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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
STIM1 6786 stromal interaction molecule 1  11GOK, D11S4896E 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
25381814   2015Cell line : -

Source : -

Sample Type : -

No. of Sample : -

Stage : -

-Up-regulation-Data provided clinicopathological significance for STIM1 and SOCE in CRC progression, and implicated a role for COX-2 in STIM1-mediated CRC metastasis.

25531324   2015Cell line : -

Source : Xijing Hospital (Xi'an, China) .

Sample Type : CRC Tumor

No. of Sample : 40

Stage : TNM Stage I-IV.

-Up-regulation-miR-185-STIM1 axis promotes CRC metastasis and may be a candidate biomarker for prognosis and a target for new therapies.


Gene Details



NC_000011.9 (3876933..4114440)

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Gene Type protein coding
Gene Family Sterile alpha motif (SAM) domain containing
Description This gene encodes a type 1 transmembrane protein that mediates Ca2+ influx after depletion of intracellular Ca2+ stores by gating of store-operated Ca2+ influx channels (SOCs). It is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocrotical carcinoma, and lung, ovarian, and breast cancer. This gene may play a role in malignancies and disease that involve this region, as well as early hematopoiesis, by mediating attachment to stromal cells. Mutations in this gene are associated with fatal classic Kaposi sarcoma, immunodeficiency due to defects in store-operated calcium entry (SOCE) in fibroblasts, ectodermal dysplasia and tubular aggregate myopathy. This gene is oriented in a head-to-tail configuration with the ribonucleotide reductase 1 gene (RRM1), with the 3' end of this gene situated 1.6 kb from the 5' end of the RRM1 gene. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2013]  
Chromosome 11
Location 11p15.5
Start 3876933  
End 4114440  
Strand +  
Gene Sequence

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Length 237508  
OMIM ID 605921   
HGNC ID HGNC:11386   
Unigene ID Hs.501735   
Ensembl ID ENSG00000167323   
PharmGKB ID PA36195   

mRNA Information


mRNA ID ?NM_001277962.1
Exon join(1..707,111850..111980,168171..168285,199824..199935, 203579..203694,214324..214501,218800..218977, 226482..226649,227180..227280,227561..227796, 230775..231159,235580..237508)  
mRNA Sequence

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Length 4380  



CDS Information


   
Location 569..2944
CDS Sequence

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CCDS ID CCDS60706.1



Protein Information


      
Protein IDNP_001264891.1
Protein Namestromal interaction molecule 1
Molecular Wt. (Da)71935
Protein Sequence

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Length 685  
Uniprot IDO14862
Ensembl Protein ID ENSP00000357112  



Post-translational Modification Information (Source : HPRD)


Residue Type site
NGlycosylation131
NGlycosylation171
SPhosphorylation608;-
SPhosphorylation614;-
SPhosphorylation521;-
TPhosphorylation665;-
SPhosphorylation575;-
SPhosphorylation519
SPhosphorylation616
SPhosphorylation618
SPhosphorylation660
SPhosphorylation668
SPhosphorylation257
SPhosphorylation523
TPhosphorylation517
SPhosphorylation512
SPhosphorylation524
TPhosphorylation626
SPhosphorylation628
SPhosphorylation667
SPhosphorylation621
SPhosphorylation620

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

No matching records from HPRD source could be found.

Pathway Information


            
Pathway Name Pathway ID
Calcium signaling pathway hsa04020
Platelet activation hsa04611


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd09573128-201  SAM_STIM1
cl15755128-201  SAM_superfamily superfamily
cd11722347-438  SOAR
cl17033347-438  SOAR superfamily
cd09504128-201  SAM_STIM-1,2-like
cd09574128-201  SAM_STIM2
cd09530131-171  SAM_Samd14
cd09487136-197  SAM_superfamily
PRK13461253-336  PRK13461
cl21478253-336  Mt_ATP-synt_B superfamily
cd09505131-190  SAM_WDSUB1
cd07590246-352  BAR_Bin3
cl12013246-352  BAR superfamily
pfam07200276-373  Mod_r
cl18243276-373  Mod_r superfamily
pfam07647131-196  SAM_2
COG1196237-434  Smc
TIGR02169239-385  SMC_prok_A
COG1196229-429  Smc
TIGR02168251-435  SMC_prok_B
smart00454129-193  SAM
TIGR02168251-460  SMC_prok_B
pfam04111241-401  APG6
TIGR02169238-454  SMC_prok_A
PRK12704214-386  PRK12704
COG1196230-434  Smc
COG0419242-434  SbcC
TIGR02168238-429  SMC_prok_B
COG0419234-434  SbcC
PRK00409233-365  PRK00409
COG1196239-343  Smc
TIGR02168253-390  SMC_prok_B
COG1196238-387  Smc
PRK03918238-387  PRK03918
COG0419241-434  SbcC
COG0419237-434  SbcC
COG1196251-419  Smc
COG4372249-434  COG4372
pfam0548352-420  SCP-1
PTZ00121246-386  PTZ00121
pfam00769253-424  ERM
TIGR02169238-390  SMC_prok_A
PTZ00121230-385  PTZ00121
COG2268250-387  YqiK
pfam13514235-430  AAA_27
PRK03918239-426  PRK03918
COG1196251-433  Smc
PTZ00121238-385  PTZ00121
PTZ00121263-385  PTZ00121
PRK12705214-381  PRK12705
pfam10174258-383  Cast
pfam06160238-386  EzrA
PTZ00121239-386  PTZ00121
PTZ00121238-385  PTZ00121
pfam00430248-337  ATP-synt_B
TIGR02168242-374  SMC_prok_B
COG1196246-426  Smc
pfam09731242-437  Mitofilin
PTZ00121263-386  PTZ00121
PRK03918237-387  PRK03918
PRK04778238-386  PRK04778
COG0711249-338  AtpF
COG1293231-401  YloA
pfam00769238-335  ERM
TIGR03319214-386  RNase_Y
COG1579239-338  COG1579
PTZ00121237-385  PTZ00121
pfam12128235-460  DUF3584
PRK11448250-336  hsdR
PTZ00121262-387  PTZ00121
TIGR01069260-384  mutS2
PTZ00121229-386  PTZ00121
PTZ00121238-385  PTZ00121
pfam12128249-389  DUF3584
PTZ00121233-387  PTZ00121
TIGR02169251-336  SMC_prok_A
pfam11600234-336  CAF-1_p150


Ontology Information


   
HPRD ID7269
Molecular ClassAdhesion molecule
Molecular FunctionReceptor signaling complex scaffold activity (GO:0030159)
Biological ProcessSignal transduction (GO:0007165)  



SNP Information


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Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO