CoReCG

Search results:

General Information

Gene_Symbol	Gene_ID	Gene_Name	Chromosome	Alias
AURKA	6790	Aurora kinase A	20	AIK; ARK1; AURA; BTAK; STK6; STK7; STK15; AURORA2; PPP1R47

Evidence
Gene
mRNA
CDS
Protein
PTM
Enzyme
PPi
Pathway
Structural
Domain
Ontology
SNP
Drug
External Links

Evidence Information

Pubmed ID	Year	Sample Information	Techniques	Mechanism	Fold Change	Remark
26259750	2015	Cell line : - Source : Fox Chase Cancer Center (FCCC) Sample Type : - No. of Sample : 61mCRC tumour samples Stage : TNM Stage IV	real time RT-PCR	Up-regulation	-	-
24104968	2013	Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : 343 CRC patients Stage : -	Tissue microarray, immunohistochemistry	Up-regulation	-	The expression of AURKA protein is a mole cular biomarker with prognostic value for patients with CRCLM, independent of established clinicopathological variables. High AURKA expression was associated with poor OS (HRR 1.55, P<0.01), with a cross-validated average HRR of 1.57 (P=0.02).
22240781	2012	Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : - Stage : -	PCR, Sequencing, Immunohistochemistry	Unknown	-	Increased AURKA-CN is common in mCRC tumours and is associated with longer OS and longer PFS during chemotherapy, particularly in KRAS wild-type tumours.

Gene Details

Chromosome: 20; NC_000020.10 (54944445..54967351, complement)
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Gene Type	protein coding
Gene Family	Serine/threonine phosphatases / Protein phosphatase 1, regulatory subunits
Description	The protein encoded by this gene is a cell cycle-regulated kinase that appears to be involved in microtubule formation and/or stabilization at the spindle pole during chromosome segregation. The encoded protein is found at the centrosome in interphase cells and at the spindle poles in mitosis. This gene may play a role in tumor development and progression. A processed pseudogene of this gene has been found on chromosome 1, and an unprocessed pseudogene has been found on chromosome 10. Multiple transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Chromosome	20
Location	20q13
Start	56369389
End	56392295
Strand	+
Gene Sequence	>gi\|568815578:c56392295-56369389 Homo sapiens chromosome 20, GRCh38.p2 Primary Assembly ACAAGGCAGCCTCGCTCGAGCGCAGGCCAATCGGCTTTCTAGCTAGAGGGTTTAACTCCTATTTAAAAAG AAGAACCTTTGAATTCTAACGGCTGAGCTCTTGGAAGACTTGGGTCCTTGGGTCGCAGGTGGGAGCCGAC GGGTGGGTAGACCGTGGGGGATATCTCAGTGGCGGACGAGGACGGCGGGGACAAGGGGCGGCTGGTCGGA GTGGCGGAGCGTCAAGTCCCCTGTCGGTTCCTCCGTCCCTGAGTGTCCTTGGCGCTGCCTTGTGCCCGCC CAGCGCCTTTGCATCCGCTCCTGGGCACCGAGGCGCCCTGTAGGATACTGCTTGTTACTTATTACAGCTA GAGGTACAAGGGGTTTGTTGAGTGGTGTTGACATGCGCGGGAGGGGTGGGTGGGCTTCAGATTGGATTTT GTCCTCCGAGATCACCTGGGTAAGAAAAGCACAGAAGGTCTCTGCTGTGTTGGAGTTCACGTTCTAGTGG GTGGGGAGACAGACGGTAAGCGTACGGAGAACTTGCAGCTGGGGTGGGTGTTACAGAGGAAAAGCAGGAG TGCGGTTTAACGGGGGCCGCTTTAGATAGAATAGCCTAAGAAGGCCCTTGTCCTGGCTGGATGAGTGGGT GAATTGATGAATGAGAACCTCCTTGCAGAGGCCTTCCCGGTCCGTACTTCTCAGACCGTAGACCTTGGAG CAGTTGTACCGGGATAACTTGCAGTGCTTGTTAAACATATAGCTCCACCGAGAGCCCGGTAAATCAGAAT CTCTGAGGGGTAGGACCCAGGTGTCTAGTTATTAACAAACTCTCCAGATGATTCTTAGGTTTCATTGAGA ACTAGGGATGCAGACCGGTGCATACAAATCGTCTGGGGACGTTAAAATGCAGAATCTGTTTTTTTAGACC TGGGGTTAGGCCTCAGAGTCTCCATTTCTAAGAACCATCCGGCTGAGGTAGACGTAGCCACTGTCCTTAA CTCTCGTAATGTCTCTTCCTCTTCCGTAACCTTCCTTGTCCCTTGAATTAAACGTTTTTCAGCAACCTAC TCAGTTCGTCCTTCCCTTCATCTCTGCAGACATGCACAGGTCTGAGGGAGGAAGGAATAAACCGTATAAA CCTCCTGCGCTATTAGCCTAACAGCTTTTCTATTCAAAATAGTAGGACTTCTGGTTTGAACTGAATGGAT CCTGTGAAAGTCATCTGGTTCTTCAATCTGGTTGCAGATTAGAGTCACCTGAAGGGCAGTCTCCTTGGCG TTGTCTCCAGAATTCTGGATTAGAATCTTATTCCATTCTGCTTGTTATTCAATTTCCCTAGAAAGAAAGG TAGAATAAATTGGAGCAAATGCCTGTAGCTTCTGTCAGAAGAATGTTGAATAAATGTTGTTAGGCCTATG TGATCTCATTAGACTGCTACTTAGAATTGTAAGGGAAGTAAAGCATTAGAGCATGTGTGAAATTAAATAT TTGATTAACACAAGTGTGCATTTCCTTGTTGCTGTTTATCAACTTTTACTTACCCACTGTTTTTTTATAA GGGCTGCAGCCTGTAGTCTGGGCCTGGCTTCATCATGGAATTATTTGCTTAATTGTAAAATGGTAATCTT AATTTTTTTTTTTGAGACAGGGTCTCACTCCATTGCCCAGGCCAGAGTGCGGGGATATTTGATAAGAAAC TTCAGTGAAGGCCGGGCGCGGTGGCTCATGCCCGTAATCCCAGCATTTTCGGAGGCCGAGGTGGGTGGAT CACCTGAGGTCGGGAGTTCCAGACCAGCCCTACCAACATAGAGAAACCCTGTCTCTACTAAAAATACAAA ATCAGCTGGGCGTGGTGGTGCATGTCTGTAATCCCAGCTACTCTGGAGGCTGAGGCAGGAGAATTGCTTG AACCCAGGAGGTGGAGGTTGCGGGTGAGCCGAGATTGCGCCATTGCACTCCAGCCTGGGCAACAAGAGCA AACTCTATCTCAAAAAAAAAAAAAAAGAAACCTCAGTGAAATGAAAGACTGAACTACACACCTGGGGGAA AAGCGTAATAAAGGGAGCAAGAAGTGCAAATGCTTATGGCAGGGGACTTATTTGCAGAAAGAAAGCCTTG TGTGGCTGGTACACGGTTGACAAGAAGAGGAGATGAAGTCAGAGAGGTAGTTAGGGTCCATGTTCTGTGA GACTTCAATAGGCCTGTCTATGCAGGTTAGGAGTTTGCATTGTTTTGATTGAGTTGGGAGCCATGGGGGT CTTCTGAACTGAGGATCAACACATCTGATTTGTTAATGAGATTGCCGGCCTCAGTGTTAAGAATGGACCA TGACAGGGTAAGGGTGGAAGTGGGGAGGCCATTGGGAGGCTGTTGGAAAAAACTCAAGGGAGAGAGAATA ATGGTTTGACCAGGTGGTAGTAGTAGAGGTGGTGAGCAGTGATCTTGAAGGCAGAGCCTACAGAATATGC TGGTGGATTAAATGAAGGGTTTGCGAGAGAGAACCTCGTAAAGGGTTATTATGCCAAGGCTTTTGGCCTG AGCAACTGACAGGATGGGTTTGCCATGCACTGAGATGAGGATGTCTAGAGACTAGATTTGGGGAGGTGAG AGTGGGGAGAGATTAGGACTTCTGTTTGGGACATGTTAGAATGGAGATGCCGCTCAGATAATCAGGTGCA GATGTTGCATAGAAAGTAGAAAATGTAGATCAAGAGTTCAGGGGAGAGGTCTGGGCTGAAGAATGAATAT TTGGGAGTCCTCAGCCTGTAGATGGTACTGAAAGCAAAGAGACTGGATGTACTCGGCTAGGGAGTAATTG GAGATGGAGAAGTCATTCTAGGCCTGAGCTCAGGGCACACCCATGAACAGGGAGGTGAGAAGTGGAGAAG GGAAGAGGTTCAGTTTTGGATATGTTAGGATTGAGGTGCCTGGCAGACATTTTTGGGAGATCCTGGGCAA ATCCTTGGATATCCAAGTCTGACAGTCCAAGGAGAGACTAGGGCAGAAGACGCACTTTGAGTGGTCCTCA TGAAGGCATTTAGAGCTGAGGCACTGGGTGATATGGATCCCTGGTGAAGGTGTAGATGGAGAAGTGGAGG GTCCAGGGACTCGTTCTTGAGTCACCCCAGACCCTTGATCTGGCAAAAATGAGACTGACCCAGCAAGGAG GGAAAGACAGGACGACTAGGTGGTAGATAAACCTGGAAGTGAAGTGAAGAAAAAAGTGTAAGATGTGATC AACCTTGTCAGATTCTGCTGAGGATGCAAGTACGGGGAAGGTGGAATTGACCCTTGGGTTTGGCAGCAGT AGGTGTCAGCCATGAGCCTGACAATGTGGTGGAGACAAAAAAGCCAGGTGGGGATGGGCTCAGGGGAGGG GAGAGGAGCAGTAGAGGTGGCAAGTGTGGACGGTTCTTCTGGAGCTTTGCTGTTGGAGAGGAGGGGGTCA TTGTTAGCAACGATAATAGAATAAAGAGGACTTTTATTTTATTTTATTGTTTTGAGACGAAGTCTCGCTC TTTTCCCATAGGCTGGAGTGCAATGGTGTGATCTCAGCTCACTGCAACCTCTGCTTCCTGGGTTTAAGTG ATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGATTACAGGTGACTGCCACCACGCTCAGCTAAGTTTTGT ATTTTTAGTAGAGACGGGGTTTCACCATGTTGGCCAGGCTGGTCTCGAACTCTTGACCTCAGGTGATCCG CCCACCTCGGCCTCCCAAAATGCTGGGATTACAGGTGTAAGCCACCATGCCCGGCCTAAAGAGGACTTTT TTAAGGTAGCAGGTATGCCAGTAGGCTGCACAGGGATGGAAGTGATCCATTAGAGGAGAGATGATGGAGC AGCAAGACCATCAGGAGTGAAGACTCCGTGACAGAGGATGGGACGCAGTGCCCAAGGGGAGGTTGGCCTT GCAGGGAAAGCACATGCCTGTCCCTCCCTCATTAGCTTCATTTGGACAAAACATGTAAAATCCGGTGTGT TGTGGAGGCCTTTTGATTGGGGAACTGTAACGCTGCCTATCGAGCAACAGCACTTTAAGCAGGTGGCTTT GTTCAAATTAAAGGTTCTTCTTTTTCTTTTCAGGCATCATGGACCGATCTAAAGAAAACTGCATTTCAGG ACCTGTTAAGGTAAATTGAATAATCTGTAATCTCATTCACATTTATAAACCCACATGGAGGTTGGTCTTG TCGGGAATTCTTTCCGCCTTTACTTTGGATTTAAATTTAGATCCCTTACTGTGATCCTGGATATGAATTA GTCACTTTTCTCGTGTTCAGTAACATTTTGCTGCTTCTTAGAGTAGCTTTTTTGTTCTGCTTTGTCTTAT AATCGGCTGCTTAAGTTTCTATATCCCTCCACTGTATGCAGGATAATAGTAATAATGCATCTGGCAGGAG TTCAAAACTTTTAAAATTGGCCATAAATATAAAATAATTAGAAAAAGGCTACCTTGAATTACTGTATTTG ATTCTAAGTTCCTATGATAACGGCCATTTAAAAAATTGCTCTATATTTAAAATGTTTCTTTTTATTTGTC TTTGTCTGAATGCCTGCTGCGTTGTGGACAGTGTGCTAATTTCAGGAGTAACTGACTTTGTATTTGGAAG TCTTAACACCCTCTCTTTGTAGAGCACTCATACCGTTGAGCTGGGGATGGACTTTGAGGCTTTCATTTCT AGCACTTGTCCCTCACTTACAATGAGCTGTTGAAGCTGAAGGAAATCTCATCCCTCCTACCCCTTTTAGT TTGATTAGCTGAGGGTGTTAGAGTTAACTTAACAATTTAAGGTTGTAATACAGTACTTACAGGCGTATAA ATAATACATTTCAAGGCTGGGCGCGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGACCAAGGAGAG TGGATCACAAGGTCAGGAGTTCAAGACCGGCCTGGCCAAGATGGTGAAACCCTGTTTCTACTAAAAATAC AAAAAATTAGCCAGGCGTGGTGGCAGGCGCCTGTCGTCCCAGCTGCTTGGGAGGCTGAGGCAGAGAATTG CTTGAACCTGGGAGGCAGAGGTTGCAGTGAGCCGAGATCATGCCACTGCACTCCAGTCTGGGTGACAGAG CAAGACTCCATCTCAAAAATAATAATAATAATACATTTTAGTAGTAACTTTGTGAAGTGTCTACATTTGT TTCCTCTTTGTCAGTTTTTTGCTCAATTCCATTTTGTCAATACTTGGAAAATGAAACATTGGTTAATCAA TAGTACAGTAATAAGCTTATTGTGGAAAATCTTCGATATATGAAAACTTAGACTCTTCTAAAACTTCATG AAGATAATACCACTGTTGAACGTTTTGACGTATTTTTTTTTGGTCTTTTTCTTAAACGTATATTATCAAA GAAATTTCAATGGAACTGAGATTTTGGCATAAAGTTTTTGTATCATAGCTTTTTGCCAAATAGCAATGTA GTGTCTATTTCCAAATTATTGAGAAATTTTAGAAAGTGTCTCCTTCATTAATGGATATTTGTTAATAAAG CATGATTTTTAGGGGTGAGGAATTGGAGGGGATAGAAGGTATCATTCAGGTATTCTTAGCCACATACTAA CTATCCTCTGGAGGTACTGATTAAAATACCTTTTCACCTTCCATCTCTTATCAGTGACATTCATTATTTT GCTATACTAGAGAACAAACTTTGTGAAATTCTCAATATATTCATCTTTTGCTTTCATGAATGCCAGAAAG TTTATTTTCTCTTCCATTCTAGGCTACAGCTCCAGTTGGAGGTCCAAAACGTGTTCTCGTGACTCAGCAA TTTCCTTGTCAGAATCCATTACCTGTAAATAGTGGCCAGGCTCAGCGGGTCTTGTGTCCTTCAAATTCTT CCCAGCGCATTCCTTTGCAAGCACAAAAGCTTGTCTCCAGTCACAAGCCGGTTCAGAATCAGAAGCAGAA GCAATTGCAGGCAACCAGTGTACCTCATCCTGTCTCCAGGCCACTGAATAACACCCAAAAGAGCAAGCAG CCCCTGCCATCGGCACCTGGTAAACTAGCTTTTGAGACTCATTGGATAGTCCTTCTTTGTCGTCGTTGCT AAAAAAGCCAGTGTATATACTTGCACTTATTGTTTGGAGCCTTAGCTTTTATATCTGTTGAGGATGGGGA GAAAATATGGTGTCTGGGTTGAAGTAACAGTGTCTGCCCATGGGCCAGACCTATGCTAAAAATACAGACC TGATTCTCACCCTCTTGGAAGAGTTGGGCACCCAGGGAGGACACAGCATAAATTGGTGTCCTTTTGATTG CTTGTTACTGAGTCTGGATGTAGGGTGCTTGCAGTAAGTGACTTGAAGGGACTGAGATCTAAAGTGTGGG GGAAATCCAGAGAAGTGGGTGAACTGAGGCAGGCTGCGGTGAGGTCACCATGGGCATTGCTGGCCATGTT AAGGAATGGGGCCTCATCTCTAGGGCATTTGGAAGCTACTGAAGCTTTTTTGAACTCAGAAGGGAACTCT GCCTTTTAGAAAGTTTACTGTGGAAGGCCAGGCGCAGTGGCTCACGCCTGTAATCCCAGCGCTTTGGGAG ACCGAGGCAGGTGGATCACCTGAGGTCAGGAGTTGGAGACCAGTCTGACCAACATGGAGAAACCCTGTCT CTACTAAAAATACAAAATTAGCCAGGCGTGGTGGTGCACGCCTGTAATCCCAGCTACTCAGGAGGCTGAG GCAGGAGAATGGCTTGAACCCAGGAGGTGGAGGTTGTGGTGAGCCGAGATTGTGCCATTGCATTCTAGCC TGGGCAACAAGAGCAAAATTCTATCTCAAAAAAAAAAAAAAAATTTACTGTGGAAGTACTGAATAAATTG GAGTAGAACGCTGGATTTAGGAGTACCAGACAGGAAGGAGGTTGAGGTCAGAGATGGCAATAACCTGCTC TGTGTGGAGCAGAGTGGATGCAATTATTTACCAACTGTTGAGTGCTCATTCCCTGCAGGCTCTGAGATAA GTGCGTGCTTCATCCACGTCATCTCTTTCAATCTTCGTAACCACTTCATGAAGGTAGCCAGTTATTAACT CAGTTTTACAGAGGAGGAAGCTAAGACTCAGAAGCAGTTAACTTATCCAAAGACAAGCCAGGATGGAGAG GTGCACACAAATTTGAGAGCTCATTTACGATGCAGACTCATTAGAACTGGGCAATAAATTGTACCTGAAA GATGAATAAAGAGGAGTTAGGGATGGTGATTAGATTGATATTAATTGAGTGAGTGTCCTGGGGGTTGAGG GGTGCACATGTGACAGGGGCATCTGGAGGAAGAGTTTGGACCAGCATCCAGATATCTGAGCAGAGCATTG TGTGCTGTTCGAGTTTGCTATGTTGGAGACAGACCAGTGGAAATGTTTCATATGTCCTTGTGGCTGATGA AATAGTTACCCCAGTCCTCTGCTGCACAACTGTTCATTGTGCATTTTGCTGAATTGGTGGCTTTTATTTT TATATTTCCCCTTGGCAGCTAATATAAATGGAGGGTGGCTGGCTTATGTTTTGCTACATGTTGGTGATAA TTCGTATGTAGGGTATGGACTGTTGGCTGGCCCACCTAGTAAGGGGAAAAAGGTGACGAGTTGGCAGCTC GTCATGCATGGGAAGATTGGTACTTCTGCCACAAAAGCTCTTCTTTGGAAACTGAGGCTTCAGAAGAGCC TGCATAGTCTGCCTTTAATTTATCAGAGAAGGGCCTGTCTATATATACGTCTGCTCATCTTTAGAAATTC TATAAAGGCTTCACATGATGGAAGTCAGGGTGTAGTAGTCCTTTTTTTCTATAAGGAAAACTTTAAAAAA AAAAAACAGATTTATCATTCTTGACATACCATTAATATTTTGGTGACCAATTCTTTGATTCACCTCTATT CACAGCTTAGCTTATCCTATATAGTTATTCTAAAAACAGGTTTTTAACTTATTCCATATAGAAAATAATC CTGAGGAGGAACTGGCATCAAAACAGAAAAATGAAGAATCAAAAAAGTAAGCTTTCTTATTTACAAAGTT CTGTACTGTTCTACTAGAATATATTATTTCGTTGCAAATTTCGTTGTGGGAACTCTGGGGAAAAAAATGA GGCCTTTATTTGCATTTAGAGGATATAAATGTTTCCAGATTTCCAATCTTAAAAAAAATGGAATTTTGTG TAATGAGGTATTTTACTAGGAACTCAAGTGCTTTAAAAAATGGCTTTCAAATTTAGAAAAAGCTTGTATG AATCTTTTATAGAAATGTGTGGAAGTTCCTCTCTGTCCTTAGAAATAACCACTACATATGGTTTATGCGT CTGTACTTTTTTATTGTACAAAAGTGCAAGTTTTTAAAAAATAGAATATGTTGCAGAACTATATACTCAT ATATGACTGAGGGTTTTGACAGTATTATAGTTTTAGTTCTTTATTGTAAAGGTTGGCTGTAATGTCTTCC CCAGGGCTTTTCTAAAAGCCTCCTCTCAGTCTCTGAACTATCTGGACTCTAGAATGTACCGGGAGGAGCG AGGAATGAACCCACAGACTCTTTTGCTTTTAGCGGTCTAACAGAGGCTAAGAGTCTAAATCCACTGGTTC TCATGCCCCAGCTAGCCTGTGGGCTCCATCCCGCTTCCATTAGTAACAGTGGCTCTGTCTCCACCACCAG AGTGGTTCTCCACCCAGAGAGAATTAGCACCTCTGGGACTGGAGGGAGCAGCTGGGGTTAGTTTGAAACA TGCCCCCAGATGGTCTGGAAGCATTCCTCCCTCTCTGGTCACTTATCCTTTTTGTGGTCTTCAGCGTTGT CATGGCCCTGTTCCTCTGAGCATAGTACGGGCTTGGGACATTTCCCATAGAGTGCTTCAGGTCTAAAACC CGAGACTGCTCCTTGTCACTGACTCTCACACCTGACGGCAGCTAGGGACGTCAGGGTTTCATGTCGTGGC AGCTCTTTGATAGTGGTTATTGCCTTGGTTCTTGCTGAGGATGCATATTGAGTGAAGTTGGAATACGAAA TTATTTGTAGAATGTGTCTGCTACTCATTGAAAATTTGTTAGAAAAGCTTTGTTTTCTTCACATTCTAAA GTGTTCAAATTCCTCCTAGGAGGCAGTGGGCTTTGGAAGACTTTGAAATTGGTCGCCCTCTGGGTAAAGG AAAGTTTGGTAATGTTTATTTGGCAAGAGAAAAGCAAAGCAAGTTTATTCTGGCTCTTAAAGTGTTATTT AAAGCTCAGCTGGAGAAAGCCGGAGTGGAGCATCAGCTCAGAAGAGAAGTAGAAATACAGTCCCACCTTC GGTGAGTTTTCAGGTTCATGTTCAAAAGAATGTTCACCAATGCTGCACCCCTCCCCCTCCTGTAATGTCA GCCTCCCACTGCCCAGGTCCCTTCACTCCCTCTTACGAGGCACTGCCTTCAAATGCATGGCCCCGTTCCT CACCTCCCCCTCCCCTATGAAAAAGATTAGATAAGCTTCTGTACTGCACTGGGTTATAAGCATTCTCCTG TGATTCTCCCATGCTCTGCATGTTAAAATAAAATTGTATTCCTTTTTTTTTTTTTAAGTATAAATTTATT TTTTAGAGGGCCTGCTTTTCATAGTACCACAAAAAATGATTAAATTTGTCATCTTTCAAAGAGCACTTAA GTGCTCTGATCCTGGAAAAATCACTTGAGGATTTAATGTTTTGTTAATAGAATAGTTTATATGGGCAAGT CTTTCTGGTGGACAGTGAAGGGGAATGGCACCCCTTATTCTGAGGTATGCAGGAATTGCGAGCAGCTACC TGCAGGTTGACTACGGCTGGTGGGTTTTTGTTTTTCCTTTTTTTCTTTCAGTGTTTTTCAAATTTGAATC AGATGCTAATACTTCAAGTCTGGCCACATCAGGCCTGGTGTGTCTCTGCCTGGCAACACCTGGCTGGGGC TGGGAGGGGCAGGCATCTCACATGGGCTGTGCTTCCCATTGCCTGCTTCCCGCTGGCCACAGTCTGCACC TGCCCAGTCTGCTCAGCACCCATCTACTGCCATTACTGATCACTGCTTTTATCTGTCACAGTGTCTGGGT GTCAAACTACTGTGGCAATGCCATGTCCTTTTTTTTTTTCCTTTTTTTTTTTGAGATGGAGTCTCGCTCT GTTGCCCAGACTGGAGTGCAGTGGCGCAATCTCAGCTCACTGCAACCTCTGCCTCCCAGGTTAAAGCGAT TCTCCTGCCTCAGCCTCCTGAGTAGCTAGGATTGCAGGCATGCACCAACAAGCCTAGCTAATTTTTGTAT TTTTAGTAGAGACGAGGTTTCACCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCGCGATCCTCCCG CCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACTGTGCCCGGCCATGTCCTTTTTTTAATAT GTAGATAATTAATATTCAGCTGAATTTTCCTCCTAAGAATAAAGGTGCCTAAAGGAAGGAAATAGTCTTA ACTAAACCAGAGGTCCATTAATACTGTGAAGTGCTTTTAAAATGATATGTGGGTGTATGTATTTTTCTTG GAGTGGGTTTATAGTTTCAGATTCTAAAGTGGGGTTTGGAGTGTGGTTTCATGTGAAACACCACTGGTTT TACATGAAGAGTTTGTTTGACATTTTGTACATAGTCTTCTGTGAGCTCCAAACCAAGTGTTAGAATGTTT ATCCTTTGTTGCAGGCATCCTAATATTCTTAGACTGTATGGTTATTTCCATGATGCTACCAGAGTCTACC TAATTCTGGAATATGCACCACTTGGAACAGTTTATAGAGAACTTCAGAAACTTTCAAAGTTTGATGAGCA GAGAACTGCTACTGTAAGTGTTCATTTATTGTCCAGGCTAATTGTGTTTCCTTTATACCTGTCCTCCATA GCAATGTACCTTTCATCATAGTAGAGTGGGTTTTGTCTTGACGTAAGGATAGCTTAATATCAAATATTTG AAGTGGAAAAATCAAAATAGCTTAGTTGTACCATATGTACAGATAAAGTCTAGAACCAGGTAGAATGTTG TATCTGCTTTTGTGCCTAGTTTGCACAGCTGTTTTCTATGGAAATGTATATAATGTATATAGATAGTCAC CCTCATTTTCTTTAATAGATGTTTTATTTTAGAATAATTTTTATTTTATTTTATTTTTTTTAAAGGGACA GGGTCTTGTTATGTTGCCCAGGCTGGACTCAAGTGATTCTCCACCTCAGCCTCCCGAGTAGCTGGGACTA CAGGTGCACACCATTGTACCTGGCTAGGATAGTTTTAGATTTACAGAAATTGTGAAGGCAGTACAGAGAG TTCCCATATACCCCACACTGAATTTCCTACTAATTCTCCTACTAACATCTTGCATTAATATGGCACATTT GTCACATTCAATGAACCAATATTGATATATAACTATTAACTCAAGTCCACATTTTATTCAGATTTTCTTA GTTTTTCTCATGATTAAATTGGGCTTATGGGTTTTTGAGAGGGAGATCAGAGGTAAAGTGCATTCTTATC ACATACCAGGGATGTAAACTCTTATGACTTTTAACTGTGGATGTCAGCTTGATCTTCTGACTCAGAGAGT GTTTGTCTGGTTTCTCCACTGTAAAGTTACTATTTTTTCCCCTTTCCGTGCTGTATTTCTTCAAAGGAAG TTACTATGAATAGCCCACACTTAAGGAGTAGAGAGTGGATGGAGTATTGCCATAAATTATCTGGAATTCT GTGCCAGAGATAAGGCTGTTCTCCCTTATTTATTTAATCATTTATTTATTTAAAGATGTAGACTCCTGGG TATTTATTTTATCTCTTGAGCTATAATGCAATACTTTATTTTGTGGTTCAGATCATTGCAACTTTGGCCA CTGGGAACTTTTTTTCTTTCTTTTTTTTTTTTTTTCTTTTTGAGACGGAGTCTCACTCTGTCGCCCAGGC TGGAGTGCAGTGGCGCTATCTTGGCTCACTGCAACCTCAGCCTCCCAGGTTGAAGCGATTCTTCTGCCTC AGCCTCCCAAGTAGCTGGAAGTACAGGCACCCACCACCACACCTGGCTAATTTTTGTATTTTTAGTAGAG ACGGGGTTTCACCATATTGGCCAGGCTGGTCTTGAACTCCTGACCTTGTGATCCACCCACCTCAGCCTCC CAAAGTGCTGGGATTACAGGCATGAGCCACCGTGCCCGGCCTGCTCTTTTTGTTTTACCAGGTTCCTGGG AAAATCATTGCAGTTTTGTCTTGCGTGTGTGTGGTTTTTTTTTGGTTTGTTTTTACACTTCCTTTTTTTT TTTTTCTTTTTTTGAGATGGAATCTCACTCTGTCGCCCAGGCTGGAGTGCAGTGGCATAATCTTGGCTCA CTGCAGCCTTCACCTCCTGGGTTCAAGCGATTCTCCTGCCTCAGCCTCCTGAGTAGCTAGGATTAACAGG CATGCACCACCACACCCGGCTCATTTTTGTATTTTTAGTAGAGATGGGGTTTTGCCATGTTGGCCAGGCT GGTCTCTAACCCCTGACCTCAGGTAATCTGCCCGCCTCAGCCTCCCAAAGTGCTAGGATTACAGGTGTGA GCCACCACGCCTGGCCTTGTACTTCCTTACTTTCTGATACAAGATGCTCAGGCCTCATCGTGTATATTTC CTGCTCCAGTCCTAGAATCGAACCACTTCTCCAAGGAGCCCTGTTTCCTTTTCTTGGAGAATGTTATTAG AAACCAAGCTCTGGGCACTTGGTGTACTCATTGCTACTATGGTGTCACTACTTTTAGGCTTTCAGCTGAC ACAGCAAGGGAATATATGTGGATAGTAATCTGTGTATAGATTTATCCATCTATCTCTTCATTAAGCATAC CATGAATTCATACTGATGTCTTCAACTTGAATCCATTACCACGTTTCATTCTAACTTCCTCCTGTTTACC TGTAAACTCCCACTCCAAAAGTGTGAAACCTGGATTTCACCGCCCACCATCCTTTTACTTATTCAATTCC AATATACATGTATAATGGTATCAGAATTGTTAACCAGCTGCCACGTGGGAACCAACTTTATCAATTAGAG TGCTTATGTGCACTTCCTTTGGCCTTTGTCTTATAGATTCCACTCATTTCCAAAGCTGCTTGGATCAACA CTTTACCCTCATGCCCTTTAGTAAGGTGGTTTCCTACATTTGTAATGCAATGAGATTTTTTTGTCACAAT CTGCATGCCCAGGATGGAATCATTTACATTTTCATATCCTGAGATTGATTTTTGTGTGTTTGCTGTAAAG TTCTATGAATTTCGACAAATACACAATGCCATGTATCCACCATTATGATATAGAGAATAGTTTCGCTGCT CTTAAGAAAAAAAAAATCCTGTGTCTCAACTACTCATCCCTTCCAACCCTTCCATCTCTGGCAACCACTG ATCTGTTTACTGTCTCTATTGCCTTTTCCAGAATATCATGTAATTGGAATCATAACAGTATGTAGCTTTT TTAGGTGGGCTTCTTCCACTTAGCAATATGCATTGAAGATTCATCTGTGTATTTTTGGAGGCATGAGAGC TTGTTCATTTCTGTTTATCACAAAATCATATTCCATTATTTCATTATATGGAAGTACCTCAGTTTATTCG TCTACTGAAGGGTATCTTGGCTGCTTCTGGTTTTTGGCAGTTATCATGTTTTGGCTGTCAACATTTGCAT GCAGGTTTTTGCGAAACAAGTCTTCAAATTAGTTGGGCACATATATAGGAGTGCTATTGCCAGCTCATAC GGTAAGACTATATTTTGCTTTGTGAGGAACTGTCAGTCTTCCAAAGTGATTTTTACATTATATTTTACAT TGCATTACAAATGTAGGAAATCACCTTACTAAAGGGCATGAGGGTAAAGTGTTGATCCAAGCAGCTTTGG AGATGAGTGGAGTCTATAAGACAAAGGCCAAAGGAAGTGCACATAAGCACTCTAATTGATAAAGTTGGTT TCCGTGGGGCAGCTGGTTAACAATTCTGATACCATTATACAACGGTAATGTGGTATCGGAACCAATGAAT TGAGGTCCTCTTGCTTCTCATAGTTGCCAACATTTGATGTCAGTGTTTTGGATTTTTGTTTGTTTGTTTT GAGACAAGGTCTCACTGTCGCCCAGACTGGAGTGCAATGGCATGATCACCCACCTCAAACTCCCTGGCTC AAGCAATCCTCCCATCTCAGCCTCCCAAGTAGCTAGGACTACAGGCATGTGCTCTCGTGCCTGGCTAATT TTTGTATTTTTTTGTAGAGACAAGGTTTTGCCTTGTTGCCCAGGTCGGTTTCGAAATCCTGGTCTCAAGT AATTCATGCCTCCCAAAATATTGGGATTACAGGAGTGAGCCACTATACCTGGCCTCTTGTTTTGCATTTT AGTTATTCTAATCGGCATGTGGTGGTATCTCATTGTTTTGATTTCTAGTTTCCTAATGACATTTGATGTT GAACGTCTCTTTTTTTTTTTGAGACGGAGTCTCGCTCTGTCACCAGGCTAGAGTGTAGTGGTGCGATTTT GGCTCACTGCAACCTCCGCCTCTTGGGTTCAAGCGATTCTCCTGCCTCAGACTCCTGAGTAGCTGGGACT ACAGGCACGTGCCACCATGCCCAGCTAATTTTTGTACTTTTAGTAGAGATGGGGTTTCGCCATGTTGGCC AGGATGGTCTTGATCTCTTGACCTTGTGATCCACCTGCCTCGGCCTCCCAAAGTGCTGGGATTATAGGCG TGAGCCACTGCGCCCGGCCTTGAACATCTTTTTATGTGTTTATTTGCCATCTGTGTATCGTCTTTGAGGC ACCTGTTGAAATCTTTTGCTCTTTTTTTTTTTGAGTTTTGAGTTTTAAGAGTTCTTTGTATATTTTGGAT GCAGGTCATCTGTCACACATGTTTTGCAAATATTTTCTCCCAATCCGTGCCTTGTATTTTTGTTCTCTTA TCTGTGTCTTTCACAAGGCTGTTTTTTATTTATTTTTTTGAGAAAGGGTTTCACTCTGTCAGCCAGGCTG GGGTGCAGTGGTGCGATCTCTGCTCACTGCAGCCTCTGCCTGTTGAGCTCAAGTGATCCTCCTGAGTAGG TGAGACTACAGGTGGGTACCACCACGCCCAGCTAATTTTTGTATTTTTTGTATAGACACGGTCTCATCAT GTTGCCCAGGTTGTTTTTTTTGAGGCATTCTTGCTTTGTCACCCAGGCTGGAGGGCAGTGACGTGATCTT GGTTCTCAGCTCACTGCAACTTCTACCTCCTGTGTTCAAGCAGTTCTCCTGCCTCAGCCTCCTGAGTAGC TGGGATTACAGGCATGAGCCACCACGCCCAGCTAATTTTTGTATTTTTAGTAGAGACAGGGTTTCATCAT GTTGGCCAGTCTGGTCTTGAACTCCTGACCTCAGGTGATTTGCCCACCTCGGCCTCCCAGAGTGTTGGGA TTGCAGGCATGAGCCACTGTACCCGGCCTCCCAGGCTGTATTTTTAATAAAAGTCCAAATGTGTCAGTTT TTTCTTTCATGATTGTGCTTTTTTGCTTCTCCTTTTTTATGTGATTAAAATTACTTGTTTTAAGAAGTTG AAGAGTCTTAGTTTGGGCCGTTTCTTATTGGATTGGCAGCTTGATAAAGCATGTTGAATGGTGGTTACTT TGATTTTTTTCTGTTTCTTGGTGGAGATCTCCGGGTAGTGTGGACATTAGTTCTCTTTTTGGCATTGATG TAAATGGCATTTAAATTCAAGTAATTTTACTTTCAGTATCTGATGAAATCATGCTACTATGGACAAATGG CTCTTTGGTCTTGTCTCTGCAACAATGACATGCTGTTTTAAAGACTTAATCTTAAATGTTTGTGCTTCTC CTAAGTAGAAATAGATCTCTAATTTGCTTTTTTAAATATTAGCTAAACAAATCAGCTTCTTATTTAATTG GCAATTAATATTTCTTTGAGTTCATCTTTTGGGCCAACTTTCTCTTACAGATCAATAAGTAAATCTATGC TCATTAATGGTAGTGACTCTACCTCAGGTACTCACATTTTACCCTTGGTTTTTTTCCTGGTAATCTTGCT TATGGTGGGTTGTAGTTTGTTGTTTCAGGTCAGTTAATCTTTTTCTTCAGTTTCTGATATTGATATCCTA CTTTAAAAGATTCACCTTATACCAACACTACAAAATTACACATTATACTACTTCTCTGTTTTCTCTCCTT ACACCCAAGGCTTCAATCTAGATGGAGTTTTGGTGTAAGCAGATAGCTGTTTGAAAGAAAATGAAAGATC ATTTCTGTCTAGATTCCTTAGCAGTTAGAATGAATACACATGTACCTGTTTTCCTTTTCAGATGAATTCA AATAAAACTAATTGTAGTGACATGTCAGTGACCTATCCATATCTGCAATCTAACAACATGTGAGGTGTGG AGGAAGTGGCAGTGCCAGAGGGCTATCATGAAACTAATAGCTTCTTGTCTGGAAGTGATTTGAGGAGTGA AATCCATTGCCCTCTCAAACTTTAATGTGTGCAATTAAAGCATCAGCAACTCAAAGTTGGTGGTCAGAAG AGCAGCTTTCTTTGTATTTGCCTTCAGTTTATTGTGGTCTGAATTTTGATCTCCGGTTTTGGGCTGAAAG AATGAAAAGTGTTTATTCTGACAGTGACATTTGGTTTTTACTCATCTGTTTAGTAAACCTTTTTGATGTA AAATAATGTTCAATCCTGTCTAGAAATTGCTGTAGAAAGCAAACTCTTCTCAAACTTTAGGCAGAGCTAA ATATATTTTTTCAATATTCAAACAGTTATCTGTATGTTAAAATAAATTCTGGGCCAGGCATGGTAGCTCA CGCTTGTAATCTCAGCACTTGGAGAGGCCAAGGTGGGAGGATCACTTGAGGTCAGGAATTAGCGACCAGC GTAGGCAACATGGGGAGACTGTCTCTACAAAAAAAAAAAAAAAAAAAAGAAAGATTAAAAATTAGCTGGG CATGGTGGCACACACCTGTAGTCCCAGCTACTCGGAAGGAGGCTGAGGTGGGAGGATTGCTTACGGCCAG GAGTTCAAGGCTGCAGTGAGGTATGATCATGCCATAGCAATCCAGGCTGGGTGACAGAGTGAGACCCTGT CTCTTAAAAATAAATAAGTAAATACATACATACTGGACTTGTTTGCTAAATCTTAGCGATAGGGACTGTA AAACTTTTCTTTTTCTTGCTTTTTTTTGAGACGGAATTTTACTCTTGTTGCCCAGGCTGGAGTGCAATGG CATGATCTCGGCTCACTGCAACCTCTACCTCCTGGGTTCAACCAATTCTCCTGCCTCAGCCTCCCGAGTA GCTGCGATTATAGGCATGCACCACTACACTTGGCTAATTTTTGTATTTTTAGTAAAGACAGGGTTTCACC ATGTTGGTCAGGCCGGTCTCGAACTCCTGACTTCAGGTGATCCACCTGTCTTGGCCTCCCAAAGTGCTGG GATTACAGGTATGAACCACTGCACCTGGCCAGGAAAACTTTTCTTACAAGATGGTAATTCGGTCGGGTGC AGTGGCTCATGTCTGTAATCCTAGCACGTTGTGAGGCTGAGATGGGAGGATCACTTGAGGCCAGGAGTTT GAGACCAGCCTGGTCAACATAGTGAGACCCCCATCTCTATTAAAAAAAAAAAAGATAGTAACTTAAGGAA ATAAAATTAACAAAAGGACTGATTTCTTATGTACTTCTATGCTGACTTAGTGTAACCCAAAATTTAACAT GCTATTTAATATGTCAGTGCAACTGCTTTTTAGTTTCTGTTTATTGTTCAGGATAATTTTTTCTCCTGAT ATTCTTGAAGTAAATTTTTAGCTTTAAACAAATTCTTCTGTCACAGAATGACCTTGGTTTTAAAAAAGGG AATTGACTATACTTGCAAAGTTCATTTTTTTTTTCTAAAAAAGAAAAAGGCAGTATTTACACATCTGAAT CCTTAATTTGTACCAGTTCTTCAGCACTGTCTTACTTCCTGGCTGCAGGGCCATTTGTTGCCGTATGGTG TTGTAACTTTAGGTTGGTGCAAAAGTAACTGTGTTTTGCATTGACATGGCACCAGCCTAAGAGCTAGCTC TAACTGGCTGAATGTCTTTTCTGACTTTCAACATCACACCAGCTGTATTAGCAGAGATGACTAAGCATTG GGTAATTTCACTTCATGCTAACCACTATAAATTGGTTCAGTTGATGTGTGTGTGTGTGTGTGTGTGTGTG TGTGTGTGTAGACTCCTATATAATTTCTACAATCCTTGCTTTAAAACCTGCAAAATGTATTTTTTGTTTT GTCTTTTCCTTTTTGAGACAGGGTCTCCTTCTGTCACCCAGGCTGAAGTGTGATCATGGCTCACTGCAGC TTTGACCTCCTGGTCTCAAGCAATCCTCCTGCCTCAGCCTCCCAAGTAGCTGGGACTACAGGCATGCACC ATCACGCTCAGCTAATTTTTAAATTTTTGTAGAGATGGAGTCTTGCTATGTTTCCCAGGCTGGTCTTGAA CCCCTGGGCTCAAGTGATCCTCCCACCTCAGTCCCCCAAAGTGTTGGGATTATAGGTGTGAGCCACTGTG CCTGGCCAAAACCTGCAAACCATGTTAAATCTATGTTGTGTTCCTTTCGGAAGAGATGTCTAATATTAAC TTGTGTTATATAAAATCTAAAACATAGGCTTTCAATATTGTTTTAACAGTATATAACAGAATTGGCAAAT GCCCTGTCTTACTGTCATTCGAAGAGAGTTATTCATAGAGACATTAAGCCAGAGAACTTACTTCTTGGAT CAGCTGGAGAGCTTAAAATTGCAGATTTTGGGTGGTCAGTACATGCTCCATCTTCCAGGTATGTAACTTT AGAGGTGGAAGTTGTTTGGTTTACCAAAGCCCTGGGAGCTAACCGTGAGCTAAATGTAAAATATTTCAGT GTAGATTTTGTGCTGTAAGAGGGGTAGGTGGCTAACCCAGAAGTACTTTGGAGTAATTTAGGCTTAATAA TAAACTAGGGTTTGCAAGAAAGTGTTATTCTGTGGAGATTTGGGGCTATTAGCAGTGTTCTAGGCCTAGG GTTGAAGATGCTTAATGTCCTTAGAGGCTAATGAAGGGATGAATGAGTCAACAGATAGGACACGTATATG ACAGAGGTGAAGTGCCCACATGTTGAGTGGGAGGAACTCTTCACCTCTGCTGCTTCCTGGATGAGGAGAT GGGGAGATGGTTCAGAGGACAGCACTGACAAAGATCTAGAGCTCAGAGTGCAGGCCATATCAGGGAACTT GAAACACTAAATTAGTTTGGTGGTGCTTTGAGGGCAGTGGTGAGAGATTCTCTTCAGTCTGCCTCTGTCA ATAGTAGGGATAGTCCTTTCTTATCCCCTGTCACAGCTGAAGCAGAGATGTCAGTCTCAAAACAATTCAA ATCTTAGCTTTCCAAGTGAACTACAATATCTTTACTGTTTTAAATTTGAGTTTAAATAAGCTTTGAAACT TCACATGAAGTGGGGCATTTTAAAACATATATCTACCGATGAAGTTTTGTCAACTTTGGAGGAGGACTCA AATTATAGCCAAATGACTTAAAAATCAAGCTAGTTAAAAAAAAAGTATAGCCTAAAATAGAATATGAGGG AGAAAACCTTTGCTTTTGTTACAGAGCACTTCTAATTGTTCCAGCAATGCACTGAATCTGCTATTGCAGT CTTTTTTTTTTTTTTTTTTTTTAAACTGGTTGTCATTAGTGGGAGCTGTTATCTGGTGAGACAAACCAGA ATAAAGACTTACAGGCTTCATGGAATCGCAGAGTTAAACTGTATCTTAACCGGTTGAATTGTGATAGAAA AGATGGCTTCTTGCTTTTTGAAAAGATTACTTACATAACCGATAGTCACTTCACTCCAAATCCCAGATGT TAATCATCATCATTTCCTGGTTATTGCCTCAGTTTGAGAACCCCCGATTCAGTCCGTCGGTGCTGATGGA GGGGTTAGATGACCAGAGTGGTAGCTTCTTAATCCTACGTCACAATTCAGTGGTGAGTGACTGTTTGTGT GCTCAGTGGGTGCCAGGCCTGGCTGAACACAGCACCAGGGCTGTGACCACGTAAGCCTCCATGGTGAAGA GCAGCTGATAACAAAGCAACACGAACCCACACAGACTGTTCTGGCTTGCTGTCTGCTGTTCCCAGCTTTT TTCCAACCTTCGTTAAAAAAACCTAAACCGATAAAAATGCGGAATTGGTAGTTGATGGCATACCTGTCTA TACAGTGCCTACGTTCAGCAGTTTTTCCCATTTAGTCAGAAGGGCTGCATCTGCTTTTTTAGTGAACACT TGAAAATACGTTGCAAACATCATGATGCTTCAACCTTAAGCACTATAATAGAATGCATTTCCTAAATAAG GATATTCTCCTATATAACTAGAACCATGATCACTCCTAAGAAAATTAACAGCATTGTCAGTATCTAATAT TTAGTCCACATTCAGATTTCTCCTATTGTCCATGACATCTTATAGCTGGTTTGTAAAATCAGAACTCAAC CAAAGCCCATGCTTTGTATTGGACTGTCTATGTGGTTGGATTGTCTCTGTGGTTGGACTGTCTCTGTGGT TGGACTGTCTCTGTGGTTGGATTGTCTCTGTGGTCTAAAGCCAGACCAGTCTCCCACTTTAAAGAGGACT TTTCTGATTGTGTTGCCACTTAACTTGGACCTTTATTCCCCGTATTTGCTGAAAACTGGAATGTAGGTCT CAGGTCCTGAAGAGATTCAGGTTAAGAAAATTTTTTTTTTTTTTTGAGACAGAGTCTCGCTCTGTCACCC AGGCTGGAGTGCAGTGGTGCGATCTTGGCTCACTACAAGCTCGCCTCCCGGGTTCACGCCATTCTTCTGC CTCAGCCTCCTGAGTAGCTAGGACTACAGGCGCACACCACCACACCCGGCTAATTTTTTGTATTTTTAGT AGATACGGCGTTTCACCATGTTAGCCAGGATGGTCTCGATCTCCTGACCTCGTGATCCGCCTCCCTCGGC CTCCCAAAGTGCTGGCATTACAGGCATGAGCCACTGCACCCAGCCAGGTTAAATATTTTTGGCAAGAGTA CTTCATAGGCCACCCTCAAAATTTCAGCATCACTCGTACCAAGTATCTATCACAAGGCAGCATGTGTCTA CATCTCCACCCCAGTGCTGTTACAGTGGGACAGTTTCTAGTGTATTGTCATTGCGACCAGGCTTTTAAGA TTCTTAGCATATCTGTAATATCCACATGCAGATGTAGAATCCAAATCGTATTTACAGAGAACTTTGCATG GCAGCTTTTATATGGTAGTGATACATTCAGTTTCTTACATTCTAGATTATTCAGGGAGGTTCTGGAGTTG GACAGATTTGGGGTTAAGCCTGATGGCTAGCTGTGTGACCTTACACACCTCGCTTCATCTGTTTCCTATG GGAATTTATAATAGTAGCTACTTCCTAGGGCACAGGATCTGGCCCAGGGGAAGACCTCAGTGTTAGTGGA CTCTTTAATGATTGTTAGCAGCTGTTGTGATCATAAAACGAGAAGCACATCAACCTGAGCCTCCCTCCGT TTTCAGGAGGACCACTCTCTGTGGCACCCTGGACTACCTGCCCCCTGAAATGATTGAAGGTCGGATGCAT GATGAGAAGGTGGATCTCTGGAGCCTTGGAGTTCTTTGCTATGAATTTTTAGTTGGGAAGCCTCCTTTTG AGGCAAACACATACCAAGAGACCTACAAAAGAATATCACGGGTAAGACGCAACTGAAAAGGACCCAGCAC ATCTGCTGGAATTCTTTCCTTATCAGCCTGAACTGCAGGCCAAGATCCGAACATCTATACTATTTGATCT CTCTAACCTGTGTTTTGTGATATTTTATCATTTGTTGTACTCCAGGTTGAATTCACATTCCCTGACTTTG TAACAGAGGGAGCCAGGGACCTCATTTCAAGACTGTTGAAGCATAATCCCAGCCAGAGGCCAATGCTCAG AGAAGTACTTGAACACCCCTGGATCACAGCAAATTCATCAAAACCATCAAATTGCCAAAACAAAGAATCA GCTAGCAAACAGTCTTAGGAATCGTGCAGGGGGAGAAATCCTTGAGCCAGGGCTGCCATATAACCTGACA GGAACATGCTACTGAAGTTTATTTTACCATTGACTGCTGCCCTCAATCTAGAACGCTACACAAGAAATAT TTGTTTTACTCAGCAGGTGTGCCTTAACCTCCCTATTCAGAAAGCTCCACATCAATAAACATGACACTCT GAAGTGAAAGTAGCCACGAGAATTGTGCTACTTATACTGGTTCATAATCTGGAGGCAAGGTTCGACTGCA GCCGCCCCGTCAGCCTGTGCTAGGCATGGTGTCTTCACAGGAGGCAAATCCAGAGCCTGGCTGTGGGGAA AGTGACCACTCTGCCCTGACCCCGATCAGTTAAGGAGCTGTGCAATAACCTTCCTAGTACCTGAGTGAGT GTGTAACTTATTGGGTTGGCGAAGCCTGGTAAAGCTGTTGGAATGAGTATGTGATTCTTTTTAAGTATGA AAATAAAGATATATGTACAGACTTGTATTTTTTCTCTGGTGGCATTCCTTTAGGAATGCTGTGTGTCTGT CCGGCACCCCGGTAGGCCTGATTGGGTTTCTAGTCCTCCTTAACCACTTATCTCCCATATGAGAGTGTGA AAAATAGGAACACGTGCTCTACCTCCATTTAGGGATTTGCTTGGGATACAGAAGAGGCCATGTGTCTCAG AGCTGTTAAGGGCTTATTTTTTTAAAACATTGGAGTCATAGCATGTGTGTAAACTTTAAATATGCAAATA AATAAGTATCTATGTCT Download Select all
Length	22907
OMIM ID	603072
HGNC ID	HGNC:11393
Unigene ID	Hs.250822
Ensembl ID	ENSG00000087586
PharmGKB ID	-

mRNA Information

mRNA ID	NM_198437.1
Exon	join(1..128,4094..4140,5763..6039,7972..8026,9120..9311, 10725..10863,18740..18888,21637..21811,21956..22907)
mRNA Sequence	>6790 ACAAGGCAGCCTCGCTCGAGCGCAGGCCAATCGGCTTTCTAGCTAGAGGGTTTAACTCCTATTT AAAAAGAAGAACCTTTGAATTCTAACGGCTGAGCTCTTGGAAGACTTGGGTCCTTGGGTCGCAG GCATCATGGACCGATCTAAAGAAAACTGCATTTCAGGACCTGTTAAGGCTACAGCTCCAGTTGG AGGTCCAAAACGTGTTCTCGTGACTCAGCAATTTCCTTGTCAGAATCCATTACCTGTAAATAGT GGCCAGGCTCAGCGGGTCTTGTGTCCTTCAAATTCTTCCCAGCGCATTCCTTTGCAAGCACAAA AGCTTGTCTCCAGTCACAAGCCGGTTCAGAATCAGAAGCAGAAGCAATTGCAGGCAACCAGTGT ACCTCATCCTGTCTCCAGGCCACTGAATAACACCCAAAAGAGCAAGCAGCCCCTGCCATCGGCA CCTGAAAATAATCCTGAGGAGGAACTGGCATCAAAACAGAAAAATGAAGAATCAAAAAAGAGGC AGTGGGCTTTGGAAGACTTTGAAATTGGTCGCCCTCTGGGTAAAGGAAAGTTTGGTAATGTTTA TTTGGCAAGAGAAAAGCAAAGCAAGTTTATTCTGGCTCTTAAAGTGTTATTTAAAGCTCAGCTG GAGAAAGCCGGAGTGGAGCATCAGCTCAGAAGAGAAGTAGAAATACAGTCCCACCTTCGGCATC CTAATATTCTTAGACTGTATGGTTATTTCCATGATGCTACCAGAGTCTACCTAATTCTGGAATA TGCACCACTTGGAACAGTTTATAGAGAACTTCAGAAACTTTCAAAGTTTGATGAGCAGAGAACT GCTACTTATATAACAGAATTGGCAAATGCCCTGTCTTACTGTCATTCGAAGAGAGTTATTCATA GAGACATTAAGCCAGAGAACTTACTTCTTGGATCAGCTGGAGAGCTTAAAATTGCAGATTTTGG GTGGTCAGTACATGCTCCATCTTCCAGGAGGACCACTCTCTGTGGCACCCTGGACTACCTGCCC CCTGAAATGATTGAAGGTCGGATGCATGATGAGAAGGTGGATCTCTGGAGCCTTGGAGTTCTTT GCTATGAATTTTTAGTTGGGAAGCCTCCTTTTGAGGCAAACACATACCAAGAGACCTACAAAAG AATATCACGGGTTGAATTCACATTCCCTGACTTTGTAACAGAGGGAGCCAGGGACCTCATTTCA AGACTGTTGAAGCATAATCCCAGCCAGAGGCCAATGCTCAGAGAAGTACTTGAACACCCCTGGA TCACAGCAAATTCATCAAAACCATCAAATTGCCAAAACAAAGAATCAGCTAGCAAACAGTCTTA GGAATCGTGCAGGGGGAGAAATCCTTGAGCCAGGGCTGCCATATAACCTGACAGGAACATGCTA CTGAAGTTTATTTTACCATTGACTGCTGCCCTCAATCTAGAACGCTACACAAGAAATATTTGTT TTACTCAGCAGGTGTGCCTTAACCTCCCTATTCAGAAAGCTCCACATCAATAAACATGACACTC TGAAGTGAAAGTAGCCACGAGAATTGTGCTACTTATACTGGTTCATAATCTGGAGGCAAGGTTC GACTGCAGCCGCCCCGTCAGCCTGTGCTAGGCATGGTGTCTTCACAGGAGGCAAATCCAGAGCC TGGCTGTGGGGAAAGTGACCACTCTGCCCTGACCCCGATCAGTTAAGGAGCTGTGCAATAACCT TCCTAGTACCTGAGTGAGTGTGTAACTTATTGGGTTGGCGAAGCCTGGTAAAGCTGTTGGAATG AGTATGTGATTCTTTTTAAGTATGAAAATAAAGATATATGTACAGACTTGTATTTTTTCTCTGG TGGCATTCCTTTAGGAATGCTGTGTGTCTGTCCGGCACCCCGGTAGGCCTGATTGGGTTTCTAG TCCTCCTTAACCACTTATCTCCCATATGAGAGTGTGAAAAATAGGAACACGTGCTCTACCTCCA TTTAGGGATTTGCTTGGGATACAGAAGAGGCCATGTGTCTCAGAGCTGTTAAGGGCTTATTTTT TTAAAACATTGGAGTCATAGCATGTGTGTAAACTTTAAATATGCAAATAAATAAGTATCTATGT CTAAAAAAA Download Select all
Length	2121

CDS Information

Location	join(4099..4140,5763..6039,7972..8026,9120..9311, 10725..10863,18740..18888,21637..21811,21956..22138)
CDS Sequence	>lcl\|NM_198437.1_cds_NP_940839.1_1 [gene=AURKA] [protein=aurora kinase A] [protein_id=NP_940839.1] [location=134..1345] ATGGACCGATCTAAAGAAAACTGCATTTCAGGACCTGTTAAGGCTACAGCTCCAGTTGGAGGTCCAAAAC GTGTTCTCGTGACTCAGCAATTTCCTTGTCAGAATCCATTACCTGTAAATAGTGGCCAGGCTCAGCGGGT CTTGTGTCCTTCAAATTCTTCCCAGCGCATTCCTTTGCAAGCACAAAAGCTTGTCTCCAGTCACAAGCCG GTTCAGAATCAGAAGCAGAAGCAATTGCAGGCAACCAGTGTACCTCATCCTGTCTCCAGGCCACTGAATA ACACCCAAAAGAGCAAGCAGCCCCTGCCATCGGCACCTGAAAATAATCCTGAGGAGGAACTGGCATCAAA ACAGAAAAATGAAGAATCAAAAAAGAGGCAGTGGGCTTTGGAAGACTTTGAAATTGGTCGCCCTCTGGGT AAAGGAAAGTTTGGTAATGTTTATTTGGCAAGAGAAAAGCAAAGCAAGTTTATTCTGGCTCTTAAAGTGT TATTTAAAGCTCAGCTGGAGAAAGCCGGAGTGGAGCATCAGCTCAGAAGAGAAGTAGAAATACAGTCCCA CCTTCGGCATCCTAATATTCTTAGACTGTATGGTTATTTCCATGATGCTACCAGAGTCTACCTAATTCTG GAATATGCACCACTTGGAACAGTTTATAGAGAACTTCAGAAACTTTCAAAGTTTGATGAGCAGAGAACTG CTACTTATATAACAGAATTGGCAAATGCCCTGTCTTACTGTCATTCGAAGAGAGTTATTCATAGAGACAT TAAGCCAGAGAACTTACTTCTTGGATCAGCTGGAGAGCTTAAAATTGCAGATTTTGGGTGGTCAGTACAT GCTCCATCTTCCAGGAGGACCACTCTCTGTGGCACCCTGGACTACCTGCCCCCTGAAATGATTGAAGGTC GGATGCATGATGAGAAGGTGGATCTCTGGAGCCTTGGAGTTCTTTGCTATGAATTTTTAGTTGGGAAGCC TCCTTTTGAGGCAAACACATACCAAGAGACCTACAAAAGAATATCACGGGTTGAATTCACATTCCCTGAC TTTGTAACAGAGGGAGCCAGGGACCTCATTTCAAGACTGTTGAAGCATAATCCCAGCCAGAGGCCAATGC TCAGAGAAGTACTTGAACACCCCTGGATCACAGCAAATTCATCAAAACCATCAAATTGCCAAAACAAAGA ATCAGCTAGCAAACAGTCTTAG Download Select all
CCDS ID	CCDS13451.1

Protein Information

Protein ID	NP_003591.2
Protein Name	Aurora kinase A
Molecular Wt. (Da)	45692
Protein Sequence	>6790 MDRSKENCISGPVKATAPVGGPKRVLVTQQFPCQNPLPVNSGQAQRVLCPSNSSQRIPLQAQKL VSSHKPVQNQKQKQLQATSVPHPVSRPLNNTQKSKQPLPSAPENNPEEELASKQKNEESKKRQW ALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLRHPN ILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCHSKRVIHRD IKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCY EFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLISRLLKHNPSQRPMLREVLEHPWIT ANSSKPSNCQNKESASKQS Download Select all
Length	403
Uniprot ID	P07585
Ensembl Protein ID	ENSP00000052754

Post-translational Modification Information (Source : HPRD)

Residue	Type	site
T	Phosphorylation	288
T	Phosphorylation	288
T	Phosphorylation	288
T	Phosphorylation	288
T	Phosphorylation	288
T	Phosphorylation	288
S	Phosphorylation	369;-
S	Phosphorylation	369;-
S	Phosphorylation	369;-
S	Phosphorylation	369;-
S	Phosphorylation	369;-
S	Phosphorylation	369;-
S	Phosphorylation	66
S	Phosphorylation	66
S	Phosphorylation	66
S	Phosphorylation	66
S	Phosphorylation	66
S	Phosphorylation	66
S	Phosphorylation	4
S	Phosphorylation	4
S	Phosphorylation	4
S	Phosphorylation	4
S	Phosphorylation	4
S	Phosphorylation	4
T	Phosphorylation	287
T	Phosphorylation	287
T	Phosphorylation	287
T	Phosphorylation	287
T	Phosphorylation	287
T	Phosphorylation	287
S	Phosphorylation	83
S	Phosphorylation	83
S	Phosphorylation	83
S	Phosphorylation	83
S	Phosphorylation	83
S	Phosphorylation	83
S	Phosphorylation	51
S	Phosphorylation	51
S	Phosphorylation	51
S	Phosphorylation	51
S	Phosphorylation	51
S	Phosphorylation	51
S	Phosphorylation	53
S	Phosphorylation	53
S	Phosphorylation	53
S	Phosphorylation	53
S	Phosphorylation	53
S	Phosphorylation	53
S	Phosphorylation	41
S	Phosphorylation	41
S	Phosphorylation	41
S	Phosphorylation	41
S	Phosphorylation	41
S	Phosphorylation	41
S	Phosphorylation	116
S	Phosphorylation	116
S	Phosphorylation	116
S	Phosphorylation	116
S	Phosphorylation	116
S	Phosphorylation	116

Enzyme Information

No matching records could be found.

PPi Information

(Click to view network : Source STRING) View

Interactant Gene ID (Source: HPRD)	Gene Symbol	HPRD ID	Ref Seq ID	Technique	References
672	BRCA1	218	NP_009231.2	in vitro;in vivo	14990569
994	CDC25B	307	NP_068660.1	in vitro;in vivo	15128871
2932	GSK3B	5418	NP_002084.2	in vitro	19060929
3832	KIF11	1023	NP_004514.2	in vivo	17939994
4830	NME1	1131	NP_937818.1	in vivo;yeast 2-hybrid	12490715
7157	TP53	1859	NP_000537.3	in vitro;in vivo;yeast 2-hybrid	12198151
10403	NDC80	6277	NP_006092.1	in vitro	14602875
10460	TACC3	5601	NP_006333.1	in vitro;yeast 2-hybrid	14602875
53615	MBD3	4653	NP_003917.1	in vitro;in vivo	12354758
83540	NUF2	10817	NP_663735.2	in vitro;in vivo	14602875

Pathway Information

Pathway Name	Pathway ID
Oocyte meiosis	hsa04114

Structure Information

PDB ID	1MQ4
Resolution	1.9
Method	X-RAY DIFFRACTION
Chains	A
Molecule	AURORA-RELATED KINASE 1
Model	View

Domain Information

ID	Location	Description
cd14116	127-384	STKc_Aurora-A
cl21453	127-384	PKc_like superfamily
cd14007	132-384	STKc_Aurora
cd14117	126-389	STKc_Aurora-B_like
cd14003	132-382	STKc_AMPK-like
cd05117	132-382	STKc_CAMK
cd05123	139-382	STKc_AGC
cd14099	131-383	STKc_PLK
cd05581	131-382	STKc_PDK1
cd05580	131-382	STKc_PKA_like
cd14663	132-382	STKc_SnRK3
cd05122	132-383	PKc_STE
cd05579	141-384	STKc_MAST_like
cd00180	139-381	PKc
cd14081	133-383	STKc_BRSK1_2
cd14008	139-383	STKc_LKB1_CaMKK
cd06606	132-383	STKc_MAPKKK
cd14186	131-383	STKc_PLK4
cd14009	139-382	STKc_ATG1_ULK_like
cd05572	139-382	STKc_cGK
cd14014	133-372	STKc_PknB_like
cd08215	132-383	STKc_Nek
cd14095	133-382	STKc_DCKL
cd05573	131-382	STKc_ROCK_NDR_like
cd06623	131-384	PKc_MAPKK_plant_like
cd05578	133-383	STKc_Yank1
cd14080	133-383	STKc_TSSK-like
cd14079	130-382	STKc_AMPK_alpha
cd05612	131-371	STKc_PRKX_like
cd14185	133-382	STKc_DCKL3
cd14074	133-383	STKc_SNRK
cd05570	139-371	STKc_PKC
cd06627	133-383	STKc_Cdc7_like
cd05611	137-382	STKc_Rim15_like
cd14209	131-382	STKc_PKA
cd14002	131-383	STKc_STK36
cd14072	133-383	STKc_MARK
cd14071	133-383	STKc_SIK
cd06609	131-393	STKc_MST3_like
cd14073	133-383	STKc_NUAK
cd14098	132-382	STKc_Rad53_Cds1
cd13999	139-379	STKc_MAP3K-like
cd14096	131-383	STKc_RCK1-like
cd14075	133-383	STKc_NIM1
cd14006	139-382	STKc_MLCK-like
cd08217	132-383	STKc_Nek2
cd05574	132-382	STKc_phototropin_like
cd05584	139-382	STKc_p70S6K
cd14162	133-382	STKc_TSSK4-like
cd14121	139-382	STKc_ULK3
cd14092	138-392	STKc_MSK_C
cd14084	135-383	STKc_Chk2
cd14187	136-385	STKc_PLK1
cd07829	133-383	STKc_CDK_like
cd05571	139-382	STKc_PKB
cd06632	136-383	STKc_MEKK1_plant
cd14083	133-382	STKc_CaMKI
cd05599	131-382	STKc_NDR_like
cd14119	139-382	STKc_LKB1
cd05582	139-371	STKc_RSK_N
cd05118	133-383	STKc_CMGC
cd14077	132-383	STKc_Kin1_2
cd14069	131-382	STKc_Chk1
cd05613	132-382	STKc_MSK1_N
cd05583	139-382	STKc_MSK_N
cd08530	132-381	STKc_CNK2-like
cd05575	139-371	STKc_SGK
cd14086	131-398	STKc_CaMKII
cd14167	131-383	STKc_CaMKI_alpha
cd14166	131-388	STKc_CaMKI_gamma
cd14078	130-383	STKc_MELK
cd14189	136-380	STKc_PLK3
cd14161	133-383	STKc_NUAK2
cd14090	136-383	STKc_Mnk
cd05610	129-381	STKc_MASTL
cd14103	139-383	STKc_MLCK
cd14188	136-380	STKc_PLK2
cd14097	133-383	STKc_STK33
cd14184	131-382	STKc_DCKL2
cd05595	139-380	STKc_PKB_beta
cd14085	130-396	STKc_CaMKIV
cd14118	139-384	STKc_CAMKK
cd05614	132-382	STKc_MSK2_N
cd05585	139-371	STKc_YPK1_like
cd14093	179-382	STKc_PhKG
cd05600	124-382	STKc_Sid2p_like
cd14165	133-383	STKc_TSSK1_2-like
cd14662	133-382	STKc_SnRK2
cd14091	132-392	STKc_RSK_C
cd14106	136-383	STKc_DRAK
cd08529	132-381	STKc_FA2-like
cd14169	133-388	STKc_CaMKI_beta
cd14665	133-382	STKc_SnRK2-3
cd05592	139-371	STKc_nPKC_theta_like
cd05590	137-371	STKc_nPKC_eta
cd06625	136-383	STKc_MEKK3_like
cd05601	131-390	STKc_CRIK
cd06614	130-384	STKc_PAK
cd14004	132-383	STKc_PASK
cd14105	130-383	STKc_DAPK
cd05602	132-371	STKc_SGK1
cd14120	139-381	STKc_ULK1_2-like
cd05589	139-371	STKc_PKN
cd05591	139-382	STKc_nPKC_epsilon
cd14005	133-382	STKc_PIM
cd08224	132-379	STKc_Nek6_7
cd14183	131-384	STKc_DCKL1
cd05619	130-382	STKc_nPKC_theta
cd05586	139-382	STKc_Sck1_like
cd05604	139-385	STKc_SGK3
cd05603	139-371	STKc_SGK2
cd06626	136-383	STKc_MEKK4
cd14202	133-383	STKc_ULK1
cd05598	132-382	STKc_LATS
cd13994	139-383	STKc_HAL4_like
cd06628	136-383	STKc_Byr2_like
cd05609	132-384	STKc_MAST
cd14194	131-383	STKc_DAPK1
cd14087	133-383	STKc_PSKH1
cd05593	125-371	STKc_PKB_gamma
cd06612	131-383	STKc_MST1_2
cd14089	132-382	STKc_MAPKAPK
cd08220	132-383	STKc_Nek8
cd14137	133-381	STKc_GSK3
cd07841	133-395	STKc_CDK7
cd05587	139-382	STKc_cPKC
cd06630	136-384	STKc_MEKK1
cd00192	137-380	PTKc
cd07840	133-382	STKc_CDK9_like
cd06917	139-391	STKc_NAK1_like
cd05596	131-364	STKc_ROCK
cd05594	125-371	STKc_PKB_alpha
cd14174	139-383	STKc_Mnk1
cd06605	131-385	PKc_MAPKK
cd14076	135-383	STKc_Kin4
cd06610	131-383	STKc_OSR1_SPAK
cd14168	131-402	STKc_CaMKI_delta
cd05597	131-382	STKc_DMPK_like
cd06611	131-389	STKc_SLK_like
cd07832	134-384	STKc_CCRK
cd14201	132-383	STKc_ULK2
cd07835	139-382	STKc_CDK1_CdkB_like
cd06613	132-383	STKc_MAP4K3_like
cd14195	133-385	STKc_DAPK3
cd13996	130-379	STKc_EIF2AK
cd06621	134-392	PKc_Pek1_like
cd14113	139-383	STKc_Trio_C
cd14196	130-383	STKc_DAPK2
cd14175	139-399	STKc_RSK1_C
cd14164	133-383	STKc_TSSK6-like
cd05616	132-371	STKc_cPKC_beta
cd14163	133-383	STKc_TSSK3-like
cd05629	131-384	STKc_NDR_like_fungal
cd14046	130-380	STKc_EIF2AK4_GCN2_rpt2
cd08225	133-383	STKc_Nek5
cd05615	130-371	STKc_cPKC_alpha
cd14179	137-392	STKc_MSK1_C
cd14114	130-383	STKc_Twitchin_like
cd07833	139-382	STKc_CDKL
cd05622	102-382	STKc_ROCK1
cd05620	139-371	STKc_nPKC_delta
cd14082	139-382	STKc_PKD
cd05624	124-364	STKc_MRCK_beta
cd05628	131-363	STKc_NDR1
cd08218	139-383	STKc_Nek1
cd06629	136-383	STKc_Bck1_like
cd05627	130-382	STKc_NDR2
cd05621	121-382	STKc_ROCK2
cd06608	131-383	STKc_myosinIII_N_like
cd14115	139-382	STKc_Kalirin_C
cd14181	168-382	STKc_PhKG2
cd14058	139-377	STKc_TAK1
cd06640	139-391	STKc_MST4
cd08221	137-383	STKc_Nek9
cd14172	131-383	STKc_MAPKAPK3
cd14094	131-383	STKc_CASK
cd07860	133-382	STKc_CDK2_3
cd14193	139-383	STKc_MLCK4
cd08219	132-378	STKc_Nek3
cd06648	139-383	STKc_PAK_II
cd07838	133-382	STKc_CDK4_6_like
cd06644	131-390	STKc_STK10
cd14173	180-383	STKc_Mnk2
cd06653	131-383	STKc_MEKK3_like_u1
cd08528	132-377	STKc_Nek10
cd06642	139-391	STKc_STK25
cd05623	123-385	STKc_MRCK_alpha
cd14070	135-383	STKc_HUNK
cd13985	137-379	STKc_GAK_like
cd14199	130-384	STKc_CaMKK2
cd14010	134-382	STKc_ULK4
cd05577	139-381	STKc_GRK
cd14180	136-390	STKc_MSK2_C
cd13986	133-380	STKc_16
cd13993	133-376	STKc_Pat1_like
cd14178	133-383	STKc_RSK3_C
cd08222	133-383	STKc_Nek11
cd14176	133-399	STKc_RSK2_C
cd07839	139-382	STKc_CDK5
cd14132	122-381	STKc_CK2_alpha
cd13987	139-382	STKc_SBK1
cd06641	139-391	STKc_MST3
cd14131	132-381	PKc_Mps1
cd14177	133-400	STKc_RSK4_C
cd13990	139-382	STKc_TLK
cd14111	140-383	STKc_SPEG_rpt2
cd07830	133-382	STKc_MAK_like
cd14190	139-383	STKc_MLCK2
cd07864	130-383	STKc_CDK12
cd14191	133-383	STKc_MLCK1
cd14200	133-384	STKc_CaMKK1
cd07836	139-382	STKc_Pho85
cd14066	139-380	STKc_IRAK
cd06643	131-390	STKc_SLK
cd14198	139-383	STKc_DRAK2
cd06647	139-383	STKc_PAK_I
cd06607	133-384	STKc_TAO
cd14104	133-391	STKc_Titin
cd14197	136-383	STKc_DRAK1
cd14171	130-383	STKc_MAPKAPK5
cd06652	132-383	STKc_MEKK2
cd07843	131-383	STKc_CDC2L1
cd07861	132-382	STKc_CDK1_euk
cd06620	130-390	PKc_Byr1_like
cd14133	133-383	PKc_DYRK_like
cd14182	180-382	STKc_PhKG1
cd14088	133-383	STKc_CaMK_like
cd05617	129-371	STKc_aPKC_zeta
cd07834	133-382	STKc_MAPK
cd13995	137-380	STKc_MAP3K8
cd06631	136-383	STKc_YSK4
cd13983	139-383	STKc_WNK
cd06624	139-383	STKc_ASK
cd14101	133-383	STKc_PIM2
cd06622	139-385	PKc_PBS2_like
cd05618	112-371	STKc_aPKC_iota
cd06659	139-383	STKc_PAK6
cd13997	132-381	PKc_Wee1_like
cd14192	139-383	STKc_MLCK3
cd07845	132-382	STKc_CDK10
cd08228	130-379	STKc_Nek6
cd08223	132-383	STKc_Nek4
cd14052	132-381	PTKc_Wee1_fungi
cd07851	122-382	STKc_p38
cd06618	123-384	PKc_MKK7
cd07852	130-383	STKc_MAPK15-like
cd14109	131-383	PK_Unc-89_rpt1
cd06651	136-382	STKc_MEKK3
cd13978	139-397	STKc_RIP
cd07873	139-382	STKc_PCTAIRE1
cd06655	139-383	STKc_PAK2
cd06639	131-383	STKc_myosinIIIB_N
cd14107	133-382	STKc_obscurin_rpt1
cd05630	137-381	STKc_GRK6
cd06633	139-383	STKc_TAO3
cd05631	137-381	STKc_GRK4
cd06617	131-389	PKc_MKK3_6
cd06656	139-383	STKc_PAK3
cd14060	140-378	STKc_MLTK
cd14102	133-383	STKc_PIM3
cd07871	139-382	STKc_PCTAIRE3
cd07866	129-382	STKc_BUR1
cd07846	131-382	STKc_CDKL2_3
cd14059	139-380	STKc_MAP3K12_13
cd06615	131-383	PKc_MEK
cd14170	131-390	STKc_MAPKAPK2
cd06654	139-383	STKc_PAK1
cd14037	134-386	STKc_NAK_like
cd07849	131-383	STKc_ERK1_2_like
cd05608	132-371	STKc_GRK1
cd05588	137-330	STKc_aPKC
cd14048	130-380	STKc_EIF2AK3_PERK
cd14100	133-383	STKc_PIM1
cd06638	131-383	STKc_myosinIIIA_N
cd05605	133-382	STKc_GRK4_like
cd08229	129-372	STKc_Nek7
cd06658	139-383	STKc_PAK5
cd07865	139-382	STKc_CDK9
cd07844	138-382	STKc_PCTAIRE_like
cd06650	131-328	PKc_MEK1
cd07880	121-363	STKc_p38gamma
cd05626	137-363	STKc_LATS2
cd05607	137-381	STKc_GRK7
cd07878	121-370	STKc_p38beta
cd06635	137-383	STKc_TAO1
cd07831	139-382	STKc_MOK
cd06634	137-383	STKc_TAO2
cd06657	139-393	STKc_PAK4
cd07855	131-383	STKc_ERK5
cd07848	133-381	STKc_CDKL5
cd07870	139-382	STKc_PFTAIRE2
cd14011	147-382	PK_SCY1_like
cd07857	133-383	STKc_MPK1
cd14112	131-383	STKc_Unc-89_rpt2
cd13989	139-329	STKc_IKK
cd07856	137-383	STKc_Sty1_Hog1
cd13979	138-379	STKc_Mos
cd07872	139-382	STKc_PCTAIRE2
cd14065	139-319	PKc_LIMK_like
cd05625	137-341	STKc_LATS1
cd06645	131-384	STKc_MAP4K3
cd05056	131-377	PTKc_FAK
cd07877	121-363	STKc_p38alpha
cd14664	139-379	STK_BAK1_like
cd14068	139-379	STKc_LRRK2
cd06636	133-383	STKc_MAP4K4_6_N
cd06619	131-383	PKc_MKK5
cd07862	131-382	STKc_CDK6
cd07879	121-382	STKc_p38delta
cd05632	133-383	STKc_GRK5
cd14047	131-380	STKc_EIF2AK2_PKR
cd14061	139-330	STKc_MLK
cd14146	139-380	STKc_MLK4
cd06649	131-340	PKc_MEK2
cd07847	139-382	STKc_CDKL1_4
cd14016	133-341	STKc_CK1
cd05148	131-343	PTKc_Srm_Brk
cd14000	139-379	STKc_LRRK
cd14158	136-332	STKc_IRAK4
cd14221	139-319	STKc_LIMK1
cd05059	132-379	PTKc_Tec_like
cd14154	139-319	STKc_LIMK
cd07863	139-383	STKc_CDK4
cd05633	130-371	STKc_GRK3
cd14050	133-381	PKc_Myt1
cd06637	133-383	STKc_TNIK
cd05041	139-379	PTKc_Fes_like
cd05606	139-382	STKc_beta_ARK
cd05046	139-378	PTK_CCK4
cd14222	139-319	STKc_LIMK2
cd05040	139-372	PTKc_Ack_like
cd14223	132-371	STKc_GRK2
cd14205	139-377	PTKc_Jak2_rpt2
cd05038	137-372	PTKc_Jak_rpt2
cd14039	139-340	STKc_IKK_alpha
cd14210	133-383	PKc_DYRK
cd06646	131-383	STKc_MAP4K5
cd14159	139-338	STKc_IRAK1
cd14110	141-383	STKc_obscurin_rpt2
cd13982	179-381	STKc_IRE1
cd14041	139-403	STKc_TLK2
cd05085	136-377	PTKc_Fer
cd05112	139-378	PTKc_Itk
cd05114	137-379	PTKc_Tec_Rlk
cd05049	137-377	PTKc_Trk
cd14040	139-395	STKc_TLK1
cd07842	133-382	STKc_CDK8_like
cd05082	128-380	PTKc_Csk
cd13991	126-314	STKc_NIK
cd14031	139-387	STKc_WNK3
cd14038	139-332	STKc_IKK_beta
cd14148	139-379	STKc_MLK2
cd05036	137-380	PTKc_ALK_LTK
cd14147	139-380	STKc_MLK3
cd05057	133-330	PTKc_EGFR_like
cd07869	131-384	STKc_PFTAIRE1
cd05060	139-377	PTKc_Syk_like
cd14108	133-382	STKc_SPEG_rpt1
cd05039	128-379	PTKc_Csk_like
cd05053	127-379	PTKc_FGFR
cd07837	131-382	STKc_CdkB_plant
cd07850	137-384	STKc_JNK
cd05099	131-379	PTKc_FGFR4
cd14033	132-380	STKc_WNK4
cd14036	135-379	STKc_GAK
cd05113	131-378	PTKc_Btk_Bmx
cd05101	107-379	PTKc_FGFR2
cd13988	139-329	STKc_TBK1
cd07858	133-385	STKc_TEY_MAPK
cd06616	130-383	PKc_MKK4
cd14022	190-382	PK_TRB2
cd14012	178-381	PK_eIF2AK_GCN2_rpt1
cd14049	134-379	STKc_EIF2AK1_HRI
cd14145	139-380	STKc_MLK1
cd05098	135-379	PTKc_FGFR1
cd05092	139-377	PTKc_TrkA
cd14063	132-378	PK_KSR
cd05084	136-372	PTKc_Fes
cd14056	138-323	STKc_TGFbR_I
cd14023	164-382	PK_TRB1
cd07853	132-383	STKc_NLK
cd05100	135-379	PTKc_FGFR3
cd05047	139-378	PTKc_Tie
cd14027	139-379	STKc_RIP1
cd14032	139-387	STKc_WNK2_like
cd05072	131-379	PTKc_Lyn
cd14150	139-378	STKc_A-Raf
cd14019	131-381	STKc_Cdc7
cd07876	130-384	STKc_JNK2
cd14030	132-380	STKc_WNK1
cd05089	131-377	PTKc_Tie1
cd05116	139-372	PTKc_Syk
cd14024	190-383	PK_TRB3
cd05045	132-377	PTKc_RET
cd05115	139-341	PTKc_Zap-70
cd14062	139-379	STKc_Raf
cd05094	132-377	PTKc_TrkC
cd14134	133-382	PKc_CLK
cd05081	139-323	PTKc_Jak3_rpt2
cd14225	133-383	PKc_DYRK4
cd14064	139-377	PKc_TNNI3K
cd05093	137-343	PTKc_TrkB
cd07867	136-329	STKc_CDC2L6
cd14144	137-371	STKc_BMPR1
cd07854	137-387	STKc_MAPK4_6
cd07859	133-382	STKc_TDY_MAPK
cd13974	148-380	STKc_SHIK
cd07868	117-329	STKc_CDK8
cd05067	131-379	PTKc_Lck_Blk
cd05052	128-377	PTKc_Abl
cd05044	139-379	PTKc_c-ros
cd05075	135-379	PTKc_Axl
cd05079	137-323	PTKc_Jak1_rpt2
cd14212	139-332	PKc_YAK1
cd14151	128-378	STKc_B-Raf
cd05034	137-379	PTKc_Src_like
cd07874	130-383	STKc_JNK3
cd14156	139-323	PKc_LIMK_like_unk
cd05032	128-379	PTKc_InsR_like
cd14026	137-391	STKc_RIP2
cd14136	133-383	STKc_SRPK
cd14025	137-329	STKc_RIP4_like
cd14142	139-329	STKc_ACVR1_ALK1
cd05088	127-378	PTKc_Tie2
cd14054	139-382	STKc_BMPR2_AMHR2
cd14155	139-319	PKc_TESK
cd14067	177-394	STKc_LRRK1
cd13976	184-383	PK_TRB
cd14211	133-345	STKc_HIPK
cd05048	130-341	PTKc_Ror
cd05576	191-371	STKc_RPK118_like
cd05035	133-379	PTKc_TAM
cd05051	131-377	PTKc_DDR
cd07875	130-383	STKc_JNK1
cd05108	132-378	PTKc_EGFR
cd14149	128-378	STKc_C-Raf
cd05054	125-380	PTKc_VEGFR
cd05033	135-341	PTKc_EphR
cd05055	131-372	PTKc_PDGFR
cd05066	135-341	PTKc_EphR_A
cd13998	140-321	STKc_TGFbR-like
cd05091	139-377	PTKc_Ror2
cd05073	124-379	PTKc_Hck
cd14214	127-382	PKc_CLK3
cd05063	139-342	PTKc_EphR_A2
cd05068	127-343	PTKc_Frk_like
cd05074	133-382	PTKc_Tyro3
cd05080	137-323	PTKc_Tyk2_rpt2
cd05050	132-377	PTKc_Musk
cd14125	133-342	STKc_CK1_delta_epsilon
cd08216	134-329	PK_STRAD
cd13980	132-379	STKc_Vps15
cd14226	130-344	PKc_DYRK1
cd05090	134-377	PTKc_Ror1
cd14228	133-345	STKc_HIPK1
cd14229	133-345	STKc_HIPK3
cd14224	133-329	PKc_DYRK2_3
cd14207	125-379	PTKc_VEGFR1
cd14135	133-383	STKc_PRP4
cd05083	130-379	PTKc_Chk
cd13968	139-276	PKc_like
cd14220	137-321	STKc_BMPR1a
cd05103	143-380	PTKc_VEGFR2
cd14018	139-372	STKc_PINK1
cd05110	139-357	PTKc_HER4
cd14055	139-329	STKc_TGFbR2_like
cd14227	133-345	STKc_HIPK2
cd14160	139-325	PK_IRAK3
cd13984	165-381	PK_NRBP1_like
cd13981	133-376	STKc_Bub1_BubR1
cd13992	142-372	PK_GC
cd05061	131-379	PTKc_InsR
cd05065	139-329	PTKc_EphR_B
cd05109	137-379	PTKc_HER2
cd14053	141-331	STKc_ACVR2
cd05069	125-372	PTKc_Yes
cd14203	137-372	PTKc_Src_Fyn_like
cd05058	137-337	PTKc_Met_Ron
smart00220	133-383	S_TKc
pfam00069	133-383	Pkinase
PTZ00263	128-371	PTZ00263
COG0515	132-392	SPS1
PTZ00426	108-382	PTZ00426
pfam07714	133-380	Pkinase_Tyr
smart00219	134-379	TyrKc
smart00221	134-372	STYKc
PHA03390	130-383	pk1
PLN00034	69-395	PLN00034
PLN00009	130-382	PLN00009
PTZ00283	119-381	PTZ00283
PTZ00266	114-372	PTZ00266
PTZ00267	179-379	PTZ00267
PTZ00036	104-382	PTZ00036
PTZ00024	135-397	PTZ00024
PRK13184	130-329	pknD
TIGR03903	159-371	TOMM_kin_cyc
PHA03209	126-323	PHA03209
PHA02988	141-378	PHA02988
PHA03210	23-323	PHA03210
PHA03212	171-381	PHA03212
PHA03207	133-329	PHA03207

Ontology Information

HPRD ID	528
Molecular Class	Serine/threonine kinase
Molecular Function	DNA repair protein (GO:0003685)
Biological Process	Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219)

SNP Information

View SNP Geneview Report

Drug Information

No matching records could be found.

External Links

ArrayExpress GO
ICGC GO
Cancer3D GO
COSMIC GO
NCG GO
TSGene GO
Tumor Gene Family of Databases GO
CCDB GO
G2SBC GO
Osteosarcoma Database GO
RCDB GO

Mechanism	Up-regulation
Biomarker	26259750, 24104968
Drug Target	-
Biological Process	Cell communication

ArrayExpress	GO
ICGC	GO
Cancer3D	GO
COSMIC	GO
NCG	GO
TSGene	GO
Tumor Gene Family of Databases	GO
CCDB	GO
G2SBC	GO
Osteosarcoma Database	GO
RCDB	GO