Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| ST13 | 6767 | suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) | 22 | SNC6, HSPABP1, HIP, P48, FAM10A1 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 23125081 | 2012 | Cell line : RKO, HT29,
SW480, SW620, LOVO, LS174T, HEK293
Source : ATCC Sample Type : - No. of Sample : - Stage : - | real time RT-PCR, Transfection, Gene Knockdown assay,MTT assay, plate colony formation, cell-cycle analysis, and migration assays | Down-regulation | - | ST13 gene is a proliferation regulator that inhibits tumor growth in CRC and may affect cell migration. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Tetratricopeptide (TTC) repeat domain containing |
| Description | The protein encoded by this gene is an adaptor protein that mediates the association of the heat shock proteins HSP70 and HSP90. This protein has been shown to be involved in the assembly process of glucocorticoid receptor, which requires the assistance of multiple molecular chaperones. The expression of this gene is reported to be downregulated in colorectal carcinoma tissue suggesting that it is a candidate tumor suppressor gene. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2013] |
| Chromosome | 22 |
| Location | 22q13.2 |
| Start | 41220539 |
| End | 41253012 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 32474 |
| OMIM ID | 606796 |
| HGNC ID | HGNC:11343 |
| Unigene ID | Hs.712713 |
| Ensembl ID | ENSG00000100380 |
| PharmGKB ID | PA36167 |
mRNA Information
| mRNA ID | ?NM_003932.4 |
|---|---|
| Exon | join(1..578,6129..6186,8670..8715,12100..12170, 16317..16383,21122..21206,21339..21449,24338..24440, 26053..26169,27335..27383,29780..29913,30343..32474) | mRNA Sequence | Download Select all |
| Length | 3567 |
Protein Information
| Protein ID | NP_003923.2 |
|---|---|
| Protein Name | suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) |
| Molecular Wt. (Da) | 94639 |
| Protein Sequence | Download Select all |
| Length | 369 |
| Uniprot ID | O94813 |
| Ensembl Protein ID | ENSP00000427548 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 75;- |
| S | Phosphorylation | 76;- |
| S | Phosphorylation | 79;- |
| S | Phosphorylation | 75;- |
| S | Phosphorylation | 79;- |
| S | Phosphorylation | 76;- |
| S | Phosphorylation | 181 |
| K | Acetylation | 153 |
| T | Phosphorylation | 93 |
| T | Phosphorylation | 107 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 3303 | HSPA1A | 774 | NP_005336.3 | in vivo | 8887650 |
| 3320 | HSP90AA1 | 777 | NP_001017963.2 | in vitro | 9452498 |
| 9398 | CD101 | 5154 | NP_004249.2 | yeast 2-hybrid | 16169070 |
| 93145 | OLFM2 | 10127 | NP_477512.1 | yeast 2-hybrid | 16169070 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd14438 | Mar-43 | Hip_N |
| cl22420 | Mar-43 | Hip_N superfamily |
| smart00727 | 319-358 | STI1 |
| cl17974 | 319-358 | STI1 superfamily |
| pfam00515 | 148-180 | TPR_1 |
| cl22897 | 148-180 | TPR_1 superfamily |
| pfam13414 | 112-179 | TPR_11 |
| PLN03088 | 114-233 | PLN03088 |
| TIGR00990 | 45-214 | 3a0801s09 |
| TIGR00990 | 47-218 | 3a0801s09 |
| pfam13414 | 146-212 | TPR_11 |
| pfam13371 | 162-223 | TPR_9 |
| COG0457 | 101-214 | TPR |
| TIGR02552 | 128-233 | LcrH_SycD |
| pfam13432 | 120-182 | TPR_16 |
Ontology Information
| HPRD ID | 5671 |
|---|---|
| Molecular Class | Adapter molecule |
| Molecular Function | Molecular function unknown (GO:0005554) |
| Biological Process | Metabolism (GO:0008152); Energy pathways (GO:0006091) |
Drug Information
No matching records could be found.