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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
STAT5B 6777 signal transducer and activator of transcription 5B  17- 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
22121102   2013Cell line : -

Source : -

Sample Type : -

No. of Sample : -

Stage : -

GenotypingPolymorhpism- JAK2, SOCS2, STAT1, STAT3, STAT5A, STAT5B, and STAT6 were associated with colon cancer; STAT3, STAT4, STAT6, and TYK2 were associated with rectal cancer.

21826656   2012Cell line : -

Source : Twin Cities Metropolitan Area, Kaiser Permanente Medical Care Program of Northern California (KPMCP) and a seven-county area of Utah.

Sample Type : Population-based case-control study

No. of Sample : Colon cancer 1,555 controls 1,956 and rectal cancer 754 controls 959

Stage : -

ImmunohistochemistryUp-regulation- Colorectal adenocarcinomas showed higher expression of STAT5a/5b than normal colonic mucosa (P?

Gene Details



NC_000017.10 (40351195..40428478, complement)

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Gene Type protein coding
Gene Family SH2 domain containing
Description The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL. [provided by RefSeq, Jul 2008]  
Chromosome 17
Location 17q11.2
Start 40351195  
End 40428478  
Strand -  
Gene Sequence

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Length 77284  
OMIM ID 604260   
HGNC ID HGNC:11367   
Unigene ID Hs.595276   
Ensembl ID ENSG00000173757   
PharmGKB ID PA36186   

mRNA Information


mRNA ID ?NM_012448.3
Exon join(55..213,44324..44461,48776..48932,51593..51682, 52905..53079,56619..56749,56998..57149,57583..57738, 58131..58310,58997..59084,59179..59301,60355..60447, 64271..64477,65964..66058,66160..66290,68733..68903, 73653..73704,74014..74121,74597..77284)  
mRNA Sequence

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Length 5171  



CDS Information


   
Location170..2533
CDS Sequence

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CCDS ID CCDS11423.1



Protein Information


      
Protein IDNP_036580.2
Protein Namesignal transducer and activator of transcription 5B
Molecular Wt. (Da)90516
Protein Sequence

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Length 787  
Uniprot IDQ9UDY2
Ensembl Protein ID ENSP00000265384  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation731
YDephosphorylation699
YDephosphorylation699
YPhosphorylation679
YPhosphorylation699
YPhosphorylation725
YPhosphorylation740
YPhosphorylation743
SPhosphorylation127;-
SPhosphorylation193
SPhosphorylation128
KAcetylation701
YPhosphorylation90
YPhosphorylation98
SPhosphorylation132
SPhosphorylation655
YPhosphorylation668

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                                                                                                                                                                                
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
919CD2471729NP_932170.1in vivo9880255   
1493CTLA4474NP_005205.2in vivo;yeast 2-hybrid16476059   
2113ETS11260NP_001137292.1in vitro;in vivo10815800   
2114ETS21263NP_005230.1in vitro;in vivo10815800   
2690GHR2971NP_000154.1in vitro;in vivo8923468   
2908NR3C1679NP_001019265.1in vitro;in vivo1   115   833   088   784   840   000   000   
3559IL2RA986NP_000408.1in vivo10602027   
3560IL2RB896NP_000869.1in vivo10602027   
5515PPP2CA8912NP_002706.1in vitro;in vivo11440634   
5594MAPK11496NP_002736.3in vitro10996427   
5777PTPN61475NP_536859.1in vivo9211920   
6776STAT5A3301NP_003143.2in vitro;in vivo9528750   
7010TEK2571NP_000450.2in vivo14726409   
7852CXCR41217NP_001008540.1in vivo10506573   
9111NMI4632NP_004679.2yeast 2-hybrid9989503   
9612NCOR22910NP_006303.3in vitro;yeast 2-hybrid11726519   


Pathway Information


                                                                        
Pathway Name Pathway ID
Acute myeloid leukemia hsa05221
AGE-RAGE signaling pathway in diabetic complications hsa04933
Chemokine signaling pathway hsa04062
Chronic myeloid leukemia hsa05220
ErbB signaling pathway hsa04012
Hepatitis B hsa05161
HTLV-I infection hsa05166
Jak-STAT signaling pathway hsa04630
Measles hsa05162
Pathways in cancer hsa05200
Prolactin signaling pathway hsa04917
Viral carcinogenesis hsa05203


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd10420573-717  SH2_STAT5b
cl15255573-717  SH2 superfamily
pfam02864332-583  STAT_bind
cl03748332-583  STAT_bind superfamily
cd10376573-712  SH2_STAT5
cd10421573-717  SH2_STAT5a
pfam01017138-330  STAT_alpha
cl19923138-330  STAT_alpha superfamily
pfam028652-126  STAT_int
cl037492-126  STAT_int superfamily
cd09919573-685  SH2_STAT_family
cd10377573-700  SH2_STAT6
smart009642-125  STAT_int
cd10375573-702  SH2_STAT4
cd10374563-705  SH2_STAT3
cd10372573-704  SH2_STAT1
cd10373573-683  SH2_STAT2
pfam00017589-668  SH2
smart00252596-636  SH2
cd00173596-636  SH2
cd10349596-627  SH2_SH2D2A_SH2D7
cd09940568-634  SH2_Vav_family
cd10417596-627  SH2_SH2D7
cd09946587-640  SH2_HSH2_like
cd09923596-623  SH2_SOCS_family
cd10351596-640  SH2_SH2D4B
cd09930587-622  SH2_cSH2_p85_like
TIGR006184-243  sbcc
TIGR00618156-303  sbcc


Ontology Information


   
HPRD ID6691
Molecular ClassTranscription factor
Molecular FunctionRNA binding (GO:0003723)
Biological ProcessRNA metabolism (GO:0016070)  



SNP Information


View SNP Geneview Report   

Drug Information


Uniprot ID DrugBank ID Name Type
P51692DB01254DasatinibSmallMoleculeDrug

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO