CoReCG

Search results:

General Information

Gene_Symbol	Gene_ID	Gene_Name	Chromosome	Alias
STAT3	6774	signal transducer and activator of transcription 3 (acute-phase response factor)	17	APRF

Evidence
Gene
mRNA
CDS
Protein
PTM
Enzyme
PPi
Pathway
Structural
Domain
Ontology
SNP
Drug
External Links

Evidence Information

Pubmed ID	Year	Sample Information	Techniques	Mechanism	Fold Change	Remark
23756862	2013	Cell line : - Source : - Sample Type : - No. of Sample : - Stage : -	Tissue microarray, immunohistochemistry	Up-regulation	-	STAT3 expression and activity constitutes an independent favourable prognostic marker for CRC.
21310826	2011	Cell line : - Source : The Nurses Health Study and the Health Professional Follow-up Study Sample Type : Case control study No. of Sample : 724 colon and rectal cancer cases Stage : -	real time RTPCR (MethyLight),Immunohistochemistry	Up-regulation	-	STAT3 activation in colorectal cancer is associated with adverse clinical outcome, supporting its potential roles as a prognostic biomarker and a chemoprevention and/or therapeutic target.

Gene Details

Chromosome 17 - NC_000017.11 (42313324..42388503, complement)
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Gene Type	protein coding
Gene Family	SH2 domain containing
Description	The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Three alternatively spliced transcript variants encoding distinct isoforms have been described.
Chromosome	17
Location	17q21
Start	42313324
End	42388503
Strand	-
Gene Sequence	>gi\|568815581:c42388503-42313324 Homo sapiens chromosome 17, GRCh38.p2 Primary Assembly AATTCAGCGGTTTCCGGAGCTGCGGCGGCGCAGACTGGGAGGGGGAGCCGGGGGTTCCGACGTCGCAGCC GAGGGAACAAGCCCCAACCGGATCCTGGACAGGCACCCCGGCTTGGCGCTGTCTCTCCCCCTCGGCTCGG AGAGGCCCTTCGGCCTGAGGGAGCCTCGCCGCCCGTCCCCGGCACACGCGCAGCCCCGGCCTCTCGGCCT CTGCCGGAGAAACAGGTGAAGGGGGTGCAGGGTGGGGCCGTTGGGGAGGCCTGGGGACCCGGGGGCTCCG CAGCGGCAGGGGGCCTCTGGGACCTTGGGGATGTTGTGATGGACGCTGCAGTGGGGCCGGGAGAGATGAA GAGACGCGGAGGGTCGCCCTGAGGGAAGACTCTTCGGGATGACAGGAGCGGGCCTCGGAAGGGACTCGGG GCGCTGGAGGGAAGTTTCGTTCTTCGGAGAAACAGAACGCGCTCGAGGGGGCACCGTGGGGCGAGGGCGC ACTCGGTTGCGGCGGCAGGAGTGAGGGACAGTCCCCCGATTTCCTGCTCCCTGGGGCCCTGGGGACGTTC CGGCCACCGGAGCGACTGTCACGCCGACGGGGATCACCGGCGCGAGTGGGGGGTCGGAAAGCGCCTCCTC CCCGCCCGGTCGGCGGCTCCCGCTGAGCCACTTCCTCCGCTTGCCCTGTTCCCGCTCCTTCAGGAGACAG CTGTGCCCTTTTGGAGGCAGGAATAGGTGTGTCTGTCGCCTGCAGCCTTACGGGCTGGCTGGTCGTGGGT AGGCTTTATTGCATAAGAATCAAGTTTCCTGTAGGGAAATTGACAGACCGGTACTCTTTCTAAATTCCCT CGCATCTTTTTCTAGGTTAAATTATGCTCCCCCCACGTCCCCGCCTTGTAAAAAAGAGAAAAAAAGACAA AATAAAATCCCCATCAACCCGTCAAGCCAGCTCTAGAGAGAGAAATAAACCTCTTGACATTGTCCTTTTC CAAATACCTGGTAAAGTCGGCCAGAAGATAAATAATTGAGCCATTGCATTTACTGGATTGTGGTGTTGCT TAATTGCATAGGACGGAATGAACCAATTGAGAGTGGGAGTTTTCTGTCTCAGAGCCAAGATCTTGGGTAA ATGCAGAGGAGAGGGAAACAAAGACAGGCTGGCCTTGAAAAAACCATGTGTGCAAACTTTACATGCATTT GGGGGGTGTGGTTGCACTGAAGTTAACAAGATTCAAACCGTCGCCCAAGTTGGTATTTCCATGTTTGGTA CACATCACTCTGTGCCATATCAGGTCGTTGTTAAGTGTGGTGACAAAATCAGTGGTTAGTCATTTTTTTA ATTAAAAATGTGTATAGTGTGTACCTGCTGGTCTTACTGTATGTGCAACTAAAGGTTTACATAGTCTGTG TATGGGTTGTAAATTTTTGGCTGGCTGTGCTGATAAAGCATTGGGCTTGAATAAAGCAAAGCAGAAAATC ATCTCAATCTTTTATATGTGGATTTAGACTGTGTTATGACTTGGTTCAGCCAGTTTTCTATCTTATTTTA TATTAAATATGTCTGTGTTCTCTGAGTCAGCACATTTATTTCCTTATTACATGTTCCAGACAGGAGTGCT AGCCCAGTTTTTGTTCAGTTTGCACAGTGGGATGGGGAAACAAGTCTGGAATTTAAAAAAAAATGTTTTA GAGGTTGGAGCCTTGATTTTAGTCTCTATATTAGCACATCCATCACAAAGAACCATTAGTAAATTCATGA ATCTTTTGTTTTTTATGTAGTTCATTTGAGAAGAATAATCACTTAGAAATATCCACAGTGCCAGGCATGG TGGTGCACACCTCTGATCCCAGCTAATTGAAGGCTGAGGTGGGAGGATTCCTTGAGTCCAGGAGTTGAGT CTGGTCTGGGCAACATGGTGAGAGGCCAGGAATTGGGTCTAGAGTCTAGTCTAAGCACCATAATGAGAAC CCATCTTTAAGAAAGAAAGAAAGGAAAGGAGGAAGAAAGGAAAGAAAAAGAAATACCCACAGCACAGTTA TGAATTAACCCACAAAGGACTTGTGAGGTGGGTAGTTCACATAACAATTACCCTAATATCGTAGATAAGA AAATTGAGGCCAAAGGATCAAGACACTTGGCCAACGCAGCAGAGTGCCATAGTGGTGGAATTTGTGCCTC CTTCTGTATATTTTGTGAAAAGTATCAGTGAAATTCTTTTTTTTTTTTTTTTTGAGTCAGAGTCTTGCTC TGTTGCCCAGGCTAGAGTGCAGTGGCGCAATCTTGGCTCACTGCAACCTCTGCCTCCTGGGTTCAAGCGA TTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGACTACAGGCGTGCGCCACCACGCCCAGCTAATTTTTGTA TTTTTAGTAGAGACCGGGGTTTTACCATATTGGCCAGGCTGGTCTTGAACTCCTGACCTTGTGATTTGCC CACCTCTATCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACCGCGCCCAGTAAGTATCAGTGAAATTC TAACATATATCTGAACAGTAAAATACCACCAATAGGCTGAAAGACTTCATGGGAGGTAAATATTCAATAA ACAGGTGAAAAAAGAAATACAAATGGAGCTTGCTTAGATTATTTTTCTAATTGCTATGTCTAACTTGGGA AGTGAGGAACTGTTTTTGGTCAGCATAATTTACCATCAGAATTTAGCTATTTACTAATGAAAAGAAATAC TAATCTAGGTTTGTTTTAGATTAAGGACAGTCATGACCTAAATGTCATTTAAACCAGAGTGCATTGTGGC TTGATCAGTGGTCATTTCTGTCTCTAGAAAGTTGCTTTAACTTCTCTGCCTCTACGTGTCTCTTGACATT CAGATATGAGGTGGGGTAGAGGTGGTGACCAACTTTCCAGACGCCTGAGTCCAAACCTTCTTAGCTTATG GTTTTCTTAGGTGATGTGCAAATCAACAAATATATACTTTTTTTTTTTTTTTTTTGAGTTGGAGTTGCAC TCTATCACCCAGGCTGGAGTGCAGTGGCATGATCGTGGCTCACTGCAACCTCCTCCTCCCGGGTTCAAGT GATTCTCGCACCTCAGCCTCCTGAGTAGCTGGGATTACAGGTGCCCGCCACTACGCCCGGCTAATTTTTG TATTTTTAGTAGAGATAAGGTTTCACTATATTGACCAGGCTGGTCTCAAACTCCTGACCTCAAGAGATCT GCCCACCTCAGCCTCCCAAAGTGCTGGGATTACAGGCGTGAACCACCTTGCCTGGCCAACATATATATAC CTTTTGCAACTTTGTCAGAGTTGCTATGAAGAATAAGTTGTATCTTGTTCACAGAAATTGCAGTCTACTG GGGGAGCTGATAAATGTTTTAACCATCCAATGTAACATGTTGTCATCAAAGAGATGGTGAGACTTTACAC TTGTGCTAACAAGGTAGCTGTTCTACATAAAAGAACATACAGTACAGATGTAGAACTTTTCTGTTATCAT AGAACGTTCTATTGGACAGTGCTAGGCTGAATGCTACAGATCTTCAGAGAAAGGAGAGGTTATGAGGCCT GGAGTTGTCTAGAAAGTCTTTTTGCCAAAGAGGGATTTCAACTGGGTCCCAAATAATGGGTGGAATTTGA TAGGTGTAAAGAATTTGCGGTGGTTTATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCAGGAGGATT GCTTGAGCCCAGGAGTTTGAGACCAGCTTGGGCAACGTGGTAAAACTCCCTCTCCCCTAAAAATAAAAAA AATTAGCCAGGCCTGGTGGCGTGGACCTGTAGTCCCAGCTACTGGTGAGACTAAGGTGGGAGGATCACCC AAGCCCCGGGGGTTAAGGCTGCAGTGAGCCGTGATCCCGCCACCGCACTCCAGCCTGGGTGACAGAGTGA GACCCTGTCTCCAAAAAAAAAAAAAATTCCTGGTAGCCCGGTAGACTAGGAGGGTAAGTAGGGGAGAAGT GATTACTTACAAAAGACATTGAATACAGGACCAAGGAATTTCAGTTCTGTTCTTTTGTAGGGGAAGCTTT TAAAACTTTCGGGGCGCCGGGCGCGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCCAGACGCG CGGATCACGAGGCCAGGAGATCGAGACCATCCTGGCTAACACGGTGAAACCCCATCTCTACTAAAAATAC AAAAAAAAGTAGCCGGGCGTTGTGGCGGGCGTCTGTAGTCCCAGCTACTCGGGAGGCTGAGGCAGGAGAA GAGCGTGAACTCGGGAGGCGGAGCTTGCAGTGAGCCGATATCGCACCACTGCACTCCAGCCTGGGCGACA GAGCGAGACTCCGTCTCAAAAAAAAAAAAAATAAATAAATAAATAAATAAATAAAACTTTGGAGCCGAAG CACTGATGTTTAATCATAGAGTGCTTACTATGTGTTAGGCACAGGCCTGATTGCCTGATGCTGGTTAATT TGTACAAAGTAAATCAGTGCATATGCCCTCTGCCCTAGGGGAGTTATTAACTGGAGTCTGACATTGTACA AAGGTAGGTATCCTGACTAGTTTGATTTGGTACTTTGGGTGAAAAAAGTATAGTGTGCTTAAGTGCAGAA GTGTTTTTTGAGGATTTTTGATTGGATACAAACCACCACTCATATTTTATGTCTTTGGCACTTAAAAATT TCACCATAACTTTTGAGTCATTTATAAAAACCACTGAAAGAGTACTTGAGGGACATCCCCGAATCCTGAA GAACTTCTGGTGTTCTGGAGCAGCCTCAGTGAGATCCAGGAGGATGGCATTGCTGGGCTGGCCCAGCCCT TATTGATTATGGTGTAAAGAATTAATATGGTGGTTATATACTCTTTGTTAGACACCTTGGCTTACAAGAC GTAAGCGTAAAGTGTAGTGCGCTTTAGTCAGTATGGCCACATGGTCCTTTGGTGGTAAATTGTTTGAGAT GCCTCCAGTTTTTAAAAGGAGTAGCATATCGGGCCAGGAGCAGTGGCTCATGCCTATAATCCCAGCACTT TGGAAGGCCGAGGCAAGAGGATTGCTTGAGCCCAGGAGTTCAAGACCAGCCTGGGCAACATAGTGAGACC ACTTTGTTTCTTTAAAAAAAAAAAAAAGGCAAAAACAGGCTGGGCATGGTGGCTGATGCCTGTAATCCCA GCGCTTTGTGAGGCAGAGGTGAGCGGATCACTTGAGGTCAGGAGTTTGAGACCAGCCTGGCCAACATGGT AAAACCCCGTCTCTACTAAAAATACAAAAATTAGCCAGGTGTGGTGGCACACGCCTGTAGTTCCAGCTAC TCTGGAGGCTGAGCCAGGAGAATTGCTTGAACCTGGGAGGTGGAGGCTGCAGTGAGCCAAGATCCTGCCA CTGCACTCCAGACTGGGGGACAGAGTGAGACATTCTGACAGTGCTACACTGAATGCTACATGTCTTCAGA GGAAGGAGAGGTTATGAGGCCTGGGAATAACATATGGAAGAATGAATTTCTGTTATGGTCAGTTCTCATT TGTCATGTTAGGATTACTGCAACTCTTACCCAGCCGGGTGTGGTGGCTCATGCCTGTAATTCCAGCACTT TGGGAGGCTGTGGGCGGATCACGAGGTCAGGAGATCGAGACCATCCTGGCTAACACGGTGAAACTCCGCC TCTACTAAAAATACAAAAAATTAGCCCAGCGTGGTGGCAGACGCCTGTAGTCCCAGCTACTCAGGAGGCT GAGGCAGGAGAATGGCATGAGTCCTGGAGGCGGAGCTTGCAGTGAGCTGAGATCGTGCCACTGCACTCCA GCCTGGGCAACAGAGTGGGACTCCATCTCAAAAAAAAAAGAAAAAAAAAAGGATTACCGCAACTCTTTAA TTCAGATCAGCAAACATGTTGAGAGCCAGGTATTGCGTCAGGCAGGATCCAAGGATAATGAAATATTGTC CGTTTTCATGAAACTGGAGATGTTGCAGGGACCGAGGTGTGTGCTATGCCAGTATGGAAGTAGGACAGGG GAGACGACAGGGCAGTGAGTGGTTCAAGACTCTGGCTCTGAAGTCAAACAGATCTGGGACTGAATCCTGG ATCTGCCACTTCCTAGTCAGAATCTGAGCCTCTATTTTCTTATCTGTAAAAGAAGATTATAACAGTGCTT ATCTTGTAGGTACTGTTGACGATTCAATAAGATAATGTGGATAAAATGCTTAGCATAGTGCCTGGCACAT AGTAAGAGCTCGGTAAATCTAAGTTCTTACTAAATATCCAAGAAAAGAGATTAATTCTTTTCAGGAGTGA GAGAAAGTCATCATTATTGAGGGGCTTTATCAGATGGGAACACCTGAATAGGGTTTTATAGGATGAATAG GAATTCTTTCCACGAAGTTGCGTTACAAAAAGTTGCATTCAAGGCTGAAGGAACATGAGGGTGCAGAGGC TTAAAACAGCCTTGTGTGTTCAGGGAGCTATAAGTAGAAGTTCTTAATTTAGGAGAACTAAACCAAGGGG AAAGGAGGCCAAGGAACCACAGTTCTTATCCCTTTTCTGTTAATAATTGGGTTTAAATGTCATTAAAATA AGTTATTTTGTCCTTTTTAGAAAAGTAATAACATGCTATTATAAAAAAAAAGACTTGTAGGAATATAAAA TGTGTGTTTTACATGTATCCTGTTAATTGACTTGCTTTTATTCAGATTTTTTGCAGCCCTTTCTGTTTAC CAGGTTATCTTGGAGACATATTTATTCCAAATTCCTTTTTTTTTTTTTTTTTGAGATGGAGTCTCGCTCT GTCGCCCAGGCTGGAGTGCAGTGGCGCTATCTTGGCTCATTGCAAGCTCCGCCTCCCGGGTTCACGCCAC TCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACAGGCGCCCGCCACCACGCCCAGCTAATGTTTTTTT TTTTATATTTTTAGTAGCGACAGGGTTTCACCGTGTTAGCCAGGATGGTCTCAATCTCCTCACATTGTGA TCCGCCTGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCAGCACGCCTGGCCTTCCAAATTC CTTTTAACAGCCTAGCAAAAGAATAATAAGGAAGGTAAATCTGCCCCTACAAGAAAATAATGCTTCGACG ATCCGGCTTTCCTTCCTGCTACCCCCAGCCATAAGAATAAATGACCTTGCTCATCACTGAAATTTTACCT GACCTTTGAATTTTTAACTGCGTCAGCCAAAGAACTTATATTTTGAGTATTCCTAAGGTGATTGCTATTG TAGTTTTGAAACACTTGGTTGGTATGTTTGAGGGTTTCATGGTCCAAAGTTACTATAGCAGTTAAAAGAG TGGACTATCAGGTCAGACCTATTGGGCTTTAATCCCAGTTCTGCCTTCTCTTAGACCTTGGGCCTGTTGT TTTCACTTCTCTGGTTTTCAGTTTCTCTGTCCACAATTGTGGAAACGAGGTCCACTTGTAGAGTAATTGA GAGGATGAAGCAAGATGATGCATATCAAGTACTTTGCATAGTGCCGGGCAGACAGGTAACATTCAAGTGC TAATAATTACTATTATTACTATTTATTTTTTGAGACAGGTTCTCACTCTGTCACCTAGGCTGGAGTGCAG CGGTGAGATCACAGCTCATGACAGCCTTGACCTCCTAGGCTCAAGTGATCCTCCTGCCTCAGCCTTCGGG GTAGCTGGGGCTACAGGTGTGTGCTACCACCCTCAGCTAATTTTCTAATTTTTTTGAGTCAGGATCTCGT CACGTTGCCTAGGCTGAATTACTCTTATTAAAAACTATAATATCAGGCCGAGTGCGGTGGCTCACGCCTG TAATCCCAGCACTTTGGGAGGCCAAGGCGGGTGGATCACCTGAGGTCAGGAGTTCAAGACCAGCCTGCCC AACAGAGTGAGACCCCCCCCGTCTCTACTAAAAATATAAAAATTAGCCAGTTGTGGTGGTGGGCACCTGT AATCCCAGCTACTCGGGAGGCTGAGGCAGGATAATCGCTTGAACCCGGGAGGCGGAGGTTGCGGTGAACC GAGATCGTGCCACTGCACTACAGCCTGGGTGACAGAGTGAGACTCTGTCTCAAAAAAACCGAAAAACAAA AAGCATAATTAGGGTGGTAACGCTTATACATAGGGGCAGGTGGAATAAAACATAATTAGGAGGTCGGGCA TGGTGGCTCACGCCTGTAATTCCAGCACTTTGGGAGGCCGAGGCGGGTCAGGAGTTCAAGACCAGCCTGC CCAACATAGTGAGACCCCGTCTCTACTAAAAATATAAAATTTAGCCTGTTGTGGTGGCGGGTGCCTGTAG TCCCAGCTACCCGGGAGGCTGAGGCAGGAGAATTGCTTTTGAACCCAGGAGGTGGGGGTTGCAGTGAGCT GAGATCGCGCCGCTGCACTCCAGCCTGGGAGACAGAGCAAGACTCCGTCACAAAAACAAAAAACAAAAAA CTGTCATATCAAAAACTAAACTAAAATGGTAATATCTGTTAGATATTACAAAGTCAGGCAAATTATGATT CATGGCAGCCACTAATGACCCAAAGGAGAGAAAGAATAATTAGCAGATTCTAACCTAATGGGAAAAAAAC TAAATGAATAGGGATGGGGGACTTACATTCTGTTAGAGGAAATTGAGGCTGTCATATAAAAGGAATAGGT AAGGCAAACTGTAAATTCCTGTTTACACAAATGCCCTTCTGATAAATCTCTGCATTGCCCACAGTCCATG ATTACCTCTCCCTTATTTTAAGTAATATTTAACACATTAAAAATGGATTACCACCCAAGGAATTGCTCCC GACCCAGAAAGTGCAGGTAGTGTTGAAGGTTTGAGGGGAAGAGGAATGATTAGAGTTGGTTGTGTCTCAG GAAGAAGCCAACAGGAGGAACCTTATTTTGAGTCAGGTAAAGAAGGTGGGAGTGAGGAGGCATCCCGGTG GCCAGGTATGAAGCTGGGAGCTGATTGCTGCACATTACTCAGCTGAATTAAATGTGCCCTCACATCTGTG TGTGTGCGTACATGCAAATGTACATGTGTATGAGTTAGTTGGAGGGGTAGACCTTTATTTTCCTGTCCTG TAACTTTCCTTTGCAAACTAATCTGTATTCAGAACAGTGTTGCAGTTAAGAACCACCCAGCTTGTCCATG AAACAGGTTCTCTCACCCCATCTCCCCAGTTTTAGAGAAGGCAGGAAAGAAAAGGCAGTGCTTTTCTTTT TTCCTGGCCGTATGCGGGGCAGGAAGAAGCCAGCAGAGCTTGAAAGAGAAAGTAAACCTTCTGGGAAATA AACGGCTTGGCTTCCCTATTGTGGAGGAGGAGTGCAAATTATTAGGGGGATGTTTGGGTAGTTTTTGTAG AAGCCATTTCTGAAAACTGATTTGGATTAGTGAAGGTAAGCCCAATTTAGGAAAACCCTGCCCAGTCTGG TGTCAGCCACCTGTTTCCCGCTTTGTTTGATTGATTTGATTAGTTTGTGGTATTCTGACCTCTCATTTTT ATTACAAGAGTTGGAAGATTTGAGTCTGAACTTGAGCACCTGCTTCGGTGAAAGCTTCCTAAAATGCATG TTTTTTCACATTTTTTCTCATGTTCATTTTGTTTTGCTTTTTAGCAAACACTTTTTCTGACAGAATCTAA AAGCATTAGACTTTTCTTGTTTTCCCCTTCTCTCCCCACAATGTAATCTTGAAAACCCAAATGTTAGCTG TGTAAATTACCTCTCCCGTAAACCAAACAAAGTGCAATATTGCATTGAGTTAGCATTGAAATAGTCGGCC TTTGAATTTTTTTCTACTTGTGGTTTAGACATAATAAATATTTCATCTCAGACTGACTTTCTCGACAAAT CAGTTTTGCATTTGGGCCTCTTTTCATCAGTATGTTTAGGGAAAGCACATTTATTGAAACATTAACCAAA ATGAAACATAATTAGGAGGCCGGGAGCGATGGCTCACGCCTGTAATCCCAGCACTTTGGGAGACCAAGGC ATGTGGATTGCTTGAGGTCAGGAGTTCAAGACCATCCTTGCCGACTTGGTGAAATCCTGTTTCTACTGAA AATACAAAAAACTAGCTGGGTGTGGTGACGCGTGCCTGTAATCCCAGCTACTCTGGAGGCTAAAGCAAGA GAATCGCTTGAACCTGGGAGGCAGAGGTTGCAGTGAGTCGAGATCGTGCCACTGCACTCCAGCCTGGGCA ACAGAGACTCCGTCTCAAACAACCAAAAAAACAAAAACAAGCATAATTAGGGTGGTAACGCTTATACATA GGGGCAGGTGGAATAATTGAAGCATTCTGGAGCCAGAAATAATCAACTGATTAAGAATAATCTGGCTGGG TGCGGTGGCTCACGCCTGTAATCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATCGCTTGAACCTGGGAG GTGGAGGTTGCAGTGAGCCGAGATCGCGCCATTGCACTCCAGCCTGGGCTATGGAGCAAGACTCCATCTC AAAAAAAAAAAAAAAAAAAATCCTGTTTCTGCAGAAATATCCCAGGTGTCCTGGGTCAGCAGTGCCCCAT AGATTCCACGGACGTTTACCCTAAGTTTTCCAATGGGAGTTCATACCTCTATACCCAGTGAGAATATTTT CTGAGTAATGGGAATGAGATTGGAGATGTAGGGTAGAGAAGATCCATACAGTCTTTGGGTTAAACTTTTT CCTCTTTGCCTAGGAAAGATTAATGCTAATCTTAACCACAGATTTGTAGTAAGAATGTATCAGTTTTGTC ATTCAGTTCTAGACTCCAGTTTTCTTTATTGTAATACCAATATTTTAGAGTAAATTTTGAAATGAATCAG TACAAAAGATATGTAGTAAGTGGAAAGTTAGTCCGCACCTTATCCTTGGGACTCTTTCCCAGGGACAGCT AGTTACCTACTATTTATCTCTCCTGAGTTACTTCATATGTATGCATGCAAACATGTTATTCTCTGGGTGT TGTTCCTTCCATATATAGCAGCAAATACACCAAACTCTGTATTTTGCTTTTTGTCACTTTATCTTAGAGA ATACTCAATGCAAATACATGTGTATATACCTCATGTTTAAAAAATCTACATAGTAAAATTAGCCAGGCAT GGTAGTGTGTGCCTGTAATCCCAGCTACTCGGGAGGCTGTGGTGGGAGAATCACTTGAACCCTGAGATCA CACCACTGGACTCCAGCCTGGGCCACAGAGCAAGATTCTGTCTCAAAAAACAAAAACAAAAACAAAAAAA CTACAGAGTAGTATTCTAGGCTATGCATATCATAAATTTGATTTCCTAATGATAGGCATAGATGATTTGC CTGGGCGGCAAATTAGCGTTGGCTGTGTCTCAGGAAGAAGCCAACAGGAGGAACCTTATTTTGAGTCAGG TTCCAAAGACAGAAACATTGTCTGACATTTGTTTTTGGGCTTATATGAATAAATCTGTACACATATATTT TTAATGTTTTAATCGTAATATGTATACTATTTGGAAATGTGGCTTTTTAGTTAACAGAGTGCATGTTTTA CCCCATTGCACTTAAACATTAACTTGGGGATAATTAAATGAGTCTGTCACTTGGACAGGCAGGAATTGTA CCCCCCACAAACCCATAAACCGCCAATTTTTTTTTTTTGAGACAGAGCCTCATTCTGTTGCCCAGGCTGG AGTGCAGTGGTGCGATCTGGGCCCACTGTAAGCTCAGCCTCCCGGGTTCATGCCATTCTCCTGCCTCAGC CTCCCAAGTAGCTGGGACTACAGGCGCCCGTCACAATGCCCGGCTAATTTTTTGTATTTTTAGTAGAGTC GGGGTTTCACCATGTTAGCCAGGATGGTCTCTATCTCCTGACCTTGTGATCCGCCCGCTTTGGCCTCCCA AAGTGCTGGAATTACAGGTGTGAGCCACCGCACCTGGCCGGTTTTTTTTTTTTTTTTTGAGATGGAGTCT TGCTCTGTTGCCAGGCTGGAGTGCAATGGCATGATCTCCGCTCACTGCAACCTCCACCTCCCGGGTTCAA GTGATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGACTACAGGCGTGTGCCACCACGCACAGCTAATTTT TGTAATTTTAGTAGAGATGGGGTTTCATTAATAATCATTAATATTAGACAACTGTCAGACTCACAGTGGT GGATACAAACTTTCTCAAATTCTGATTTTTACTCTAAAGCTCAAATTTTATCATTGGCAACAAATATTGT CAGTTGCTTTCCCTGAACAGACAGCTTCCCTTCTTTCATTTTTGAGAAAATATCTGCCAGTATCCCAGTT GGTTTATCAATCATTCTTTCTCTTTTTTTTTTTGAGACGGAGTCTCACTCTGTCACCCAGGCTGGAGTGC AGTGGCATGATCTCGGCTCACTGCAACCTCCACCTCCCAGGTTCCAGCAATTCTCCTGCCTCAGCCTCCC GAGTAGCTGGGATTACAGGGGCTAGCAGCCACACCTGGCTAATTTTTGCATTTTTAGTAGAGACAGGGTT TTACCATGTTGGCCAGGCTGATCTTGAACTCCTGACCTCATGATATGCCCACCTTGGCCTCCCAAAGTGC TGGGATTACAGGTGTGAGCCATTGCGCCCGGCTCTATTATTTCTTTTCTTTCTTTCTTTTTCTTTTTTTT TTTTGAGATGGAGTTTCGCTCTTGTTGCCCAGGCTGGAGTGCAATGGCGCGATCTCGGCTCACCACAACC TCCGCCTCCCGAATTCAAGTGATTCTCTTGCCTAAGCCTCCCGAGTAGCTGGGATTACAGGCATGTGCCA CCACACCCGTCTAGTTTTGTATTTTTATTAGAGATGGGGGTTTCTCCATGTTGGTCAGGCTGGTCTCGAA CTCCCAACCTCAGGAGATCTGCCTGCCTCAGCCTCCCAAAGTACTGGGATTACAGTTTTGAGCCACCTGA CCCGGTTTGCTTATTATTTCTTTTAAATTTAAAAAATAATAAATAAAGGGGCCATGAGAGCGAAGAGTTT GAGAAAGGTTGGTCTAAAGGTTTTAACATAAGAATCCCTGGGTTATTTGCTTAAAAAGAAGAAAGAATCT ATGGATCTGCCTGAGAGGGTCTGATGTAGTTTATCTGGGGTCATCCTCACAGGCATAGCAGATATTCTGA TTCAGATGGTCCTTGGTCCTTAGTTTGAGAAATGTGGCTTTACAAGGCCCATAGAATATAAAGTCTTCTT TGGATTAGTGAAGTCATGTCCACAGGGTTTAGAAAATGTTTTTGTTTTAGAGATAAAGGTAAGTGGAAGA GTAGACATGTAGTGAATGAGGGAAAATGTTTTAGAGATTTCTTTTTATTCTGTTTACTCTTCTTGGTATG CACGTACCTGAATATTAAGGATATTTTATGAAGTCATGACATTACCAGATTAATGTTGGTTTTGTTTTAA GGTACTTTCTGACTGCTGGGGTTAATTCCTACAGACGATTCTGGTAAAGAATAGCCTTTAAGTTTTAAAA GTGTTGACTTATTTCAGATGTCTTAATAAAGTTAACTTCCAGTTATTACATGTAACGTATATAAAGCTCT CATTTTCCTTTATTCTCGTTAATTGTTTGCATAACAAATTCAAAGGGAAATTTGCTTGGCAGAGATCAGA TAGCAGAGATGAGATTTAAAAACAGGTAATTTGGCTACTAGCCTGGGAGTTTGAAGATTCCAAGTTTGCA TCCATGTGTAGTCACTTAACATTTCTGTCCTTATCTGTAAATGGGAATAACACCTACTTGATAGGGTTGT TACATTATCTTGGCCACCTCAGGTTCTCTTTGGCTGAGTGATTGACTGGAAAACGCAATGTGAATTCATG CTTCAGACTGGGTTCTTTTTTTTTTTTTTTTTTGAGATGGAGTTTCACTCTTATTGCCCAGGCTGGAGTG CAATGGCACGATCTCAGCTCACTGCAACCTCTGCCTCCCAGGTTCAAGCGATTCTCCTGCCTCAGGCTCC CGAGTAGCTGGGATTACAGGCATGCACCACCATGCCTGGCTAATTTTTTTGTATTTTTAGTAGAGACGGG GTTTCACTGTGTTGGTCAGACTGGTTTCAAACTCCTGACCTCAGGTGATCCACCTGCTTCAGTCTCCCAA AGTGCTGGGATTACAGGCATGAGCCACCGCACCCAGCCCAGGCTAGGTTCTATATGGGTGTGCTTTTTAG AATTTAGATCATGGGCTATCCCCAACACAAACTGGATAATGTTTCTTTCTAGATTCTCTCTAAGCGTGTA TTCTCTTTCTTTCCTAGGCACAGCCACCACTTCACTTACATTGTGGGATTATAATTTCATGAGTAGTGGA ATTTCCTTAACCTTCTCTTGTGTGGGAGCTGAAGGACAAAATGAGATATTCTCTGAAGAGTGGTTACATC ATGCAAAACTATGATGTGTAATGAGGTCACTTAGTTTTCTAAGTACATTATACATTTTGATAAGATTTTC ATAGAAAAGCTTGTCTCCTTGGGGAGATCACTCATCTTCCATCTTGACTATTATTTAAACTTTATGGGTC AGATTTATCTTTTTAAAAACTTAACCATAAAGCTCAATTAATTTTTTTTTTTTTTTTTTGAGACGGAGTC TCGCTCTGTTGCCCAGGCTGGAGTGTAGTGGCGCGATCTCGGCTCACTGCAAGCTCTGCCTCCCAGGTTC ATGCCATTCTCCTGCCTCAGCCTCCTGACTAGATGGGACTACAGGCGCCCGCCACGATGCCCGGCTAATT TTTTGTATTTTTAGTAGAGACGGGGTTTCACCGTGTTAGGATGGTCTCGATCTCCTGACCTCGTGATCCA CCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAAGCGTGAGCCACCGCGCCCGGCTCAATTAATATATTT TAAAAATTAATAGACTTTATTATTTTTATTTTATTTTATTTTTGAGGCAGAGTCTCGCTCTGTCACCCAG GCTGAGTGCAGTGGTGTGATCTTGGCTCACTGCAAACTCCACCTCCCGGGCTCAAGTGATTCTCCTGCCT CAGCCTCCTAAGTAGCTAGGATTACAGGTGCCTGCCACCATACCCGGCTAGTTTTTGTAATTTTAGTAGA TACGTGTTTTCTTTCTTTTCTTTTCTTTTTTTTGAGATGGAGTTTCACTCTTTTTGCCCAGGCTGGAGTG CAATGGCATGATCTCGGCTCACTGCAACCTCCGCCTCCCAGGTTCAAGTGATTCTCCTGCCTCAGCCTCC CAAGTAGCTGAGATTATAGTTGTCTGCCACCACGCCTGGCTAATTTTTTGTATGTTTGATAGAGACAGGG TTTCACTATGTTAGCCAGGATGTCTCGATCTCTTGACCTCGTGATCCGCCTGCCTTGGCCTCCCAAAGTG CTGGGATTACAGGCGTGAGCCACTGCGGCCAGTCTAGACTTTATTTTTTAAAGCAGTGTTAGTTTTACAG AAAAATTATGTGGAAAGTACAGAGAGTTTCCATATACCCCTTACTTTCTCCCACAACTTCTATTATTAAC ATCTTGCATTAGTATAGTACGTCCCTTACAACTAATGAACCAACTCGATACATTATTATTAACCAAATTC CTGAGTTTATTTTATTTCTATTTTTATTTTATTATTATTATTTTTTAGAGGTAGGGTCTCACTGTGTTGT CCAGGCCAGGTTGCAGTGGCATCATCATAGCTTGCTATAGCCTGAAACTCCTGGGCTCAAGCAATCCTCC TGCCTCAGTCTCCCAAAGTGTTGGAATTACAGGTGTGAGCCACTCTGTCCAGCCTGAAGTCCATAGTTTA CATTACATTTCACTCTGTTGAGCATTCTATGGATTTTGACAAATGTGTGATGATGTATATTTGCCAGTAC ACAATTATATAAAATAGTTTTACTGCCCTAGAAACCCCCTGTGCTCCACCTATTCATTCCTCTGCTGAAC CACTGGCAACCACTGATCTTTTATAATATCTCCATAGTTTTGTCTTTTCCAGAATGTCATATAGTTGGAC ATACAGTGTGTAGCCTTTTCAGATTGGCTTCTTTCAGTAAATGATATGCATTTCAGGTTTCTTCATGTTT TTTTGTGGCTTGATAGGTTGTTTCTTTTCATTGGTGAGTAATACTCTATTGTATGGATATACCACATGTT GTTTATCAAACATTCACCTGAAGGATAGACATCTTGGTTGCTTCCAAGTTTGAGCAGTTATGAATAAAGC TGCTATAAACATTCCAGTGCAGGACTTTTCACCTCCTCTGGATAAATATCAAGGAGTGCAATTGCTAGAT CATATGGTAAGAGTATGTTTAGTTTTGTAAGAAGCTATCAAACTATATTCAAAGTGACTGTACCATTATA CATTCCCATCAGCAGTGAGTGAGAGTTCCTGTTACTCCACATCTTCACCAGCATTTAGTGGTGTCAGTGT TTTGGATTTTAGCCATTTTAATGGGTGTATAATGGTATACCTATTAAAATTGGTTTTTTTTGGAGACAGA GTTTCACAGTTTCACTCTTGTTGCCCTGGCTGGAGTGCAATGGCGCAATCTCGGCTCACTGCAGCCTCCG CCTCCCAGTTTCAAGTGATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGATTACAGGTGCACGCCACCAT GTTCTGCTAATTTTTTTGTATTTTAGTAGAGATGGGGTTTCACTGTGTTACCCAGGCTGGTCTTGAACTC CTGAGCTCAGGTAATCCACCTGCCTCAGCTTCCCAAAGTGTTAGGATTACAGGCATGAGCCACCGCACCT GGCCTCAATTTTTTTTTTTTTTTTTTTGAGACAGAGTTTTGCTCCTGTTGACCAGGCTGGAGTGCAGTGG CACAATCTCGGCTCACTGCAACCTCCGCCTCCTGAGTTCAAGCGATTCTCCTGCCACAGCCTCCTGAGTA GCTGGGATTATAGGCGCCCGCCACTACGCCTGGCTAATTTTTTTTTTTTTTTTAATTAGAGACGAGGTTT CTCCATGTTGGTCAGGCTGGTCTTGAACTCCCCGTTCTCAGGTGATCCGCCTGCCTCAGCCTCCCAAAGT GCTGAGATTACAGGTGTGAGCCACCGTGCCCCGCCTGTTTTGGCTTTTACTGTGAAGACGTGTTAGCCGC TGTGATGACTAGCAAGTGTGGCCCTCCACCCAGTCGCTCTGGGCTCCCAGCTCCTGCATCCTGCTGCAAA CTTGACATCTTCCCTCAAGTAACTTGTAGTTGTCTCCTGTCTACTTGCCCAAAATATAACTCTTAAACTT TTCTCTCTGCAAGTTTGTGCCTCTCTCCCTGTCTGACTTCCCCATCTAAATAAATGGTAGACCACCATCT ACTCCTTTGTGCAAGCCAGAAATCTAGGAATCATCCTTAAATTCCCTGTTCTGTCTTATCTCTGCTTTCA TTCAAAGCATCAGCAAATCCTGTTGGTTCTACCTCTGAAGTTTTCTCAAATACTGTTACTTGACTCATCC TGACTTTTGTTTCTGCTTTATGTTAGGCTAAATGCCCTGAAAACTCTTTTGTACAAAACACCTAGAAATA CTGGATAAACTGGGCTTAACAGGGAGGCCCGGTGTGGTGGCTCACGCCTGTAATCCCAGAACTTTGGGAG GCCAAGGTGGGTGGATCACCTGAGGTCAGGAGTTCCAGACCAGCCTGGCCAATACGTAGTGAAACCCCAC CTCTACTAAAAAAAAAAAAAAAAATTAGCTGGGTGTTGTGGTGCACACCTGTAGGTGGTGCATGCTTGAA CTTGGGAGGCGGAGGTTGCAGCGAGCTGAGATCGCGCCACTGCACTTCAGCCTGGGTGACAGAGCAGGAT TCTGTCTCTTAAAAAAAAAAACAAAAAAAGAAAAACAGGAAAATCTTCAGAAGCAAAAACCAAACAATCT CACCAAAGAAATGAGAAGATGGCTGGGCGCGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGA GGCGGGCAGATCACCCGAGATGGGCAGATCACCCGAGGTCAGGAATTCGAGACCAGCCTGGCCAATATGG TGAAACCCCGTCTCTGCTAAAAATACAAAAATTAGCCAGGTGTGGTGGCAGGCGCCTGTAATCCCAGCTA CTCAGGAGGCTGAGGCAGGAGAATCGCTTGAACCTGGGAGGCGGAGGTTGCAGTGAGCCGAGATCATGCC ACTGTACTCTAGCCTGGACGACAGAGCAAGACTCTGTCTCAAAAAAAAAAAAGGCTGGGTGTGGTGGCTC ATGCCTATAATCCTAGCACTTTGGGAGGCCAAGGTGGGCGGATCACTTGAGGCCAGGTGAACATGGCGAA ACCCCATCTCTACTAAAAATACTAAAGTTAGCTGGGCATGGTGGTGGGTGCCTGTAATCCCAGCTACTCG GGAGGCGAGGCAGGAGAATCGCTTGAACCAGGAGGTGGAGGTTACAGTGAACCGAGATCTCGCCACCGCA CTCTAGTCTGGGCGACAGAGCAAGACTCCGTCTCAAAAAACAACAACAAAAAACCAACACATGGCCAAAG TGCAGTGACTTACATCTGTATAATCCCAATGTTTTGGGAGGCTGAGGCAGGAGGATCGCTTGAGTCCAGG AATTTGAGACCAGCCTGGGCAACATAGACCTCATCACCAAAAAAAAAATATTTTTTAATTAGCTGGGTTT GGCAGCATGTACCTGTAGTCCTAGCTACTCAGGAGGCTGAGGTGGGAGGATCACTTAGGCCCAGGAGTTT GATAGTTCGAGGTTATAGTGAGCTATGATCCTGCCACTGCACTCCAGCCTGGGCCACAGAGTGAGACCCT GTCTCTTAGAAACAAAACAAAACAAAAAAAAGAAACTGAATTAAAAACAACAAGAACAAAAATGCTGCTT TTTGTTATTGAGTTGTAGCCCAAGTTTCTTGAGGGTAAAGCATTGAAAAGCAGGCAGTAATAGATTTGCT GTTTAAAGAGATTTACTTGCAGCACTATTCACAATAGCAAAGACATGGAATCAACCTAAATGCCCATCAG TGACAAATTGGATAAAGAAAATGTGGTACATACACTGTGGAATACTATGCAGCCATAAAAAACAACGAGA TCATGTTTTTGTTTGTTTGTTTGTTTGTTTGTTTTTGAGATGGAGTCTTGCTCTATTGCCCAGGCTGGAA TGCAGGTGGCACGATTTCAGCTCACTGCAACCTCCGCCTCCCAGGTTCAAGCAATTCTCTGCCTCAGCCT CCCGAGTAGCTGGGATTACAGGTGCCCTCCACCATGCCTGGCTAATTTTTGTATTTCTAGTAGAGATGGG GTTTCACCGTGTTGGGCAGGCTGTTCTTGAACTCCTGACCTCATGATCCTCCCACCTCGGCCTCCCAAAG TGCCGGGATTACGTGTGAGCCACCGTGCTCGGCTGAGATCATGTTTTTGCAGGAACATGGATGGAGCTGG AGGCTATTATCCTTAGCAAAGTAATGCAGGAACAGAAAACCGAAGACCACGTGTTCTCACTTATAAGTGG GAGCTAAATGATAAGGACTTGTGAACACAAAGAAGGAAACCACAGATACTGGGGTTTACTTGAGGGTGGA GAGTGGGAGGAGGGAGAGGAACAGAAAAGATAACTATTGGGTATTGGGCTTAATACTTAATATTTTATCA AAATAAGCTGTACAACAAACCCCTCTGACATGAGTTTACCTATATAACAAACTTGCACGTGTAACCCCAA ACCTAAAATAAAAGTTAAAAAAAAAAAAAAAGGCTGGTTGCATTGGGAGGCTGAGGCAGGCAGAGCACTT GAGGCCAGGAATTCGAGACCAGCTTGGCTAACGTGGAGAAACCCTGTCTCTACTAAAAATTCAAAAATTA GCCAGGTGTGGTGGTGCATGCCTGCAGTCCCAGCTACCAGGGAGGCTGAGGCAGGAGAATTGCTTGAACT CAGGAGGCAGAGGTTGCAGTGAGCTGAGATTGCACCACTGCATTCCAGCCTGGGCGACAGGGCGAGACCT TGTCTCAAAAAACAAAACAAAACAAAACAAAAACCTGTCACTTTGGGAATATCTCAAACCTAGTCATCCA AGTGGTTGTACGATTTTAGTGTCTGCATATCAATATTTAGTGTGATCTACTTTCTTAGATTCTCAAATAC TGCCAATGGGCACATGTCATGAAATAATGTCTTTTAGAGGACAAGAGAGTGCTAAAGTCTCATTATTGCA GTTTAAGAAAAACAATTCTGTAACAGTTTAACTTTATAGGAAATGCCTTTTGTTTATTTATTTTTTTTCT TTTGAGGCTTAGATTTTTATTTTTATGTTTTTAGAGATGGGGTCTTCCTATGTTACCCAGGCTGGCCTTG AATTCCTGGGCTCAAGTGATCTTCCTGCTTCAGCCTCCTGAGTAGCTGGGACTAGACGTCCACTACTGCT CCTGGCTGGAAGTTTAGATTTTAATTTAAACTCTTCTATTGGGAAACTTTGTATGTTTGCTTTACCACTT AACATTTGCATGCATTATTGTACCTATTGTCTCCTACTTAAGGAAGGGCAGTTTATGCTGTTATATGAAG TGAATTAACCTCCTATGGTACTTCAGTTTTCTCTATGCTAAAAGTGTGTTCTAGATTTTTGAAAAACTTA CTTAATTTTCATTCATTTATTCAAATATTTGAGCATTCTGTAGTTGCTGGGGAAATAGCAGTGAACTGAA GAATGTCTTTGTTCTTATGGGGCTTAAGTTCCTAGTTGATCATATTGGAAGGAGATACATGAAAAAAGAA ATATATGAACAATGGAGGGCGATGAGTACTGTAAAGGAGAATTCAGCAGGGGAGATGTTGCTGTTTTAGA TAGAGGGGTGTCAAGAGACATTGTGCAGAGACCTGAACGAAGTGAGGGAGCAAGCCATGGAGATATCTAG GGAAAGAGCCTATCAGGTGGAGAGAAGAGTCCTAGGGCAGAAACGGGCAAGGTGTGTTCCAGGAGCAGAG AGGGGACAGCTGTGAGCAAGGGGAGAGTTGTAGGGAAGGAGGCAAAGAGAGACATCTGGGGCAAAATGGA TTGACTGGTGGGCCGTGGTAGGACTTTGGATTTTTTCCTGAGTGGGTTTTGAGCAGGGGAATGAAATGAT CTGACTCTGGTTTTTTTTTTTTTTGGAGACAAAATCTTGCTCTGTTGCCGAGGCTGAAGTGCAGTGGCGC AATCTCGGCTCATTGCAACATCTACTTCCTGGGTTCAAGCTATGCTCCTGCCTCAGCCTCCCGAGTAGCT AGGATTACAGGCTTGGGCCACCATGCCGGCGAATTTCTGTTTTTATTTTTATTTTTTATTTATTTTTATG TTTATGTTTTTTGAGACGGAGTCTCGCTGTGTCACCCAGGCTGGAGTGCAGTGGCGCGATCTCAGCTCAC TGCAACCTCTGCCTCCCCGGTTCAAGCAACTTCTCCTGCCTCAGCCTCCCGAGTAGCTGAGATTACAGGC GCCTGCCACTACACCTGGCTAATTTTTGTATTTTTAGTAGAAACGGGATTTCACCTTGTTGGCCAGGCTG GTCTCGAACTCCTGACCTTAATTTATCTGCTCGCCTTGGCCTCCCAAAGTGCTGGGATGACAGGTTTGAG CCACCGTGCCAGCCAGGACTCTTATTTTGAAAGGATCTGTAATGTGGAGAATAGAAGGTAGAGGGACAAG GATGAAAGCATCCAGGCCAGTTAGCCTAGTCCAGCTATCTAGGTAAGAGATGCTGGTGGCCTGGATTAAG GCTGCGTCAGTGGGAGGTTGTGAGAAAGGCTCACCTTCCTTTTTTTTTTTTTTTTTTTTTTTTGAGACAG GATCTTACTCTGTCTCCCAGGCTGGAGTGCAGTGGTGCAATCTCAGCTTACTACAACCTCCGCCTCCTGG GCTCAAGTGATACCCCCACCTCAGCCTCCCAAGTAGCTGGGATCACAGGCTTGCGCCACTATATCCGGCT AATTTTTGTATATTTCGTAGAGACAGGGTTTTGCCATGTTGCCTAGGCTGGTCTCAAACTCCTGAGCTCA AGTGATCCACCCGCCTCAGCCTCCTAAAGTGCTGGGATTATAGGCCTGAGCCATTGTGCCCGGTCACTTC CAGATTTTGAAGACAGAGCCAACAGGATTTGTTAATGGATTAGGTGTGGCAGGAGGAGGGGGAGGAAGAG AGAGAGAGACTGGAGTTGAAGTTAAGGCTCATTTCAAGGTTTTTAGCCTCAACATGTGCAGGAATGGAGT TGTCACTTGCTAGAATGGGGGAGACTGGAGGAGAAGCCGGCTGGGAGAGGTTTTTAATGAAGGGGTTGGC TTTGGATACATTAAGTTTGACATGCATTTTAGACATCCAGGTGGAGATATTGAAGAGGCAGTTGGCTATA AGTGTCTGATGTTCATATTAGCGGATGGGGCTAGAGACATAAATTTGAGAATTGTCAGTGTATAAACGTT GTTTTGAAAGAAAGTGGGGCTGAATAATTTAGAAAGGAGTGCATAGAGAAAATAAGTTTACTATTAAAAT AGCTTTAACAGGCCGGGCACGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCTGGGGTGGGCAGA TCAAAAGGTCAGGAGTTTGAGACCAGCCTGGCCAATATGGTGAAACCCTGTCTCTACTGAAAATACAAAA ATTAGCCAGGCGTTGTACCGGGCACCTGTAGTCCCAGCTACTTGGGAGGTTGAGGCAGGAGAATCACTTC AACCCGGGAGGTGGAGGTTGCAGTGAGCCAAGATCACGCCACTGCACTCCATCCTGGGCAACAGAGCAAG ACTCCGTCTCAAAAAAAAAAACAAAAAAAAACAAAAAAAAAAAACTTTAACAGCAAAGCCTCTTCCTTTA AAATTATGAATTTTTTTCTTATGGAAGTTGGACTCTTTCATTATTAAGTCTACATTCAATCACTATGTTA GTAAAAATGTTGTTCTAGTTGCCGAATGCAATAAACCAGCTCAGACTTAGTGGCCTAAAGCAGCAATCAT TTGACTATGTTCGAAGATGCCGTGGGCAGGAATTTAGATAACAGCAGGGATGGCTTGTCTTTGCTCTGCG ATGTCTGAGGTCTCACTGAGAAAACTCAAGCGGCTGGGGGTAATAATCATCTGGAATTTTCTTTACTCCT GTATCTGATGTCTGGGCTGCGATGACTCAAAGGCTGATTTCAGCTGAGACTGTAGACCACGTGCCTACTT GTGGCCTCCCCTTTTGCCTTGGGTTTCTCACAGAATGTGGCTGGTTCTGGAGAATGAGACTTCCAATGAA ATCAGGTGGAAATGACATCTCGCCGCTTTCAGCATGCTCTATTGGTTGGAACAGTTATGGACTTAGCTAG ATTCAAAGGAAGGGAACAAAGACCCCCTCCTCTCAGAGAGTGGGGCATAATGAGAGAATTTAGGGCCATG TTATCCAACCACCACAAATGCCTTCTGAATTTGAGGTTCTGCCTCAAAAGTTCATAGTTCCTTTGACTGA AGGACTTCTATATATCCAAGCATCGTCAGCCCCAGGTATATTGTTCCATGTAAGTGACCAGGACTACCTT AGTATTTCGTATAGGGAAAGTGACCTGAATAAATTTGAGAAAAGAATCTTCCTTCTCTCCAGTAAGCACT GAGGTAAGCATTGAGCCATATTATAGGTTTATGACTTTGAGACTCAGAAATTTAAATTCTTGGCCAGGCG CAGTGGCTCACGCCTGTAACCCCAACACTTTGGGAGGCCAAGGCAGGCAGATCACTTGAGGTCAGGAGTT TGAGACCAACCTGGCCAAAATGGTGAAACTCCATCTCTACGAAAAATACAAAAATTAGCCAGGTGTGGTG GCGGGCACCTGTAATCCCAGCTACTTGGGAGGCTGAGGTAAGAGAATGGCTTAAGTTCTCTTTATCTGCT TTATTTCAGTTGCCTCTCTTAGATGAATATTAATGACTTACATAGCATTTTAGATCAGTGGATGTTTTTG TGATTCTTTTATTTGAGCTTTGGCCAAAGATAACAGTACCCACAGGTTTTTTCCAGCTACTCGCTCTTCT CCCTTCAGTGGCCCTCGAGCCTGGAAAATCTGACATGACAATGTGCTTGCTCAACCTACCACTGTTTTTC TTTTGAAAAGTTTGGCAGCCTGTTTCTGACTCCTATGAAGGTGAATTCCTCAGCATTCACAGTTTATTAG AAAAATACTTTGCTTCTCTCCAAACTCGAAATTCAAGATAACCAAACCTATATATAGGCTGATCTTTCAG GATGCAGTTGTCATGTTGATGCCATGCTTTTCAGTATCGTGGCCATCATCTGTTCAGTAGGGGAGGTGTA CTTCTGTAATGGGAGGTGGTGGTTATGTGTGTGTGCAAGTGTTTATTTGGTGTCTTAAGTTAGCCTGTGG GAAGTTCTAAATCAGGATGGTACGTGGTTGCCAGCAGAGAGCTGCTCCTCAAGTGAAGGAGGTAGAATCA AAGCCAATAGGAAAGAGCCTCAGATGCTTATATATGTACCGTGGGGATTCAGAGTGAAAGCAGTCATTGG ACTAGGGGTGGGGTTAGGGAGAGCCTGTCTGACAGACACAAGAAAGGGATGGATAACGCCACCCAGAGAA AAAAGCATTTTAGGCAAGAACAAATATGAAAAAGGAACAAAGTCTGTGGGTGGGGGGCAAGGAGGAGATA AGTTGACTTGAAGGAAGACAACACTTATGAAAGTCACCTGGAGGCTGGGTGCCATGGCTCATGCCTATAA TCGCAGCACTTTGGGAGGCCGAGGTAGGAGGACAACTTGAGCCCAGGAGTTCGAGACCATCCTGGGCAAC ATGGTGAGACTGAGTCTCTACCAAAAAAAAAAAAAAAAGAAAATTATCCAGACATGGTGGCATGTGCCTG TAATCCCAGTTACTCAGGAGGCTGAGGTGGGAGGGTTGCTTGAGCCCAGGAGGTTGAGGCTGCAGTGAGC TGTGATCGTATTATTGCACTCCAGCCTGGGTAACAGAGCAAGACCCTGTCTCAAAAAATGAAAGTCATCT GTAGGCTGGAGAGAGGAACTGGAAGGGGCTAAAGTTGGCTGAGTAGTTACAGAGCCTGAGATAAGGGTAA AGATTTTGCATTGGACAATGAGATGTTAGTGTGTGTTTTTGAGCTGGGGAGTGCTGTGATTTTACTCTTA TTGAAGAATCACTGAAGGATTATTCTTGAATCAGTGATTCTTGATCATTCTTGAATTTTTCAAACAGCAA AACTGGAAGAGTTGGCCTATTCCTCAGAATATTTTCTAATTGGGCGCAGTGTCCTCACTTGGGAGAACCT GGCTACACACTTTAGTTGTAATTCACTCCAGTCGTTCATTCATTCAATACCTATTTTTTCAGCACCTATT ATGAGCCAGACACTATGCTGGATGCCAGGGTTCAGGGTAGGACACGCTAGTGAGCAAAAGCCAAGACTCT TCTTGTCTTCATGGGGCTTTCAGTCCAGCATAGTGGTTATGAGTCCAAGTTAATGGAGTCACAGTACTTG GGTGCAAGTCATGGTGATGGTGATAGAAGGAAGGCATGTGTGAGGGCCAGTGGCAGGCAGGAGCCTGGTG TTTTTGAGGACCTGAAGAAGGAGCAGAGTGAGTGCCAGGAACTTAGCCACCAGCTGGTACCAGCCATACG AGAGGGGCAGAGCCAGCCAGGATGTCGGTCATGCTAGTAATGAGTACAAACACTTACATGCTGCACGCTA TTGGGCTCCTGAGTGCTACGTGTTCATTAGCTCGATGAATTTGTACAGCAACCCTGTGAGGTAAGCACTG TTCTCTCCCCTTTCTATAGATGAGGAAATTAAGGCACAAAGAGGATAAATAACTGGCACCAGCTACACGC TAAGTGATCGAAGTGGTGGAACCAGGATTCAAATCCATGCTATTCTGCCTTAAGATAACAAATCTTGTTT TTTAGCCTAAGAACAGAGCAGTCATCAGGAGGGTTTTAAGTAGGGGTGTGGCAAGATCAAGTTTGTGTCT TGAAAAGGTCTCTCTACCCACAGTGTGGAAAATGGCCTGGAGGCAAGCACACAGATGTTGGGAGACAGTT AACAGCTCTTGCCATGGCCCCCTATGCATTTTGGCTCTGATGTTTCTGCCTGATTTTTCTCTTGCCTCTG CCTCTTTTCCTGAGGGGATGGCAGGTTTTACCATTCAGCTGGAGTACAAACCCTGAACCCTTTTTGGTTA AATATCTACTTGCTTTTCCTACAGTATTATTTTGAGTTGCTGTGGCTGTAATGTCTTGAGGGAATCGAGC TTGACAGTAATTTATAGAACAAACAGTTTTTAGAGACTGTGTGGCCCAATTGCCCTCTCAATGTTGGCAC TCCTGCCATGACATTTACCATGCTGAGCATGTGACCGCCATCTGAATACCAAATGCCACAGGAACCTGGG AGGTTGTCACTTACTCCTCCCTTTCTCTGAGTCACCTTTGCCCTTCAGTCAGTCACCAAGTCCCATCACA TGTAGCTCTGTAATGTCACAGAAGATGGATGTCTGCCTCAAAACACTTACAATGCTGCTACCTAAATTGG GCAGCCACGACCTCCCACCAGGATTATTGCAGCCTGAGGGATCTTTTTGAAATGTAAATCAAACTATCAC TTGTCTGTTTAAAGCTTTTCAAAGACTTACCCCATTGCCCTTGGAAGAAAGTGCAGATATCTTGACAGGA GAGCCTTCTCCAGCCTCCTCTTCTGCCGTGGTCTCCTTGTACAGTCTCTACAGTGTACTGCTTCATTAGA ACCCTGGAGATTATTATTTGCTAGTTCTGGGCTAAGAACTGGCACCTGGCTTTGTAGAGCTCCTCAGGAG ATTCTGAGGCGTATTCAGAGTTGAGCCCTGATCTCTGCTCTGATTTCGAGGTTCTCGTTATATTTATTAA TGATCACGAAAAAATTTATTATTATTCTTTGGCCTCACTTTAGCATCATCTGAGGAATTTTTTTTTTTTT TTGACAGAGTTTTGCTCTTGTTGCCCAGGCTGGAGTGCAATGGCGTGATCTCAGCTCACTGCAACCTCCG CCTCCCGGGTTCAAGAGATTCTCCTGCCTCAGCCTCCCAAGTAGCTGAAATTACAGGCATCCACCACCAT GCCTGCTAATGTTTTTGTATTTTTTAGTAGAGGTGGGCTTTCACAGTGTTGGTCAGGCTGGTTTTGAACT CCTGACGTCAGCTGATCCACCCACCTAGGCCCCCCAGAGTGCTGGGATTACAGGTGTGAGCCACCGTGCC CAGCCGTAGCTTTCGAAATTTGAAACCTGGTCCCACTGTCAGAGGTTCCAATTTGGCACTGGTTTGGTTC CCAGGCATCTTTCTTGCTGTATATATTTTTTAGTGTCAGCCAGGGTGGAGACCTCTGTATTACTTCATGG GGAAGAATTTGGGAGAAGATGTTGTGAGGAGACAGGTTCTAGTCCTAGAGTGATTTATCCTTTCTCGTAC AGATTTCCAGGTATTTGAGGGGCCACTCTTCTGTAATTCATGTTTTTCTCTCCTAACCTCACTCCTGTTG CCTGCATCTTCTTGCTGAGCAAAATATTCAAGGTCTTCAACTCCTCACACCCTGGTTGTCCCTCCCTGGA TGTGTTTGGTTGTTTTAGTGTTCCATTTCAATTTTGATACACAGAATTAGAATAGCATCCAGATGTGGGT CTGTTACAGCTAGACTACTAGATCCTTCAAAATCCAAGTACTAGTATGTCTATTAAAATACCATAAGATC ACATTGGCTAGTTACAATGGTTGGTTTGTGGGTTACTTAAAAATCAACTAAAATTCTTTTTTTTTTTTTG AGATGGAGTTTTGCTCTTGTTGCCTAGGCTGGAATGCAATGACACAATCTTGGCTCACTGCCACCTCTGC CTCCCAGGTTCAAGCAATTCCCCTGCCTTAGCCTCCTGAGTAGCTGGGATTACAGGCATGTGCCACCATG GCCAGCTAATTCTGTATTTTTAGTAGAGATGAGGTTTTTCCATGTTGGTCAGGCTGGTCTCGAACTCCCG ACCTCAGGTGATCCACCTGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACTGAGCCTGGC CAAAATTCCCACTTTCTAATACTCCTGTAGTAGCTGGGTACGGTGGGTCACATCTGTAATCCCAGCACTT TTGGAGGCTGAGGCTGGAGGATCGCTTGAGCCTAGGAGTTCGAGACCAGCCTGGGCAAGATGGCCAGACG CCATCTCTAATTTAAAAAAAAGAAAAAACAAGACTCCTATAGTGGTGAAGAACAGACATTCCGAAAACAG ACTGTGCGTTATGATTCCAGCTCCATGCCTTTACTACCTGTGTTGTGACTTTGGATAAATCACTTAAAAA TCTTTTTTTTTTTTTTTTTTTTTTGAGACGGAGTCTTGCTCTGCCGCCCAGGCTGGAGTGCAGTGGCGCG ATCTCGGCTCACTGCAAGCTCTGCCTCCCAGGTTCACACCATTCTCCTGCCTCAGCCTCCCAAGTAGCTG GGACTGCAGGTGCCCGCCACTACACCTGGCTAATTTTTTGTATTTTTAGTAGAGACGGGGTTTCACCGTG TTAGCCAGGATGGTCTCGATCTCCTGTCCTCGTGATCCACCCGCCTCAGCCTCTCAAAGTGTTGGGATTA CAGGCGTGAGCCACCGCACCCGGCCAAATCACTTAAAATTCTGTGCCTCAGTTTCTCCTCTGTAAAGTGG GATAAAAATAGTACCTATCTGATAGGGTTGTTACAATTATGAAATGAGCAAATAAGTATGTCAAGTGTTT AAAACAGCGCCTGGCTTCTTGTAAAAAGTGCTATATAAATCATAGCTATAATCATTACTTATTTCGACTG CTCTTTAACCAAGGTTCTTATTTTTCATCTTTTTCTTTTGTTTTGAATATCACTTAGTGTTTTCACCTTT TACTCTTTTTAGGACCTAGAGCCATCCTAGGTGAAATACGTATGGAGATATTTGATCAGGTCACCACCCA GCTCTCCTGACCTCCCTTCTCTCCTTAAATTAACATGCCAAATCACAGCATCACTGACTCCTTCCCTCCC GATATGATAAGAGTGTGCATTGAAATGCATGTATTTTACTTAGCAGGGAAAGCTGATTAGTGATTATCAC ACTTAACCCCTAGTGAATCTGATGGATTAACCTGCTTTCCAGGACACTAAGGAAATGGGTTTAAGATAAG AAATATCTGGCTGGGTGCGGTGGCTTTACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGTGGGCAGAT CACGAGGTCAGGTGATTGAGATCATCCTGGCTAACACGATGAAACCCCCTCTTTACTAAAAATACAAAAA ATTAGCCGGGTGTGGTGGCGGGCGCCTGGAGTCCCAGCTACTCGGGAGGCTGAGGCAAGAGAATGGTGTG AACCCAGGAGGCAGAGCTTGCAGTGAGCTGAGATTGTGCCCACCGCATTCCAGCCTGGGCAACAGAGTGA GACTACATCTCAAAAAAAAAAAAAAAAAAAGTAAGAAATGTCCATGAAAGGGAGACCCTGGGGGAAAGGA ACAATAACTGCAGCTCTGAGGATCTGGCACCAGCAGCACCAGCACAGAGGGATGCTGTACAACCATTATT GATTTTAACTTTACAACAGTTCTTCAAAGGAGAGAGAGTTCCCTGTTTTACTGAAGAGAAAGCCCATTTG GTAGTGAAATACCATTCCCAAAGACAAATAGCTAATAAATGTCAGGCAGGGTTTTGCACCCAGGCCCATC CAGCTCCCGTCTCTACTGTCCTTTCCCCCACACCACACTGATACAGAGGAATGTGTCTGGTTGGGGAAGT GGAAGTGTTCCCAAGTGGGGAGGTCATCTGATGCACAAATTTGGTCTGTTTTGTGGGTTTTCTTGTTTTA GTTTTAGTTTTTGTAGAGCTCAGACCTGTTCTTAGGCAGCTTTAACAATCAACTGTGCACTCAGTAATTG ACAAATCATGTTTGTTACTTTTAATTTAGAGGGAATTAGGTTTGTTAAGCTCTTGCTCCTTCTTTAGAGA TGGGGTCTAGCTCTGTCACCCAGGCTGGAGCGCAGTGGTATGATCACAGCTCACTGCAGTCTCAATCTGC TCAAGTGATCCTCCTGCCTCAGCCTCCATGGGACTACAAGCATGGGCCACCATGCTAGGCTAATTTTAAA AAAATTTTTTTGTAGAGGCAAGGTCTCACGGTGTTGCCCAGGCTGGTCTTGAACTCCTGAGCTCAAGCAA TCCCTCTTCCACCTTGGCCTCTCAAAGTGCTAGAATTATAGGCATGAGCCACCATGCCTGGCCTTTACTT CTTTCATATATTCAAATTTTGTCATATTAGTAGGGAACTATAACTCAAGTTTTCTTATAGATTGATGTTC ATTTTTACAAGCTTGATCGTCATTGGTTTTTAATTTTAAAGCAAATCCTGTTATATGTAATTGAACATTA CAGTAATTATAGTAATTTGTTTCAGATTGGGCACTCAAGTGTTAATATTTTGTCTCTTTAGGAAATCAAA ACTAGATTTATATATAGACTTCTTATTGCAAGTATCTAGTCTTAAATCTTACAAAGGTACTATTTGGACT TAAAACTATGAAATTGTGTGCTTACTATATAAGTGTACTTATTTTGAGTTATGTTTTAAACTTGAAATTC CATTCTTAATGTCTAGAGTAATTATGAATGGTTAAATTATGAATGACTCTAATAGTTTAAAGCTACAGTA TTTATTTATTTATTTATTTAATTTATTTTTTGAGATGGAGTTTCGCTCTTGTCGCCCAGGCTGGAGTGTA GTGGCACCATCTTGGTTCACTGCAACCTCTGCCTCGCGGGTTCAAGTGATTCTCCTGCCTCAGCCTCCCA AGTGGCTGGGATTACAGGTGTATTTCACCATGCCTGGCTAATTTTTGTATTTTTAGTAGAGACAGGCTTT TGCCATGTTAGCCTGGCTGGTCTCGAACTCCTGACCTCAGGTGACCTACCCTCCTCAGCCTCCCAAGGAT TACAAGCATGAGCCACCACACCTGGCCTACAGTATTTTAATGTGGACTCTCTGTCATCCATTATGCTGTT TATCCTGTGGTGAAAATTTTATGAAGATTGAATGTTTTTCTCTAGCGTGAATTGCTTTCTCTTACTTTTC TCATTTTTTTCCTTCCTAATCTACTTGCAGATACTTCAGATTATTTTTAGAACGTGGTATGGTGAGAACA AATAAATTGGGGTTTCCAAATCTTAATAAATTATGTGGCCCTCAGTGGGATTAGCAGGGTTGTATTGAAA ACACCAATAGAAACAAAATAGTTCTTTTATGCGCTTTAAATAAAAATTTCTTTTCAGGCCAGGCGCAGTG GCTCACACCTGTAATCCCAGCACCCTGGGAGGCTGAGGCAGGCAGATCACCTCAGGTCAGGAGTTTAAGA CAAGCCTGGCCAACATGGTGAAGCGCCGTCTCTACTAAAAATACAAAAATTAGCCGGGTATGATGGCGCA TGCCTGTAATCCCAGCTACTCCAGAGGCTGAGGCATGAGAATCACTTGAACTCAGGAGATGGAGGTTGCA GTGAGCTGAGATGGTGCCACTGCACTCTAGCCTGGGCAACAGAGTGAGATTCTGTCTCAAACAACAACAA CAACAATAACAAAACATCTCTTTTCAGGCCAGGTACTGTGGCTCACGCCTGTAATCCCAGCACTTTGGGA GGCCAAAACAGGAGGGTCGCTTGAGACCAGGAGTTTGAGACCAGCTTGGGCAGCTGGTCTCTATTTGAAC AAACAAACAAACAAACACAATACTCTTTTCATAGAAAAATGTTTACTACACAATAAACTTTAAAAGAATA TGCAGCTGTATTAATGCTATGACTCCAATGTAAAAAAAAAAAAATATATATATATATATACACACACACA AACACATTCTGAAATAGATTTAAAGGAATTACATCAACATGTCAATTTTTATTTTTTCGGAGACAGGGTC TCGCTGTGTCACCCAAGCTGGAGTACAGTGGTGCAATCACAGCTCACTGCAGCCTTGACTTCCTGGCCTC AAGTGATCCTCCCCCCTCAGCCTCCCAAAGTGCTGGGGTCACAGACCACCACACCTGGCAACATGTCAGT TTTTGTTCTGCATAGTGGGATGGTGGGATATGGATGTTTTTATCTTTTATTTTCTTTTTTATATTTTTCT AAATTTTCCACATTGAACATTATTTTATAATCTTTCAAACATATCTCTTAAAAGGACTGGTTCCTATAGA ATTCAGTGCAAGAAATCTTCTGTGTTTCTTTATACTTTGGTTGCCTTGATCACTGGGCCTTTCCTGACAG CAAAGAAGAGGTTAGTGTAGGCAGCAGATAAAACACAGGTATGCTCTATTTAAAATGCATGTATTTATAA TAAAAGTATAGGTGGTACCCAAAGGAAAATGTCATGACACATTGCAAAGTGGAACAGAAGTTATCTTTAG ATCACTTTCTGTTCTGGATTATTGTATGAGCCTGATTTTCGTCTCTCTTTCCGCCTTCCCTCACCCTCGT TGTAAATCCACTAGTGCATGGATGTGAAGTACAAGTCTTAACTTTAAAAAGTTTTATGAAGCTGTGTAGT AAATCCCTTTTGTAAGTGGTCTTGACTGCGTTTCTCAATATATCTTTTGGTTTCATTAGATTCAAGTATA TAAATGAGAACTGTAACTTTGGACAGACTTTTTCAGTCATCTTTACGGTAATAAGTTCCCAATTAGACAA TAGTTATTTGTTTTATGACTTGCTGTTGGTAGGTTATCCCCAAGGGACTGAGAAATTCCTGTTTTGAAAA GTCCAAAAAGTCTTTGATGACTTGCTGTTTCATTTTTTTCTTTTCTCTTCAGTTATAGAAAACAGGATTA CACCCACCTTGCCTTTGTACAGTGCATCTACTATCTGCTGACTTAACCTGAGTAAATGCTTTGAATTGAG CCCCATATAATGTCCTAAGGCAGCCTATATGGAGTAATGAATTGTCTTCTCTCTTATGCACCCAGAGTGG TAGTTGGCACTCAAGTTGTTCCTCAGATAACTTTGTGTGTTCTGGGGCTCAATGAAGTAGTTATTAAGTC ACAGGCTTGGGGAGAACATTCATCCTATGGCATTGAATGAAGTGTTGCCCAATTCTAGAATGTCTAATAA AATTTTTTTAAAAACCCACAGGCTTAGAATTATTCCGTAGATATGAAGTAATGTAGTTAGAACTTAGTGG AGTTCTTTAGATTAACTTGTAATTTGAAAAACCAAAATTGAAATTGTGAAATAACATGGGCTCTTTGAGG TCTTTTCCAGTAAAACAGTTACAGTAAAGCTGCTTGGCAGTGATTTTCCTAGACACTTTGGCTAGTCATC TCCTGTGACTGCTGTTAATTAAATATGGTTTGTAGCTAAGCAGCCTGTAAGGAGAAGACTATGGAAGTAT TTGCATATTCTCTCCTTGAAAATACTACCTGGTCTTTGGCTTTAAGTTATACTTTTATTTTCCCCTGTAG AATAACTATTAAAGTATTACCTATGGTGATTAGACTAAGAAGTAAAACATGAAATCAGTCATTGTTGGTG CCCTGGTGCCTTCTTTTTTTTTTTTTTGAGACAGAGTCTCACTCTGTTGCCCAGGCTGGAGTGCAATGGC ACGATCTTGGCTCACTGCAACCTCTGCCTCCCAGGTTCAAGCGATTCTCCTGCCTCAGCCTCCCAAGTAG CTGAGACTACAGGCGCCCACCACCACGCCTGGCTAATTTTTGAATTTTTAGTAGAGACAGGGTTTCACTA TATTGGCTAGGCTGGTCTCAAACTCCTGACCTTGTGATCCGCCCACCTCAGCCTCCCAAAGTGCTGGGAT TATAGGTGTTAGCCACTGTGCCCAGCCTGGTGCTTTAATTTTATGGAAAAAACTACTAGCTGGTTTCTGT TTTAAGAAATAACACAGGCCGGGTGCCATGACTTGCGCTTGTACTCCCAGCAGTTTGGGAGGCCGAGGCG GGCGGATCACGAGGTCAGGAGTTTGAGACCAGCCTGGCCAACATAGTGAAACCCCGTCTCTACTAAAAAT ACAAAAATTAGCCGGGCGTGGTGGGGCATGCCTGTAGTCCCAGCTACTCGGGAGGCTGAGGCAGGAGAAT CGCTTGAACCTGGGAGGTGGAGGCTGCAGTGAGCCAAGATCGCCCCACTGCACACCAGCCCGGGTGACAG TATTTCATCTCAAAAAAAAAAAAAAAAAAAAGAACACAATTATTGTACTACTTACTAGCCCTCCTCTGTC CCCAGCTAAAAATAAGAACAGCAACAACCAAAAAATCCTTAGTTATGTACTGGAAATGAATTAGATAATT TTCAATAACTTACACGTTTTTAGGATATGTTAGTTTGAAAATGCAAATATTCATGCATGACCCCAGTGTT AATCTATGATGGAGCAGGTATAGTGGGATGCTGTTTCATGATTTAATTTGGACCTTCAGGGAGTAGACTG TGATGCCTCTGCATTTGTATCCAAGACAAATAATTAAATAGTCTATTTTTGGCTGGGCATGATGCCTCAT GCCTGCAGTCCCAGCACTTTGGGAGGCTGAGGTGGGAGGATCGCTTGAGGCCAGGAGTTCAAGATCAGTC TGGGCAACAAAATGAGACCTTGTCTCTACAAAAACTACAAAAAATTAGCTGAACATTGTGGCTTGTGCCC CTAGTCCCAGCTACTCAGGTCCCTGAGTTAGGAGGATTGCTTGAGCCCAGGAGTTGGAGGTTACAGTGAT CTATATTTGCCACTGCACTCCAGCCTGGGTGACAGAGAGAGACCCTGTCTCAAAAAATAAAGTCTGTTTT TAAAATTAATTTTAAACACTGGAGTTTATTACAAAAAGCAGTTGGTTCTTTTTTTAAATCATTTTTTTTT AGGAGAACCACCGCTTTTTGGCTACATTGTCTAGAGTAGCAGTGTTCAATAAAAATAAGATCCAAGTCAC ATATGTAATGTTAAGTTTTCTTTTAGTTTCTTTTTCTTTTCTTTTCTTTTCTCTTCTTTCTTTCTTTCTT TCTTTTTTTTTTTTTTGATATGCAGTCTCACTCTGTTGCCCAGGCTGGAGTGCAGTGGCACGATCTCGGC CCACTGCAACCTCCGCCTCCCGGGTTCAAGCAATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACA GGCATGTGCCACCATACCCAGCTAATTTTTGTATTTTTAGTAGAGATGGAGCTTTGCCATGTTGGCCAGT CTGGTCTCAAACTCCTGACCTCGGGTGATCCACATGCTTTGGCCTCCCTAAGTGCTGGGATTACAGGCAT GAGCCACCATGCCCTACCAATGTTAAGTTTTCTAGTAGCCATATTAAAAGAAGTAAAAAGAAATGGGTGA AGTTAATTTTAATAATATATTTTATTTAACCCAATATATCTAAAATATTATCATTTCAACATGAACAAGA TACTTTACATTCTTTTGTTTTTCACTAAGTCCTCAAAATCCAGTGTGTATTTTATATTGACAGCATAGTT CAGTTTGAAGCAGCCACATTTCAAGTGCTCAGTAGCCACATGTGGCTAGTGACTCCATACTGGACTGTGT AGGTTTAGAGTTTCAGTAAATTTGTATGCAATAGAATCTACATAAATTGGCATATTATGCAGATTTCTTT GTATGCACATCAGTTCTTGCATAGCATAAGTCAGGTCATGATGCTTTTAGTCTATGAGGCAGATTTTTTT TTTTTTTTTTTTGAGACAGAGTCTCACTTGGTCACCCAGGCTGGAGTGTAGATGCACAATCTTGGCTCAC TGCAACCTCCATGTGAGGCAGATTTTAACTTGGCCCTAATGCAAATATTGTAAGAGAGATCTAATGGCCT TTGATTTCTTACAGAGGGCAATCAATACATGCCATGGTTACAATGCTTCAGCATATAGTATGCACGTCAG CCACTGCTTTTACTCTGGCTAGTGCTTAGTGTACCTGTACCACTGCCCAGGCAGCATTTGTCCTGTGGCA GGTGAATCTTAGGGTGGAAGGTGGCAAGTAACATTGCTTTTTTTTGAGAGGGAGTCTTGCTGTATTGCCC AGGCTGGAGTGCAGTGGTGCGATCTCGGCTCACTACAACCTCCACCTCCCGGGTTCAAGTGATTCTCCTG CCTCAGCCTCCTGAGTAGCTGGGATTACAGACGGCCACCACCATGCTCGGCTAATTTTTGTATTTTTAGT AGAGACGGGGTTTCACTATGTTGGCCAGGCTGGTCTCGAACTCCTGACCTCGTGATCCACCCGCCTCGGC CTCCCAAAGTTCTGGGATTACAGGTGTGAGCCACCGTGCCCAGCCTACATTTTTAAATTAATTAATTATA AGCAGGATCTCACTGTGTTGGCCAGACTGGTCTTGAACTGATAAGAGTTCAAGACCAGCCTAGGCAACAT GGTAAAACCCTGTCTACTAAAAAATACAAAAAAAAAAATTAGCTGGGCATGGTGGTGCGTGCCTATAATC CCAGCTACTTGGGAGGCTGAGGCAGGAAAATCGCTTGAACCCGGGAGACTGAAGTTGCAGTGAGGTGAGA TTGCACCACTGCACTCCAGCCTAGGCGATTCCATCTCAAAAACAATAACAACAAAATAACATTGTTGGAA TATTTAGTTAATTTATAGAAGCGTATTGGCCTAATTGGGGCAAATACCTTATTCTGACATTCTCTCTATT TGCTTTACTGAGCTTTTTCACCAGTGGAATTTAAGCCCTTGATACATGAGGAGGGAAAATACCTTGGAGC TGTGCTGCACATGTAAAGTACACAGGAGATTTAGAAAACTTCGTAGCAAAAAAAAGAGTGTAAAGTATCT CATTAATAGTTTTTGTGGGCTGGACACGGTGGCTCAAGCCTATACTCTTGGCACATTGGGAGGCTGAGAT GCATGAGTCTAGGAGTTTGAGACCAGCCTGGGCAACACAGTAGGACCCCGTCTCTACAAAAATAATCAGC CAGATGTGGTGCGCATCTGTAGTCCCAGTTACTTGAGAGGCTGAGGTGGGAGGATCGTTTGAGCTGGGAA GTTGAGGCTACAGTGAGCTGTGATTGAACCACTGCACTCCAGCCTGGGTGACAGAGTGCCTGTCTCCAAA AAATAAATAAATAAATAATAATATGTTTTGTATGTTCATATGTTGCAATAACATTTTGGATATATTAAAT GAAATAAAATACATTAAAATTAATTTCACCTGTTTCTTTTCTTTTCTTTTTTTTTTTTTTTTTTGAGATG GAGTCTCGCTATGTCATCAGGCTGGAGTGCAGTGGCACGATCTCGGCTCACTGCAACCTCCTCCTCCTGG GTTCAAGCGATTCTTCTGCCTCAGCCTCCCTAGTAGCTGGGATTAAAGGCATGTGCCACCACACCCAGCT AATTTTTGTATTTTTAGTAGAGACGGGGTTTCACCATATTGGCCAGGATGGTCTCGATCTCCTGACCTCA TGATCCGCCTGCCTTGGCCTCCCAAAGTTCTGGGATTACAGGCGTGAGCCACTGCACCCAGCCTCTTTTA ACTTTTTAAGTATGGCTACCAGAAAATTTAAAATGCATGTGTGGCCTGTATTCTATTTCTGTTGGATGCT GCTGCCTTAGATTATTAATTATTCAATGTAAAGACTGCTGGGAGGTACTACCTGCACTTCCCTGAATATA TGCTTGAGAGCTCCACCAGCCGTCTTCACAGTAGCAAGAGGGGTATTCTGAGTCTGTCCCCCAAAGAGGG AGGGAGAAGTGCAGCCCTCTCAGGTTCTGTCAGAAAACCTGATCCCAGGCCAGGCGTGGTAGCTTACGCC TGTAATCCCAGCACTTTGGGAGGTTGAGGCAGGAGGATTGCTTAAGCCCAGGAGTTCGAGACCAGCCTGG GCAACACAGTGAAGACCCTATCTCTACAAAAATTTTTTTAAAAAAATTAGCCAGGTGCAGCAATGCTGCC TGTACTCCCAGCTGCTTGGGAGGCTGAGGTAGGAGGATTGCCTGAGCCCAGGAGTTAGAGGTTGCAGGAG TTAGAGGTTCCACGATCGCACCTTTCATTCCGTTACATTTGCTGCCTTGAGAACAGAAGACCTGCTGGTT TTGTTGCCAGTTTGCTCAGTCATTTTTATGAAAAAGCCAGTGCTAACTAGGTGCTTCTTCGTGCCTTCTC TGAGAATCAAGAACTCTAGTATGTTTGCGTGTGTTCAGTCTCTCATTAAATGTTCTCACTATCCCAGAGA ACCATCTCATTGGACCTTGGTCTGTACATACCTTCATCTTTGGCTCTGACTTGTAATTATTTTTAGAACT TCTCTTTTTTTTTTTTTGGAGACAGAGTTTTGCTCTAGTTGCCAGACTGGAATGCAGTGGCACGATCTCA GCTCACCTCAACCTCTGCCTTCCAGGTTCAAGCAATTCTCCTGCCTCAACCTCTTGAGTAGCTGTAATTA CAGGCATGTGCCACCACGCCTGGCTAATTTTGTGTTTTTAGTAGAGACAGGGTTTCTCCAAGTTGGTCAG GCTGGTCTCAAACTCCCGACCTCAGGTGATCTGCCCGCCTTGGCCTCCCAAAGTGCTGGGATTACAGGCG TAAGCCACTGCGCCTGGCCTAATTTTAGAACTTGTTAAAACAACTTGGCCTCTATTGATATTTCCATGAC CCATGCTATTCAGAAAGAGGATTACAGGTAATTAGCTGGCTGGGTTTCTCATACCAGAGCATTTCACTGG GATGTTCCTGAACCTGGGACAACTTTTATGCCTGGCATTTTTCTTTCCTTCTCTGTTGTCCCAGACTAAG CAATTTTTAAAATAGTTATTATTTGTTGAGTAGGAGAATCTCAGGCAGATCTTCCTGGATCCTCATTTAT ACTTTTAAACCTGTAGTCTTGGAATTAGTGCTCTGTCCCCCAACCCCAAACATCCAATTTCTACATTTTG GCTACAGTACAGGTTTACTGTGTATAACTAAAAGGGCTGTGGAGGAGAAAGAAAGGAACCGACATTTGTT GGGCATCTGTTATGTGCCATGCACTGAGCTGGATGCTGTAGGAATATCTCAATACCTCTGAGGAGTGGGA ATTATTATCTCTATTTTATAGACAAGGGAATAGAAATCTGGGAGTTAAGTAATTTTTTAATTTCACACAC TTCTGGTAGATAATGGATTCTAGAACCTGGCATAATAGCCACTTGTCATCCCAGTGTAAAAGAGATGTGT GGCCAGATGGGGTGGCTCACATATGTAATCCCAGCACTTTGGGAAGCCGAGGCAGGAGGATGACTTGAGC CCAGGAGTTCAAGACCAGCCTGGGCATGTTTTGTTTGTCTCACGAAACATTTTTTAAAAAATGAGTGTGG CATGGTGTTGTGTGCCTATAGTCCCAGCTCCTCGGGAGGCTGAGGTGGGAGGATCTCTTGAGCCCATGAT CATGCCATTGCACTCTAGCCTGGGCCACAGAGCAAGACTCTGTCTTCAAAAAATAATAAAAAGGAGCTGT GATTATCCCAAGGTGGGGATTGTGAATGTGTTTGTATTGTTCTAAACTGGGAGAAACAGGCTGGGTGTGT TGGCTTATGCCTGTAATCTCAGCACTTTGGGAGGCCAAGGTGGGAGGATCACTTGAGTCCAGGAGTTCAA GGCCACCCTGGGCAACAGGCAAAAAATAGAGACCCCATCTCTATTTTTTAAAAATAAAATAAACTGGGAG AAAGAAGCAGGGTCCTCCCCAGAGCATCTTTATCCCTAGTCACAGACCTGACACCTGTGTTGGGCAATGG CTACTTCTAGATTGTTTACCCCTACTGGGACTTGTGGTGAACATATGCACACTTTGGTTTACAGTTGGGA CCCCTGATTTTAGCAGGATGGCCCAATGGAATCAGCTACAGCAGCTTGACACACGGTACCTGGAGCAGCT CCATCAGCTCTACAGTGACAGCTTCCCAATGGAGCTGCGGCAGTTTCTGGCCCCTTGGATTGAGAGTCAA GATTGGTAAGTCCTTCTTAAGTGACTCTCCAAATTGTTAGGTTTCAGTTTGAGTCAAGAGACATGAACTC TTAATGTCATGCCTTGCTGTTCCATTAAAAAATGTATGGGTACAGGTGATGGGGAAAATGAGATCAGGAG ATAAAGGGGCACCCTTTGGTCTTGTAAAGCCTTTTTTATCTTAGAAGGGCATGTGGGCAACTGTCTTTGA CACATTGAAACCGCCTGTATGGTGGTGGATGTCTTGAAGGTTGATTTGGACCTCATTTACTTGGGCAGAT CCTCTATATATTCTGATAATCCAGTGATGTGGTAGACATATTTTTTCTCTGAATGTGAATTCTGTCATAG CTAGAACTTTGGGTTGATACTTGTAATTCCCCTTTAGTTAAAGGAAGGAGCCACAGGGGTGTATTAGTCT GTTCTCAATTTGCTATAAAGAAATACCTGAGACTGGGTAATTTATAAGAAAAGAGGTTTAATCGGCTCAT AGTTCTGCAGGCTATATAGGAAGCATAGCAGCATCTGCTGCTGGGGAGGCCTCAGCAAGCTTCCAATCAT GGCGGAAGGCAGAGAGGGAGCAGGCAGGTCACATGGCCACAGCAAGAGCAAGAGAGCAAGGGGGAGGTGC CACACACTTTTAAACTATCAGATCTCACAAGAACTCACTGTCTCGAGGACAGTATCAACAGGGATGGTAT TAAACCATTCATGAGAAACCCACCCCCATGATCCAGTCACCTTCCACCAGGCCCCACCTCAAACAGTGGG GGTTACATTTCAGTATGAGATTTGGGCAGGGATGTAGATCCAAACTAGATCACAGGATAAGGGAAGTAGA TTCCATTCATAGAGCAGATAATGGCACAGATGTCCAGCAACTATTTTCTTCACTTTAATATGCTCAGGCT CACTACTGATTTTGGTTTAATTCAGGCCAGTGTTAATATGACCTGGTTTTTCCAGAATGCATACTCTGAT TTGGTGAAGGGCCAGGAGGTGATTCACAGATGTTGGAGATAGGCCATCCCAGCCTGGGATTACTTATTTG TACTAATAAATCTGACCAGAGTTAATTGAGGGTTTAAAGCAAAACAGCATATCTGTCTACTTTGCTCAAA TATTTTACAAATACAACAGATTATGAGAGTGGGTAATAATATCTGGAATAATTGTTTTTTTGTTTTGTGG TTTTTTTTTTTTTTTTTTTGAGATGGAGTCTGGCTGTAGCCCAGGCTGGAGTGCAGTGGTACAGTCTCGG CTCACTGCACCTCTGCCTCTTGGATTCAAGCGATTCTCCCGCCTCAGCCTCCCGAGTAGCTGGGATTACA GGTGCCCACCACCACACCTGGCTAATTTTTTATTTTTAGTAGAGACAGCGTTTCACCATGTTGGCCAGGT TGGTCTGGAACTCCTGACCTCAGGTGATCCGCCTGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCATG AGCCACCATGCCTGGCCTGGAATAATTGTTAATAATTATTACATTGATGGCATTTTATTGCTGAGCAAGA AGAATCTAACATGATGAATGGGTTATAGCATCAGGTTTGCTTTGTTTTTTTGTTTTTTTCCTCTTTCTTG ATGGTGATTTCTGTGTTTGTGTGTATGCGTCGGCTTCAGAGCCATTCTTTATCATTCTTCCTTTTCCTAG GGCATATGCGGCCAGCAAAGAATCACATGCCACTTTGGTGTTTCATAATCTCCTGGGAGAGATTGACCAG CAGTATAGCCGCTTCCTGCAAGAGTCGAATGTTCTCTATCAGCACAATCTACGAAGAATCAAGCAGTTTC TTCAGGTATGATGAGAAACTGAGGACAAGGAGAAACAGGACCCGCAGAGTCGGGTGTTAGTGTTCTTTCC TGGAAGCATCTCTTTTCTCATTTGGCTAAGTAACGAGAATCTATCTTGTATTTTCAATCACAGGAGAAGT AATTAGCCCTTTCTCAAAGCTCTGTATACTTACCCGTGAGCATCATTACCTGAGAATCACTTCTCTTGTC ACAGTTGAAGTAATAAAGTGATTGTTATGTTAATCATACATGTTAGCATGTTAACGCGGTCCACTGATAG GAAGATGACTCTCACTGTTACATGTTAAATGTTTGACCATAATGGGATACTTCTTGACTAAGTCAGTAGC TTCCCTGCAAGACCAGGATAGTATACTGTGTAAAGACTCAGACAAGGCCAGGCATGGTGGCTCACGCCTG TAATCCCAACACCTTAGGAGGTTGAGGTGGGAGGATTGCTTGAGCCTGGGAGTTTTGAGACCAGCTTGGG CAACATAACAAGACACCATCTCTACAGAAATTTTTTTTAAAAACTAGCTGATTGTGGTGGCATGCACCTG TAGTCCCAGCTACTCAGAAGGCTGAGGTGAGAAAATTGTTTGAGCCTGGGAGGTCGAAGCTGCAATAAGC CGTGATTGCGCCACTGCACTCCAGCCTGGCGGACAGAGTGAGAGCCAGTCTCAAAAAAAAAAAAAAAAGA CTCAGGCTAATGTGCCTTCTGTTACAGAAATAGTAACGACCTCCCCTTCGCCCCCCGCCGACAGAGAGCC TTCACCCAGGCTCTGAAGCCTTTGTTCCGTTGTTTCCTAGAATAAATGCTTTCCTTGATGAATACATTAG TTTTAAGGTGCCACAGTTCAGTCCACATCTCCATGGTCTGCTGCTGATTTTTATTCTCTTTCTCTCCTAC TTATAGAGCAGGTATCTTGAGAAGCCAATGGAGATTGCCCGGATTGTGGCCCGGTGCCTGTGGGAAGAAT CACGCCTTCTACAGACTGCAGCCACTGCGGCCCAGGTGAGACCTGAGACAAAACAAATCCCTGGTCTGGG AGGAATGGAAAATCAAACAACTTTATAATGAGATAAATTATTAGATCTACTAAAAAAGAAGGAAAAGAAA TTAAATAGATCAATAATCATAAAAATACATTGAAAAACTCTAAAAAAAAAGAAAGTTCCACCCCCCAAAA TACATTGAAAAACTCTAAAAAAAAGAAAGTTCCACCAAAAGAATCCAACAGACCCAATGGTTTAAAAGTT TTGTTTTGTTCTGACAAATTTTCTTTGTTTTTCTTTTTTTTTTTTTCTGAGACAGAGTTTTGCTCTTGTT ACCCAGGCTAGAGTGCAATGGCGCGATCTTGGCTCACTGCAACCTCCACCTCCAGGGTTCAAGTGATTCT CCTGCCTCAGCCTCAAGAGTAGCTGGGATTATAGGCGTGTGCCACCACACCCAGCTAATTTTGTATTTTT AGTAGAGACGGGGTTTCTTCATGTTGGTCAGGCTGGTCTCGAACTCCTGACCTCAGGTGATCCGCCCGCC TCAGCCTCCCACAGTGCTGGGATTACAGGCGTGAGCCACTGTGCCCGGCCTGTTCTGACAAACTTTCATA GTACAGATTATTCCAATATCATTCAAACTTTTCCAAAGTATAGGAAAACAAGGGATGTTTTCAGCTTATT TTATGAGGCTGGAAAAATCCTCATATCAAAACCTAAAAAACAGCCAGGTGTAGTAGCTCACGCCTGTAAT CCCAGCACTTTGGGAGGCTGAGACGGGCAGATTGCCTGAGCCTCAGGAGTTCGAGACCAGCTGGGGCAAT GTAGCGAGACCTCATCTCTCTTTTTTTTTTTTTTTGAGACAGAGTCTCTCTCTGTCGTCCAGGCTGGAGT GCAGTGGTGCCATCTTAGCTCACTGCAACCTCCGCCTCCCAGGTTCAAGCGATTCTCTTGCCTCAGCCTC CCGACTAGCTGGGACTACAGGTGTGTGCCACCAAGCCTGGCTAATTTTTTGTATTTTTTTTAGTAGAGAT GGGGTTTCACCTTGTTAGGCAGGATGGTCTTGATCTCCTGACTTCATGATCCACCGGCCACAGCCTCCCA AAGTGCTGGGATTATAGGCATGAGCCACCACGCCCAGCCTTTTTTTTTTTTTTGAGACAGAGTCTTGCTC TGTTGCCAGGCTGGAGTGCAGTGGCGTGATCTCAGCTCACTGCAACTTCTGCCTCCCAGGTTCAAGCTAT TCCCCTGCCTCAGCCTCCCAAGTAGCTGGGACTACAGGCGCGCGCCACCACACCCAGCTAATTTTTTGTG TTTTTAGTAGAGATGGGGTTTCACTGTGTTAGCCAGGATGGTCTCGATCTCTTGACCTCGTGATCCGCCC GCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCAACCGCACCTGGCTTAATTAAGGATCTTTCT AAACACAAGAAAGAATATTTATCAGAAACCAAAGGGAGCATGATGCACAGTGGTGAAACACTATTCTCAG TAAAAACAGCAAAAGATAAGGATGTCTTTTACCATTGATACTTTTCTGAGGGATCCAGCCTATGCAAAAA GAAAAAGAAATGAGGGTACAAATATTGGAAAGCAAGGGACAGAACTCTTATTATTTACAGATAGATAGGT CTTCCTCGAAGATCCAAGAGAAACAAAACTAACAATAACAATTGGAACTAGCAAGGTTTAGAAAGGCCAT TGTATACAAGATAAATATTTTTAGAATCTGCAGTTCCCCTAATCAGTAGCAGCAGTAACCTGTTAGAAGA TGTAATGAAAGTAAAGATCTGGGCCAGGCACGATGTCTCACGCCTGTAATCCAAGCACTTTGGGAGGCCA AGGTGGGCAGATCATGAGGTCAAGAGATTGAGACCATCCTGGCCAACATGATGAAACCCCATCTCTACTA AAAATACAAAAATTAGCTGGGTGTGGTGGTACGCGCCTGTAGTCCCAGCTACTCGGGAAGCTGGGGCAGG AGAATCGCTTGAACCTGGGAGGCGGAGGTTGTAGTGAACCAAGATTGCGCCACTGCACTCCTGGGCGACA GAGCGAGACTCCGACTGAAAAAAAAAAAAAAAAAAAAAGAAAGATCTGATTCATAGTAGTAAAACTAAAT GTATGCAATTTGCATATACTATTGGTATGTATGGGAAAATATCTGGAAACACATATACTAAATCATTAAA GTAGTCGGTCATAGGAGACTTTTTTACTTTCTGTGAGGGGTTTTACCGTCTTTAATATCCTATAATCAGG GACATTTTTTCTTTTTCTCCGTGACCCCCTGCTTTTTAAAAAATTGTGGTGAAATACACATAACATTACA TTTCAAATTTACCTTTGTAACCTTTGTTTTTTTTTTTTTTTTTTGAGACAGTCTCACTCTGTCACCCAGG CTGGAGTGCAGTGGTGTGATCACAGCTCACTGCAGCCTCAACCACCTGGGCCCTAGCGATCCTCCTGCCT CAGCCTTATGAGTAGCTGGGACTACAGGCACATGCCACCATGCCCAGCTAATTTTTTTTTTTTTTTTTTT TGGTAGAGATGGGCTCTTGCCATGTTTCCCAGGCTGGTGTTGAACTCCTGGGCTCATCAACTGATGAGAA AGAGCTCTCCAGGCAGAAAGAAGATCATGTTCAAAGACAGAAACAGAAATGTGTATTCTTGGGAGAAGTG TAGAAAGTTCAGCATCTGATTGGGTCGGGGAAGACAAGCTAGTCAAGGCCACATGATGTTTTAATTAGTC ATGCCTAACAGTGGGGCCCTGGAAGAGCAGTTTACCACAAGGGGCCAACTGCTTCGGTTTGAACCCGCAG CCCTGCCACTTGCTCTGTAACCTTAAGTAAACAATTTTTACTCTCTCTGTTCCTCCAATGGGAGTGATAA CAATACCTTCTTCATAGAATTAATTCATACATGTAAAATGCTTAGAACAGTATCTGACACATAAATGCAA AATAATTTAACTGCTTTCTGCTGCTGCTGACATCACTATCATCACCCTCACCATTACTGTAGGAAATGGG GACCCAGTGAAGAATTTTTTTTTTTTCTTTTGAGACAGAGTCTCACTCTGTCACCCAGGCCGGAGTGCAG TGACGCGATTTCGGCCCACTGCAACCTCTGCCTCTCAGGTTCAAGCGATTCTCATGTCTCAGCTTCCCAA GTAGCTGGGATTACAGGCATGAGCCACCACACTGGGCTAATTTTTTGTATTTTTAGTGAGATAGGGTTTC ACCATATTGGCCAGGCTGGTCTCAAACTCCTGACCTCAGGTGATCCATCCACCTCGGCCTCCCAAAGTGC TGGGATTACAGGCATAAGCCACTGTGTCCGGCCCTAGTGAGGAATTTTAAGCAGAAAACTGATATGCTCA GGTGTGAGCGAGGTGGTAGGTAACACTTACTGTGCAGTGCCCTGTAGCCCAAGAGGTTAGCACACAGGCA TTTGCTCAGGCAGCACTAGGATTTTCTGCTGTGGAAAACCTTTGTATTTTATCCTGCTCCACAAGATAAA AATAAGTGGTTTAAGTCAATTTGGATAGAGGCTCCAACTTACCATGGGAGGTAGGAAAGCCAAAGTTATC CCAAGGATGTTTTCAATCGTACGGATTAGGGGTCTGCAAACTGTGAGCGTGGCCCAAATCCAGCCTGCTG CTTGTTTTTGTAAATGAGGTTTTTTCGGAACCCAGCCACACTCATTTATTTATGCATTATCTGTGGCTGC TTTGGTGCTGCAGTGGCAGGGCTATTTGTGGCAGGGACTGTATGACCCAGGAAACCAAAAATATTTACCC TCTGTCCCTTAGAGAAAAAGTTTGCAACCCCTGATATAAAGCTATAAGTTGGTTATTTGTGGCCTCAACC CAGGCCTCACTGCTATTTTTTCTGTTTACAATACCTGGCATGCTCTTAAGTGTCTAGAATTGGTTAAAGA TAGAAGAGTGGATGTAATCCCTGCTACCAAGGGCTGTCAGGCTAGTTGGGATTATAAGTACACAAACACT CAAAGTGAGAAAAACACAGAAAAGGATGTGTGTCATTTTGTCTAAGGAAGTTGAATAAGATTTCTCAGGA AAAGAAACATTTGAACTGAATTTGAAGGTGAGTGAGTTCAGGTGTGTTTGGGCTGAAGCCCAGGCCATGC TGAGTGGATAGCGGGTGGGAAGAGAGTGTGGAAACACACTGCATGCAGGGAAGAGTTGGGAGTCTGGGGT GACCAAGGCACAGGGAGGGAAAGTTGAAGTTATCAATTGTGTGAAACAGCTTTCTGTGTTGGCCTGAGAT GTTTATAGCTGGAAGCAGTGGGGAGCCAATACAGTTTTTTACGAAGGTATTAGAGGTGGGTTTCTGTGGG TGATCGTTAATCATGTTTTCTCCCTTTAAGTGTAGTCCTGCTTGAGAAATAGACATGAGAAAGGAATGAA GGTTAAAACATCAGCTGTATTGTTGGTAAAACTAGAATGGAAAGTGTGGCTTGAGCTGGTAACCATAGGG GCTTTCCAATGCCTGTGCCCTGAGTTAGATCTTGGGGTAGAGAGACTGGATGTGCAGAGCAGCACCCCCA CCCCACCCCAGCCATCCATATGGAGCTTCAGCTGCCATAGACCAACAAGGCAGAGGGATAGGCCTCTAGA CCTGCTTCTAGAAACCAGGCTGCTGCTCTTGCTTATGGTGGGCCCTAGGAAGGCAAGAGTGAGAGGAGGG AGGCACCAGCTTAGGTGCTGGGTTCTTTGAAGATCTGTGTGTACACAGAGTCTTTCTCTCCATCTTACCA ATCAGATGAGTCACTGTCACTGTGGGAAGAAGTAGGGGCATGGGTCACCTTCCCAAAACTTCTAAGAAGT TTGTATTCTGTGGGCTTGGATAGGGACCATGGGAAAGGAAGAGAATGGTTGCCCATAAAACTGGCTGTAG TGTGGCCTCAAACTTCTGGACTTAAATGATCCTCCCACCTCAGCCTCCCAAGTAGCTAGAACTACAGGTA TATGCCACCATGCCCAGCTAGTTAAAAAAAAATTTTTTTTTTTTTTTGGTTGAGATGAGGTCTCTTTCTA TGTTCCCTGGGCCGGTCTCAAACTCCCAGCCTCAAGTGATCCTCCTGCCTTGGTTTCCCAAAGTGCTAGG ATTATAGGTGGGAGCTACCATGCCTAGCCCAAGCCTGTAATTTTTTTTTTTTTTTTTTGAGATGGAGTTT CACTTTTGTTGCTCAGGCTGGAGTGCATGGCGCAGTCTTGGCTCACCACAACCTCCACCTCCCGGGTTCA GGCGATTCTCCTTCCTCAGCCTCCCGAGTAGCTGGGATTACAGGCATGCACCACCAAGCTCAGCTAACTT TGTATTTTTAGTAGAGATGGGTTTCTCCGTGTCGGTCAGGCTGGTCTCAAACTCCTGACCTCAGGTAATC TGCCCACCTTGGCCTCCCAAAGTGCTGGGATTACAGGCATCAGCCACCGCACCTGGCACGAACCTGTAAT TTTTAAGTTTCATATGCTATTTATTTTTTGTTATTTCTTTAATTCATTCATTCATTTATTCATTCGAGAT GGGGCCTCACTATGTTGACTAGGCTAGTTTTGAACTCCTGGCCTCAAGCAGTCCTCCCACTTCAGCCTTC CCAAGTGCTGATATTATAGGTGTGAGCTGCTACATCCAGCCTTCTTTCTTCTTTTTCTTTTTCCATGTGC TATTTGACATTTTCCAAGGTACCAGCCTCCCCTTCTCCCCAAGATAATATCTTTTAATATGGAATTTCAT CCCTAGGGCAGGACTTTTTTTTTATTATCCCTCAGAAATATACTGGACACCACGTTTAAGTAGACATCCA ACATCTGCTGTCATAAATTGTTTTGAATTTTTTGACATACTTGCCCATGAGGTTTTTGAAGGCATAGACC ATGTCTTAGCTGAACATGTGGTCTCTTAGTGCCATAAAGGGGGTTTATGGTATGACCTGTGTAGTGTCAC CTGTGTAGTGACAGCACCACTGCCTCTGTTTCCCTTCCTCTTGTGATGGCAGCAGCGTCTCAAGCCAAAC AAGAAGGGTAGTTAGGGTGGGATGGAAGCTGGGTAGAGGTATTCCTCTCCCCATAGTTCTGTGTTCACAT GTGCATTGACCTCCTTTTTGGCAGCAAGGGGGCCAGGCCAACCACCCCACAGCAGCCGTGGTGACGGAGA AGCAGCAGATGCTGGAGCAGCACCTTCAGGATGTCCGGAAGAGAGTGCAGGTGATGCAAGTTACAAGCCT CGGGCAGGGAGCTTTCATTAATTTTTTTTTTTTTTTTTGAGACAGGGTCTTGCTCTGCCACTCAGGCTGG GCTGCAGTGGCATGATCACAGCTCACTGCAGCCTCGACCTCTCAGGCCCAAGCGATCCTCCTACCTCATC CTCCCAAGTAGCCGGGACCACAGGCATGCACCACCACGCCCAGCTAATTAAAAAAAAAAAATTTGTAGAG ATGGGGGTCTCCCTGTGTTGTCCAGGCTGATCATGAACTCCTGGGCTCAAGTGATCCTCCCAACTCAGCC TCTCAAAGTGCTGGCATTACAGGCGTGAGCCACTGCACCTGGCCAACAGGGAGCCTTCTCTTGGGGATAC TGCCTGCAGGTCCTGCATGTATCTTTTTTGAGGTTTTGGCTTCATTTGAATTCTCCTCAGAAACTTTATA TTTTCTGTTCCCAAGGAAATCTTTCTTTACTTCTGTTTTTTTGTTTGCTTATTTTAAACAGGATCTAGAA CAGAAAATGAAAGTGGTAGAGAATCTCCAGGATGACTTTGATTTCAACTATAAAACCCTCAAGAGTCAAG GAGGCAAGTGAATATTAGAGATGTTAAAATCTCTAGAAAGTGAGTTTGTGTTGTTGAGTTGAAAGACTCA TTTGTCTTAACTCTGTTTAGATCTTAAGGCGGGCGGGGCGCAAGGGAGGTACGGGTCCTCAAAGGAGCCT GGTCATTAAGGACAGGAGTATTCCCTCAGGTCCAGGAGTATTCCCTCAGGTCCAGGAGTATTCCCTCAGG TCAAGGAGTATTCCCTCAGGTCAAGGAGTATTCCCTCAGGTCCAGGAGTATTCCCTCAGGTCCAGGAGTA TTCCCTCAGGTCCAGGAGTATTCCCTCAGGTCCAGGAGTATTCCCTCAGGTCCAGGAGTATTCCCTCAGG TCAAGGAGTATTCCCTCAGGTCCAGGAGTATTCCCTCAGGTCCAGGAGTATTCCCTCAGGTCCAGGAGTA TTCCCTCAGGTCCAGGAGTATTCCCTCAGGTCCAGGAGTATTCCCTCAGGTCAAGGAGTATTCCCTCAGG TCCAGGAGTATTCCCTCAGGTCCAGGAGTATTCCCTCAGGTCCAGGAGTATTCCCTCAGGTCAAGGAGTA TTCCCTCAGGTCCAGGAGTATTCCCTCAGGTCCAGGAGTATTCCCTCAGGTCCAGGAGTATTCCCTCAGG TCCAGGAGTATTCCCTCAGGTCCAGGAGTATTCCCTCAGGTCCAGGAGTATTCCCTCAGGTCCAGGAGTA TTCCCTCAGGTCCAGGAGTATTCCCTCAGGTCAAGGAGTATTCCCTCAGGTCCAGGAGTATTCCCTCAGG TCCAGGAGTATTCCCTCAGGTCCAGGAGTATTCCCTCAGGTCAAGGAGTATTCCCTCAGGTCAAGGAGTA TTCCCTCAGGTCAAGGAGTTTTTTCTTCCTTCGCAGACATGCAAGATCTGAATGGAAACAACCAGTCAGT GACCAGGCAGAAGATGCAGCAGCTGGAACAGATGCTCACTGCGCTGGACCAGATGCGGAGAGTAAGGGCA TAGGTCGGACCACTTCCCCCATGTGTCTCGCTCACTTGCGGGATTTCAGCGTCTTGTGGCAGAACTTGCT TGGTTTCTAAGAAGTTCCTGCTCTGGAGTTGACTAAAGAATGTGGTTAGAGACAGTCTGAGGAAATGTTT TCTGACTTTGTTTTGGTTTCCAACCAGAGCATCGTGAGTGAGCTGGCGGGGCTTTTGTCAGCGATGGAGT ACGTGCAGAAAACTCTCACGGACGAGGAGCTGGCTGACTGGAAGAGGCGGCAACAGATTGCCTGCATTGG AGGCCCGCCCAACATCTGCCTAGATCGGCTAGAAAACTGGTAAAGGATGAAAGAAGCTTTTCCTTTCTTT CTCGAAAGCTAGATTGAATTCTGATCTTAACTGCAGGCCCACAGAATTGGTACTATATCTCCAACGTGGG GACTTTTCCATATTCAAATTTAGCCCAAGAATTAAAGTTTTTACTTTATTTCGGCCAGGCGCTGTGGCTC ACACCTGTAATCCCAGCACTTTGGGAGACCAAGATGGGCGGATCACTTGAGGTCAGGAGTTTGAGACCAG CCTGGCCAACATGGTGAAAACACATCTCTACTAAAAACATAAAAAAATTAGCCGGGCGTGGTGGTGCGCA CCTGTAGTCCCAGCTACTCTGGGCGGCTGAGGCAGGAGAATCACTTGAACCTGGGATATGGAAGTTGCAG TGAGCGGAGATCTTACTACCGCACACCAACCAGCCTGGGAGACAGAGTGAGACTCCATCTCAAAAAAATA AAAATAAAATAAAGTTTTTACTTTATTTGGAGAAACTTTGTTTTAAAAAATGTATTTATATTATTATATT TTAAGTATATTTTACTTAATAATTCAATTAAGGCTTTTGGTTTAACTGTATTTAACAGATAGACAAACCT TTTAATTTTAGTTATTTTAGTAATCTAAAATGACACATGCCCTTTTTAAGGGAAAAAATTCAAATACAGA AAATTAATCAAGAGAAGAAAAAATTTTTAAATGAAATCATCAGCAGTACTAGTAGTTAAAATTTAGTTGA TGCTCAATCTAGACATCTGTCATTATGTATATACACATTATGTATATACACATAAAGATAGAAATTTATA CAGTTTATATTAGGATCATTTTTTTTTCTTTTTTTGGAGTCAGGGTCTCACTGTGTTACCCAGTCTAGAG TACAGTTATGCAGTCATGGCTCACTGGAGCCTTGACCTCCTGGGCTCAGGCAGTCTTCCCACCTTAGCCT TCTCAGTAGCTGGGACTACAGGCATGCACCACCACACCTGGCTAATTTTTAAATTTTTTATAGAGACAGG GTCTTACTTTGTTGCCTGGGCTGGTCTCAAATTCCTGGGCTCAAGGGATCATCCCACTTCGGCCTCTCAA AAGCTCTGGAATTATAGATGTGAGCTGCCGTGCCCAGCCCAGGATCTTCCTTTATATGCTTTTCTGTAAT TTGCACTTTTACCTTCATCCAGCATATCTTACTGCAACCCTTCCTGTGCAAGGCCCTATAGTGAGCATGT TGCACCAGCTTGCCTTAGGAGAAACTTGAGATACAGAGCCTGCACTGGAAATTTAGCGCAACTCTACATG AGAATGCCTGTCTATTCATATCCTCACTAACCCTGAGTGTTGTTAATTTACTGAAAGCAGTTTTAAATGC TTCCTGACCAGGGAACGAAGAAGCTTAAGTTCTGGGAATGGGAGGATAGAAGTGCCAGAAAAGAGCTCAG GAGTTCAGAAATCCCTGCAGCGGTCCCCCTCCCTCTCCTTTCACTTTCTGTCTTTCTGGTCTTTTGGTCT TTGTTACACTAGTGATAAACCATCAAAGAATGATGGAATGATGCTAACTTCTCTCTTTTTTTAATTTTTT TGAGACAGAGTCTCACTCTGTCACCCAGGTTAGAGTGCAGTGGCATGATCTTGGCTTACTGCAACCTCCT CCTCCCAGGTTCAAGCGATTCTTAGTCACAACCTTCCAAGTAGCTGGGATTACAGGCCCATGCCACCATG CCTGGCTATTTTTTTGTATTTTAGTAGATCGACCTGCCTCGGCCTCTCAAATTTTTGGGATTACAGGTGT CAGCCACTGCACCTGGCCTAATATCTCTATTCTTGGAGATAGATTTAATGAGCTTTTTCTCCCTCTCTAT TCACTTATTCCTTGTGCATGTTATCAATATTTTGAAACATAATGTCATGTCCTTTGATCAGTTGAAGGCT GACATTGAAAAGGCTTATGGGGATTGGGTGTTGTGGCTCACGCCTGTAAATCCCAATGCTTTGGGAGGCA GAGTCGGGAGGATCACTTGAACCCAGGAGTTTGAGACCAGCCTGGGCAACAAAGTGAGATCCCATCCCTA CAAAAATTTAAAAAACTAGACATGTGCCATTACACTTCAGCCTGGGTGACAGAGTGAGACTCCATCTCAA AAAACTAAACTAAACTAAACAGGCATGGTGGCACACACCTATAGTTCTAGCTACTCAGGAAGCTGAGGTA GGAGGATCACTCATGTCCAGGAGTTGGAGGAGGCAGTGAGCTATGATCATGCCATTGCACTGCACTAGGC CACAGAGTGGGACCCTGTCTCAAAAAAAAAAAAAGAAAGAAAGAAAAGAAAGGGCTCATGTAGTTCAAGC CCTTCTCTTCATGCAAGGGGATGCTAAGGCCCATGATGGTGAAGGGCCTGGCAAAGCTTGCACAGATAGT GTGTGACAGAGCTGGCTCAAACCCATCTTTGGGAGCTGTCTAATCTCTTTTTCTGAGTCTTTATGTTCAT AGACAAGTTAGGATGAGTAAAGTAAGTGCTAAATTCCATATTTCGTGTTCTGCATATCTGGGCTCAGATG CTTGTCATTTTCCAGTGATAACTCCATCAATGCCTCCTAGTGGTATAAATTTTAATACTTCTTGTGTGCC CAGCCCCCTCTTAGAAATTTGAGATTTTAGGAAGGGACTAGTAATAAAAGGTAAAATAAATTATTTTCTG GCCAGGCATGGTGGCTCACACCTGTAATGCCAGTACTTCGGGAGGTCGAGGCAGATGGATCACCTGAGGT CAGGAGTTCAAGACCAGCCTGGCCAACAAGGCAAAATCCCATCTCTACTAAAAATGCAAAAATTATCCGG GAGTGGTGGTGGGTGCCTGTAATCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATCACTTGAACTTGGGA GGCGGAGGTTGCAGTGAGCTGAGACTGTGCCACTGCACTCCAGCCTGGGCAACAGAGTAAGACTCTATCT CAAAAAAAAAAAAAAAAAAAAAAAGGCCAGGCGCAGTGGCTTACACCTGTAATCTCTCAGGAGGCTCAGG CAGGAGAATCACTTGAACCCGGGAAATGGAGGTTGCAGTGAGCCGAGATTGCACCACTGCACTCCAGCTC AAAAAATAAATAAATAAATAAATTATTTTCTTTTTTTATTTATTTTTTCAGCATCCACCCAACATGGTGA AAAATTCCTCTTTTCTTAATGTCACTGAACTGTAAACTTAAGATGAAAAATTGTAAATTTCATGCTATAT ATATTTCACCACAATAAAAAAATTCCTTGTTCTTATTGTAGTGGTCTCCATGTCTTCAGTATTTCCTTCC CCTTCTCCATCTCACCTGTATACATTCACTTTGGTAATTAGCATCTTTCTTAATTTATTGGCAGGATAAC GTCATTAGCAGAATCTCAACTTCAGACCCGTCAACAAATTAAGAAACTGGAGGAGTTGCAGCAAAAAGTT TCCTACAAAGGGGACCCCATTGTACAGCACCGGCCGATGCTGGAGGAGAGAATCGTGGAGCTGTTTAGAA ACTTAATGAAAAGGTAATTTAGCATCCTTGTCCCTTTCCCTCATCTAAAAAATACCTAAAGACTCACGTG GTAGAGTGAGAGGCGGGCTGACTTCTGGTCATGGCCGTGGCGCGTGAGCCCATCTTCTCTTTCCTCAGTG CCTTTGTGGTGGAGCGGCAGCCCTGCATGCCCATGCATCCTGACCGGCCCCTCGTCATCAAGACCGGCGT CCAGTTCACTACTAAAGTCAGGTAGGCCATGCCACTTCCATTTCCAGTAGAGATTTTACTGAGGGACACT GTTAGGGTGAGGGTAGAGTTGGTGGCCAGGGTCATTCTTTCCAGGTGTGGTGTCACAGGCAGTACACTGT TGCGGGGTTGAAATTTGTTGCCATACTATCTGCTTGCTCTCTGATTCTGATGTCAAAAGCAAAAGAGCAG TCATCTTTTTGAAGGTACCTGGGCATATTCCTATGATTGTAGACCTGGAGTCTCAGGCCACAGCTTCTCC TTCTGCCCAAGGGACAAAATAATGTCATCTATTTTCTGTTCTTTGAGGCTACTCTTCCCTGTGGATTTTA AGGGAAAGAGTAAGGCTTAGTGATGGGGAAGCTGAGAGGCCCCAGGGCAGGTGGGTGGTGGGCCTGTAGG GTGAGGTGTTACTTTCACACTCAAGTCAGAACAGGTGTGCTGGGGTTTTGACCTTCTGCAGCAAAATTTC CCTCCTCAGAAACTTAGTATGGTGTTCGGTTTCAGGATTAATAGAACAAAATGCCAGCTGCACAGCATGT GTTCCTGTAATATTTTTCATTATATGGCTTTGATTATCCTTTTGTGAATCTCTCACAACTTTAAGTTGTT AGTTCTTAGATGTTTTCTCAGTACCTTTGGCTTGAAGGAGTGATACTCATCTTTTGTTTTTGTTTGAGAC AGGGTCTCACTCTCACCCAGGCTGGTGTGCAGTGGCATGATCTCAGCTCACTGCAACCTCCATCTCCCAG GTTCAAGTGATTCTTGTGCCTCAGCCTCCTGAGTAACTGGGAATAGAGGTGCGTGCCACCACACCCGGCT AATTTTTTTTTTTTTGAGACAGAGTCTCGCTCTTTCGGCCAGGCCAGAGTGCGTGTTGCAATCTCAACTC ACTGCAACCTCCACCTCCCAGGTTCAAGCGATTCTCCTGCCTTAGCCTCCCTGAGTAGCTGGACCGGCAC ACTCCACCATGCCCGGCTAATTTTTGTATTTTTAGTAGAGACAGGGTTTCTCCATGTTGGCCAGGCTGGT CTCAAAACTCCTGACCTCAGTAATCCACCCACCCCGGCCTCCAAAAGTGCTGGGATTACAGATGTGAGCC ACCACGCTCGGCCTTTTTTTTTTTTTTTTTTTTTTTGAGATGGAGTCTTTCTCTATCACCCAGGCTAGAG TGCTGAGGTGTGATCTCGGATCACTGCAGCCTCTGCCTCCTGGGTTCAAGTGATTCTCCTGCCTCAGCCT CCCAAGTAGCTGGGATTACAGGTACCTGCCACCATGCCCGGCTGATTTTTGTATTTTTAGTAGAGACGGG GTTTCACCATCTTGGCCAGGCTGGTCTCGAACTCCTGACCTTGTGATCCACCTGCCTTGGCCTCCCAAAG TGCTGGGATTACAGGTGTGAGTCACCGCACCCAGCCCTATTTTAATTTTTTTAAAGAGAGAGATAGGGGC CAGGCACGGTGGCTCTCGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGTGGGTGGATCACCTGAGGTCG GGAGTTCGAGACCATCCTGACCAACATGGAGAAACTCTGTCTCTACTAAAAATACAAAATTAGCTGAGCG TGGTGGCGCGCGCCTGTAATCCCAGCTACTTGAGAGGCTGAGGCAGGAGAATCACTTGAACCCAGGAGGC GGAGGTTGCGGTGAACGGAGATTGCGCCATTGCACTCCAGCCTGGGTAACGAGAGAAACTGTCTCAAAAA AAAAAAAAGAGAAAGAGAGATAGGATCTCGCTCTGTCATCTAGGCTAGAGTGCAGTGGCATGATCATAGA TCACTGTAGCCTTGAACTCCTGGGCACAAGTGATCCTCTTGCCTCAGCCTCCCGAGTAACTGCGACTACA GGTACATGCTACCACACCCCGCTAATTTTTAAATTTTTTATAGATGTGGGCTCTCACTTTGTTGCCCAGA CTGTTATGGAACTCCTGGGCTCAAGGGATCCTCCCAGCTTGGCCTCCCACAGTGCTGAGATTATAGATGT GAGCCTGTAATTATAGACAGCTTGGCCTATTTACCTGTTGGAAATGAAGAATTATGAATTTTACATTTCT TCAAGAAAAGGTTATGGGAGAGTTACTGACTTTTTTTCCTTGGATTTTTTCTTTTTAAATAGGTTGCTGG TCAAATTCCCTGAGTTGAATTATCAGCTTAAAATTAAAGTGTGCATTGACAAGTAAGTACTCCTATCTTA GCTCTGTTTTTCAAATGAGGAATAGAAAAATGAGAACTTTGACAGACATCATTTGAACTAGAGACTCTGT CTTTATTCAGAGATCTTCATTTTGTGGACAAAAGTTTTCAAAAGCCTTGGGGTGCATTGTCATTTACGTG TCTGAACAAAGCCACAAAGCTGGGGGTACAGATTTGATTTGTGGTTGCTATTGTGACAACCAGTCCCTCT TTTCCTTGTTTAGTTTTTTACTTGTACATGTCATTCATGCATATTATATATAAGACTGAGATCATGTGTT AATTAACGACTGGGATACGTTCTGCAAAATGTATCATTAGGCAATTTTGTTGTGCAAATGTTGTAGAGTA TATAGTCCTTACACAAACCTGGGTGGCAGAACCTACTGCACACCTACGCTATGTGGCAGAGCCTACTGGT CGTAGGCTGTAAACCTGTACAGTATGTTACTGTGCTGAATACCGTAGGCAATTGTAACACATCTCAATGA AGTAGGAATTTTTCAGCTCCATGATAATCTTATGGGACCACCATCATATATGCATTTTGTTGTTGACCGA AACGTCGTTATATATTCTTTCCATACATAGCATGTGGAAAGAATAGATCTCTTTTTTTTAATTGTTCCAC ACTTTACCATATAATGGAATACGCAAAATTTCACAATACCTTTCAGGATGTAAAATACATATACCCTTTG ACGACATTAGAAAAGAGAAAATGTGGGCCGGGCGCGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAG GCCGAGGCGGGCGGATCACGAGGTCAGGAGATCGAGACCATCCTGGGTAACACGGTGAAACCCCGTCTCT ACTAAAAATACAAAAAAACTAGCTGGGCGTGGTGGCGGGCACCTGTAGTCCCAGCTACTCAGGAGGCTGA GGCAGGAGAATGGCATGAACCTGGGAGGTGGAGTTTGCAGTGAGCCAAGATCACACCACTGCACTCCAGC CTGGGCGACAGAGACTCCATCTCAAAAAAAAAAAAAAAGAAAAGAAAAGAGAAAATGTGGCTGGGCGCGG TGGCTCACGCCTGTAATCTCAGCACTTTGGGAGGCTGAGGTGGGCAGATCACCTGAGGTCGAGAGTTCGA AACCAGCCCGACCAACATGGAGAAACCTTGTCTCTACTAAAAATACAAAATTAGCCAGGTGTGTTGGCGC ATGCCCGTAATCCCAGCTACACGGGAGGCTGAGGCAGGAGAATCACTTGAACTCAGGAGGTGGAGGTTGT GGTGAGCCGAGATCACACCATTGCACTCCAGCCTGGGCAACAAGAGCGAAACTATCTCAAAAAAAAAAAA AGAAAAAAGAAAAGATAAAATGCATTCTTATTTTTAGTTGATGTAATTATGTGGAAATTTCATGAGGATG CACTGGAAAATAATGAAATAAGGGAGTTGACGAAGGTGGTAGGTTTAATAAGTACATATGCAATATGAAA CATAGGTTCCCCTTCCTATGGGGAGGCAACCAACTGTGCCTGCTACGCAGAGGTGTTATGTTGCGCTGAT CAACTGTAACTGAATAGTTTAAAGAAATGCCCAGGAGCACAGAGGTTTTTTCATGACAGTAAATAACAGG TGGTCAAAGTAGGCTTTTTGAAGAAACACAGAGCCTATTTTATTAACAACAGTCTGTGTTCTTACAGAGA CTCTGGGGACGTTGCAGCTCTCAGAGGGTAAGTTCAGCCTAGAGGCTTCCTTTTGTTCCGTTTAACCTAA CTTCATCCTCCGGCTACTTGGTCACCTACATAGTTGATTGTTCCCCTGTGATTCAGATCCCGGAAATTTA ACATTCTGGGCACAAACACAAAAGTGATGAACATGGAAGAATCCAACAACGGCAGCCTCTCTGCAGAATT CAAACACTTGGTATGTGGGAGGAGCTCCCCTTCACAAAGGGCCTCTGGCTGCCGGAGAGGGCTAGGGAGA GCCTCACAGGACACCTGCCTTTTTCTTTTCTTACAGACCCTGAGGGAGCAGAGATGTGGGAATGGGGGCC GAGCCAATTGTGATGTAAGTTTTGTTGGGGATGAAAGACAACTGGGGTGTTTTCCTTGAGGGAGAGAGGG GTAAAGATCCTTCTTAATCCCCAGAATTAGAAACATCAACCTGTTCTTTCAGCTGTAGTTATTCCAAAAA GTCACTTCAGGCCAAAGTGACATGAACAGAAGTTCCATGTGCCATGGAGCTCTCTGGCTTGGAACATTTC CGTGAATATCTGGGAGTTGGCTCCTCCTTAAGGAGAAGTGGAAAGTCCCTTGCTGAGTTGTTCTCCACAC CCATGTGGTATAAAGCAGCTTTCCACCTTGCCTGGGGCTTTCCAAATTCCCCATCCAGCTCCTGCGGCTG ACCCTGCTTGGCTCCATTTTTAGTGCCCTGTTTTTCTCTCCCACTGAGGTGGGATAGAGGGTGTAAAAGC AACAGATTTGAGTTAAACTTTAAAATAAATGACCACCTTGCATTAGCTTGCTTAGGAAAAGAGTACATAA AATAAAATGAACAAACAAAAACCCATCTTGTTCTTTATCCCCCTTATTTTCTGCTTTTCATTGATTCAGA TTATTGGATTCTTATTGTCAAGAATAAACTTTAAACAAACAAACAAAAAAAGGTAAATGTGACGGAAGGC TAGTTTTCAGTCATTTTTAAAAATTGTGATGCCCCGTTCTTTTTCTTACATTTGTCCCCTGAACAATTCT TCCTCTTTAAAATGTAGCAGTCCTAGCTGGGCGTGCTGGCTCACACCCCGTACTTTGGGATGCCAAGGCA GGCTGGTCACTTGAGGTCAGGAGTTCAAGACCAGCCTGGCCAACATGGTGAAAGCCCGTCTCTACTAAAG ATACAAAAATTAGCTGGGTGTGGTGGTGCACGCCTGTAGTCCCAGTTACTGGGGAGGCTGAGGCATGAGA ATCGCTTGAACCTGAGAGGTGGAGCTTGCAGTGAGCCAAGATTTTGCCACTGCACTCTAGCCTGGGCAAC AGAGTGAAACTCTGTCTCAAAAAAATAAATAAAATAAAATGTAGCAGTCCTTTTTAAAAATGTGGAATTT TACTTGACAGTAGAGTGAAGTAGCCTGTATGCAATGATATGGGAAAATGTACATGACATATTAAGAAAAA GCAAAATGTAAAATAATTTGAATAGTATTATTAGTATATGTGTTTTAAAAATACACTATACTCTTATGTG TATTCATATGTATATTAAGAAATTCTGGAGGAATATACCAGCAGTGCTATGTGTATTAGTGCTGCTGTTG GTATCCATGGCTATTCTAGACTGTCTCTGTGATATTTGCATTTTAAACTGAATATATTACTTTTATAATC AGAAAAATAGTATTAAAAATGAATTATAATTTAATTTCTTTTTTCTTTTTTTTTTTTGAGTCGGAGTCTC GTTCTATCGGATTGCAGTGGTGCGATCTCAGCTCACTGCAACCTCTGCCTCCTAGGTTCAAGCGATTCTC CTGTCTCAGCCTCCCAAGTAGCTGGGACGATAGGTGCATGCCACCACGCCTGGCTAATTTTTGCATTTTT AGTAGAGACAGGGTTTCACCATATTGGTCAGGCTGGTCTTGAACTCCTGACCTCGTGATCCACCCATCTC GGCCTCCGAAAGTGCTGGGATTACAGGCATGAGCCGCTGTGCCCAGACTAGAATTCAATTTTTGAGAATT CATTGACAACTCTTACTTAAAATAAGGTTGCTGTACTGATGTGAGACATTGTTGTAGTCAGTTTGGAAAA CAATTTGGCAGTATAAAAATGAACATACCTGTAAACCAACGGTGCCATTCCCAGGATTTAATAGCAGAGA AATCTTTGCATATATGTCCCAGGAGACATATATAAAGTGGACATCAGCCTGATTATAAGCTCTAAATGCA ACCCAAATAAATACCCATCAACATTAGAATGAATACATTATTTGTGGTATAGACACAATGGAATACTCCG CAGCTGTGAAAAGGAATACACTGCAGATACACATAACCATGTGGATTCATTTCACATCAAGTGAAAAGTG AATCCCAAAAGAATTCATTGGAGTCCATAAGTGTAAGGTTCACAAATGTCCCAAACTAAACAATACCTGC ATTGCTTAGATAAACAAATATGGTAAAACTGTAAAAAAACAAAACAAAACAAGACAAAAAGGGCTAGGAA ATGATAAACCCAAAAGACAAAATAGCAGTTATTTCTGAGGGAGGAGGGAAGGGGATGGGGTTGGGGAAGG GCACCCAGAGAATTTTAGGAGTGATGGACTTTTCCTTAAATTGAATGGTGGGTTCATATTGTTTTGTTAT TCTTTGTGCCTTACGTATTTTACAAATAACCAATTGGATCTATGTAATATTATAATACAAACTGAGTAAA GGATTAGGTTGAGGATCACAGCATTGGAAGTTCTTGGTGTTGAAGAGAGTAAGTGCCGAGCAAGTTGTGT CCCTGGCAGTTTGTTTGTGACCACCTGGTGGCTTACCCTTCTTGGTGTGGTGAGGCTTGGCATGTCACTT TCCTTGGCTGTGGCTGTTAGTACTGAATGCCATTCTCTCTGAGGAAAAGTGTCCTTCTCTTTTTTATTGA TTGACTGATTGATTGAGACAGAGTCTCACTCTGTCACCCAGGCTGGAGTGCAGTGGCGTGATCTCGGCTC ACTGCATCCTCTGCCTCCTGGGTTCAAGCGATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGACTACAGG CGCCCACTACCACACCCAGCTAATTTTTGTATTCTTAGTAGAAACGGGGTTTCACCAAATTATTGGCCAG GCTGGTCTCGAACTCCTGACCATGTGATCCACCTGCCTCGGCCTCCCAAAATGCTGGGATTGTAGGTGTG AGCCATCACGCTCAGCCTTTTTTTTTATTTAATTTAATTTTTTTTTAAGACAGGGTCTCACTCTGTCACC CCAGCTAGAGTGCAGTGGCACAATCATAGCTCGCTGCAGCCTCCATCTCCTAGGCTCAAGCCATCCTCCC ACCTCAGCCTCTCGAGTAGCTGGGGCTATAGGTGTGCACCACCACACCCAGCTAATTTTTGTATTTTTTG CAGAGATGGAGTTTTGCTGTGCTGCTTAGACTGGTCTCGAACTCCTGGGCTCAGGCAATCCTCCTGCCTT GGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACCACACCTGGCCTAAGAGTGTCCTTCTCGTTACT GTAGGCTTCCCTGATTGTGACTGAGGAGCTGCACCTGATCACCTTTGAGACCGAGGTGTATCACCAAGGC CTCAAGATTGACCTAGAGGTAAGTTCTGCAGCAGAATCGGTGAGAGGCTACGTACAGGGGTGACTCAGGA CAAAAACTTCCACTGGGATTTTTACAAGAGAAGGTGGAATGATTACTGTTTGCTTAACACTGTGTTTATT TTTGCTTACTTTTCTCCAAAAAAATCCTTGGCATCCCATCTGGCAATAAAGTCTTGCTTGAATGCTTAGA AGATGTGTGTATATTCAGCTTTCAGCAAACTTGATATGAAAATCTCTATTTAGAAATTGATTGGCCGGGC GCGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCGGGTGGATCACGAGGTCAGGAGTTC GAGACCAGCCTGGCCAACATGACGAAACCCCGTCTCTACTAAAATACAAAAATTAGCTGGGTATGGTGGC GGACGCCTATAATCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATCACTTGAACCTGGGAGGCAGAGGTT GCAGTGAGCTGAGATTGTGCCATTGCACTCCAGCCTGGGTGACAGAGTGAGACTCCGTCTCAAAAAAAAA AAAAAGAAATTAGAACTGACTTTATAAAGTTTGGGCATAAGAGTCTTAGCAGCCAGTGTGTTTAGTATAC AGAAAATTGTGGCAATGACATTCTCCTTTCCCAACTTTCTTGATTTTTAAATTAAGATATACCTAGAAAA GCAGGAATCCTGGTCTTTGATTCCTGAGACCTCCCTGTTTCATGTGAAGATACAGCTTCAAGTCTTGGAG AATGCCTCCAAGGTCTTAAAAATGGGGAATCTGTGGATTGTGAGTCAAGCTTTGAGCAAGTCAGGTTTTA CAAGGGACCGGTATATTCCGACTGCAGCCTGAGTTGTGTGGCCACGCTGGGCATTCTTTCCACTATGAGT GCTCACTGAGCTGACTCACTCACACTCCTCGCCTAGAGTTGGCAGCAGGTGTGGTTTATGGCATGTCCTT TCATTCTGAGCCCCGTGAGATGCGGGTGAAGAGATTTCCAAGGCTGTGAGAGCCCCTCTGCCTCCCCAGC TCAGTCCCCACTCCCTCCGCAGACCCACTCCTTGCCAGTTGTGGTGATCTCCAACATCTGTCAGATGCCA AATGCCTGGGCGTCCATCCTGTGGTACAACATGCTGACCAACAATCCCAAGGTTAGTGCCCCCTCCTTTT AGTTGGTGCCCCGGGATCTCTTGCGACTTAGGGGTACCTAGTATAGACAATGAGCACCATCCCTCATCTA AACAAGCAAATGTGTTCTTTCCAATAGAATGTAAACTTTTTTACCAAGCCCCCAATTGGAACCTGGGATC AAGTGGCCGAGGTCCTGAGCTGGCAGTTCTCCTCCACCACCAAGCGAGGACTGAGCATCGAGCAGCTGAC TACACTGGCAGAGAAACTCTTGGGTCCGCATTTCACCCCTTCTCCCTCCCGCCCACCCGCCCAGAAAAGG GATCCGGCCCATAGGGCTGTTCATTTGGGCCATGTCTACTGAGCATTAGGCCATGTTTCTTTCCTGAGCA AGGCGCTGTGCTGGTGCCAGGAAACAGGGGAGTTGGGGAGTTGGGGTGCAGAGACAGTTTGCAGTTTTCA GTCGAGGTGATCATTTTTGAGGTGGGAGGTAGATTTCTTTTCTCCTGGTTGCTGTCTCATTCACCCACTC TATCTAACTTTAGAAGATCTTTTAAGTGTGTGTTGGAAGGTGGCACTAAAGGCTTGACATTCCCTGTCCA TTTTTTTAATAAACTATAGGCTAGTTGGTTTTTTTTGTCTTATTTTATTTATTTATTTATTTTTTTGAGA CGAGTCTTGCTCTGTTGCCCAGGCTGGAGTGCAGTAGTGTGATCTCGGCTCACTGCAACCTCCGCCTTCT GGGTTCAAGCGATTCTTCTGCCTCGGCCTCCCGAGTAGCTGAGACTACAGGTGCTCACCACCACGCCCAG CTAATTTTTGTATTTTTAGTAGAGACGGGGTTTTACCATGTTGGCCAGGATAGTCTCCGTCTCTTCACCT CGTGATCCGCCCACCTCGGCCTCCTAAAGTGCTGGGATTACAGGCTTGAGCCACTGTGCCCAGCGTAGGC TAGTTTTTAAAAAAGAATTAGTGGAATATTTTATGTGCCACCTGGGCTAGAAGTAGCTTTGTTCTAATAA AGCTGTTGCCACCAAATACACCTGTCTGACACCCGATGTCAGCTTGTTAGTGAGTGCTGCTGTTGGTTCC CAGCCTACCACCCGAGGTTGGGAAGAGCAGGGGGACTTGTTATATCACCCTCCATCCCTGCTGGGCTACC CAGCAACACAAGTGAGTCAAATGATGGGATAGTGTTTGTCCTCATGTGCACACACACAACAGTGCCTACC TTCAAAGATGTGAAAGCTGATTATTTTGTGGCCCATTGTGGGATGAATGTGTGTGTGTTCTGTTTTAAGA AATAACCTCTTGACCCCAAGCTGAAAATGTACTACTTGACTCTTTTTCTTTCCTTCAGGACCTGGTGTGA ATTATTCAGGGTGTCAGATCACATGGGCTAAATTTTGCAAAGTAAGCAATCTTGTTAAATTCTCGTGGGA ATGGGAATGCTCACCTGCACGGCTGTCGTTGAGGGCTCTGGCTTGAAGGCCCTGAACTCTTGGTCCAGCG GCCAGTAGGACCTGCCTGAAGGTAGACGGGCCTGAGGATTTGGGTGATGCACTGCACCCCTAGGAAGGGA AGGGCTGGGATGGCAGTAGACTTGGCTTTCCCATTACTCTTTTCTCCAGGAAAACATGGCTGGCAAGGGC TTCTCCTTCTGGGTCTGGCTGGACAATATCATTGACCTTGTGAAAAAGTACATCCTGGCCCTTTGGAACG AAGGGTAGGTTGGACAGAGTGTGCACAGATGTAACCAAGTCCCCTGCTCTCAGCAAGCCAGTGGCAGGGG ATGGATGCCCTGTTAGCAATAACAACATTGTTCCTCCTCCTTGGCTCCAGGTACATCATGGGCTTTATCA GTAAGGAGCGGGAGCGGGCCATCTTGAGCACTAAGCCTCCAGGCACCTTCCTGCTAAGATTCAGTGAAAG CAGCAAAGAAGGAGGCGTCACTTTCACTTGGGTGGAGAAGGACATCAGCGGTAAGGGAGGCTCCCACCCA CCCCACCTGCTGGTGGCTGCTGAGGCCTCATCACTGCTTCTAGTTGCAAGCACCTACTGCCCCCTGGTGG GTGGAGATGGCCTTGACTCCCTGTTTCACTCAGACTCGCAAAACACATTTGCGTGACTTCTAAATCCTTC CAGCTGAAGGATTGGTTTGCTTTGTTTTGCTTGCTCCAGTGACTATTTGTTGAGAATTTTGCAATTTAAA TTGTATTCTTCATCTCTTTTTCTACTTAACCCTGTTAATATATCTTACGCAAGTAGTTATATTCAAGTTT ATTTTCTATGACCCAACTAGTAGCCTCTTCTTAATTAGAAGCCAGCCTGAATATTTCCACAGTGCCAGGC CACTGAACAGGGTGTTCAGGGTCTCAACACTAGGGTGGCTTAAGTCTTTTCCCCTTCGAGGAAAGAAAAA ATGGGCAGTTTTCTCTGAGATGACCTAGCTGTAGGTTCCATGATCTTTCCTTCCCATGTCCTGTGACAGG TAAGACCCAGATCCAGTCCGTGGAACCATACACAAAGCAGCAGCTGAACAACATGTCATTTGCTGAAATC ATCATGGGCTATAAGATCATGGATGCTACCAATATCCTGGTGTCTCCACTGGTCTATCTCTATCCTGACA TTCCCAAGGAGGAGGCATTCGGAAAGTATTGTCGGCCAGAGAGCCAGGAGCATCCTGAAGCTGACCCAGG TAGTTGTTGATTTTCCATGTTCCTGGCATTTAATTTTTGGGAAAAGTTGGAAATTTTGGGATCCTTGGAG GATAGATAGGCAAATGCCTGAATAACCTGGGGGATAATTATTTCTCCTTATGGGAAAGAATTGTAGTGAG TGCTTTTGTTGGGGTGACCGATGGGATTTGAGAGGAGAATCAGAATCACTTAGAGTAGTGTAGTTCCTGC TCCACAGAGAGTGCATGAGTCTAAAGAGGGGATACAGCCTGGGCAATATGGTGAAACCTCGTCTCTACAA AAAATCCAAAAAAATTACCCGGTGTGGTGGCACGCATTTGTAGTCGTAGCTACTTGGGAGGCTGAGGTGG GAGGATCACCTGAGCCAAGGAGTTCAAGGCTGTAGTGAGCGGTGATCATGCCACCGCACTCCAGCCTGGC TGATAGAGTGAGATACTGTGTCAAAAAATAAAAATAAAGAGGGGATCAATACACATACGTCCCCCAAAAC ATGCCTGAAACACGAGAAGGGAAAGTGAGGGCAGTTAACAGGATGCCCTGCTGGCACAGTGCTTCTTAGT AGATGCTAGAAGGTTTGAGGCCCAGATTTCAGCCCAGCATATGGCTTTTTGCCTGTAACTGAACCATGTC AGTGTGCCAGATGGTCTGAAGAAAGGGTTTCTGGAGGAAATTATTATTAGCTGCATGGGAGTATGGTTTA CACTAGAGTAGAAGAGCTGGGAGCATCACGTTTGAAGGGGAAGACAGTGACTGGGTGGAGGGGCAAGGGA TTAGTATTTAGAGTGTGCAACTATTGAAAATAAGGTATATTTTAATGTGTAAGAGGACATGTACTTATAT GTTATATATAAATTATTTTAGCTGGGTGAAGTGGCTCATGCCTATAGTCCTAGCACTTTGGGAGGCCCAG GCGGGAGGATCACTTGAGCCTGGGAGTTTGAGAACAGCCTAGACAACATAGTGAGACCCTATCTATACAA AAATAATTTTTTTTAAATTAGCCACGTGTGGTGGTTTGTGCCTGTAGTCCTAGCTACTCGGGAGGCTGAG GTGGGAGGATTGCTTAAGCCCAGGAGGTTGAGGCTGCAGTGAGCCATGATCGCACCACTGCACTCCAGCC TGGGTGACAGAGCAAGACCTTGACTCACCAAAAAAAAAAAAAAAAAAAAGAGAGAGAAATTAAAAATACT GTAATCTCAGCTGGGCATGGGGGTTCACACCTGCAGTCCTAGCACTTTGGGAGGCTGAAGCAGGAGGATC ACTTGAGGCCAGGAACTCAAGACCAGCCTGGCAACATAGCAAGACCCCACTACACACACACACACACACA CACACAAAGAAGAGAAAGAAAAAAACGAAACAAAACTGTAATCTCTGCAGCTGTCCTCAGTGTGGAGGGG GTAGCCCTGTCTGTTCCCCTTCAGCACTTGCTGTTTTGACTCTCTGGGTTCTTTGTGCAGGTCTTGATGG GGAGTCTCTGGTTTGCCATTCTTTGTTTGATTTAACTTTCTGTAATCATAAAGCCAATGATGGGCTTTTT TTTTTTTTTTTTTTTTAGACTAAGTCTTGCTCTATCACCCAAGCTGGAGTGCAGTGGCACCATCTCGGCT CACTGCAACCTCCACCTCCCGGTTCAAGCAATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGATTATGGG CTTGTGCCACCATGCCCAGCTGATTTTTGTATTTTTTGTAGAGAAAGGGTTTCGCCATGTTGGCCAGGCT GGCCTCGAACTCCTGACCTCAGGTGATCTGCCCACTTCAGCCTCCCAAAGTGCTGGGATTACAGGCGTGA GCCACTGTGCCTGGCCTAATGATGGGCTCTTTAATGTGATCCTTTAGGGTTGGCGCCTTGCCCTAGTTGC TGTTGAAAAAACTATTTTTGTCCAAATAGCACACACACAGAAACCTACCAACTTCCCTCCCACTTTTTCC TAGGAATTCCTTCTGAGGGATTTCTTGAGATGGGGCAGAATGGGGCTTGGAAGAGGGAGTTGGAGCTAAT TGACCGTTGCCTTTCTCCTTTGTTGGGGTCCTGAGTCTTGTTCCTGCTGTAAGAGTTACTCACTTCCTGT CTGCCACCTATCTCCCTTTGCATGTGTGCTTCAGTTGGGAGATCTGTTTATCAGCCCCTGCCACACGGCT CTTTGTTCCTTCTGCAGAGGACGTTGGGGTCCCACGGCTGGTCCTTTTGACTCATTTTGCTTTCAAGGTC CCACCTCCCAGTCTGAGGCTGCATCCTCCATTACCATCGCCCTTCCTGTGGGCTGGGAGGCCAGGTCCTT TCCTGCCCAGCGATGTCAGCGTTTCCTCAGGGGCCAGGCACTCATCAGGAGAAAGGAACTAATTACTTGA GTAATTTGCCTTGCCTTGCTGAGAGGAGTGTGCCCTGAGGGACTCCATGTGAGTGTGGTGACGGGTGTGG GGGTGTCCCTGTGTTATTTTAAAATGGGTGCCTTCAGGACGATGAGCATGTGACCATTTCCTCTCTATTT CCATCACAAGAGTATTATGGTATGAGGGTCTCAGGTTAGATTATCCTCCCAAGACTCTTCTCTCTTCCTT CTCTACTGGAAGCCCACATAGCATTTCCTTATGGCTTGAGGGAGAGGTTCGGAGCCACTTACAAATTAGA TAAAGTACATTTACAATCTTGTACAAAGCCACACAATGAAGTCATTTTTCTCAGCTTTTTTTTTTTTTTT TTTTTTTTTTTTGAGCCTGAGTCTCGCTCTATCGTCCAGACTGGAGTGCAGTGGCGCGATCTTGCTTCAC TGAAACCTCTGCCTCCCAGGTTCAAGAGATTCTCATACCTCAGCCTCCTGAGTAGCTGGGATTACAGACA TGCACCACTATGCCTGGCTAATTTTTGGATTTTTAGTAGAGACCGGGTTTCACCCTGTTGGCCAGGCTGG TCTCGAACCCCTGACCTCAAGTGATCTTCCCGCCTGGGCCTCCCAAAGTGCTGGGATTATAGGTGTGAGC CACAGTGCCCAGCCTTGTTTTTGTTTTTGTTTTGTTTTGACAGTCTGTCACTCTGTCACCCAGGCTGGAG TGCAGTGGTGCGATCTCACCTCACTTCAGCCTCTGCCTCCCAGGTTCAAGTGATTCTCCTGTCTCAGCCT CCTGAGTAGCTGGGATTACAGGCGTGCCACCACGCCCAGCTATTTTTGTAATTTCATTAAAGACAGGGTT TCCCCATGTTGGTGAGGCTGGTCTTGAACTCCTGGCCTCAAGTGATCCACCTGCTTCAGCCTCCCAAAGT GCAGGGATTACAGGCATGAGCCACTGTGCCTGGCCTCAGCTATCTTGAATGCTGGAGAATTAAATCCTTT TCTGTCTAGGGTGTCAGCTCCCTAAGGGCTGGGCCAAAACAGTTGGATTTATAAGACACTAGAGTCTTGC CTCAGTAGCTCCTTTGAATTCTGCACTGAATTGATCAGTTTCTTGGCCCAAAGTAAACTCAGATGGCAGC CCAAGAGCCACTCTGCAGTGCCTTCTTTCACATGGTCATCATGCTCTCTGATCCCTCAGGTTCTGTCTAA GCCTCATGTTTTATGACCGTGCTGTTCTCAGCCCACCTCACCCTGCCCCATGCCTTCTCAATGGTTTGTT CACCTGAATTCCCCAGATTTCATGCCAGTATCCCCAAGGTTCCTTGACCTCTTGGTGTAAGCATTCAGCA TCTAAAATTCATTTTATTCCCGTCAACGCATTTCTAACTGTAGAACAAGAATTATAAATGACAAAGCTCA TAGAAAATTGGCACCTTGTCTTCCCCCTCCCTCTTATTTTATACATAAAAGAGAATATGGGCTGGGCATT GTGGCCAAGGCTGGGCATGATAGCTCATACTTGTAATCCAGCACTTTGGGAGGGTGAGGCAGATGGATCA CCTGAGGTCAGGAGTTCAAGACCAGCCTGGCCAACATGGTGAAACCTCATCTCTACTAAAATTACAAAAA AAAAATTAGCTAGGCATGGTGGCAGATGCCTGTAATCCAGCTACTCAGGAGGCTGATGAAGGAGAATCAC TTGAACCCTGGAGGCAGAGGTTGTAGAGAGCCAAGATGGCGCTACTGCACTCCAACCTGGGCGAAAGAGA GCAAGACTCCGTCTCAAAAAAAAAAAAGACAAAAATTAGCCAGGCATGGTGGTGCCACCTGTAGTCCCAG CTGCTTGGGAGCCTAAGGCAGGAGAATCGTTTTGACCTGGGAGTAGGAGGTTGCGGTAACCGAGATTGTG CCACTGCACTTGAGCCTGGGCAACAGAGTGAGACTCTGTCTCAAAACAATAAGAACAACAGCAACAAAAG AGAGAGACCATGCCTTGCTCCAGGTCTCTTAGCTATTGAAGATGTACCTGGACCCAGGTCTCCGGTCTTC TAGTTGAAGCAATTGTACTGCCTTACAAAGTCACATTCTCTTTGGTGCTTTTTGATTGACGTATTTATCC AACTAGAAAGTTACTCATGCCCTCATCCAAAAATGTGGTAGAGGCCAGATTAGTGCTGGTAGGAATAAGA GATATAACCTTTGGCTTTGGAACCACAAGCATTAGCAGTCTCCATGTTCTTTAAAGACTTGGTGATATTG GTATTTAGGCTGGACACCATGCAAAGACTACACAGGCTCGGTTCCTGCATGCAGAGAAGTTATCTAAGAG ATATGACCAGGCCGGAATAGAATGCTCAGACCACGTGGAGGCTGTTAAACTTTTACATAATCTAGGGAAA GAAGGGACACAAGGTGGCATTAGTCTAGGGTCAGGTGGGAAAAGGTTATGCTGAAAAGTCTCTGCAGCTC AGGACAGCTTTGTGCAAAGAACTGAAGTTCACAGCTGCTAGTGCCTGGGAGATCAAATAGTATAAATGAG GGCAGACAACCCTGAGGGGCAGATGGAGCTTTCCAGACAATCTTGGCATGAGGATGAGTGAGTTTCAAAT CAGTCCTGCCGAGGCAGATGGCTTCCTCCAGCTCTGCTTACTGAATGCGAAGTCACAGTCAGTAAGAAAA CTGGTTTTCTTCTTCCCAGGCGCTGCCCCATACCTGAAGACCAAGTTTATCTGTGTGACACCGTAAGTGG CTTCCTTTCCCCGTTTTGCCTTCATTTCTAATATCCTCAGTTATCCCTGGGAATGGGACACTGGGTGAGA GTTAATCTGCCAAAGGTTGGAAGCCCCTGGGCTATGTTTAGTACTCAAAGTGACCTTGTGTGTTTAAAAA GCTTGAGCTTTTATTTTTCTGTTGGAGACCAGAGTTTGATGGCTTGTGTGTGTGTGTTTTGTTCTTTTTT TTTTTTCCATTGTGTCTTGTCAACCCCCCGTTTCCCCTCCTGCTGCCCCCCATTTCCTACAGAACGACCT GCAGCAATACCATTGACCTGCCGATGTCCCCCCGCACTTTAGATTCATTGATGCAGTTTGGAAATAATGG TGAAGGTGCTGAACCCTCAGCAGGAGGGCAGTTTGGTGAGTATTTGGTTGACAGACTTTGTCCCTATAAG GGAAGTTGGTCCCCTTTGTGTGATGCTCTCACATGTACACACCGAGAGCTGGTCACTCGGAATGGTAGGA GATTCTAGAGCTTTGCTTTCCAAAAGAGATGGTATGAATGCCACATGTGTGAGTATAAATCTTCTAGCAG CCACACTGGAAATAGACGAACTTAATTTTTACAATATATTTTATTTAACCCACTAAATCCAACATACTCT CAATTTAACATTTCAGAAAAAGTTGAGGCTGGGTGAGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAG GCCGAGGTGGGTGGATCACTTGAGGTCAGGAGTTCGAGACCAGTCTGACCAAAATCTCTAAAATATAAAA ATTAGCTGGGCATGGTGGCGCATACCTGTAATCCCAGCTACTCAAGAAGCTGAGGTGGGAGGATCGCTTG AGCCTGGGAGGTGGAGGTTGCAGTGAGCAGAGATCGTGCCACTGCACTCCAGCCTGGGCGACAGAGTGAG ACTCCATCTCAAATAAACAAAACTAAACTAAAAAGAAAAAGTTGAGACCTTTTTTTATTCTTTTTTTTCA TACTAAGCCTTTAAAATCCAGTGGGCTTTTGACAGCCACAGCACAGCTCAGTTTGGACAAACCAAATCTC AAATGCTTGGTGGCCACGTGTGTCTCGGGGCTCCTGAATTAAACAGTAGATCAAGGGCAGAAGATCTCAG GACAGCCTTAGAGCTTCTGTAAACATGGAGCTCTGGGAATCAGTTAAGGTGGGAATGAGAAAGGACCCTT CCCGAGGCAGGGTCCTCCAGGGAGGAGGGTAAATCTGGCTTTTCTGACCATCCCTGGGCCTTAAGGGGCA GGAGATTGGATAGCAGTGGTAGCCTGGGCCCTGTCCTCTGAAGGGCTGGGGGCGTGGCCTGCCAGTTGCA GAGGGTGGACAACTGAACTAGTTTTCCCTGTCTGTCCCTCCAGAGTCCCTCACCTTTGACATGGAGTTGA CCTCGGAGTGCGCTACCTCCCCCATGTGAGGAGCTGAGAACGGAAGCTGCAGAAAGATACGACTGAGGCG CCTACCTGCATTCTGCCACCCCTCACACAGCCAAACCCCAGATCATCTGAAACTACTAACTTTGTGGTTC CAGATTTTTTTTAATCTCCTACTTCTGCTATCTTTGAGCAATCTGGGCACTTTTAAAAATAGAGAAATGA GTGAATGTGGGTGATCTGCTTTTATCTAAATGCAAATAAGGATGTGTTCTCTGAGACCCATGATCAGGGG ATGTGGCGGGGGGTGGCTAGAGGGAGAAAAAGGAAATGTCTTGTGTTGTTTTGTTCCCCTGCCCTCCTTT CTCAGCAGCTTTTTGTTATTGTTGTTGTTGTTCTTAGACAAGTGCCTCCTGGTGCCTGCGGCATCCTTCT GCCTGTTTCTGTAAGCAAATGCCACAGGCCACCTATAGCTACATACTCCTGGCATTGCACTTTTTAACCT TGCTGACATCCAAATAGAAGATAGGACTATCTAAGCCCTAGGTTTCTTTTTAAATTAAGAAATAATAACA ATTAAAGGGCAAAAAACACTGTATCAGCATAGCCTTTCTGTATTTAAGAAACTTAAGCAGCCGGGCATGG TGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGATCATAAGGTCAGGAGATCAAGACCAT CCTGGCTAACACGGTGAAACCCCGTCTCTACTAAAAGTACAAAAAATTAGCTGGGTGTGGTGGTGGGCGC CTGTAGTCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATCGCTTGAACCTGAGAGGCGGAGGTTGCAGTG AGCCAAAATTGCACCACTGCACACTGCACTCCATCCTGGGCGACAGTCTGAGACTCTGTCTCAAAAAAAA AAAAAAAAAAAAGAAACTTCAGTTAACAGCCTCCTTGGTGCTTTAAGCATTCAGCTTCCTTCAGGCTGGT AATTTATATAATCCCTGAAACGGGCTTCAGGTCAAACCCTTAAGACATCTGAAGCTGCAACCTGGCCTTT GGTGTTGAAATAGGAAGGTTTAAGGAGAATCTAAGCATTTTAGACTTTTTTTTATAAATAGACTTATTTT CCTTTGTAATGTATTGGCCTTTTAGTGAGTAAGGCTGGGCAGAGGGTGCTTACAACCTTGACTCCCTTTC TCCCTGGACTTGATCTGCTGTTTCAGAGGCTAGGTTGTTTCTGTGGGTGCCTTATCAGGGCTGGGATACT TCTGATTCTGGCTTCCTTCCTGCCCCACCCTCCCGACCCCAGTCCCCCTGATCCTGCTAGAGGCATGTCT CCTTGCGTGTCTAAAGGTCCCTCATCCTGTTTGTTTTAGGAATCCTGGTCTCAGGACCTCATGGAAGAAG AGGGGGAGAGAGTTACAGGTTGGACATGATGCACACTATGGGGCCCCAGCGACGTGTCTGGTTGAGCTCA GGGAATATGGTTCTTAGCCAGTTTCTTGGTGATATCCAGTGGCACTTGTAATGGCGTCTTCATTCAGTTC ATGCAGGGCAAAGGCTTACTGATAAACTTGAGTCTGCCCTCGTATGAGGGTGTATACCTGGCCTCCCTCT GAGGCTGGTGACTCCTCCCTGCTGGGGCCCCACAGGTGAGGCAGAACAGCTAGAGGGCCTCCCCGCCTGC CCGCCTTGGCTGGCTAGCTCGCCTCTCCTGTGCGTATGGGAACACCTAGCACGTGCTGGATGGGCTGCCT CTGACTCAGAGGCATGGCCGGATTTGGCAACTCAAAACCACCTTGCCTCAGCTGATCAGAGTTTCTGTGG AATTCTGTTTGTTAAATCAAATTAGCTGGTCTCTGAATTAAGGGGGAGACGACCTTCTCTAAGATGAACA GGGTTCGCCCCAGTCCTCCTGCCTGGAGACAGTTGATGTGTCATGCAGAGCTCTTACTTCTCCAGCAACA CTCTTCAGTACATAATAAGCTTAACTGATAAACAGAATATTTAGAAAGGTGAGACTTGGGCTTACCATTG GGTTTAAATCATAGGGACCTAGGGCGAGGGTTCAGGGCTTCTCTGGAGCAGATATTGTCAAGTTCATGGC CTTAGGTAGCATGTATCTGGTCTTAACTCTGATTGTAGCAAAAGTTCTGAGAGGAGCTGAGCCCTGTTGT GGCCCATTAAAGAACAGGGTCCTCAGGCCCTGCCCGCTTCCTGTCCACTGCCCCCTCCCCATCCCCAGCC CAGCCGAGGGAATCCCGTGGGTTGCTTACCTACCTATAAGGTGGTTTATAAGCTGCTGTCCTGGCCACTG CATTCAAATTCCAATGTGTACTTCATAGTGTAAAAATTTATATTATTGTGAGGTTTTTTGTCTTTTTTTT TTTTTTTTTTTTTTGGTATATTGCTGTATCTACTTTAACTTCCAGAAATAAACGTTATATAGGAACCGTC Download Select all
Length	75180
OMIM ID	102582
HGNC ID	HGNC:11364
Unigene ID	Hs.463059
Ensembl ID	ENSG00000168610
PharmGKB ID	-

mRNA Information

mRNA ID	XM_005257617.2
Exon	join(1..225,39987..40115,41791..41935,42847..42945, 49095..49190,49692..49773,50647..50741,50918..51069, 54455..54613,54739..54831,56973..57032,58728..58757, 58857..58950,59047..59094,62305..62388,63443..63541, 63658..63793,64879..64931,65150..65244,65361..65500, 66010..66222,71280..71322,71603..71715,72704..75180)
mRNA Sequence	>6774 GGTTTCCGGAGCTGCGGCGGCGCAGACTGGGAGGGGGAGCCGGGGGTTCCGACGTCGCAGCCGA GGGAACAAGCCCCAACCGGATCCTGGACAGGCACCCCGGCTTGGCGCTGTCTCTCCCCCTCGGC TCGGAGAGGCCCTTCGGCCTGAGGGAGCCTCGCCGCCCGTCCCCGGCACACGCGCAGCCCCGGC CTCTCGGCCTCTGCCGGAGAAACAGGATGGCCCAATGGAATCAGCTACAGCAGCTTGACACACG GTACCTGGAGCAGCTCCATCAGCTCTACAGTGACAGCTTCCCAATGGAGCTGCGGCAGTTTCTG GCCCCTTGGATTGAGAGTCAAGATTGGGCATATGCGGCCAGCAAAGAATCACATGCCACTTTGG TGTTTCATAATCTCCTGGGAGAGATTGACCAGCAGTATAGCCGCTTCCTGCAAGAGTCGAATGT TCTCTATCAGCACAATCTACGAAGAATCAAGCAGTTTCTTCAGAGCAGGTATCTTGAGAAGCCA ATGGAGATTGCCCGGATTGTGGCCCGGTGCCTGTGGGAAGAATCACGCCTTCTACAGACTGCAG CCACTGCGGCCCAGCAAGGGGGCCAGGCCAACCACCCCACAGCAGCCGTGGTGACGGAGAAGCA GCAGATGCTGGAGCAGCACCTTCAGGATGTCCGGAAGAGAGTGCAGGATCTAGAACAGAAAATG AAAGTGGTAGAGAATCTCCAGGATGACTTTGATTTCAACTATAAAACCCTCAAGAGTCAAGGAG ACATGCAAGATCTGAATGGAAACAACCAGTCAGTGACCAGGCAGAAGATGCAGCAGCTGGAACA GATGCTCACTGCGCTGGACCAGATGCGGAGAAGCATCGTGAGTGAGCTGGCGGGGCTTTTGTCA GCGATGGAGTACGTGCAGAAAACTCTCACGGACGAGGAGCTGGCTGACTGGAAGAGGCGGCAAC AGATTGCCTGCATTGGAGGCCCGCCCAACATCTGCCTAGATCGGCTAGAAAACTGGATAACGTC ATTAGCAGAATCTCAACTTCAGACCCGTCAACAAATTAAGAAACTGGAGGAGTTGCAGCAAAAA GTTTCCTACAAAGGGGACCCCATTGTACAGCACCGGCCGATGCTGGAGGAGAGAATCGTGGAGC TGTTTAGAAACTTAATGAAAAGTGCCTTTGTGGTGGAGCGGCAGCCCTGCATGCCCATGCATCC TGACCGGCCCCTCGTCATCAAGACCGGCGTCCAGTTCACTACTAAAGTCAGGTTGCTGGTCAAA TTCCCTGAGTTGAATTATCAGCTTAAAATTAAAGTGTGCATTGACAAAGACTCTGGGGACGTTG CAGCTCTCAGAGGATCCCGGAAATTTAACATTCTGGGCACAAACACAAAAGTGATGAACATGGA AGAATCCAACAACGGCAGCCTCTCTGCAGAATTCAAACACTTGACCCTGAGGGAGCAGAGATGT GGGAATGGGGGCCGAGCCAATTGTGATGCTTCCCTGATTGTGACTGAGGAGCTGCACCTGATCA CCTTTGAGACCGAGGTGTATCACCAAGGCCTCAAGATTGACCTAGAGACCCACTCCTTGCCAGT TGTGGTGATCTCCAACATCTGTCAGATGCCAAATGCCTGGGCGTCCATCCTGTGGTACAACATG CTGACCAACAATCCCAAGAATGTAAACTTTTTTACCAAGCCCCCAATTGGAACCTGGGATCAAG TGGCCGAGGTCCTGAGCTGGCAGTTCTCCTCCACCACCAAGCGAGGACTGAGCATCGAGCAGCT GACTACACTGGCAGAGAAACTCTTGGGACCTGGTGTGAATTATTCAGGGTGTCAGATCACATGG GCTAAATTTTGCAAAGAAAACATGGCTGGCAAGGGCTTCTCCTTCTGGGTCTGGCTGGACAATA TCATTGACCTTGTGAAAAAGTACATCCTGGCCCTTTGGAACGAAGGGTACATCATGGGCTTTAT CAGTAAGGAGCGGGAGCGGGCCATCTTGAGCACTAAGCCTCCAGGCACCTTCCTGCTAAGATTC AGTGAAAGCAGCAAAGAAGGAGGCGTCACTTTCACTTGGGTGGAGAAGGACATCAGCGGTAAGA CCCAGATCCAGTCCGTGGAACCATACACAAAGCAGCAGCTGAACAACATGTCATTTGCTGAAAT CATCATGGGCTATAAGATCATGGATGCTACCAATATCCTGGTGTCTCCACTGGTCTATCTCTAT CCTGACATTCCCAAGGAGGAGGCATTCGGAAAGTATTGTCGGCCAGAGAGCCAGGAGCATCCTG AAGCTGACCCAGGCGCTGCCCCATACCTGAAGACCAAGTTTATCTGTGTGACACCAACGACCTG CAGCAATACCATTGACCTGCCGATGTCCCCCCGCACTTTAGATTCATTGATGCAGTTTGGAAAT AATGGTGAAGGTGCTGAACCCTCAGCAGGAGGGCAGTTTGAGTCCCTCACCTTTGACATGGAGT TGACCTCGGAGTGCGCTACCTCCCCCATGTGAGGAGCTGAGAACGGAAGCTGCAGAAAGATACG ACTGAGGCGCCTACCTGCATTCTGCCACCCCTCACACAGCCAAACCCCAGATCATCTGAAACTA CTAACTTTGTGGTTCCAGATTTTTTTTAATCTCCTACTTCTGCTATCTTTGAGCAATCTGGGCA CTTTTAAAAATAGAGAAATGAGTGAATGTGGGTGATCTGCTTTTATCTAAATGCAAATAAGGAT GTGTTCTCTGAGACCCATGATCAGGGGATGTGGCGGGGGGTGGCTAGAGGGAGAAAAAGGAAAT GTCTTGTGTTGTTTTGTTCCCCTGCCCTCCTTTCTCAGCAGCTTTTTGTTATTGTTGTTGTTGT TCTTAGACAAGTGCCTCCTGGTGCCTGCGGCATCCTTCTGCCTGTTTCTGTAAGCAAATGCCAC AGGCCACCTATAGCTACATACTCCTGGCATTGCACTTTTTAACCTTGCTGACATCCAAATAGAA GATAGGACTATCTAAGCCCTAGGTTTCTTTTTAAATTAAGAAATAATAACAATTAAAGGGCAAA AAACACTGTATCAGCATAGCCTTTCTGTATTTAAGAAACTTAAGCAGCCGGGCATGGTGGCTCA CGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGATCATAAGGTCAGGAGATCAAGACCATC CTGGCTAACACGGTGAAACCCCGTCTCTACTAAAAGTACAAAAAATTAGCTGGGTGTGGTGGTG GGCGCCTGTAGTCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATCGCTTGAACCTGAGAGGCGG AGGTTGCAGTGAGCCAAAATTGCACCACTGCACACTGCACTCCATCCTGGGCGACAGTCTGAGA CTCTGTCTCAAAAAAAAAAAAAAAAAAAAGAAACTTCAGTTAACAGCCTCCTTGGTGCTTTAAG CATTCAGCTTCCTTCAGGCTGGTAATTTATATAATCCCTGAAACGGGCTTCAGGTCAAACCCTT AAGACATCTGAAGCTGCAACCTGGCCTTTGGTGTTGAAATAGGAAGGTTTAAGGAGAATCTAAG CATTTTAGACTTTTTTTTATAAATAGACTTATTTTCCTTTGTAATGTATTGGCCTTTTAGTGAG TAAGGCTGGGCAGAGGGTGCTTACAACCTTGACTCCCTTTCTCCCTGGACTTGATCTGCTGTTT CAGAGGCTAGGTTGTTTCTGTGGGTGCCTTATCAGGGCTGGGATACTTCTGATTCTGGCTTCCT TCCTGCCCCACCCTCCCGACCCCAGTCCCCCTGATCCTGCTAGAGGCATGTCTCCTTGCGTGTC TAAAGGTCCCTCATCCTGTTTGTTTTAGGAATCCTGGTCTCAGGACCTCATGGAAGAAGAGGGG GAGAGAGTTACAGGTTGGACATGATGCACACTATGGGGCCCCAGCGACGTGTCTGGTTGAGCTC AGGGAATATGGTTCTTAGCCAGTTTCTTGGTGATATCCAGTGGCACTTGTAATGGCGTCTTCAT TCAGTTCATGCAGGGCAAAGGCTTACTGATAAACTTGAGTCTGCCCTCGTATGAGGGTGTATAC CTGGCCTCCCTCTGAGGCTGGTGACTCCTCCCTGCTGGGGCCCCACAGGTGAGGCAGAACAGCT AGAGGGCCTCCCCGCCTGCCCGCCTTGGCTGGCTAGCTCGCCTCTCCTGTGCGTATGGGAACAC CTAGCACGTGCTGGATGGGCTGCCTCTGACTCAGAGGCATGGCCGGATTTGGCAACTCAAAACC ACCTTGCCTCAGCTGATCAGAGTTTCTGTGGAATTCTGTTTGTTAAATCAAATTAGCTGGTCTC TGAATTAAGGGGGAGACGACCTTCTCTAAGATGAACAGGGTTCGCCCCAGTCCTCCTGCCTGGA GACAGTTGATGTGTCATGCAGAGCTCTTACTTCTCCAGCAACACTCTTCAGTACATAATAAGCT TAACTGATAAACAGAATATTTAGAAAGGTGAGACTTGGGCTTACCATTGGGTTTAAATCATAGG GACCTAGGGCGAGGGTTCAGGGCTTCTCTGGAGCAGATATTGTCAAGTTCATGGCCTTAGGTAG CATGTATCTGGTCTTAACTCTGATTGTAGCAAAAGTTCTGAGAGGAGCTGAGCCCTGTTGTGGC CCATTAAAGAACAGGGTCCTCAGGCCCTGCCCGCTTCCTGTCCACTGCCCCCTCCCCATCCCCA GCCCAGCCGAGGGAATCCCGTGGGTTGCTTACCTACCTATAAGGTGGTTTATAAGCTGCTGTCC TGGCCACTGCATTCAAATTCCAATGTGTACTTCATAGTGTAAAAATTTATATTATTGTGAGGTT TTTTGTCTTTTTTTTTTTTTTTTTTTTTTGGTATATTGCTGTATCTACTTTAACTTCCAGAAAT AAACGTTATATAGGAACCGTAAAAA Download Select all
Length	4953

CDS Information

Location	join(39988..40115,41791..41935,42847..42945,49095..49190, 49692..49773,50647..50741,50918..51069,54455..54613, 54739..54831,56973..57032,58728..58757,58857..58950, 59047..59094,62305..62388,63443..63541,63658..63793, 64879..64931,65150..65244,65361..65500,66010..66219, 71280..71322,71603..71715,72704..72759)
CDS Sequence	>lcl\|NM_003150.3_cds_NP_003141.2_1 [gene=STAT3] [protein=signal transducer and activator of transcription 3 isoform 2] [protein_id=NP_003141.2] [location=219..2528] ATGGCCCAATGGAATCAGCTACAGCAGCTTGACACACGGTACCTGGAGCAGCTCCATCAGCTCTACAGTG ACAGCTTCCCAATGGAGCTGCGGCAGTTTCTGGCCCCTTGGATTGAGAGTCAAGATTGGGCATATGCGGC CAGCAAAGAATCACATGCCACTTTGGTGTTTCATAATCTCCTGGGAGAGATTGACCAGCAGTATAGCCGC TTCCTGCAAGAGTCGAATGTTCTCTATCAGCACAATCTACGAAGAATCAAGCAGTTTCTTCAGAGCAGGT ATCTTGAGAAGCCAATGGAGATTGCCCGGATTGTGGCCCGGTGCCTGTGGGAAGAATCACGCCTTCTACA GACTGCAGCCACTGCGGCCCAGCAAGGGGGCCAGGCCAACCACCCCACAGCAGCCGTGGTGACGGAGAAG CAGCAGATGCTGGAGCAGCACCTTCAGGATGTCCGGAAGAGAGTGCAGGATCTAGAACAGAAAATGAAAG TGGTAGAGAATCTCCAGGATGACTTTGATTTCAACTATAAAACCCTCAAGAGTCAAGGAGACATGCAAGA TCTGAATGGAAACAACCAGTCAGTGACCAGGCAGAAGATGCAGCAGCTGGAACAGATGCTCACTGCGCTG GACCAGATGCGGAGAAGCATCGTGAGTGAGCTGGCGGGGCTTTTGTCAGCGATGGAGTACGTGCAGAAAA CTCTCACGGACGAGGAGCTGGCTGACTGGAAGAGGCGGCAACAGATTGCCTGCATTGGAGGCCCGCCCAA CATCTGCCTAGATCGGCTAGAAAACTGGATAACGTCATTAGCAGAATCTCAACTTCAGACCCGTCAACAA ATTAAGAAACTGGAGGAGTTGCAGCAAAAAGTTTCCTACAAAGGGGACCCCATTGTACAGCACCGGCCGA TGCTGGAGGAGAGAATCGTGGAGCTGTTTAGAAACTTAATGAAAAGTGCCTTTGTGGTGGAGCGGCAGCC CTGCATGCCCATGCATCCTGACCGGCCCCTCGTCATCAAGACCGGCGTCCAGTTCACTACTAAAGTCAGG TTGCTGGTCAAATTCCCTGAGTTGAATTATCAGCTTAAAATTAAAGTGTGCATTGACAAAGACTCTGGGG ACGTTGCAGCTCTCAGAGGATCCCGGAAATTTAACATTCTGGGCACAAACACAAAAGTGATGAACATGGA AGAATCCAACAACGGCAGCCTCTCTGCAGAATTCAAACACTTGACCCTGAGGGAGCAGAGATGTGGGAAT GGGGGCCGAGCCAATTGTGATGCTTCCCTGATTGTGACTGAGGAGCTGCACCTGATCACCTTTGAGACCG AGGTGTATCACCAAGGCCTCAAGATTGACCTAGAGACCCACTCCTTGCCAGTTGTGGTGATCTCCAACAT CTGTCAGATGCCAAATGCCTGGGCGTCCATCCTGTGGTACAACATGCTGACCAACAATCCCAAGAATGTA AACTTTTTTACCAAGCCCCCAATTGGAACCTGGGATCAAGTGGCCGAGGTCCTGAGCTGGCAGTTCTCCT CCACCACCAAGCGAGGACTGAGCATCGAGCAGCTGACTACACTGGCAGAGAAACTCTTGGGACCTGGTGT GAATTATTCAGGGTGTCAGATCACATGGGCTAAATTTTGCAAAGAAAACATGGCTGGCAAGGGCTTCTCC TTCTGGGTCTGGCTGGACAATATCATTGACCTTGTGAAAAAGTACATCCTGGCCCTTTGGAACGAAGGGT ACATCATGGGCTTTATCAGTAAGGAGCGGGAGCGGGCCATCTTGAGCACTAAGCCTCCAGGCACCTTCCT GCTAAGATTCAGTGAAAGCAGCAAAGAAGGAGGCGTCACTTTCACTTGGGTGGAGAAGGACATCAGCGGT AAGACCCAGATCCAGTCCGTGGAACCATACACAAAGCAGCAGCTGAACAACATGTCATTTGCTGAAATCA TCATGGGCTATAAGATCATGGATGCTACCAATATCCTGGTGTCTCCACTGGTCTATCTCTATCCTGACAT TCCCAAGGAGGAGGCATTCGGAAAGTATTGTCGGCCAGAGAGCCAGGAGCATCCTGAAGCTGACCCAGGC GCTGCCCCATACCTGAAGACCAAGTTTATCTGTGTGACACCAACGACCTGCAGCAATACCATTGACCTGC CGATGTCCCCCCGCACTTTAGATTCATTGATGCAGTTTGGAAATAATGGTGAAGGTGCTGAACCCTCAGC AGGAGGGCAGTTTGAGTCCCTCACCTTTGACATGGAGTTGACCTCGGAGTGCGCTACCTCCCCCATGTGA Download Select all
CCDS ID	CCDS32657.1

Protein Information

Protein ID	NP_003141.2
Protein Name	signal transducer and activator of transcription 3 (acute-phase response factor)
Molecular Wt. (Da)	87850
Protein Sequence	>6774 MAQWNQLQQLDTRYLEQLHQLYSDSFPMELRQFLAPWIESQDWAYAASKESHATLVFHNLLGEI DQQYSRFLQESNVLYQHNLRRIKQFLQSRYLEKPMEIARIVARCLWEESRLLQTAATAAQQGGQ ANHPTAAVVTEKQQMLEQHLQDVRKRVQDLEQKMKVVENLQDDFDFNYKTLKSQGDMQDLNGNN QSVTRQKMQQLEQMLTALDQMRRSIVSELAGLLSAMEYVQKTLTDEELADWKRRQQIACIGGPP NICLDRLENWITSLAESQLQTRQQIKKLEELQQKVSYKGDPIVQHRPMLEERIVELFRNLMKSA FVVERQPCMPMHPDRPLVIKTGVQFTTKVRLLVKFPELNYQLKIKVCIDKDSGDVAALRGSRKF NILGTNTKVMNMEESNNGSLSAEFKHLTLREQRCGNGGRANCDASLIVTEELHLITFETEVYHQ GLKIDLETHSLPVVVISNICQMPNAWASILWYNMLTNNPKNVNFFTKPPIGTWDQVAEVLSWQF SSTTKRGLSIEQLTTLAEKLLGPGVNYSGCQITWAKFCKENMAGKGFSFWVWLDNIIDLVKKYI LALWNEGYIMGFISKERERAILSTKPPGTFLLRFSESSKEGGVTFTWVEKDISGKTQIQSVEPY TKQQLNNMSFAEIIMGYKIMDATNILVSPLVYLYPDIPKEEAFGKYCRPESQEHPEADPGAAPY LKTKFICVTPTTCSNTIDLPMSPRTLDSLMQFGNNGEGAEPSAGGQFESLTFDMELTSECATSP M Download Select all
Length	769
Uniprot ID	P01562
Ensembl Protein ID	ENSP00000276927

Post-translational Modification Information (Source : HPRD)

Residue	Type	site
Y	Phosphorylation	705
Y	Phosphorylation	704
Y	Phosphorylation	705
Y	Phosphorylation	704
Y	Phosphorylation	705
Y	Phosphorylation	704
Y	Phosphorylation	705
Y	Phosphorylation	704
Y	Phosphorylation	705
Y	Phosphorylation	704
Y	Phosphorylation	705
S	Phosphorylation	727
S	Phosphorylation	726
S	Phosphorylation	727
S	Phosphorylation	726
Y	Phosphorylation	705
Y	Phosphorylation	704
K	Acetylation	685
K	Acetylation	685
K	Acetylation	685
S	Phosphorylation	727
S	Phosphorylation	726
S	Phosphorylation	727
S	Phosphorylation	726
K	Acetylation	685
K	Acetylation	685
K	Acetylation	685
S	Phosphorylation	727
S	Phosphorylation	726
Y	Phosphorylation	674
Y	Phosphorylation	657
Y	Phosphorylation	705
Y	Phosphorylation	705
S	Phosphorylation	727
Y	Phosphorylation	704
S	Phosphorylation	726
Y	Phosphorylation	705
S	Phosphorylation	691;-
S	Phosphorylation	691;-
T	Phosphorylation	714
T	Phosphorylation	713
T	Phosphorylation	717
T	Phosphorylation	716
Y	Phosphorylation	686
Y	Phosphorylation	686
Y	Phosphorylation	539
Y	Phosphorylation	539
Y	Phosphorylation	539

Enzyme Information

No matching records could be found.

PPi Information

(Click to view network : Source STRING) View

Interactant Gene ID (Source: HPRD)	Gene Symbol	HPRD ID	Ref Seq ID	Technique	References
1441	CSF3R	737	NP_724781.1	in vitro	9864141
1616	DAXX	4424	NP_001135442.1	in vivo	16331268
2185	PTK2B	3131	NP_004094.3	in vitro	14963038
2321	FLT1	1297	NP_002010.2	in vivo	15703780
2623	GATA1	2372	NP_002040.1	in vitro;in vivo	15673499
2624	GATA2	673	NP_116027.2	in vitro;in vivo	15673499
3091	HIF1A	4517	NP_001521.1	in vitro;in vivo	18985005
3280	HES1	770	NP_005515.1	in vitro;in vivo	15156153
3455	IFNAR2	3850	NP_997468.1	in vivo	12105218
3480	IGF1R	932	NP_000866.1	in vitro;in vivo	11463827
3654	IRAK1	2235	NP_001560.2	in vitro	15465816
5156	PDGFRA	1429	NP_006197.1	in vitro	9484840
5159	PDGFRB	1423	NP_002600.1	in vitro	9484840
5371	PML	23	NP_150241.2	in vivo	12506013
5757	PTMA	1778	NP_001092755.1	in vitro;in vivo;yeast 2-hybrid	15242774
6775	STAT4	2779	NP_003142.1	in vitro	15522880
6776	STAT5A	3301	NP_003143.2	in vivo	9398404
6777	STAT5B	5037	NP_036580.2	in vivo	9398404
7852	CXCR4	1217	NP_001008540.1	in vivo	10506573
388585	HES5	16240	NP_001010926.1	in vitro;in vivo	15156153

Pathway Information

Pathway Name	Pathway ID
Acute myeloid leukemia	hsa05221
Adipocytokine signaling pathway	hsa04920
AGE-RAGE signaling pathway in diabetic complications	hsa04933
Chemokine signaling pathway	hsa04062
Epstein-Barr virus infection	hsa05169
FoxO signaling pathway	hsa04068
Hepatitis B	hsa05161
Hepatitis C	hsa05160
HIF-1 signaling pathway	hsa04066
Inflammatory bowel disease (IBD)	hsa05321
Insulin resistance	hsa04931
Jak-STAT signaling pathway	hsa04630
Measles	hsa05162
MicroRNAs in cancer	hsa05206
Pancreatic cancer	hsa05212
Pathways in cancer	hsa05200
Prolactin signaling pathway	hsa04917
Proteoglycans in cancer	hsa05205
Signaling pathways regulating pluripotency of stem cells	hsa04550
Toxoplasmosis	hsa05145
Viral carcinogenesis	hsa05203

Structure Information

No matching records could be found.

Domain Information

ID	Location	Description
cd10374	554-715	SH2_STAT3
cl15255	554-715	SH2 superfamily
pfam02864	321-574	STAT_bind
cl03748	321-574	STAT_bind superfamily
pfam01017	139-319	STAT_alpha
cl19923	139-319	STAT_alpha superfamily
cd10372	564-711	SH2_STAT1
smart00964	2-120	STAT_int
cl03749	2-120	STAT_int superfamily
cd10375	564-711	SH2_STAT4
pfam02865	2-122	STAT_int
cd09919	564-689	SH2_STAT_family
cd10373	564-714	SH2_STAT2
cd10377	564-695	SH2_STAT6
cd10376	564-707	SH2_STAT5
cd10420	564-723	SH2_STAT5b
cd10421	564-689	SH2_STAT5a
pfam00017	584-674	SH2
smart00252	586-639	SH2
cd00173	584-615	SH2
cd00176	116-248	SPEC
cl02488	116-248	SPEC superfamily
cd10338	576-652	SH2_SHA
pfam12128	111-316	DUF3584
COG5281	84-290	COG5281
COG4372	61-216	COG4372
pfam05622	124-316	HOOK
TIGR02169	83-292	SMC_prok_A
COG3096	100-247	MukB
TIGR00618	6-290	sbcc

Ontology Information

HPRD ID	936
Molecular Class	Transcription factor
Molecular Function	Growth factor activity (GO:0008083); Hormone activity (GO:0005179)
Biological Process	Cell communication (GO:0007154); Signal transduction (GO:0007165); Anti-apoptosis (GO:0006916); Lipid metabolism (GO:0006629); Wound healing (GO:0042060); Cell proliferation (GO:0008283); Cell motility (GO:0006928)

SNP Information

View SNP Geneview Report

Drug Information

No matching records could be found.

External Links

ArrayExpress GO
ICGC GO
Cancer3D GO
COSMIC GO
NCG GO
TSGene GO
Tumor Gene Family of Databases GO
CCDB GO
G2SBC GO
Osteosarcoma Database GO
RCDB GO

ArrayExpress	GO
ICGC	GO
Cancer3D	GO
COSMIC	GO
NCG	GO
TSGene	GO
Tumor Gene Family of Databases	GO
CCDB	GO
G2SBC	GO
Osteosarcoma Database	GO
RCDB	GO

Mechanism	Up-regulation
Biomarker	23756862
Drug Target	-
Biological Process	Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism