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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
ST14 6768 suppression of tumorigenicity 14 (colon carcinoma)  11SNC19, HAI, MT-SP1, TMPRSS14 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
16237759   2015Cell line : -

Source : -

Sample Type : -

No. of Sample : -

Stage : -

MTT assay,wound healing assay, invasion assay.Unknown-SNC19/ST14 gene overexpression increases the local invasion of colorectal cancer cells in vitro.


Gene Details



NC_000011.9 (130029682..130080257)

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Gene Type protein coding
Gene Family Serine peptidases / Transmembrane
Description The protein encoded by this gene is an epithelial-derived, integral membrane serine protease. This protease forms a complex with the Kunitz-type serine protease inhibitor, HAI-1, and is found to be activated by sphingosine 1-phosphate. This protease has been shown to cleave and activate hepatocyte growth factor/scattering factor, and urokinase plasminogen activator, which suggest the function of this protease as an epithelial membrane activator for other proteases and latent growth factors. The expression of this protease has been associated with breast, colon, prostate, and ovarian tumors, which implicates its role in cancer invasion, and metastasis. [provided by RefSeq, Jul 2008]  
Chromosome 11
Location 11q24-q25
Start 130029682  
End 130080257  
Strand +  
Gene Sequence

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Length 50576  
OMIM ID 606797   
HGNC ID HGNC:11344   
Unigene ID Hs.504315   
Ensembl ID ENSG00000149418   
PharmGKB ID PA36168   

mRNA Information


mRNA ID ?NM_021978.3
Exon join(1..274,28328..28487,28744..28871,29083..29153, 29953..30110,30327..30362,30668..30908,34363..34502, 34854..34951,36553..36662,36784..36914,38055..38159, 38522..38632,38722..38835,39161..39283,40165..40351, 48624..48898,49656..49792,49876..50576)  
mRNA Sequence

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Length 3319  



CDS Information


   
Location 194..2761
CDS Sequence

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CCDS ID CCDS8487.1



Protein Information


      
Protein IDNP_068813.1
Protein Namesuppression of tumorigenicity 14 (colon carcinoma)
Molecular Wt. (Da)34746
Protein Sequence

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Length 855  
Uniprot IDO14745
Ensembl Protein ID ENSP00000262613  



Post-translational Modification Information (Source : HPRD)


Residue Type site
GProteolytic Cleavage149
NGlycosylation302
NGlycosylation772

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                           
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
2150F2RL12960NP_005233.3in vitro10831593   
3082HGF799NP_000592.3in vitro1   237   281   910   962   000   
5328PLAU1883NP_002649.1in vitro10962009   
6692SPINT15494NP_857593.1in vitro;in vivo10373425   
64866CDCP116696NP_073753.3in vivo16007225   


Pathway Information


      
Pathway Name Pathway ID
MicroRNAs in cancer hsa05206


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd00190615-852  Tryp_SPc
cl21584615-852  Tryp_SPc superfamily
cd00041340-444  CUB
cl00049340-444  CUB superfamily
cd00041227-332  CUB
cl00049227-332  CUB superfamily
cd00112525-559  LDLa
cl00104525-559  LDLa superfamily
cd00112454-486  LDLa
cl00104454-486  LDLa superfamily
cd00112488-523  LDLa
cl00104488-523  LDLa superfamily
cd00112567-602  LDLa
cl00104567-602  LDLa superfamily
pfam00431340-444  CUB
smart00042349-444  CUB
pfam0139085-193  SEA
cl0250785-193  SEA superfamily
smart00042227-331  CUB
pfam00057525-559  Ldl_recept_a
smart00192525-556  LDLa
pfam00431228-331  CUB
pfam00057454-486  Ldl_recept_a
smart00192454-483  LDLa
smart00192486-520  LDLa
pfam00057492-523  Ldl_recept_a
pfam00057565-602  Ldl_recept_a
smart00192566-599  LDLa
pfam02408350-429  CUB_2
smart00020614-849  Tryp_SPc
pfam00089615-849  Trypsin
COG5640614-849  COG5640
pfam09342622-737  DUF1986


Ontology Information


   
HPRD ID11948
Molecular ClassSerine protease
Molecular FunctionTransferase activity (GO:0016740)
Biological ProcessMetabolism (GO:0008152); Energy pathways (GO:0006091)  



SNP Information


View SNP Geneview Report   

Drug Information


Uniprot ID DrugBank ID Name Type
Q9Y5Y6DB00013UrokinaseBiotechDrug

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO