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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| SSX2 | 6757 | synovial sarcoma, X breakpoint 2 | X | HOM-MEL-40, HD21, MGC3884, MGC15364, MGC119055, CT5.2a |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 12124339 | 2002 | Cell line : Colo205 Source : - Sample Type : Serum samples No. of Sample : - Stage : - | real time RT-PCR,SADA | Up-regulation | - | Three of the 13 antigens were cancer/testis antigens (MAGEA3, SSX2, and NY-ESO-1), which are expressed exclusively in normal gametogenic tissues and aberrantly expressed in a broad range of cancer types. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | The product of this gene belongs to the family of highly homologous synovial sarcoma X (SSX) breakpoint proteins. These proteins may function as transcriptional repressors. They are also capable of eliciting spontaneous humoral and cellular immune responses in cancer patients, and are potentially useful targets in cancer vaccine-based immunotherapy. This gene, and also the SSX1 and SSX4 family members, have been involved in t(X;18)(p11.2;q11.2) translocations that are characteristically found in all synovial sarcomas. This translocation results in the fusion of the synovial sarcoma translocation gene on chromosome 18 to one of the SSX genes on chromosome X. The encoded hybrid proteins are likely responsible for transforming activity. Alternative splicing of this gene results in multiple transcript variants. This gene also has an identical duplicate, GeneID: 727837, located about 45 kb downstream in the opposite orientation on chromosome X. [provided by RefSeq, Jul 2013] |
| Chromosome | X |
| Location | Xp11.22 |
| Start | 52725946 |
| End | 52736277 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 10332 |
| OMIM ID | 300192 |
| HGNC ID | HGNC:11336 |
| Unigene ID | Hs.289105 |
| Ensembl ID | ENSG00000241476 |
| PharmGKB ID | PA162404839 |
mRNA Information
| mRNA ID | ?NM_001164417.2 |
|---|---|
| Exon | join(1..116,1459..1547,1986..2100,2636..2731,4598..4647, 6650..6785,9140..9244,9710..10332) | mRNA Sequence | Download Select all |
| Length | 1348 |
Protein Information
| Protein ID | NP_001157889.1 |
|---|---|
| Protein Name | synovial sarcoma, X breakpoint 2 |
| Molecular Wt. (Da) | 40030 |
| Protein Sequence | Download Select all |
| Length | 188 |
| Uniprot ID | Q86VB7 |
| Ensembl Protein ID | ENSP00000352071 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 181 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Transcriptional misregulation in cancer | hsa05202 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd07765 | 24-61 | KRAB_A-box |
| cl02581 | 24-61 | KRAB_A-box superfamily |
| pfam09514 | 155-188 | SSXRD |
| cl09744 | 155-188 | SSXRD superfamily |
| pfam01352 | 24-62 | KRAB |
| smart00349 | 23-82 | KRAB |
Ontology Information
| HPRD ID | 5406 |
|---|---|
| Molecular Class | Transcription regulatory protein |
| Molecular Function | Receptor binding (GO:0005102) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.