Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| BRAF | 673 | B-Raf proto-oncogene, serine/threonine kinase | 7 | BRAF1 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 24859797 | 2014 | Cell line : - Source : Royal Melbourne, Melbourne Private and Western Hospitals, Australia. Sample Type : CRC tumor and Normal tissue No. of Sample : 505 Stage : - | Tissue microarray and immunohistochemistry | Mutation | - | Immunohistochemistry using the BRAF V600E VE1 antibody is an accurate diagnostic assay in CRC. The test provides a simple, clinically applicable method of testing for the BRAF V600E mutation in routine practice. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | |
| Description | This gene encodes a protein belonging to the raf/mil family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERKs signaling pathway, which affects cell division, differentiation, and secretion. Mutations in this gene are associated with cardiofaciocutaneous syndrome, a disease characterized by heart defects, mental retardation and a distinctive facial appearance. Mutations in this gene have also been associated with various cancers, including non-Hodgkin lymphoma, colorectal cancer, malignant melanoma, thyroid carcinoma, non-small cell lung carcinoma, and adenocarcinoma of lung. A pseudogene, which is located on chromosome X, has been identified for this gene. |
| Chromosome | 7 |
| Location | 7q34 |
| Start | 140715951 |
| End | 140924764 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 208814 |
| OMIM ID | 164757 |
| HGNC ID | HGNC:1097 |
| Unigene ID | Hs.550061 |
| Ensembl ID | ENSG00000157764 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | XM_011516529.1 |
|---|---|
| Exon | join(54..199,74553..74654,89893..90156,115770..115873, 116703..116805,123205..123353,124284..124403, 130298..130457,137181..137217,141608..141744, 143072..143189,146690..146774,147677..147853, 170532..170578,171372..171490,175347..175478, 184819..184953,208729..208814) | mRNA Sequence | Download Select all |
| Length | 2949 |
CDS Information
| Location | join(62..199,74553..74654,89893..90156,115770..115873, 116703..116805,123205..123353,124284..124403, 130298..130457,137181..137217,141608..141744, 143072..143189,146690..146774,147677..147853, 170532..170578,171372..171490,175347..175478, 184819..184953,208729..208737) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | - |
Protein Information
| Protein ID | NP_004324.2 |
|---|---|
| Protein Name | B-Raf proto-oncogene, serine/threonine kinase |
| Molecular Wt. (Da) | 84306 |
| Protein Sequence | Download Select all |
| Length | 766 |
| Uniprot ID | Q04760 |
| Ensembl Protein ID | ENSP00000362463 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| T | Phosphorylation | 401 |
| T | Phosphorylation | 440 |
| S | Phosphorylation | 446 |
| T | Phosphorylation | 599 |
| S | Phosphorylation | 602 |
| S | Phosphorylation | 729 |
| S | Phosphorylation | 365 |
| S | Phosphorylation | 429 |
| S | Phosphorylation | 430 |
| S | Phosphorylation | 365 |
| T | Phosphorylation | 119 |
| S | Phosphorylation | 446 |
| S | Phosphorylation | 750;- |
| S | Phosphorylation | 151;- |
| S | Phosphorylation | 147;- |
| T | Phosphorylation | 373;- |
| S | Phosphorylation | 419;- |
| S | Phosphorylation | 319 |
| S | Phosphorylation | 333 |
| S | Phosphorylation | 335 |
| S | Phosphorylation | 364 |
| S | Phosphorylation | 447 |
| S | Phosphorylation | 363 |
| K | Acetylation | 418 |
Enzyme Information
| EC | 2.7.11.1 |
|---|---|
| Name | non-specific serine/threonine protein kinase A-kinase AP50 kinase ATP-protein transphosphorylase calcium-dependent protein kinase C calcium/phospholipid-dependent protein kinase cAMP-dependent protein kinase cAMP-dependent protein kinase A casein kinase casein kinase (phosphorylating) casein kinase 2 casein kinase I casein kinase II cGMP-dependent protein kinase CK-2 CKI CKII cyclic AMP-dependent protein kinase cyclic AMP-dependent protein kinase A cyclic monophosphate-dependent protein kinase cyclic nucleotide-dependent protein kinase cyclin-dependent kinase cytidine 3',5'-cyclic monophosphate-responsive protein kinase dsk1 glycogen synthase a kinase glycogen synthase kinase HIPK2 Hpr kinase hydroxyalkyl-protein kinase hydroxyalkyl-protein kinase M phase-specific cdc2 kinase mitogen-activated S6 kinase p82 kinase phosphorylase b kinase kinase PKA protein glutamyl kinase protein kinase (phosphorylating) protein kinase A protein kinase CK2 protein kinase p58 protein phosphokinase protein serine kinase protein serine-threonine kinase protein-aspartyl kinase protein-cysteine kinase protein-serine kinase Prp4 protein kinase Raf kinase Raf-1 ribosomal protein S6 kinase II ribosomal S6 protein kinase serine kinase serine protein kinase serine-specific protein kinase serine(threonine) protein kinase serine/threonine protein kinase STK32 T-antigen kinase threonine-specific protein kinase twitchin kinase type-2 casein kinase betaIIPKC epsilon PKC Wee 1-like kinase Wee-kinase WEE1Hu |
| Class | Transferases; Transferring phosphorus-containing groups; Protein-serine/threonine kinases |
| Sysname | ATP:protein phosphotransferase (non-specific) |
| Substrate | ATP [CPD:C00002]; protein |
| Product | ADP [CPD:C00008]; phosphoprotein |
| Reaction (IUBMB) |  |
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 5594 | MAPK1 | 1496 | NP_002736.3 | in vitro | 14654779 |
| 5604 | MAP2K1 | 1469 | NP_002746.1 | in vitro;in vivo | 773 172 081 570 008 000 000 000 000 000 000 000 |
| 5906 | RAP1A | 1545 | NP_002875.1 | in vivo | 9560161 |
| 7533 | YWHAH | 215 | NP_003396.1 | yeast 2-hybrid | 8668348 |
| 10971 | YWHAQ | 886 | NP_006817.1 | yeast 2-hybrid | 8668348 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Acute myeloid leukemia | hsa05221 |
| Alcoholism | hsa05034 |
| Bladder cancer | hsa05219 |
| cAMP signaling pathway | hsa04024 |
| Chemokine signaling pathway | hsa04062 |
| Chronic myeloid leukemia | hsa05220 |
| Colorectal cancer | hsa05210 |
| Endometrial cancer | hsa05213 |
| ErbB signaling pathway | hsa04012 |
| Focal adhesion | hsa04510 |
| FoxO signaling pathway | hsa04068 |
| Glioma | hsa05214 |
| Hepatitis C | hsa05160 |
| Insulin signaling pathway | hsa04910 |
| Long-term depression | hsa04730 |
| Long-term potentiation | hsa04720 |
| MAPK signaling pathway | hsa04010 |
| Melanoma | hsa05218 |
| mTOR signaling pathway | hsa04150 |
| Natural killer cell mediated cytotoxicity | hsa04650 |
| Neurotrophin signaling pathway | hsa04722 |
| Non-small cell lung cancer | hsa05223 |
| Pancreatic cancer | hsa05212 |
| Pathways in cancer | hsa05200 |
| Progesterone-mediated oocyte maturation | hsa04914 |
| Prostate cancer | hsa05215 |
| Proteoglycans in cancer | hsa05205 |
| Rap1 signaling pathway | hsa04015 |
| Regulation of actin cytoskeleton | hsa04810 |
| Renal cell carcinoma | hsa05211 |
| Serotonergic synapse | hsa04726 |
| Thyroid cancer | hsa05216 |
| Vascular smooth muscle contraction | hsa04270 |
Structure Information
| PDB ID | 1UWH |
|---|---|
| Resolution | 2.95 |
| Method | ?? X-RAY DIFFRACTION |
| Chains | A, B |
| Molecule | B-RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE |
| Model | View |
Domain Information
| ID | Location | Description |
|---|---|---|
| cd14062 | 463-715 | STKc_Raf |
| cl21453 | 463-715 | PKc_like superfamily |
| cd01816 | 156-227 | Raf_RBD |
| cl00155 | 156-227 | UBQ superfamily |
| cd00029 | 235-280 | C1 |
| cl00040 | 235-280 | C1 superfamily |
| cd14151 | 448-721 | STKc_B-Raf |
| cd14150 | 456-720 | STKc_A-Raf |
| cd14149 | 444-726 | STKc_C-Raf |
| cd13999 | 463-711 | STKc_MAP3K-like |
| cd14063 | 456-719 | PK_KSR |
| cd00192 | 463-715 | PTKc |
| cd14153 | 456-719 | PK_KSR2 |
| cd05068 | 448-707 | PTKc_Frk_like |
| cd14152 | 456-731 | STKc_KSR1 |
| cd06606 | 456-705 | STKc_MAPKKK |
| cd14014 | 458-721 | STKc_PknB_like |
| cd14059 | 463-716 | STKc_MAP3K12_13 |
| cd14058 | 463-722 | STKc_TAK1 |
| cd05034 | 462-707 | PTKc_Src_like |
| cd14066 | 463-717 | STKc_IRAK |
| cd08215 | 463-714 | STKc_Nek |
| cd05122 | 458-711 | PKc_STE |
| cd00180 | 463-714 | PKc |
| cd14061 | 463-715 | STKc_MLK |
| cd05148 | 450-707 | PTKc_Srm_Brk |
| cd05039 | 450-717 | PTKc_Csk_like |
| cd05072 | 450-707 | PTKc_Lyn |
| cd05033 | 452-712 | PTKc_EphR |
| cd13978 | 463-713 | STKc_RIP |
| cd05067 | 449-707 | PTKc_Lck_Blk |
| cd05041 | 461-714 | PTKc_Fes_like |
| cd05117 | 458-655 | STKc_CAMK |
| cd06613 | 461-705 | STKc_MAP4K3_like |
| cd14158 | 445-715 | STKc_IRAK4 |
| cd14203 | 461-715 | PTKc_Src_Fyn_like |
| cd05032 | 450-715 | PTKc_InsR_like |
| cd05059 | 456-714 | PTKc_Tec_like |
| cd14060 | 464-715 | STKc_MLTK |
| cd05069 | 446-715 | PTKc_Yes |
| cd14148 | 463-717 | STKc_MLK2 |
| cd06627 | 456-705 | STKc_Cdc7_like |
| cd14064 | 463-715 | PKc_TNNI3K |
| cd05073 | 448-715 | PTKc_Hck |
| cd14147 | 456-717 | STKc_MLK3 |
| cd05070 | 448-715 | PTKc_Fyn |
| cd05057 | 451-719 | PTKc_EGFR_like |
| cd05038 | 453-718 | PTKc_Jak_rpt2 |
| cd05071 | 448-715 | PTKc_Src |
| cd14003 | 458-712 | STKc_AMPK-like |
| cd05048 | 451-710 | PTKc_Ror |
| cd06612 | 463-717 | STKc_MST1_2 |
| cd05063 | 451-717 | PTKc_EphR_A2 |
| cd05040 | 461-710 | PTKc_Ack_like |
| cd14145 | 451-711 | STKc_MLK1 |
| cd14146 | 463-714 | STKc_MLK4 |
| cd08529 | 459-711 | STKc_FA2-like |
| cd05053 | 450-721 | PTKc_FGFR |
| cd13996 | 463-714 | STKc_EIF2AK |
| cd05066 | 457-717 | PTKc_EphR_A |
| cd05065 | 457-717 | PTKc_EphR_B |
| cd06614 | 461-656 | STKc_PAK |
| cd13983 | 463-711 | STKc_WNK |
| cd05113 | 456-715 | PTKc_Btk_Bmx |
| cd06632 | 460-712 | STKc_MEKK1_plant |
| cd05061 | 450-733 | PTKc_InsR |
| cd05083 | 450-715 | PTKc_Chk |
| cd05084 | 460-710 | PTKc_Fes |
| cd14002 | 459-669 | STKc_STK36 |
| cd05044 | 463-715 | PTKc_c-ros |
| cd05055 | 450-715 | PTKc_PDGFR |
| cd05112 | 453-711 | PTKc_Itk |
| cd13979 | 449-705 | STKc_Mos |
| cd06611 | 445-711 | STKc_SLK_like |
| cd14205 | 461-715 | PTKc_Jak2_rpt2 |
| cd05046 | 463-715 | PTK_CCK4 |
| cd14056 | 462-696 | STKc_TGFbR_I |
| cd05052 | 450-715 | PTKc_Abl |
| cd05058 | 463-717 | PTKc_Met_Ron |
| cd14009 | 463-663 | STKc_ATG1_ULK_like |
| cd06628 | 460-713 | STKc_Byr2_like |
| cd14080 | 458-713 | STKc_TSSK-like |
| cd14027 | 465-710 | STKc_RIP1 |
| cd05056 | 450-715 | PTKc_FAK |
| cd08217 | 461-711 | STKc_Nek2 |
| cd05062 | 450-715 | PTKc_IGF-1R |
| cd05123 | 463-704 | STKc_AGC |
| cd14025 | 461-722 | STKc_RIP4_like |
| cd05036 | 451-715 | PTKc_ALK_LTK |
| cd06626 | 460-672 | STKc_MEKK4 |
| cd06623 | 463-705 | PKc_MAPKK_plant_like |
| cd05099 | 449-722 | PTKc_FGFR4 |
| cd08225 | 461-711 | STKc_Nek5 |
| cd06629 | 456-670 | STKc_Bck1_like |
| cd05074 | 452-717 | PTKc_Tyro3 |
| cd05060 | 462-710 | PTKc_Syk_like |
| cd14154 | 463-721 | STKc_LIMK |
| cd08530 | 456-713 | STKc_CNK2-like |
| cd14162 | 457-711 | STKc_TSSK4-like |
| cd14007 | 459-712 | STKc_Aurora |
| cd14099 | 458-712 | STKc_PLK |
| cd05082 | 450-715 | PTKc_Csk |
| cd05091 | 461-710 | PTKc_Ror2 |
| cd13997 | 461-712 | PKc_Wee1_like |
| cd05085 | 460-710 | PTKc_Fer |
| cd13998 | 463-705 | STKc_TGFbR-like |
| cd14664 | 463-655 | STK_BAK1_like |
| cd06609 | 456-705 | STKc_MST3_like |
| cd05064 | 451-710 | PTKc_EphR_A10 |
| pfam02196 | 155-227 | RBD |
| cd06631 | 456-712 | STKc_YSK4 |
| cd06610 | 463-705 | STKc_OSR1_SPAK |
| cd06608 | 444-712 | STKc_myosinIII_N_like |
| cd05051 | 451-710 | PTKc_DDR |
| cd01760 | 157-227 | RBD |
| cd06607 | 463-705 | STKc_TAO |
| cd05054 | 450-710 | PTKc_VEGFR |
| cd06647 | 453-704 | STKc_PAK_I |
| cd05114 | 456-718 | PTKc_Tec_Rlk |
| cd14008 | 463-711 | STKc_LKB1_CaMKK |
| cd14000 | 463-710 | STKc_LRRK |
| cd06630 | 460-705 | STKc_MEKK1 |
| cd14053 | 461-659 | STKc_ACVR2 |
| cd14026 | 463-724 | STKc_RIP2 |
| cd06917 | 463-734 | STKc_NAK1_like |
| cd08218 | 461-711 | STKc_Nek1 |
| cd13992 | 458-710 | PK_GC |
| cd14155 | 463-721 | PKc_TESK |
| cd14202 | 463-707 | STKc_ULK1 |
| cd14069 | 456-664 | STKc_Chk1 |
| cd05050 | 451-715 | PTKc_Musk |
| cd06633 | 461-717 | STKc_TAO3 |
| cd06646 | 443-712 | STKc_MAP4K5 |
| cd05110 | 463-719 | PTKc_HER4 |
| cd05111 | 460-723 | PTK_HER3 |
| cd05049 | 451-710 | PTKc_Trk |
| cd14081 | 455-677 | STKc_BRSK1_2 |
| cd14042 | 472-719 | PK_GC-A_B |
| cd14033 | 463-704 | STKc_WNK4 |
| cd14065 | 463-650 | PKc_LIMK_like |
| cd08528 | 463-705 | STKc_Nek10 |
| cd14010 | 463-704 | STKc_ULK4 |
| cd08223 | 458-711 | STKc_Nek4 |
| cd05098 | 450-715 | PTKc_FGFR1 |
| cd05081 | 463-717 | PTKc_Jak3_rpt2 |
| cd06645 | 441-711 | STKc_MAP4K3 |
| cd05090 | 451-714 | PTKc_Ror1 |
| smart00455 | 157-227 | RBD |
| cd05035 | 457-715 | PTKc_TAM |
| cd05106 | 447-719 | PTKc_CSF-1R |
| cd14098 | 462-672 | STKc_Rad53_Cds1 |
| cd06643 | 448-711 | STKc_SLK |
| cd14057 | 461-715 | PK_ILK |
| cd05108 | 463-719 | PTKc_EGFR |
| cd08222 | 459-711 | STKc_Nek11 |
| cd05080 | 461-711 | PTKc_Tyk2_rpt2 |
| cd14097 | 458-656 | STKc_STK33 |
| cd06637 | 453-711 | STKc_TNIK |
| cd14143 | 461-696 | STKc_TGFbR1_ACVR1b_ACVR1c |
| cd05045 | 456-717 | PTKc_RET |
| cd14047 | 456-711 | STKc_EIF2AK2_PKR |
| cd06648 | 462-658 | STKc_PAK_II |
| cd06642 | 453-711 | STKc_STK25 |
| cd06636 | 453-711 | STKc_MAP4K4_6_N |
| cd06644 | 443-660 | STKc_STK10 |
| cd14055 | 461-705 | STKc_TGFbR2_like |
| cd06641 | 461-732 | STKc_MST3 |
| cd14144 | 461-696 | STKc_BMPR1 |
| cd06656 | 453-704 | STKc_PAK3 |
| cd05075 | 456-722 | PTKc_Axl |
| cd05079 | 463-717 | PTKc_Jak1_rpt2 |
| cd14159 | 463-655 | STKc_IRAK1 |
| cd05581 | 459-661 | STKc_PDK1 |
| cd08220 | 463-712 | STKc_Nek8 |
| cd05109 | 463-719 | PTKc_HER2 |
| cd05043 | 466-712 | PTK_Ryk |
| cd05101 | 450-715 | PTKc_FGFR2 |
| cd14095 | 458-701 | STKc_DCKL |
| cd14142 | 456-649 | STKc_ACVR1_ALK1 |
| cd14222 | 463-718 | STKc_LIMK2 |
| cd06625 | 460-705 | STKc_MEKK3_like |
| cd08224 | 458-660 | STKc_Nek6_7 |
| cd14054 | 461-696 | STKc_BMPR2_AMHR2 |
| cd06605 | 463-712 | PKc_MAPKK |
| cd14049 | 462-713 | STKc_EIF2AK1_HRI |
| cd07829 | 461-667 | STKc_CDK_like |
| cd06634 | 461-722 | STKc_TAO2 |
| cd06639 | 438-711 | STKc_myosinIIIB_N |
| cd14032 | 463-704 | STKc_WNK2_like |
| cd05107 | 445-717 | PTKc_PDGFR_beta |
| cd13993 | 463-665 | STKc_Pat1_like |
| cd06655 | 453-704 | STKc_PAK2 |
| cd14030 | 453-704 | STKc_WNK1 |
| cd05100 | 450-715 | PTKc_FGFR3 |
| cd05092 | 443-715 | PTKc_TrkA |
| cd14663 | 459-713 | STKc_SnRK3 |
| cd14068 | 463-710 | STKc_LRRK2 |
| cd06635 | 451-723 | STKc_TAO1 |
| cd14046 | 461-666 | STKc_EIF2AK4_GCN2_rpt2 |
| cd06654 | 453-678 | STKc_PAK1 |
| cd14120 | 463-708 | STKc_ULK1_2-like |
| cd14204 | 457-722 | PTKc_Mer |
| cd13985 | 463-705 | STKc_GAK_like |
| cd14006 | 463-663 | STKc_MLCK-like |
| cd14221 | 463-721 | STKc_LIMK1 |
| cd06659 | 462-656 | STKc_PAK6 |
| cd14186 | 459-711 | STKc_PLK4 |
| cd05102 | 450-717 | PTKc_VEGFR3 |
| cd14187 | 460-656 | STKc_PLK1 |
| cd05097 | 451-710 | PTKc_DDR_like |
| cd05118 | 462-712 | STKc_CMGC |
| cd05578 | 463-666 | STKc_Yank1 |
| cd05104 | 450-715 | PTKc_Kit |
| cd14031 | 463-704 | STKc_WNK3 |
| cd14137 | 456-710 | STKc_GSK3 |
| cd06640 | 453-711 | STKc_MST4 |
| cd05116 | 463-720 | PTKc_Syk |
| cd14220 | 461-696 | STKc_BMPR1a |
| cd14072 | 463-663 | STKc_MARK |
| cd14189 | 460-712 | STKc_PLK3 |
| cd06616 | 463-712 | PKc_MKK4 |
| cd05115 | 463-707 | PTKc_Zap-70 |
| cd05572 | 463-695 | STKc_cGK |
| cd07830 | 458-653 | STKc_MAK_like |
| cd05579 | 463-663 | STKc_MAST_like |
| cd14164 | 458-710 | STKc_TSSK6-like |
| cd14156 | 463-721 | PKc_LIMK_like_unk |
| cd14075 | 463-656 | STKc_NIM1 |
| cd14093 | 481-698 | STKc_PhKG |
| cd05103 | 450-711 | PTKc_VEGFR2 |
| cd13989 | 463-657 | STKc_IKK |
| cd14201 | 463-702 | STKc_ULK2 |
| cd14188 | 492-711 | STKc_PLK2 |
| cd05095 | 451-710 | PTKc_DDR2 |
| cd06638 | 445-711 | STKc_myosinIIIA_N |
| cd05096 | 451-710 | PTKc_DDR1 |
| cd14121 | 461-657 | STKc_ULK3 |
| cd14084 | 458-666 | STKc_Chk2 |
| cd06653 | 459-712 | STKc_MEKK3_like_u1 |
| cd14103 | 463-656 | STKc_MLCK |
| cd05595 | 463-704 | STKc_PKB_beta |
| cd06624 | 460-713 | STKc_ASK |
| cd08219 | 463-712 | STKc_Nek3 |
| cd14192 | 463-669 | STKc_MLCK3 |
| cd05105 | 450-717 | PTKc_PDGFR_alpha |
| cd05047 | 463-714 | PTKc_Tie |
| cd13982 | 462-711 | STKc_IRE1 |
| cd14207 | 450-711 | PTKc_VEGFR1 |
| cd13994 | 463-656 | STKc_HAL4_like |
| cd07838 | 459-649 | STKc_CDK4_6_like |
| cd14184 | 459-712 | STKc_DCKL2 |
| cd05577 | 463-656 | STKc_GRK |
| cd06652 | 459-695 | STKc_MEKK2 |
| cd08221 | 463-711 | STKc_Nek9 |
| cd06658 | 462-658 | STKc_PAK5 |
| cd14077 | 449-660 | STKc_Kin1_2 |
| cd14067 | 463-706 | STKc_LRRK1 |
| cd14078 | 463-660 | STKc_MELK |
| cd05630 | 500-710 | STKc_GRK6 |
| cd06618 | 564-712 | PKc_MKK7 |
| cd05575 | 463-704 | STKc_SGK |
| cd14082 | 456-665 | STKc_PKD |
| cd07841 | 458-656 | STKc_CDK7 |
| cd14048 | 461-705 | STKc_EIF2AK3_PERK |
| cd05620 | 463-656 | STKc_nPKC_delta |
| cd14071 | 463-656 | STKc_SIK |
| cd14050 | 458-713 | PKc_Myt1 |
| cd06621 | 455-724 | PKc_Pek1_like |
| cd14079 | 455-661 | STKc_AMPK_alpha |
| cd05042 | 461-669 | PTKc_Aatyk |
| cd05580 | 459-656 | STKc_PKA_like |
| cd05089 | 450-716 | PTKc_Tie1 |
| cd05582 | 463-675 | STKc_RSK_N |
| cd05593 | 463-658 | STKc_PKB_gamma |
| cd14193 | 463-656 | STKc_MLCK4 |
| cd05093 | 457-722 | PTKc_TrkB |
| cd14167 | 463-661 | STKc_CaMKI_alpha |
| cd08228 | 459-656 | STKc_Nek6 |
| cd14087 | 463-660 | STKc_PSKH1 |
| cd14076 | 455-656 | STKc_Kin4 |
| cd05616 | 463-656 | STKc_cPKC_beta |
| cd14073 | 461-660 | STKc_NUAK |
| cd14052 | 463-648 | PTKc_Wee1_fungi |
| cd14131 | 456-712 | PKc_Mps1 |
| cd14116 | 450-656 | STKc_Aurora-A |
| cd07851 | 450-721 | STKc_p38 |
| cd06657 | 462-658 | STKc_PAK4 |
| cd05087 | 461-669 | PTKc_Aatyk1 |
| cd14119 | 463-710 | STKc_LKB1 |
| cd14219 | 456-696 | STKc_BMPR1b |
| cd14004 | 461-712 | STKc_PASK |
| cd14191 | 459-665 | STKc_MLCK1 |
| cd14070 | 455-657 | STKc_HUNK |
| cd07840 | 463-653 | STKc_CDK9_like |
| cd14043 | 469-710 | PK_GC-2D |
| cd06620 | 461-711 | PKc_Byr1_like |
| cd14001 | 461-663 | PKc_TOPK |
| cd05571 | 463-663 | STKc_PKB |
| cd14083 | 461-656 | STKc_CaMKI |
| cd05619 | 463-663 | STKc_nPKC_theta |
| cd14183 | 459-667 | STKc_DCKL1 |
| cd07871 | 462-667 | STKc_PCTAIRE3 |
| cd05604 | 463-658 | STKc_SGK3 |
| cd14206 | 461-688 | PTKc_Aatyk3 |
| cd07877 | 450-670 | STKc_p38alpha |
| cd07873 | 462-669 | STKc_PCTAIRE1 |
| cd14107 | 459-705 | STKc_obscurin_rpt1 |
| cd14094 | 453-701 | STKc_CASK |
| cd05094 | 457-722 | PTKc_TrkC |
| cd13988 | 463-656 | STKc_TBK1 |
| cd05605 | 500-656 | STKc_GRK4_like |
| cd14181 | 481-700 | STKc_PhKG2 |
| cd14169 | 458-661 | STKc_CaMKI_beta |
| cd14141 | 466-649 | STKc_ACVR2a |
| cd14160 | 463-715 | PK_IRAK3 |
| cd14163 | 459-693 | STKc_TSSK3-like |
| cd14012 | 476-713 | PK_eIF2AK_GCN2_rpt1 |
| cd14096 | 461-680 | STKc_RCK1-like |
| cd14209 | 463-657 | STKc_PKA |
| cd14111 | 453-656 | STKc_SPEG_rpt2 |
| cd14086 | 461-656 | STKc_CaMKII |
| cd05592 | 515-657 | STKc_nPKC_theta_like |
| cd14114 | 461-704 | STKc_Twitchin_like |
| cd07833 | 462-724 | STKc_CDKL |
| cd05587 | 519-656 | STKc_cPKC |
| cd05603 | 463-656 | STKc_SGK2 |
| cd05607 | 515-658 | STKc_GRK7 |
| cd07836 | 461-738 | STKc_Pho85 |
| cd13987 | 549-690 | STKc_SBK1 |
| cd05594 | 463-704 | STKc_PKB_alpha |
| cd14045 | 471-710 | PK_GC_unk |
| cd06651 | 460-657 | STKc_MEKK3 |
| cd08226 | 480-690 | PK_STRAD_beta |
| cd14110 | 492-663 | STKc_obscurin_rpt2 |
| cd14133 | 463-705 | PKc_DYRK_like |
| cd14182 | 479-656 | STKc_PhKG1 |
| cd14140 | 466-651 | STKc_ACVR2b |
| cd07870 | 461-661 | STKc_PFTAIRE2 |
| cd14036 | 463-720 | STKc_GAK |
| cd14037 | 456-711 | STKc_NAK_like |
| cd05583 | 463-657 | STKc_MSK_N |
| cd14166 | 463-656 | STKc_CaMKI_gamma |
| cd14194 | 459-656 | STKc_DAPK1 |
| cd13995 | 463-711 | STKc_MAP3K8 |
| cd14161 | 461-656 | STKc_NUAK2 |
| cd14185 | 459-693 | STKc_DCKL3 |
| cd05086 | 461-663 | PTKc_Aatyk2 |
| cd07834 | 463-730 | STKc_MAPK |
| cd14165 | 459-659 | STKc_TSSK1_2-like |
| cd13975 | 460-706 | PKc_Dusty |
| cd14210 | 463-652 | PKc_DYRK |
| cd05612 | 462-656 | STKc_PRKX_like |
| cd14085 | 458-700 | STKc_CaMKIV |
| cd06617 | 556-712 | PKc_MKK3_6 |
| cd05088 | 463-714 | PTKc_Tie2 |
| cd07847 | 462-653 | STKc_CDKL1_4 |
| cd07844 | 462-669 | STKc_PCTAIRE_like |
| pfam00130 | 235-280 | C1_1 |
| cd14106 | 463-656 | STKc_DRAK |
| cd14017 | 458-705 | STKc_TTBK |
| cd05608 | 463-656 | STKc_GRK1 |
| cd14195 | 459-656 | STKc_DAPK3 |
| cd14118 | 558-710 | STKc_CAMKK |
| cd05570 | 463-710 | STKc_PKC |
| cd14105 | 459-656 | STKc_DAPK |
| cd05615 | 463-656 | STKc_cPKC_alpha |
| cd14190 | 463-656 | STKc_MLCK2 |
| cd07854 | 463-665 | STKc_MAPK4_6 |
| cd05602 | 463-704 | STKc_SGK1 |
| cd05584 | 463-691 | STKc_p70S6K |
| cd07856 | 461-730 | STKc_Sty1_Hog1 |
| cd14090 | 459-657 | STKc_Mnk |
| cd14005 | 456-713 | STKc_PIM |
| cd07872 | 461-667 | STKc_PCTAIRE2 |
| cd14196 | 459-665 | STKc_DAPK2 |
| cd05037 | 457-711 | PTK_Jak_rpt1 |
| cd07845 | 462-670 | STKc_CDK10 |
| cd05632 | 500-656 | STKc_GRK5 |
| cd07869 | 461-669 | STKc_PFTAIRE1 |
| cd14038 | 462-656 | STKc_IKK_beta |
| cd14198 | 500-705 | STKc_DRAK2 |
| cd08229 | 459-656 | STKc_Nek7 |
| cd05631 | 500-656 | STKc_GRK4 |
| cd14088 | 496-704 | STKc_CaMK_like |
| cd14168 | 497-661 | STKc_CaMKI_delta |
| cd07878 | 450-729 | STKc_p38beta |
| cd14199 | 562-713 | STKc_CaMKK2 |
| cd14074 | 463-693 | STKc_SNRK |
| cd14200 | 558-710 | STKc_CaMKK1 |
| cd06619 | 456-705 | PKc_MKK5 |
| cd14104 | 459-665 | STKc_Titin |
| cd14091 | 463-675 | STKc_RSK_C |
| cd14665 | 463-692 | STKc_SnRK2-3 |
| cd07842 | 463-669 | STKc_CDK8_like |
| cd14117 | 443-661 | STKc_Aurora-B_like |
| cd05611 | 463-665 | STKc_Rim15_like |
| smart00109 | 235-280 | C1 |
| cd07863 | 463-669 | STKc_CDK4 |
| cd07880 | 450-665 | STKc_p38gamma |
| cd06622 | 456-725 | PKc_PBS2_like |
| cd07843 | 462-668 | STKc_CDC2L1 |
| cd14112 | 453-656 | STKc_Unc-89_rpt2 |
| cd14113 | 463-656 | STKc_Trio_C |
| cd07879 | 450-665 | STKc_p38delta |
| cd05609 | 515-677 | STKc_MAST |
| cd13986 | 461-717 | STKc_16 |
| cd08216 | 460-658 | PK_STRAD |
| cd14173 | 479-656 | STKc_Mnk2 |
| cd14175 | 458-675 | STKc_RSK1_C |
| cd05614 | 463-657 | STKc_MSK2_N |
| cd07832 | 462-696 | STKc_CCRK |
| cd07866 | 459-667 | STKc_BUR1 |
| cd14132 | 448-665 | STKc_CK2_alpha |
| cd13990 | 463-705 | STKc_TLK |
| cd05613 | 463-657 | STKc_MSK1_N |
| cd14136 | 556-671 | STKc_SRPK |
| cd14051 | 462-705 | PTKc_Wee1 |
| cd14197 | 519-704 | STKc_DRAK1 |
| cd14092 | 555-671 | STKc_MSK_C |
| cd14177 | 461-675 | STKc_RSK4_C |
| cd14176 | 459-675 | STKc_RSK2_C |
| cd05573 | 459-658 | STKc_ROCK_NDR_like |
| cd05590 | 461-663 | STKc_nPKC_eta |
| cd07875 | 443-711 | STKc_JNK1 |
| cd05574 | 501-693 | STKc_phototropin_like |
| cd07865 | 461-651 | STKc_CDK9 |
| cd14662 | 463-692 | STKc_SnRK2 |
| cd05617 | 519-669 | STKc_aPKC_zeta |
| cd14016 | 456-705 | STKc_CK1 |
| cd14039 | 463-656 | STKc_IKK_alpha |
| cd07855 | 461-669 | STKc_ERK5 |
| cd05618 | 519-663 | STKc_aPKC_iota |
| cd14108 | 459-666 | STKc_SPEG_rpt1 |
| cd05606 | 463-704 | STKc_beta_ARK |
| cd05591 | 515-663 | STKc_nPKC_epsilon |
| cd05589 | 463-656 | STKc_PKN |
| cd05077 | 457-714 | PTK_Jak1_rpt1 |
| cd07831 | 462-665 | STKc_MOK |
| cd07874 | 451-692 | STKc_JNK3 |
| cd07852 | 556-708 | STKc_MAPK15-like |
| cd14157 | 463-652 | STKc_IRAK2 |
| cd07860 | 461-677 | STKc_CDK2_3 |
| cd07864 | 463-661 | STKc_CDK12 |
| cd14178 | 459-672 | STKc_RSK3_C |
| cd07862 | 463-665 | STKc_CDK6 |
| cd05633 | 456-664 | STKc_GRK3 |
| cd07846 | 463-711 | STKc_CDKL2_3 |
| cd14208 | 457-714 | PTK_Jak3_rpt1 |
| cd07850 | 463-664 | STKc_JNK |
| cd13968 | 463-596 | PKc_like |
| cd14223 | 458-664 | STKc_GRK2 |
| cd14174 | 556-656 | STKc_Mnk1 |
| cd05598 | 561-656 | STKc_LATS |
| cd05588 | 563-664 | STKc_aPKC |
| cd13977 | 461-705 | STKc_PDIK1L |
| cd05610 | 463-663 | STKc_MASTL |
| cd14044 | 499-710 | PK_GC-C |
| cd05586 | 463-656 | STKc_Sck1_like |
| cd07839 | 461-669 | STKc_CDK5 |
| cd14179 | 463-656 | STKc_MSK1_C |
| cd14125 | 459-609 | STKc_CK1_delta_epsilon |
| cd07858 | 559-653 | STKc_TEY_MAPK |
| cd07849 | 559-721 | STKc_ERK1_2_like |
| cd07853 | 463-693 | STKc_NLK |
| cd05585 | 515-660 | STKc_YPK1_like |
| cd14011 | 493-697 | PK_SCY1_like |
| cd14171 | 512-656 | STKc_MAPKAPK5 |
| cd07876 | 451-710 | STKc_JNK2 |
| cd07857 | 559-653 | STKc_MPK1 |
| cd14139 | 461-646 | PTKc_Wee1b |
| cd05624 | 448-656 | STKc_MRCK_beta |
| cd06650 | 451-655 | PKc_MEK1 |
| cd14212 | 458-655 | PKc_YAK1 |
| cd05623 | 463-701 | STKc_MRCK_alpha |
| cd14138 | 461-646 | PTKc_Wee1a |
| cd06615 | 563-655 | PKc_MEK |
| cd14180 | 463-656 | STKc_MSK2_C |
| cd07848 | 463-687 | STKc_CDKL5 |
| cd08227 | 480-659 | PK_STRAD_alpha |
| cd14134 | 463-668 | PKc_CLK |
| cd14109 | 558-665 | PK_Unc-89_rpt1 |
| cd14115 | 463-656 | STKc_Kalirin_C |
| COG3642 | 499-600 | Bud32 |
| pfam00069 | 457-713 | Pkinase |
| pfam07714 | 457-714 | Pkinase_Tyr |
| smart00219 | 457-711 | TyrKc |
| smart00221 | 457-711 | STYKc |
| smart00220 | 458-712 | S_TKc |
| COG0515 | 458-733 | SPS1 |
| PTZ00266 | 448-712 | PTZ00266 |
| PTZ00263 | 440-656 | PTZ00263 |
| PTZ00267 | 559-717 | PTZ00267 |
| PLN00034 | 460-711 | PLN00034 |
| PHA03212 | 494-740 | PHA03212 |
| PTZ00024 | 457-740 | PTZ00024 |
| PHA03209 | 535-650 | PHA03209 |
| PHA03207 | 466-662 | PHA03207 |
| PTZ00283 | 566-663 | PTZ00283 |
| PRK13184 | 518-695 | pknD |
| PHA02988 | 471-716 | PHA02988 |
| PHA03390 | 545-689 | pk1 |
| PHA03211 | 535-648 | PHA03211 |
| TIGR03903 | 480-653 | TOMM_kin_cyc |
| PTZ00036 | 433-669 | PTZ00036 |
Ontology Information
| HPRD ID | 761 |
|---|---|
| Molecular Class | Serine/threonine kinase |
| Molecular Function | GTPase activity (GO:0003924) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| P15056 | DB00398 | Sorafenib | SmallMoleculeDrug |
| P15056 | DB08881 | Vemurafenib | SmallMoleculeDrug |
| P15056 | DB08896 | Regorafenib | SmallMoleculeDrug |
| P15056 | DB08912 | Dabrafenib | SmallMoleculeDrug |