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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| STAT4 | 6775 | signal transducer and activator of transcription 4 | 2 | - |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 25864744 | 2015 | Cell line : SW480, Caco2 Source : - Sample Type : - No. of Sample : - Stage : - | Microarray, immunohistochemistry,MTT and Transwell assays | Up-regulation | - | Increased expression of STAT4 is positively correlated with the depth of invasion in CRC patients. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | SH2 domain containing |
| Description | The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is essential for mediating responses to IL12 in lymphocytes, and regulating the differentiation of T helper cells. Mutations in this gene may be associated with systemic lupus erythematosus and rheumatoid arthritis. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Aug 2011] |
| Chromosome | 2 |
| Location | 2q32.2-q32 |
| Start | 191894302 |
| End | 192037404 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 143103 |
| OMIM ID | 600558 |
| HGNC ID | HGNC:11365 |
| Unigene ID | Hs.80642 |
| Ensembl ID | ENSG00000138378 |
| PharmGKB ID | PA36185 |
mRNA Information
| mRNA ID | ?NM_001243835.1 |
|---|---|
| Exon | join(1..254,2100..2553,14196..14306,36628..36740, 71783..72302,72880..73589,97969..98097,99416..99560, 169848..169946,172983..173075,176402..176480, 179658..179743,181215..181366,183253..183411, 184352..184444,187404..187463,187954..187971, 188062..188155,191639..191683,205025..205108, 206876..206974,209874..210009,211576..211625, 212168..212262,212547..212683,213024..213215, 214657..214723,215093..215201,216307..216597) | mRNA Sequence | Download Select all |
| Length | 4674 |
Protein Information
| Protein ID | NP_001230764.1 |
|---|---|
| Protein Name | signal transducer and activator of transcription 4 |
| Molecular Wt. (Da) | 90516 |
| Protein Sequence | Download Select all |
| Length | 748 |
| Uniprot ID | O94762 |
| Ensembl Protein ID | ENSP00000317636 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 721 |
| S | Phosphorylation | 721 |
| Y | Phosphorylation | 693 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 3725 | JUN | 1302 | NP_002219.1 | in vivo | 11801649 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Hepatitis B | hsa05161 |
| Inflammatory bowel disease (IBD) | hsa05321 |
| Jak-STAT signaling pathway | hsa04630 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd10375 | 553-700 | SH2_STAT4 |
| cl15255 | 553-700 | SH2 superfamily |
| pfam02864 | 316-563 | STAT_bind |
| cl03748 | 316-563 | STAT_bind superfamily |
| pfam01017 | 137-314 | STAT_alpha |
| cl19923 | 137-314 | STAT_alpha superfamily |
| cd10372 | 553-699 | SH2_STAT1 |
| cd10374 | 543-702 | SH2_STAT3 |
| cd09919 | 553-677 | SH2_STAT_family |
| cd10373 | 553-707 | SH2_STAT2 |
| smart00964 | 2-121 | STAT_int |
| cl03749 | 2-121 | STAT_int superfamily |
| pfam02865 | 2-121 | STAT_int |
| cd10377 | 553-695 | SH2_STAT6 |
| cd10420 | 553-694 | SH2_STAT5b |
| cd10376 | 553-684 | SH2_STAT5 |
| cd10421 | 553-676 | SH2_STAT5a |
| pfam00017 | 569-641 | SH2 |
| smart00252 | 575-634 | SH2 |
| cd10417 | 566-607 | SH2_SH2D7 |
| cd10349 | 576-607 | SH2_SH2D2A_SH2D7 |
| cd00173 | 573-632 | SH2 |
| cd09931 | 569-605 | SH2_C-SH2_SHP_like |
Ontology Information
| HPRD ID | 6369 |
|---|---|
| Molecular Class | Transcription factor |
| Molecular Function | Cell adhesion molecule activity (GO:0005194) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.