGCACTTTGGGAGGCTGAGGTGGGCAGATCACGAGGTCAAGAGATCGAGACCATCCTGG CCAACCAACATGGCGAAACCCCGTCTCTACTAAAAATACAAAAATTAGCTGGGCGTAGGGGCGCACGCCT GTAGTCCCAGCTACTTGAGGGGCTGGGGCAGGAGAATCGCTTGAACCCCGGAGGCGGAGGTTGCAGTGAG CCAAGATCGCGCCACTGCACTCCAGCCCGGGCGACAGAGCGAGACTCCGTCTCAAAAAAAAAGAGAGAGA GAGAAATGATGGGCTGGGCCAGTGCCCCACCCCTGTAATCACAACACTGGGAGGCCAAGGTGGGAGAATC GCTTGAGCCTGGGAGCTGAAGACCAGCCTGGGCAATACAGTAGGACCTCATGTCTACAAAAAAATTATTA AAAATTAGCCAAGGCTGGGTGCGGTGGCTCATGCCTATAATCCCGGGGGTGAAGTTGAGCCCAGGAGTTT GAGACCAGCCTGGGCAACATGGCAAAACCCTGTCTCTACCAAAAATACAAAAAAATTAGCCAGGGGTGGT GGTACGTGTCTGTAGTTCCAGCTACTTAGGAGGCTGAGATGGAAGGATTGCTTGAGCCCAGGAGGCAGAG GTGGCAGTGAGCTGAGATCACACCACTGCACTCCAGCCTGGGTGACAGAGCAAGACCCTGTCTCAAAAAC AAACAAAAAAAATGATGAAGTGACAGTTCCAGTAGTCCTACTTTGACACTTTGAATGCTCTTTCCTTCCT GGGGATCCAGGGTGTCCACCCAATTGTGGTTGTGCAGCCAGATGCCTGGACAGAGGACAATGGCTTCCAT GGTAAGGTGCCTGCATGTACCTGTGCTATATGGGGTCCTTTTGCATGGGTTTGGTTTATCACTCATTACC TGGTGCTTGAGTAGCACAGTTCTTGGCACATTTTAAATATTTGTTGAATGAATGGCTAAAATGTCTTTTT GATGTTTTTATTGTTATTTGTTTTATATTGTAAAAGTAATACATGAACTGTTTCCATGGGGTGGGAGTAA GATATGAATGTTCATCACAAAAACATAAATCAAGGCCGGGCATGGTGGCTCATGCCTATAATTCCAGCAC TTTGGGAGGTCAAGATGGAGGTCAAGGTGGGAGCCTAGAAGTTCGAGACCAGCCTGGGCAACATAAGGAG ACTTCATCTGTACAACAAATTTAAAAAGTAGCTGGGTGTGGTGGCAGATGCCTGTAGTCGCAGCTACTTG GGAAGCTGAGGTGGGAGGATCACTTGAGCTCAGGAGGTTGATGCTTCAGTGAGCCACGATCACACCACTG TACTCCAGCCTGGGCGACAGAGCGAGACCGTGTCTCAAAAAGAAAAAAGAAAGTATAAATTTACACAAAA ACAATAAAATAATCCCAGTAATTCCACCACTTGGAGATGATCACCATAAAACTCCACCAGGCATATGTGC GTATATATACACGTGTATTTTATAAAATGTGATCATAATTACACTGTTTTGCTTTTTTCCTTAAGATATT ACATACATTTTTCCACATCGTTAAATTACAGTGCTGTTTTCCTGGTGGCTTTCCTTTAACAGATTGAAGT TCATGTTAATACAGTTGCCAGAGGCTGTGGGCTTTCACTGTCACCAGGAGTCACTCCTAGGGCCTCTTCA GAGCAAGGCCTTATGTCCTGAAGCATTGCCTTTTTTTTTTTTTTTTGAGGTGGAGTCTCACTCTGTCACT TAGCAGGCTGGAGTGCAGTGGCCCAGTCTTGGCTCACTGCAACCTCCGCCTCCTGGGTTTAAATGATTCT CCTGCCTCAGCCTCAGGGCGGATCACCTGACATCAGGAGTTTGAGACCAGCCTGGCCAATATGGCGAAAC CCCATCTCTACTAAAAATACTAAAAAAAATTAGCCAGGCATGGTGGCACGCACTTGTAGTCCCAGCTACT TGGGAGACTGAGGCAGGAGAATCGCTTGAACCCAGGATGTTGAGGTTGCAGTGAGCTGAGATCACACCAT CACAATCCAGCCTGAGTGACAGAGTGAGACTCCATCTGAAAAAAAAGAAAAAACAATTAGCCTGGCATGG TGGCAGGCACCTGTAATCCCTGCTACTTGGGAGGCTGAGGCAGGAGAATTGCTTGAACCCGGGAGGTGGA GGTTGCAGTGAGCTGAGATCGTGCCATTGCATTCCAGGCTGAGCAACAAGAGCAAGACTCCGTCTCAAAA AAAAAAAAAAAAAAAAAAAAAGGCCAGGTGCAGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCA AGGTGGGTGGATCACCTGAGGTCAGGAGTTCCAGAGCAGCCTGGCCAACATTGTGAAACCCCCGTCTCTA CTAAAAATACAAAAATTAGCTGGGTGTGATGGCATGTGCCTGTAATTCCAGCTACTCAGGAGGCAGAGAC AGGAGAATTGCTTGAACCCAGGAGGCGGAGGTTGAATGAGCCGAGATTGCGCCATCACACTCTAGCCTCG GCGACAGAGCAAGACTCCGTCTCAAAAAAAAAAAAAAAAAATTAGCTTCTACCTCATTAATCCTAAGAAC TCATACAACCAGGACCCTGGAGTCGATTGATTAGAGCCTAGTCCAGGAGAATGAATTGACACTAATCTCT GCTTGTGTTCTCTGTCTCCAGCAATTGGGCAGATGTGTGAGGCACCTGTGGTGACCCGAGAGTGGGTGTT GGACAGTGTAGCACTCTACCAGTGCCAGGAGCTGGACACCTACCTGATACCCCAGATCCCCCACAGCCAC TACTGACTGCAGCCAGCCACAGGTACAGAGCCACAGGACCCCAAGAATGAGCTTACAAAGTGGCCTTTCC AGGCCCTGGGAGCTCCTCTCACTCTTCAGTCCTTCTACTGTCCTGGCTACTAAATATTTTATGTACATCA GCCTGAAAAGGACTTCTGGCTATGCAAGGGTCCCTTAAAGATTTTCTGCTTGAAGTCTCCCTTGGAAATC TGCCATGAGCACAAAATTATGGTAATTTTTCACCTGAGAAGATTTTAAAACCATTTAAACGCCACCAATT GAGCAAGATGCTGATTCATTATTTATCAGCCCTATTCTTTCTATTCAGGCTGTTGTTGGCTTAGGGCTGG AAGCACAGAGTGGCTTGGCCTCAAGAGAATAGCTGGTTTCCCTAAGTTTACTTCTCTAAAACCCTGTGTT CACAAAGGCAGAGAGTCAGACCCTTCAATGGAAGGAGAGTGCTTGGGATCGATTATGTGACTTAAAGTCA GAATAGTCCTTGGGCAGTTCTCAAATGTTGGAGTGGAACATTGGGGAGGAAATTCTGAGGCAGGTATTAG AAATGAAAAGGAAACTTGAAACCTGGGCATGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCAA GGTGGGCAGATCACTGGAGGTCAGGAGTTCGAAACCAGCCTGGCCAACATGGTGAAACCCCATCTCTACT AAAAATACAGAAATTAGCCGGTCATGGTGGTGGACACCTGTAATCCCAGCTACTCAGGTGGCTAAGGCAG GAGAATCACTTCAGCCCGGGAGGTGGAGGTTGCAGTGAGCCAAGATCATACCACGGCACTCCAGCCTGGG TGACAGTGAGACTGTGGCTCAAAAAAAAAAAAAAAAAAAGGAAAATGAAACTAGAAGAGATTTCTAAAAG TCTGAGATATATTTGCTAGATTTCTAAAGAATGTGTTCTAAAACAGCAGAAGATTTTCAAGAACCGGTTT CCAAAGACAGTCTTCTAATTCCTCATTAGTAATAAGTAAAATGTTTATTGTTGTAGCTCTGGTATATAAT CCATTCCTCTTAAAATATAAGACCTCTGGCATGAATATTTCATATCTATAAAATGACAGATCCCACCAGG AAGGAAGCTGTTGCTTTCTTTGAGGTGATTTTTTTCCTTTGCTCCCTGTTGCTGAAACCATACAGCTTCA TAAATAATTTTGCTTGCTGAAGGAAGAAAAAGTGTTTTTCATAAACCCATTATCCAGGACTGTTTATAGC TGTTGGAAGGACTAGGTCTTCCCTAGCCCCCCCAGTGTGCAAGGGCAGTGAAGACTTGATTGTACAAAAT ACGTTTTGTAAATGTTGTGCTGTTAACACTGCAAATAAACTTGGTAGCAAACACTTCCA Download Select all
Length	81189
OMIM ID	113705
HGNC ID	HGNC:1100
Unigene ID	Hs.194143
Ensembl ID	ENSG00000012048
PharmGKB ID	PA25411

mRNA Information

mRNA ID	NM_007294.3
Exon	join(1..213,1369..1467,9705..9758,18951..19028, 20528..20616,21223..21362,25604..25709,28195..28240, 29562..29638,30624..34049,34452..34540,42909..43080, 48870..48996,50963..51153,54246..54556,57789..57876, 61533..61610,62111..62151,68349..68432,74367..74421, 76290..76363,77781..77841,79682..81189)
mRNA Sequence	>gi\|237757283\|ref\|NM_007294.3\| Homo sapiens breast cancer 1 (BRCA1), transcript variant 1, mRNA GTACCTTGATTTCGTATTCTGAGAGGCTGCTGCTTAGCGGTAGCCCCTTGGTTTCCGTGGCAACGGAAAA GCGCGGGAATTACAGATAAATTAAAACTGCGACTGCGCGGCGTGAGCTCGCTGAGACTTCCTGGACGGGG GACAGGCTGTGGGGTTTCTCAGATAACTGGGCCCCTGCGCTCAGGAGGCCTTCACCCTCTGCTCTGGGTA AAGTTCATTGGAACAGAAAGAAATGGATTTATCTGCTCTTCGCGTTGAAGAAGTACAAAATGTCATTAAT GCTATGCAGAAAATCTTAGAGTGTCCCATCTGTCTGGAGTTGATCAAGGAACCTGTCTCCACAAAGTGTG ACCACATATTTTGCAAATTTTGCATGCTGAAACTTCTCAACCAGAAGAAAGGGCCTTCACAGTGTCCTTT ATGTAAGAATGATATAACCAAAAGGAGCCTACAAGAAAGTACGAGATTTAGTCAACTTGTTGAAGAGCTA TTGAAAATCATTTGTGCTTTTCAGCTTGACACAGGTTTGGAGTATGCAAACAGCTATAATTTTGCAAAAA AGGAAAATAACTCTCCTGAACATCTAAAAGATGAAGTTTCTATCATCCAAAGTATGGGCTACAGAAACCG TGCCAAAAGACTTCTACAGAGTGAACCCGAAAATCCTTCCTTGCAGGAAACCAGTCTCAGTGTCCAACTC TCTAACCTTGGAACTGTGAGAACTCTGAGGACAAAGCAGCGGATACAACCTCAAAAGACGTCTGTCTACA TTGAATTGGGATCTGATTCTTCTGAAGATACCGTTAATAAGGCAACTTATTGCAGTGTGGGAGATCAAGA ATTGTTACAAATCACCCCTCAAGGAACCAGGGATGAAATCAGTTTGGATTCTGCAAAAAAGGCTGCTTGT GAATTTTCTGAGACGGATGTAACAAATACTGAACATCATCAACCCAGTAATAATGATTTGAACACCACTG AGAAGCGTGCAGCTGAGAGGCATCCAGAAAAGTATCAGGGTAGTTCTGTTTCAAACTTGCATGTGGAGCC ATGTGGCACAAATACTCATGCCAGCTCATTACAGCATGAGAACAGCAGTTTATTACTCACTAAAGACAGA ATGAATGTAGAAAAGGCTGAATTCTGTAATAAAAGCAAACAGCCTGGCTTAGCAAGGAGCCAACATAACA GATGGGCTGGAAGTAAGGAAACATGTAATGATAGGCGGACTCCCAGCACAGAAAAAAAGGTAGATCTGAA TGCTGATCCCCTGTGTGAGAGAAAAGAATGGAATAAGCAGAAACTGCCATGCTCAGAGAATCCTAGAGAT ACTGAAGATGTTCCTTGGATAACACTAAATAGCAGCATTCAGAAAGTTAATGAGTGGTTTTCCAGAAGTG ATGAACTGTTAGGTTCTGATGACTCACATGATGGGGAGTCTGAATCAAATGCCAAAGTAGCTGATGTATT GGACGTTCTAAATGAGGTAGATGAATATTCTGGTTCTTCAGAGAAAATAGACTTACTGGCCAGTGATCCT CATGAGGCTTTAATATGTAAAAGTGAAAGAGTTCACTCCAAATCAGTAGAGAGTAATATTGAAGACAAAA TATTTGGGAAAACCTATCGGAAGAAGGCAAGCCTCCCCAACTTAAGCCATGTAACTGAAAATCTAATTAT AGGAGCATTTGTTACTGAGCCACAGATAATACAAGAGCGTCCCCTCACAAATAAATTAAAGCGTAAAAGG AGACCTACATCAGGCCTTCATCCTGAGGATTTTATCAAGAAAGCAGATTTGGCAGTTCAAAAGACTCCTG AAATGATAAATCAGGGAACTAACCAAACGGAGCAGAATGGTCAAGTGATGAATATTACTAATAGTGGTCA TGAGAATAAAACAAAAGGTGATTCTATTCAGAATGAGAAAAATCCTAACCCAATAGAATCACTCGAAAAA GAATCTGCTTTCAAAACGAAAGCTGAACCTATAAGCAGCAGTATAAGCAATATGGAACTCGAATTAAATA TCCACAATTCAAAAGCACCTAAAAAGAATAGGCTGAGGAGGAAGTCTTCTACCAGGCATATTCATGCGCT TGAACTAGTAGTCAGTAGAAATCTAAGCCCACCTAATTGTACTGAATTGCAAATTGATAGTTGTTCTAGC AGTGAAGAGATAAAGAAAAAAAAGTACAACCAAATGCCAGTCAGGCACAGCAGAAACCTACAACTCATGG AAGGTAAAGAACCTGCAACTGGAGCCAAGAAGAGTAACAAGCCAAATGAACAGACAAGTAAAAGACATGA CAGCGATACTTTCCCAGAGCTGAAGTTAACAAATGCACCTGGTTCTTTTACTAAGTGTTCAAATACCAGT GAACTTAAAGAATTTGTCAATCCTAGCCTTCCAAGAGAAGAAAAAGAAGAGAAACTAGAAACAGTTAAAG TGTCTAATAATGCTGAAGACCCCAAAGATCTCATGTTAAGTGGAGAAAGGGTTTTGCAAACTGAAAGATC TGTAGAGAGTAGCAGTATTTCATTGGTACCTGGTACTGATTATGGCACTCAGGAAAGTATCTCGTTACTG GAAGTTAGCACTCTAGGGAAGGCAAAAACAGAACCAAATAAATGTGTGAGTCAGTGTGCAGCATTTGAAA ACCCCAAGGGACTAATTCATGGTTGTTCCAAAGATAATAGAAATGACACAGAAGGCTTTAAGTATCCATT GGGACATGAAGTTAACCACAGTCGGGAAACAAGCATAGAAATGGAAGAAAGTGAACTTGATGCTCAGTAT TTGCAGAATACATTCAAGGTTTCAAAGCGCCAGTCATTTGCTCCGTTTTCAAATCCAGGAAATGCAGAAG AGGAATGTGCAACATTCTCTGCCCACTCTGGGTCCTTAAAGAAACAAAGTCCAAAAGTCACTTTTGAATG TGAACAAAAGGAAGAAAATCAAGGAAAGAATGAGTCTAATATCAAGCCTGTACAGACAGTTAATATCACT GCAGGCTTTCCTGTGGTTGGTCAGAAAGATAAGCCAGTTGATAATGCCAAATGTAGTATCAAAGGAGGCT CTAGGTTTTGTCTATCATCTCAGTTCAGAGGCAACGAAACTGGACTCATTACTCCAAATAAACATGGACT TTTACAAAACCCATATCGTATACCACCACTTTTTCCCATCAAGTCATTTGTTAAAACTAAATGTAAGAAA AATCTGCTAGAGGAAAACTTTGAGGAACATTCAATGTCACCTGAAAGAGAAATGGGAAATGAGAACATTC CAAGTACAGTGAGCACAATTAGCCGTAATAACATTAGAGAAAATGTTTTTAAAGAAGCCAGCTCAAGCAA TATTAATGAAGTAGGTTCCAGTACTAATGAAGTGGGCTCCAGTATTAATGAAATAGGTTCCAGTGATGAA AACATTCAAGCAGAACTAGGTAGAAACAGAGGGCCAAAATTGAATGCTATGCTTAGATTAGGGGTTTTGC AACCTGAGGTCTATAAACAAAGTCTTCCTGGAAGTAATTGTAAGCATCCTGAAATAAAAAAGCAAGAATA TGAAGAAGTAGTTCAGACTGTTAATACAGATTTCTCTCCATATCTGATTTCAGATAACTTAGAACAGCCT ATGGGAAGTAGTCATGCATCTCAGGTTTGTTCTGAGACACCTGATGACCTGTTAGATGATGGTGAAATAA AGGAAGATACTAGTTTTGCTGAAAATGACATTAAGGAAAGTTCTGCTGTTTTTAGCAAAAGCGTCCAGAA AGGAGAGCTTAGCAGGAGTCCTAGCCCTTTCACCCATACACATTTGGCTCAGGGTTACCGAAGAGGGGCC AAGAAATTAGAGTCCTCAGAAGAGAACTTATCTAGTGAGGATGAAGAGCTTCCCTGCTTCCAACACTTGT TATTTGGTAAAGTAAACAATATACCTTCTCAGTCTACTAGGCATAGCACCGTTGCTACCGAGTGTCTGTC TAAGAACACAGAGGAGAATTTATTATCATTGAAGAATAGCTTAAATGACTGCAGTAACCAGGTAATATTG GCAAAGGCATCTCAGGAACATCACCTTAGTGAGGAAACAAAATGTTCTGCTAGCTTGTTTTCTTCACAGT GCAGTGAATTGGAAGACTTGACTGCAAATACAAACACCCAGGATCCTTTCTTGATTGGTTCTTCCAAACA AATGAGGCATCAGTCTGAAAGCCAGGGAGTTGGTCTGAGTGACAAGGAATTGGTTTCAGATGATGAAGAA AGAGGAACGGGCTTGGAAGAAAATAATCAAGAAGAGCAAAGCATGGATTCAAACTTAGGTGAAGCAGCAT CTGGGTGTGAGAGTGAAACAAGCGTCTCTGAAGACTGCTCAGGGCTATCCTCTCAGAGTGACATTTTAAC CACTCAGCAGAGGGATACCATGCAACATAACCTGATAAAGCTCCAGCAGGAAATGGCTGAACTAGAAGCT GTGTTAGAACAGCATGGGAGCCAGCCTTCTAACAGCTACCCTTCCATCATAAGTGACTCTTCTGCCCTTG AGGACCTGCGAAATCCAGAACAAAGCACATCAGAAAAAGCAGTATTAACTTCACAGAAAAGTAGTGAATA CCCTATAAGCCAGAATCCAGAAGGCCTTTCTGCTGACAAGTTTGAGGTGTCTGCAGATAGTTCTACCAGT AAAAATAAAGAACCAGGAGTGGAAAGGTCATCCCCTTCTAAATGCCCATCATTAGATGATAGGTGGTACA TGCACAGTTGCTCTGGGAGTCTTCAGAATAGAAACTACCCATCTCAAGAGGAGCTCATTAAGGTTGTTGA TGTGGAGGAGCAACAGCTGGAAGAGTCTGGGCCACACGATTTGACGGAAACATCTTACTTGCCAAGGCAA GATCTAGAGGGAACCCCTTACCTGGAATCTGGAATCAGCCTCTTCTCTGATGACCCTGAATCTGATCCTT CTGAAGACAGAGCCCCAGAGTCAGCTCGTGTTGGCAACATACCATCTTCAACCTCTGCATTGAAAGTTCC CCAATTGAAAGTTGCAGAATCTGCCCAGAGTCCAGCTGCTGCTCATACTACTGATACTGCTGGGTATAAT GCAATGGAAGAAAGTGTGAGCAGGGAGAAGCCAGAATTGACAGCTTCAACAGAAAGGGTCAACAAAAGAA TGTCCATGGTGGTGTCTGGCCTGACCCCAGAAGAATTTATGCTCGTGTACAAGTTTGCCAGAAAACACCA CATCACTTTAACTAATCTAATTACTGAAGAGACTACTCATGTTGTTATGAAAACAGATGCTGAGTTTGTG TGTGAACGGACACTGAAATATTTTCTAGGAATTGCGGGAGGAAAATGGGTAGTTAGCTATTTCTGGGTGA CCCAGTCTATTAAAGAAAGAAAAATGCTGAATGAGCATGATTTTGAAGTCAGAGGAGATGTGGTCAATGG AAGAAACCACCAAGGTCCAAAGCGAGCAAGAGAATCCCAGGACAGAAAGATCTTCAGGGGGCTAGAAATC TGTTGCTATGGGCCCTTCACCAACATGCCCACAGATCAACTGGAATGGATGGTACAGCTGTGTGGTGCTT CTGTGGTGAAGGAGCTTTCATCATTCACCCTTGGCACAGGTGTCCACCCAATTGTGGTTGTGCAGCCAGA TGCCTGGACAGAGGACAATGGCTTCCATGCAATTGGGCAGATGTGTGAGGCACCTGTGGTGACCCGAGAG TGGGTGTTGGACAGTGTAGCACTCTACCAGTGCCAGGAGCTGGACACCTACCTGATACCCCAGATCCCCC ACAGCCACTACTGACTGCAGCCAGCCACAGGTACAGAGCCACAGGACCCCAAGAATGAGCTTACAAAGTG GCCTTTCCAGGCCCTGGGAGCTCCTCTCACTCTTCAGTCCTTCTACTGTCCTGGCTACTAAATATTTTAT GTACATCAGCCTGAAAAGGACTTCTGGCTATGCAAGGGTCCCTTAAAGATTTTCTGCTTGAAGTCTCCCT TGGAAATCTGCCATGAGCACAAAATTATGGTAATTTTTCACCTGAGAAGATTTTAAAACCATTTAAACGC CACCAATTGAGCAAGATGCTGATTCATTATTTATCAGCCCTATTCTTTCTATTCAGGCTGTTGTTGGCTT AGGGCTGGAAGCACAGAGTGGCTTGGCCTCAAGAGAATAGCTGGTTTCCCTAAGTTTACTTCTCTAAAAC CCTGTGTTCACAAAGGCAGAGAGTCAGACCCTTCAATGGAAGGAGAGTGCTTGGGATCGATTATGTGACT TAAAGTCAGAATAGTCCTTGGGCAGTTCTCAAATGTTGGAGTGGAACATTGGGGAGGAAATTCTGAGGCA GGTATTAGAAATGAAAAGGAAACTTGAAACCTGGGCATGGTGGCTCACGCCTGTAATCCCAGCACTTTGG GAGGCCAAGGTGGGCAGATCACTGGAGGTCAGGAGTTCGAAACCAGCCTGGCCAACATGGTGAAACCCCA TCTCTACTAAAAATACAGAAATTAGCCGGTCATGGTGGTGGACACCTGTAATCCCAGCTACTCAGGTGGC TAAGGCAGGAGAATCACTTCAGCCCGGGAGGTGGAGGTTGCAGTGAGCCAAGATCATACCACGGCACTCC AGCCTGGGTGACAGTGAGACTGTGGCTCAAAAAAAAAAAAAAAAAAAGGAAAATGAAACTAGAAGAGATT TCTAAAAGTCTGAGATATATTTGCTAGATTTCTAAAGAATGTGTTCTAAAACAGCAGAAGATTTTCAAGA ACCGGTTTCCAAAGACAGTCTTCTAATTCCTCATTAGTAATAAGTAAAATGTTTATTGTTGTAGCTCTGG TATATAATCCATTCCTCTTAAAATATAAGACCTCTGGCATGAATATTTCATATCTATAAAATGACAGATC CCACCAGGAAGGAAGCTGTTGCTTTCTTTGAGGTGATTTTTTTCCTTTGCTCCCTGTTGCTGAAACCATA CAGCTTCATAAATAATTTTGCTTGCTGAAGGAAGAAAAAGTGTTTTTCATAAACCCATTATCCAGGACTG TTTATAGCTGTTGGAAGGACTAGGTCTTCCCTAGCCCCCCCAGTGTGCAAGGGCAGTGAAGACTTGATTG TACAAAATACGTTTTGTAAATGTTGTGCTGTTAACACTGCAAATAAACTTGGTAGCAAACACTTCCAAAA AAAAAAAAAAAAAA Download Select all
Length	7224

CDS Information

Location	233..5824
CDS Sequence	>lcl\|NM_007294.3_cds_NP_009225.1_1 [gene=BRCA1] [protein=breast cancer type 1 susceptibility protein isoform 1] [protein_id=NP_009225.1] [location=233..5824] ATGGATTTATCTGCTCTTCGCGTTGAAGAAGTACAAAATGTCATTAATGCTATGCAGAAAATCTTAGAGT GTCCCATCTGTCTGGAGTTGATCAAGGAACCTGTCTCCACAAAGTGTGACCACATATTTTGCAAATTTTG CATGCTGAAACTTCTCAACCAGAAGAAAGGGCCTTCACAGTGTCCTTTATGTAAGAATGATATAACCAAA AGGAGCCTACAAGAAAGTACGAGATTTAGTCAACTTGTTGAAGAGCTATTGAAAATCATTTGTGCTTTTC AGCTTGACACAGGTTTGGAGTATGCAAACAGCTATAATTTTGCAAAAAAGGAAAATAACTCTCCTGAACA TCTAAAAGATGAAGTTTCTATCATCCAAAGTATGGGCTACAGAAACCGTGCCAAAAGACTTCTACAGAGT GAACCCGAAAATCCTTCCTTGCAGGAAACCAGTCTCAGTGTCCAACTCTCTAACCTTGGAACTGTGAGAA CTCTGAGGACAAAGCAGCGGATACAACCTCAAAAGACGTCTGTCTACATTGAATTGGGATCTGATTCTTC TGAAGATACCGTTAATAAGGCAACTTATTGCAGTGTGGGAGATCAAGAATTGTTACAAATCACCCCTCAA GGAACCAGGGATGAAATCAGTTTGGATTCTGCAAAAAAGGCTGCTTGTGAATTTTCTGAGACGGATGTAA CAAATACTGAACATCATCAACCCAGTAATAATGATTTGAACACCACTGAGAAGCGTGCAGCTGAGAGGCA TCCAGAAAAGTATCAGGGTAGTTCTGTTTCAAACTTGCATGTGGAGCCATGTGGCACAAATACTCATGCC AGCTCATTACAGCATGAGAACAGCAGTTTATTACTCACTAAAGACAGAATGAATGTAGAAAAGGCTGAAT TCTGTAATAAAAGCAAACAGCCTGGCTTAGCAAGGAGCCAACATAACAGATGGGCTGGAAGTAAGGAAAC ATGTAATGATAGGCGGACTCCCAGCACAGAAAAAAAGGTAGATCTGAATGCTGATCCCCTGTGTGAGAGA AAAGAATGGAATAAGCAGAAACTGCCATGCTCAGAGAATCCTAGAGATACTGAAGATGTTCCTTGGATAA CACTAAATAGCAGCATTCAGAAAGTTAATGAGTGGTTTTCCAGAAGTGATGAACTGTTAGGTTCTGATGA CTCACATGATGGGGAGTCTGAATCAAATGCCAAAGTAGCTGATGTATTGGACGTTCTAAATGAGGTAGAT GAATATTCTGGTTCTTCAGAGAAAATAGACTTACTGGCCAGTGATCCTCATGAGGCTTTAATATGTAAAA GTGAAAGAGTTCACTCCAAATCAGTAGAGAGTAATATTGAAGACAAAATATTTGGGAAAACCTATCGGAA GAAGGCAAGCCTCCCCAACTTAAGCCATGTAACTGAAAATCTAATTATAGGAGCATTTGTTACTGAGCCA CAGATAATACAAGAGCGTCCCCTCACAAATAAATTAAAGCGTAAAAGGAGACCTACATCAGGCCTTCATC CTGAGGATTTTATCAAGAAAGCAGATTTGGCAGTTCAAAAGACTCCTGAAATGATAAATCAGGGAACTAA CCAAACGGAGCAGAATGGTCAAGTGATGAATATTACTAATAGTGGTCATGAGAATAAAACAAAAGGTGAT TCTATTCAGAATGAGAAAAATCCTAACCCAATAGAATCACTCGAAAAAGAATCTGCTTTCAAAACGAAAG CTGAACCTATAAGCAGCAGTATAAGCAATATGGAACTCGAATTAAATATCCACAATTCAAAAGCACCTAA AAAGAATAGGCTGAGGAGGAAGTCTTCTACCAGGCATATTCATGCGCTTGAACTAGTAGTCAGTAGAAAT CTAAGCCCACCTAATTGTACTGAATTGCAAATTGATAGTTGTTCTAGCAGTGAAGAGATAAAGAAAAAAA AGTACAACCAAATGCCAGTCAGGCACAGCAGAAACCTACAACTCATGGAAGGTAAAGAACCTGCAACTGG AGCCAAGAAGAGTAACAAGCCAAATGAACAGACAAGTAAAAGACATGACAGCGATACTTTCCCAGAGCTG AAGTTAACAAATGCACCTGGTTCTTTTACTAAGTGTTCAAATACCAGTGAACTTAAAGAATTTGTCAATC CTAGCCTTCCAAGAGAAGAAAAAGAAGAGAAACTAGAAACAGTTAAAGTGTCTAATAATGCTGAAGACCC CAAAGATCTCATGTTAAGTGGAGAAAGGGTTTTGCAAACTGAAAGATCTGTAGAGAGTAGCAGTATTTCA TTGGTACCTGGTACTGATTATGGCACTCAGGAAAGTATCTCGTTACTGGAAGTTAGCACTCTAGGGAAGG CAAAAACAGAACCAAATAAATGTGTGAGTCAGTGTGCAGCATTTGAAAACCCCAAGGGACTAATTCATGG TTGTTCCAAAGATAATAGAAATGACACAGAAGGCTTTAAGTATCCATTGGGACATGAAGTTAACCACAGT CGGGAAACAAGCATAGAAATGGAAGAAAGTGAACTTGATGCTCAGTATTTGCAGAATACATTCAAGGTTT CAAAGCGCCAGTCATTTGCTCCGTTTTCAAATCCAGGAAATGCAGAAGAGGAATGTGCAACATTCTCTGC CCACTCTGGGTCCTTAAAGAAACAAAGTCCAAAAGTCACTTTTGAATGTGAACAAAAGGAAGAAAATCAA GGAAAGAATGAGTCTAATATCAAGCCTGTACAGACAGTTAATATCACTGCAGGCTTTCCTGTGGTTGGTC AGAAAGATAAGCCAGTTGATAATGCCAAATGTAGTATCAAAGGAGGCTCTAGGTTTTGTCTATCATCTCA GTTCAGAGGCAACGAAACTGGACTCATTACTCCAAATAAACATGGACTTTTACAAAACCCATATCGTATA CCACCACTTTTTCCCATCAAGTCATTTGTTAAAACTAAATGTAAGAAAAATCTGCTAGAGGAAAACTTTG AGGAACATTCAATGTCACCTGAAAGAGAAATGGGAAATGAGAACATTCCAAGTACAGTGAGCACAATTAG CCGTAATAACATTAGAGAAAATGTTTTTAAAGAAGCCAGCTCAAGCAATATTAATGAAGTAGGTTCCAGT ACTAATGAAGTGGGCTCCAGTATTAATGAAATAGGTTCCAGTGATGAAAACATTCAAGCAGAACTAGGTA GAAACAGAGGGCCAAAATTGAATGCTATGCTTAGATTAGGGGTTTTGCAACCTGAGGTCTATAAACAAAG TCTTCCTGGAAGTAATTGTAAGCATCCTGAAATAAAAAAGCAAGAATATGAAGAAGTAGTTCAGACTGTT AATACAGATTTCTCTCCATATCTGATTTCAGATAACTTAGAACAGCCTATGGGAAGTAGTCATGCATCTC AGGTTTGTTCTGAGACACCTGATGACCTGTTAGATGATGGTGAAATAAAGGAAGATACTAGTTTTGCTGA AAATGACATTAAGGAAAGTTCTGCTGTTTTTAGCAAAAGCGTCCAGAAAGGAGAGCTTAGCAGGAGTCCT AGCCCTTTCACCCATACACATTTGGCTCAGGGTTACCGAAGAGGGGCCAAGAAATTAGAGTCCTCAGAAG AGAACTTATCTAGTGAGGATGAAGAGCTTCCCTGCTTCCAACACTTGTTATTTGGTAAAGTAAACAATAT ACCTTCTCAGTCTACTAGGCATAGCACCGTTGCTACCGAGTGTCTGTCTAAGAACACAGAGGAGAATTTA TTATCATTGAAGAATAGCTTAAATGACTGCAGTAACCAGGTAATATTGGCAAAGGCATCTCAGGAACATC ACCTTAGTGAGGAAACAAAATGTTCTGCTAGCTTGTTTTCTTCACAGTGCAGTGAATTGGAAGACTTGAC TGCAAATACAAACACCCAGGATCCTTTCTTGATTGGTTCTTCCAAACAAATGAGGCATCAGTCTGAAAGC CAGGGAGTTGGTCTGAGTGACAAGGAATTGGTTTCAGATGATGAAGAAAGAGGAACGGGCTTGGAAGAAA ATAATCAAGAAGAGCAAAGCATGGATTCAAACTTAGGTGAAGCAGCATCTGGGTGTGAGAGTGAAACAAG CGTCTCTGAAGACTGCTCAGGGCTATCCTCTCAGAGTGACATTTTAACCACTCAGCAGAGGGATACCATG CAACATAACCTGATAAAGCTCCAGCAGGAAATGGCTGAACTAGAAGCTGTGTTAGAACAGCATGGGAGCC AGCCTTCTAACAGCTACCCTTCCATCATAAGTGACTCTTCTGCCCTTGAGGACCTGCGAAATCCAGAACA AAGCACATCAGAAAAAGCAGTATTAACTTCACAGAAAAGTAGTGAATACCCTATAAGCCAGAATCCAGAA GGCCTTTCTGCTGACAAGTTTGAGGTGTCTGCAGATAGTTCTACCAGTAAAAATAAAGAACCAGGAGTGG AAAGGTCATCCCCTTCTAAATGCCCATCATTAGATGATAGGTGGTACATGCACAGTTGCTCTGGGAGTCT TCAGAATAGAAACTACCCATCTCAAGAGGAGCTCATTAAGGTTGTTGATGTGGAGGAGCAACAGCTGGAA GAGTCTGGGCCACACGATTTGACGGAAACATCTTACTTGCCAAGGCAAGATCTAGAGGGAACCCCTTACC TGGAATCTGGAATCAGCCTCTTCTCTGATGACCCTGAATCTGATCCTTCTGAAGACAGAGCCCCAGAGTC AGCTCGTGTTGGCAACATACCATCTTCAACCTCTGCATTGAAAGTTCCCCAATTGAAAGTTGCAGAATCT GCCCAGAGTCCAGCTGCTGCTCATACTACTGATACTGCTGGGTATAATGCAATGGAAGAAAGTGTGAGCA GGGAGAAGCCAGAATTGACAGCTTCAACAGAAAGGGTCAACAAAAGAATGTCCATGGTGGTGTCTGGCCT GACCCCAGAAGAATTTATGCTCGTGTACAAGTTTGCCAGAAAACACCACATCACTTTAACTAATCTAATT ACTGAAGAGACTACTCATGTTGTTATGAAAACAGATGCTGAGTTTGTGTGTGAACGGACACTGAAATATT TTCTAGGAATTGCGGGAGGAAAATGGGTAGTTAGCTATTTCTGGGTGACCCAGTCTATTAAAGAAAGAAA AATGCTGAATGAGCATGATTTTGAAGTCAGAGGAGATGTGGTCAATGGAAGAAACCACCAAGGTCCAAAG CGAGCAAGAGAATCCCAGGACAGAAAGATCTTCAGGGGGCTAGAAATCTGTTGCTATGGGCCCTTCACCA ACATGCCCACAGATCAACTGGAATGGATGGTACAGCTGTGTGGTGCTTCTGTGGTGAAGGAGCTTTCATC ATTCACCCTTGGCACAGGTGTCCACCCAATTGTGGTTGTGCAGCCAGATGCCTGGACAGAGGACAATGGC TTCCATGCAATTGGGCAGATGTGTGAGGCACCTGTGGTGACCCGAGAGTGGGTGTTGGACAGTGTAGCAC TCTACCAGTGCCAGGAGCTGGACACCTACCTGATACCCCAGATCCCCCACAGCCACTACTGA Download Select all
CCDS ID	CCDS11453.1

Protein Information

Protein ID	NP_009225.1
Protein Name	breast cancer 1, early onset
Molecular Wt. (Da)	207591
Protein Sequence	>lcl\|NM_007294.3_prot_NP_009225.1_1 [gene=BRCA1] [protein=breast cancer type 1 susceptibility protein isoform 1] [protein_id=NP_009225.1] [location=233..5824] MDLSALRVEEVQNVINAMQKILECPICLELIKEPVSTKCDHIFCKFCMLKLLNQKKGPSQCPLCKNDITK RSLQESTRFSQLVEELLKIICAFQLDTGLEYANSYNFAKKENNSPEHLKDEVSIIQSMGYRNRAKRLLQS EPENPSLQETSLSVQLSNLGTVRTLRTKQRIQPQKTSVYIELGSDSSEDTVNKATYCSVGDQELLQITPQ GTRDEISLDSAKKAACEFSETDVTNTEHHQPSNNDLNTTEKRAAERHPEKYQGSSVSNLHVEPCGTNTHA SSLQHENSSLLLTKDRMNVEKAEFCNKSKQPGLARSQHNRWAGSKETCNDRRTPSTEKKVDLNADPLCER KEWNKQKLPCSENPRDTEDVPWITLNSSIQKVNEWFSRSDELLGSDDSHDGESESNAKVADVLDVLNEVD EYSGSSEKIDLLASDPHEALICKSERVHSKSVESNIEDKIFGKTYRKKASLPNLSHVTENLIIGAFVTEP QIIQERPLTNKLKRKRRPTSGLHPEDFIKKADLAVQKTPEMINQGTNQTEQNGQVMNITNSGHENKTKGD SIQNEKNPNPIESLEKESAFKTKAEPISSSISNMELELNIHNSKAPKKNRLRRKSSTRHIHALELVVSRN LSPPNCTELQIDSCSSSEEIKKKKYNQMPVRHSRNLQLMEGKEPATGAKKSNKPNEQTSKRHDSDTFPEL KLTNAPGSFTKCSNTSELKEFVNPSLPREEKEEKLETVKVSNNAEDPKDLMLSGERVLQTERSVESSSIS LVPGTDYGTQESISLLEVSTLGKAKTEPNKCVSQCAAFENPKGLIHGCSKDNRNDTEGFKYPLGHEVNHS RETSIEMEESELDAQYLQNTFKVSKRQSFAPFSNPGNAEEECATFSAHSGSLKKQSPKVTFECEQKEENQ GKNESNIKPVQTVNITAGFPVVGQKDKPVDNAKCSIKGGSRFCLSSQFRGNETGLITPNKHGLLQNPYRI PPLFPIKSFVKTKCKKNLLEENFEEHSMSPEREMGNENIPSTVSTISRNNIRENVFKEASSSNINEVGSS TNEVGSSINEIGSSDENIQAELGRNRGPKLNAMLRLGVLQPEVYKQSLPGSNCKHPEIKKQEYEEVVQTV NTDFSPYLISDNLEQPMGSSHASQVCSETPDDLLDDGEIKEDTSFAENDIKESSAVFSKSVQKGELSRSP SPFTHTHLAQGYRRGAKKLESSEENLSSEDEELPCFQHLLFGKVNNIPSQSTRHSTVATECLSKNTEENL LSLKNSLNDCSNQVILAKASQEHHLSEETKCSASLFSSQCSELEDLTANTNTQDPFLIGSSKQMRHQSES QGVGLSDKELVSDDEERGTGLEENNQEEQSMDSNLGEAASGCESETSVSEDCSGLSSQSDILTTQQRDTM QHNLIKLQQEMAELEAVLEQHGSQPSNSYPSIISDSSALEDLRNPEQSTSEKAVLTSQKSSEYPISQNPE GLSADKFEVSADSSTSKNKEPGVERSSPSKCPSLDDRWYMHSCSGSLQNRNYPSQEELIKVVDVEEQQLE ESGPHDLTETSYLPRQDLEGTPYLESGISLFSDDPESDPSEDRAPESARVGNIPSSTSALKVPQLKVAES AQSPAAAHTTDTAGYNAMEESVSREKPELTASTERVNKRMSMVVSGLTPEEFMLVYKFARKHHITLTNLI TEETTHVVMKTDAEFVCERTLKYFLGIAGGKWVVSYFWVTQSIKERKMLNEHDFEVRGDVVNGRNHQGPK RARESQDRKIFRGLEICCYGPFTNMPTDQLEWMVQLCGASVVKELSSFTLGTGVHPIVVVQPDAWTEDNG FHAIGQMCEAPVVTREWVLDSVALYQCQELDTYLIPQIPHSHY Download Select all
Length	1863
Uniprot ID	P20585
Ensembl Protein ID	ENSP00000265081

Post-translational Modification Information (Source : HPRD)

Residue	Type	site
S	Phosphorylation	428
T	Phosphorylation	1394
S	Phosphorylation	1525
S	Phosphorylation	468
S	Phosphorylation	1531
S	Phosphorylation	430
S	Phosphorylation	468
S	Phosphorylation	353
S	Phosphorylation	1497
S	Phosphorylation	1497
S	Phosphorylation	1143
S	Phosphorylation	1450
S	Phosphorylation	393
S	Phosphorylation	1456
S	Phosphorylation	355
S	Phosphorylation	393
T	Phosphorylation	509
T	Phosphorylation	509
T	Phosphorylation	509
T	Phosphorylation	462
T	Phosphorylation	509
T	Phosphorylation	509
T	Phosphorylation	468
D	Proteolytic Cleavage	1155
D	Proteolytic Cleavage	1155
D	Proteolytic Cleavage	1155
D	Proteolytic Cleavage	1108
D	Proteolytic Cleavage	1155
D	Proteolytic Cleavage	1114
S	Phosphorylation	988
S	Phosphorylation	988
S	Phosphorylation	988
S	Phosphorylation	941
S	Phosphorylation	988
S	Phosphorylation	947
S	Phosphorylation	243
S	Phosphorylation	279
S	Phosphorylation	313
S	Phosphorylation	380
S	Phosphorylation	398
S	Phosphorylation	1189
S	Phosphorylation	1330
S	Phosphorylation	1387
S	Phosphorylation	1423
S	Phosphorylation	1457
S	Phosphorylation	1466
S	Phosphorylation	1524
S	Phosphorylation	1542
S	Phosphorylation	1189
S	Phosphorylation	1330
S	Phosphorylation	1423
S	Phosphorylation	1457
S	Phosphorylation	1466
S	Phosphorylation	1524
S	Phosphorylation	1143
S	Phosphorylation	1189
S	Phosphorylation	1330
S	Phosphorylation	1423
T	Phosphorylation	1394
S	Phosphorylation	1387
S	Phosphorylation	1283
S	Phosphorylation	1340
S	Phosphorylation	1376
S	Phosphorylation	1410
S	Phosphorylation	1477
S	Phosphorylation	1495
S	Phosphorylation	1142
S	Phosphorylation	284
S	Phosphorylation	320
S	Phosphorylation	353
S	Phosphorylation	420
S	Phosphorylation	438
S	Phosphorylation	284
S	Phosphorylation	320
S	Phosphorylation	1189
S	Phosphorylation	1330
S	Phosphorylation	1387
S	Phosphorylation	1423
S	Phosphorylation	1148
S	Phosphorylation	1289
S	Phosphorylation	1346
S	Phosphorylation	1382
S	Phosphorylation	1416
S	Phosphorylation	1483
S	Phosphorylation	1501
S	Phosphorylation	245
S	Phosphorylation	281
S	Phosphorylation	315
S	Phosphorylation	382
S	Phosphorylation	400
S	Phosphorylation	284
S	Phosphorylation	320
S	Phosphorylation	353
S	Phosphorylation	420
S	Phosphorylation	438
S	Phosphorylation	308
T	Phosphorylation	967
S	Phosphorylation	1423
S	Phosphorylation	1280
S	Phosphorylation	1457
S	Phosphorylation	1143
S	Phosphorylation	1280
S	Phosphorylation	1572
S	Phosphorylation	308
S	Phosphorylation	1387
S	Phosphorylation	1457
S	Phosphorylation	1423
S	Phosphorylation	1102
S	Phosphorylation	1143
S	Phosphorylation	1096
S	Phosphorylation	1280
S	Phosphorylation	1280
S	Phosphorylation	1233
S	Phosphorylation	1239
S	Phosphorylation	1423
S	Phosphorylation	320
S	Phosphorylation	1423
S	Phosphorylation	279
S	Phosphorylation	1376
S	Phosphorylation	320
S	Phosphorylation	1382
S	Phosphorylation	281
S	Phosphorylation	313
S	Phosphorylation	1457
S	Phosphorylation	1457
S	Phosphorylation	1410
S	Phosphorylation	353
S	Phosphorylation	1416
S	Phosphorylation	315
S	Phosphorylation	353
T	Phosphorylation	250
T	Phosphorylation	1394
T	Phosphorylation	1347
T	Phosphorylation	291
T	Phosphorylation	291
T	Phosphorylation	1394
T	Phosphorylation	1353
T	Phosphorylation	252
T	Phosphorylation	291
S	Phosphorylation	1524
S	Phosphorylation	1524
S	Phosphorylation	1524
S	Phosphorylation	1524
S	Phosphorylation	1387
S	Phosphorylation	1387
S	Phosphorylation	322;-
S	Phosphorylation	1466;-
S	Phosphorylation	1419;-
S	Phosphorylation	362;-
S	Phosphorylation	1457;-
S	Phosphorylation	1466;-
S	Phosphorylation	1425;-
S	Phosphorylation	324;-
S	Phosphorylation	1245;-
S	Phosphorylation	1239;-
S	Phosphorylation	1245;-
S	Phosphorylation	1239;-
S	Phosphorylation	1245;-
S	Phosphorylation	1239;-
S	Phosphorylation	1198;-
S	Phosphorylation	1192;-
S	Phosphorylation	1245;-
S	Phosphorylation	1239;-
S	Phosphorylation	1245;-
S	Phosphorylation	1239;-
S	Phosphorylation	1204;-
S	Phosphorylation	1198;-
S	Phosphorylation	1336;-
S	Phosphorylation	1342;-
S	Phosphorylation	1336;-
S	Phosphorylation	1342;-
S	Phosphorylation	1336;-
S	Phosphorylation	1342;-
S	Phosphorylation	1289;-
S	Phosphorylation	1295;-
S	Phosphorylation	1336;-
S	Phosphorylation	1342;-
S	Phosphorylation	1336;-
S	Phosphorylation	1330;-
S	Phosphorylation	1342;-
S	Phosphorylation	1301;-
S	Phosphorylation	1295;-
T	Phosphorylation	1720;-
T	Phosphorylation	1700;-
T	Phosphorylation	576;-
T	Phosphorylation	556;-
T	Phosphorylation	1720;-
T	Phosphorylation	1700;-
T	Phosphorylation	1720;-
T	Phosphorylation	1700;-
T	Phosphorylation	1673;-
T	Phosphorylation	1653;-
T	Phosphorylation	616;-
T	Phosphorylation	596;-
T	Phosphorylation	616;-
T	Phosphorylation	596;-
T	Phosphorylation	1659;-
T	Phosphorylation	1679;-
T	Phosphorylation	578;-
T	Phosphorylation	558;-
T	Phosphorylation	616;-
T	Phosphorylation	596;-
S	Phosphorylation	1497;-
S	Phosphorylation	1499;-
S	Phosphorylation	355;-
S	Phosphorylation	1499;-
S	Phosphorylation	1499;-
S	Phosphorylation	1452;-
S	Phosphorylation	395;-
S	Phosphorylation	1458;-
S	Phosphorylation	357;-
S	Phosphorylation	395;-
S	Phosphorylation	1211;-
S	Phosphorylation	1212;-
S	Phosphorylation	1211;-
S	Phosphorylation	1212;-
S	Phosphorylation	1211;-
S	Phosphorylation	1212;-
S	Phosphorylation	1164;-
S	Phosphorylation	1165;-
S	Phosphorylation	1211;-
S	Phosphorylation	1212;-
S	Phosphorylation	1211;-
S	Phosphorylation	1212;-
S	Phosphorylation	1170;-
S	Phosphorylation	1171;-
S	Phosphorylation	1217;-
S	Phosphorylation	1218;-
S	Phosphorylation	1217;-
S	Phosphorylation	1218;-
S	Phosphorylation	1217;-
S	Phosphorylation	1218;-
S	Phosphorylation	1170;-
S	Phosphorylation	1171;-
S	Phosphorylation	1217;-
S	Phosphorylation	1218;-
S	Phosphorylation	1217;-
S	Phosphorylation	1218;-
S	Phosphorylation	1176;-
S	Phosphorylation	1177;-
M	Methylation	1
S	Phosphorylation	395
S	Phosphorylation	398
S	Phosphorylation	395
S	Phosphorylation	398
S	Phosphorylation	395
S	Phosphorylation	398
S	Phosphorylation	348
S	Phosphorylation	351
S	Phosphorylation	395
S	Phosphorylation	398
S	Phosphorylation	395
S	Phosphorylation	398
S	Phosphorylation	354
S	Phosphorylation	357
S	Phosphorylation	403
S	Phosphorylation	403
S	Phosphorylation	403
S	Phosphorylation	356
S	Phosphorylation	403
S	Phosphorylation	403
S	Phosphorylation	362
S	Phosphorylation	405
S	Phosphorylation	405
S	Phosphorylation	405
S	Phosphorylation	358
S	Phosphorylation	405
S	Phosphorylation	405
S	Phosphorylation	364
S	Phosphorylation	753
S	Phosphorylation	753
S	Phosphorylation	753
S	Phosphorylation	706
S	Phosphorylation	753
S	Phosphorylation	753
S	Phosphorylation	712
S	Phosphorylation	1187
S	Phosphorylation	1191
S	Phosphorylation	1187
S	Phosphorylation	1191
S	Phosphorylation	1187
S	Phosphorylation	1191
S	Phosphorylation	1140
S	Phosphorylation	1144
S	Phosphorylation	1187
S	Phosphorylation	1191
S	Phosphorylation	1187
S	Phosphorylation	1189
S	Phosphorylation	1191
S	Phosphorylation	1146
S	Phosphorylation	1150
S	Phosphorylation	1328
S	Phosphorylation	1328
S	Phosphorylation	1328
S	Phosphorylation	1281
S	Phosphorylation	1328
S	Phosphorylation	1328
S	Phosphorylation	1287
S	Phosphorylation	1460
S	Phosphorylation	316
S	Phosphorylation	1460
S	Phosphorylation	1460
S	Phosphorylation	1413
S	Phosphorylation	356
S	Phosphorylation	356
S	Phosphorylation	1481
S	Phosphorylation	1460
S	Phosphorylation	1419
S	Phosphorylation	318
S	Phosphorylation	356
N	Glycosylation	909
N	Glycosylation	913
N	Glycosylation	916
N	Glycosylation	909
N	Glycosylation	913
N	Glycosylation	916
N	Glycosylation	909
N	Glycosylation	913
N	Glycosylation	916
N	Glycosylation	862
N	Glycosylation	866
N	Glycosylation	869
N	Glycosylation	909
N	Glycosylation	913
N	Glycosylation	916
N	Glycosylation	909
N	Glycosylation	913
N	Glycosylation	916
N	Glycosylation	868
N	Glycosylation	872
N	Glycosylation	875
S	Phosphorylation	114
S	Phosphorylation	114
S	Phosphorylation	114
S	Phosphorylation	114
S	Phosphorylation	67
S	Phosphorylation	114
S	Phosphorylation	114
S	Phosphorylation	114
S	Phosphorylation	114
S	Phosphorylation	114
S	Phosphorylation	114
S	Phosphorylation	114
S	Phosphorylation	1007
S	Phosphorylation	1007
S	Phosphorylation	1007
S	Phosphorylation	960
S	Phosphorylation	1007
S	Phosphorylation	1007
S	Phosphorylation	966
S	Phosphorylation	1009
S	Phosphorylation	1009
S	Phosphorylation	1009
S	Phosphorylation	962
S	Phosphorylation	1009
S	Phosphorylation	1009
S	Phosphorylation	968
S	Phosphorylation	694
S	Phosphorylation	694
S	Phosphorylation	694
S	Phosphorylation	647
S	Phosphorylation	694
S	Phosphorylation	694
S	Phosphorylation	653
S	Phosphorylation	423
S	Phosphorylation	426
S	Phosphorylation	423
S	Phosphorylation	426
S	Phosphorylation	423
S	Phosphorylation	426
S	Phosphorylation	376
S	Phosphorylation	379
S	Phosphorylation	423
S	Phosphorylation	426
S	Phosphorylation	423
S	Phosphorylation	426
S	Phosphorylation	382
S	Phosphorylation	385
S	Phosphorylation	434
S	Phosphorylation	434
S	Phosphorylation	434
S	Phosphorylation	387
S	Phosphorylation	434
S	Phosphorylation	434
S	Phosphorylation	393
S	Phosphorylation	1164
S	Phosphorylation	1164
S	Phosphorylation	1164
S	Phosphorylation	1117
S	Phosphorylation	1164
S	Phosphorylation	1164
S	Phosphorylation	1123
T	Phosphorylation	1196
T	Phosphorylation	1196
T	Phosphorylation	1196
T	Phosphorylation	1149
T	Phosphorylation	1196
T	Phosphorylation	1196
T	Phosphorylation	1155
S	Phosphorylation	1286
S	Phosphorylation	1286
S	Phosphorylation	1286
S	Phosphorylation	1239
S	Phosphorylation	1286
S	Phosphorylation	1286
S	Phosphorylation	1245
S	Phosphorylation	420
S	Phosphorylation	1545
S	Phosphorylation	1577
S	Phosphorylation	433
S	Phosphorylation	1577
S	Phosphorylation	1577
S	Phosphorylation	1530
S	Phosphorylation	473
S	Phosphorylation	473
S	Phosphorylation	1598
S	Phosphorylation	1536
S	Phosphorylation	435
S	Phosphorylation	473
S	Phosphorylation	1542
S	Phosphorylation	1542
S	Phosphorylation	438
S	Phosphorylation	1563
Y	Phosphorylation	1202
Y	Phosphorylation	1202
Y	Phosphorylation	1202
Y	Phosphorylation	1155
Y	Phosphorylation	1202
Y	Phosphorylation	1202
Y	Phosphorylation	1161

Enzyme Information

No matching records could be found.

PPi Information

(Click to view network : Source STRING) View

Interactant Gene ID (Source: HPRD)	Gene Symbol	HPRD ID	Ref Seq ID	Technique	References
25	ABL1	1809	NP_009297.2	in vitro;in vivo	12024016
1022	CDK7	15993	NP_001790.1	in vitro	15282296
2274	FHL2	4026	NP_001441.4	in vitro;in vivo	14550570
3428	IFI16	969	NP_005522.2	in vivo	14654789
4087	SMAD2	3221	NP_005892.1	in vitro	15735739
4088	SMAD3	4380	NP_005893.1	in vitro;in vivo	15735739
4089	SMAD4	2995	NP_005350.1	in vitro	15735739
4215	MAP3K3	3965	NP_976226.1	in vivo;yeast 2-hybrid	15205325
4331	MNAT1	4042	NP_002422.1	in vitro	15282296
5451	POU2F1	1250	NP_002688.2	in vitro	11777930
5499	PPP1CA	15942	NP_001008709.1	in vitro;in vivo	12438214
5660	PSAP	1460	NP_001035930.1	in vitro;in vivo	11313879
5981	RFC1	24	NP_002904.3	in vivo	10783165
6774	STAT3	26	NP_644805.1	in vivo	11163768
7153	TOP2A	536	NP_001058.2	in vivo	15965487
7277	TUBA4A	1851	NP_005991.1	in vivo	12353262
7314	UBB	6771	NP_061828.1	in vitro	11320250
7528	YY1	2482	NP_003394.1	in vitro	11777930
8295	TRRAP	4310	NP_003487.1	in vitro;in vivo	16260778
8328	GFI1B	5088	NP_004179.3	yeast 2-hybrid	16713569
8900	CCNA1	4946	NP_003905.1	in vitro	103 735 349 244 350
9555	H2AFY	13624	NP_613258.2	in vivo	12419249
23633	KPNA6	9465	NP_036448.1	yeast 2-hybrid	8955125
26747	NUFIP1	5073	NP_036477.2	in vitro;in vivo;yeast 2-hybrid	15107825
63967	CLSPN	9257	NP_071394.2	in vitro;in vivo	15096610
79184	BRCC3	6465	NP_077308.1	in vitro	14636569
203068	TUBB	1852	NP_001060.1	in vivo	12353262

Pathway Information

Pathway Name	Pathway ID
Fanconi anemia pathway	hsa03460
MicroRNAs in cancer	hsa05206
PI3K-Akt signaling pathway	hsa04151
Ubiquitin mediated proteolysis	hsa04120

Structure Information

No matching records could be found.

Domain Information

ID	Location	Description
cd00162	23-68	RING
cl17238	23-68	RING superfamily
cd00027	1650-1724	BRCT
cl00038	1650-1724	BRCT superfamily
cd00027	1763-1842	BRCT
cl00038	1763-1842	BRCT superfamily
pfam04873	648-978	EIN3
cl04813	648-978	EIN3 superfamily
pfam12820	344-507	BRCT_assoc
cl15108	344-507	BRCT_assoc superfamily
smart00292	1758-1842	BRCT
pfam00097	24-64	zf-C3HC4
smart00184	24-64	RING
pfam13923	24-64	zf-C3HC4_2
pfam13639	23-65	zf-RING_2
pfam00533	1650-1723	BRCT
pfam00533	1759-1842	BRCT
pfam15227	24-64	zf-C3HC4_4
pfam14634	23-65	zf-RING_5
pfam13920	23-71	zf-C3HC4_3
pfam13445	24-62	zf-RING_UBOX
pfam14835	18-64	zf-RING_6
pfam02891	22-64	zf-MIZ
pfam11789	22-62	zf-Nse
smart00292	1662-1723	BRCT
PLN03208	22-73	PLN03208
COG5574	23-65	PEX10
TIGR00599	22-84	rad18
COG5432	18-136	RAD18
pfam12678	24-65	zf-rbx1

Ontology Information

HPRD ID	4509
Molecular Class	Transcription regulatory protein
Molecular Function	RNA binding (GO:0003723)
Biological Process	Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219)

SNP Information

View SNP Geneview Report

Drug Information

No matching records could be found.

External Links

ArrayExpress GO
ICGC GO
Cancer3D GO
COSMIC GO
NCG GO
TSGene GO
Tumor Gene Family of Databases GO
CCDB GO
G2SBC GO
Osteosarcoma Database GO
RCDB GO

Mechanism	Down-regulation/Mutation
Biomarker	23496813
Drug Target	-
Biological Process	Regulation of gene expression, epigenetic

ArrayExpress	GO
ICGC	GO
Cancer3D	GO
COSMIC	GO
NCG	GO
TSGene	GO
Tumor Gene Family of Databases	GO
CCDB	GO
G2SBC	GO
Osteosarcoma Database	GO
RCDB	GO