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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
STAT1 6772 signal transducer and activator of transcription 1, 91kDa  2STAT91, ISGF-3 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
20098684   2010Cell line : HCT116 , DLD 1

Source : -

Sample Type : -

No. of Sample : -

Stage : -

real time RT-PCR,Microarray,,Luciferase Assays,Western Blotting Up-regulation-miR-145 is reported to be down-regulated in several cancers,miRNA targets have previously been implicated in cancer, including YES, FSCN1, ADAM17, BIRC2, VANGL1 as well as the transcription factor STAT1. Both YES and STAT1 were verified as direct miR-145 targets.


Gene Details



NC_000002.11 (191833762..191878976, complement)

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Gene Type protein coding
Gene Family SH2 domain containing
Description The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein can be activated by various ligands including interferon-alpha, interferon-gamma, EGF, PDGF and IL6. This protein mediates the expression of a variety of genes, which is thought to be important for cell viability in response to different cell stimuli and pathogens. Two alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]  
Chromosome 2
Location 2q32.2-q32
Start 191833762  
End 191878976  
Strand -  
Gene Sequence

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Length 45215  
OMIM ID 600555   
HGNC ID HGNC:11362   
Unigene ID Hs.642990   
Ensembl ID ENSG00000115415   
PharmGKB ID PA36183   

mRNA Information


mRNA ID ?NM_007315.3
Exon complement(join(38814..41627,45384..46511,46807..47115))  
mRNA Sequence

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Length 4251  



CDS Information


   
Location436..1431
CDS Sequence

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CCDS ID CCDS2309.1



Protein Information


      
Protein IDNP_009330.1
Protein Namesignal transducer and activator of transcription 1, 91kDa
Molecular Wt. (Da)97326
Protein Sequence

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Length 750  
Uniprot IDQ15848
Ensembl Protein ID ENSP00000320709  



Post-translational Modification Information (Source : HPRD)


Residue Type site
YPhosphorylation701
SPhosphorylation727
YDephosphorylation701
SDephosphorylation727
YDephosphorylation701
YPhosphorylation701
YPhosphorylation701
YPhosphorylation701
SPhosphorylation727
KSumoylation703
SPhosphorylation727
RMethylation31
RMethylation31
YDephosphorylation701
SPhosphorylation727
YPhosphorylation701
YPhosphorylation701
YPhosphorylation701
YPhosphorylation701
YPhosphorylation701
YPhosphorylation701
YPhosphorylation701
YPhosphorylation701
YPhosphorylation701
YPhosphorylation701
YPhosphorylation701
YPhosphorylation701

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
147ADRA1B80NP_000670.1in vivo10652206   
660BMX2111NP_975010.1in vitro9373245   
672BRCA1218NP_009231.2in vitro;in vivo10792030   
1387CREBBP2534NP_004371.2in vitro898   676   910   848   577   
1432MAPK142619NP_001306.1in vitro11226159   
1845DUSP32553NP_004081.1in vitro11238845   
2033EP3004078NP_001420.2in vivo1   582   451   589   867   690   000   000   
2176FANCC1967NP_000127.2in vitro;in vivo10848598   
2321FLT11297NP_002010.2in vivo15703780   
3297HSF1778NP_005517.1in vitro;in vivo9880553   
3455IFNAR23850NP_997468.1in vitro;in vivo11301323   
3459IFNGR1127NP_000407.1in vivo751   416   515   494   521   
3560IL2RB896NP_000869.1in vivo10602027   
3561IL2RG2391NP_000197.1in vivo11418623   
3659IRF1961NP_002189.1in vitro;in vivo10764778   
3725JUN1302NP_002219.1in vivo10490649   
3791KDR1867NP_002244.1in vitro;in vivo10961983   
4192MDK1200NP_002382.1in vitro9452495   
5610EIF2AK21468NP_002750.1in vitro;in vivo913   514   511   278   865   
6714SRC1819NP_005408.1in vivo9344858   
6774STAT326NP_644805.1in vivo12070153   
6776STAT5A3301NP_003143.2in vitro;in vivo10358045   
6777STAT5B5037NP_036580.2in vitro;in vivo10358045   
6850SYK2514NP_003168.2in vivo15467722   
7132TNFRSF1A1861NP_001056.1in vitro10848577   
7133TNFRSF1B1862NP_001057.1in vitro;in vivo10848577   
7852CXCR41217NP_001008540.1in vivo10506573   
8772FADD3909NP_003815.1in vitro;in vivo10848577   
10379IRF9960NP_006075.3in vitro;in vivo8943351   
10399GNB2L11503NP_006089.1in vitro;in vivo11301323   
84285EIF1AD14411NP_115701.2yeast 2-hybrid16189514   


Pathway Information


                                                                                                            
Pathway Name Pathway ID
AGE-RAGE signaling pathway in diabetic complications hsa04933
Chemokine signaling pathway hsa04062
Hepatitis B hsa05161
Hepatitis C hsa05160
Herpes simplex infection hsa05168
Inflammatory bowel disease (IBD) hsa05321
Influenza A hsa05164
Jak-STAT signaling pathway hsa04630
Leishmaniasis hsa05140
Measles hsa05162
Osteoclast differentiation hsa04380
Pancreatic cancer hsa05212
Pathways in cancer hsa05200
Prolactin signaling pathway hsa04917
Thyroid hormone signaling pathway hsa04919
Toll-like receptor signaling pathway hsa04620
Toxoplasmosis hsa05145
Tuberculosis hsa05152


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd10372557-707  SH2_STAT1
cl15255557-707  SH2 superfamily
pfam02864317-567  STAT_bind
cl03748317-567  STAT_bind superfamily
pfam01017136-315  STAT_alpha
cl19923136-315  STAT_alpha superfamily
cd10375557-692  SH2_STAT4
cd10374550-710  SH2_STAT3
smart009642-121  STAT_int
cl037492-121  STAT_int superfamily
pfam028652-121  STAT_int
cd09919557-682  SH2_STAT_family
cd10373557-710  SH2_STAT2
cd10377557-706  SH2_STAT6
cd10376557-709  SH2_STAT5
cd10420557-709  SH2_STAT5b
cd10421557-682  SH2_STAT5a
pfam00017578-622  SH2
pfam12162715-739  STAT1_TAZ2bind
cl13580715-739  STAT1_TAZ2bind superfamily
cd00173580-608  SH2
cd10349580-622  SH2_SH2D2A_SH2D7
smart00252579-622  SH2
cd10416571-621  SH2_SH2D2A
cd10338571-606  SH2_SHA
cd10417570-607  SH2_SH2D7
pfam13204511-580  DUF4038
cl22871511-580  Glyco_hydro_2_C superfamily


Ontology Information


   
HPRD ID4806
Molecular ClassTranscription factor
Molecular FunctionDNA binding (GO:0003677)
Biological ProcessRegulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219)  



SNP Information


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Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO