CoReCG

Search results:

General Information

Gene_Symbol	Gene_ID	Gene_Name	Chromosome	Alias
STK11	6794	Serine/threonine kinase 11	19	PJS; LKB1; hLKB1

Evidence
Gene
mRNA
CDS
Protein
PTM
Enzyme
PPi
Pathway
Structural
Domain
Ontology
SNP
Drug
External Links

Evidence Information

Pubmed ID	Year	Sample Information	Techniques	Mechanism	Fold Change	Remark
10896921	2000	Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : 50 (UICC stage I, n=9;stage II, n=10; stage III, n=17; stage IV, n=14) Stage : TNM Stage I-IV	Methylation specific PCR , Genomic PCR amplification and sequence analysis	Methylation	-	In sporadic colorectal cancer, hypermethylation of the LKB1/STK11 promoter and allelic loss at the STK 11 gene locus are rare events but LOH at 19p13.3 was associated with advanced tumour stage.
9809980	1998	Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : 71 patients for allelic deletions (loss of heterozygosity) and STK11 gene mutations Stage : -	STKII Mutation Analysis by SSCP, Sequencing, Allelic Deletion Analysis	Mutation	-	Data indicate the heterogeneity of PJS and the infrequent involvement of the STK11 gene in colorectal cancer.
10429655	1999	Cell line : - Source : - Sample Type : - No. of Sample : 80 sporadic colorectal cancers, six small-intestinal cancers, and 40 gastric cancers. Stage : -	SSCP	Mutation	-	If the STK11 gene is one of the mutational targets of microsatellite instability, its inactivation may be associated with tumor development in a small proportion of colorectal cancers.
20622004	2010	Cell line : - Source : Utah, the Northern California Kaiser Permanente Medical Care Program (KPMCP) and the Twin Cities Metropolitan area of Minnesota (colon cancer study only). Sample Type : Population-based case-control studies No. of Sample : Colon 1574 cases, 1940 controls and rectal 91 cases, 999 controls Stage : -	HapConstructor,Chi-squared test.	Polymorhpism	-	Observed a statistically significant association between tagSNPs of the STK11 gene and risk of rectal cancer.

Gene Details

Chromosome: 19; NC_000019.9 (1205798..1228434)
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Gene Type	protein coding
Gene Family	-
Description	This gene, which encodes a member of the serine/threonine kinase family, regulates cell polarity and functions as a tumor suppressor. Mutations in this gene have been associated with Peutz-Jeghers syndrome, an autosomal dominant disorder characterized by the growth of polyps in the gastrointestinal tract, pigmented macules on the skin and mouth, and other neoplasms. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008]
Chromosome	19
Location	19p13.3
Start	1205799
End	1228435
Strand	+
Gene Sequence	>gi\|568815579:1205799-1228435 Homo sapiens chromosome 19, GRCh38.p2 Primary Assembly GCGTGTCGGGCGCGGAAGGGGGAGGCGGCCCGGGGCGCCCGCGAGTGAGGCGCGGGGCGGCGAAGGGAGC GCGGGTGGCGGCACTTGCTGCCGCGGCCTTGGATGGGCTGGGCCCCCCTCGCCGCTCCGCCTCCTCCACA CGCGCGGCGGCCGCGGCGAGGGGGACGCGCCGCCCGGGGCCCGGCACCTTCGGGAACCCCCCGGCCCGGA GCCTGCGGCCTGCGCCGCCTCGGCCGCCGGGAGCCCCGTGGAGCCCCCGCCGCCGCGCCGCCCCGCGGAC CGGACGCTGAGGGCACTCGGGGCGGGGCGCGCGCTCGGGCAGACGTTTGCGGGGAGGGGGGCGCCTGCCG GGCCCCGGCGACCACCTTGGGGGTCGCGGGCCGGCTCGGGGGGCGCCCAGTGCGGGCCCTCGCGGGCGCC GGGCAGCGACCAGCCCTGAGCGGAGCTGTTGGCCGCGGCGGGAGGCCTCCCGGACGCCCCCAGCCCCCCG AACGCTCGCCCGGGCCGGCGGGAGTCGGCGCCCCCCGGGAGGTCCGCTCGGTCGTCCGCGGCGGAGCGTT TGCTCCTGGGACAGGCGGTGGGACCGGGGCGTCGCCGGAGACGCCCCCAGCGAAGTTGGGCTCTCCAGGT GTGGGGGTCCCGGGGGGTAGCGACGTCGCGGACCCGGCCTGTGGGATGGGCGGCCCGGAGAAGACTGCGC TCGGCCGTGTTCATACTTGTCCGTGGGCCTGAGGTCCCCGGAGGATGACCTAGCACTGAAAAGCCCCGGC CGGCCTCCCCAGGGTCCCCGAGGACGAAGTTGACCCTGACCGGGCCGTCTCCCAGTTCTGAGGCCCGGGT CCCACTGGAACTCGCGTCTGAGCCGCCGTCCCGGACCCCCGGTGCCCGCCGGTCCGCAGACCCTGCACCG GGCTTGGACTCGCAGCCGGGACTGACGTGTAGAACAATCGTTTCTGTTGGAAGAAGGGTTTTTCCCTTCC TTTTGGGGTTTTTGTTGCCTTTTTTTTTTCTTTTTTCTTTGTAAAATTTTGGAGAAGGGAAGTCGGAACA CAAGGAAGGACCGCTCACCCGCGGACTCAGGGCTGGCGGCGGGACTCCAGGACCCTGGGTCCAGCATGGA GGTGGTGGACCCGCAGCAGCTGGGCATGTTCACGGAGGGCGAGCTGATGTCGGTGGGTATGGACACGTTC ATCCACCGCATCGACTCCACCGAGGTCATCTACCAGCCGCGCCGCAAGCGGGCCAAGCTCATCGGCAAGT ACCTGATGGGGGACCTGCTGGGGGAAGGCTCTTACGGCAAGGTGAAGGAGGTGCTGGACTCGGAGACGCT GTGCAGGAGGGCCGTCAAGATCCTCAAGAAGAAGAAGTTGCGAAGGATCCCCAACGGGGAGGCCAACGTG AAGAAGTAAGTATGGCTTGCTGGGGTCGGGGCCGGGCCGGGCCAGTCACGGTGCTGATGGTTCTGTCTTC CTTCCTTCTCTCCTCCCTCCCTCCCTTACTTCCTCTTAACACCCTGAGCTGGACCCGTCTGGCGCCTGTG TCCTCCGTGCCAGGGAGAGCGTGGTTGGGGGCCTGCGTTACGGACTTTCACTCAGGCAAGGCCAGTTGTC GCAGCGGGGCGTGCGTTTGCATGGGCTCTTGGACTCCAGTTAAAATGCCCTGGTAGCGAAACCCTCCTGA GAAGGGAGCGGCCCCCAATCCCCTAAGACTAGCCCCTTGGCTCCCCCAGCTGTCCAAGGAGCAGAGGCGC CCAGTGGAATCAGCCTGTGTTTGTTTGGGCCCCGAGAGTTTGTGTGCGGCCGCCAACACGTTTTCTGCGC AGTGTGTGGCCGTTACCGGGGCCAGGCGAAATGTGATTTGTTTATCCTGTCAGAGGGGAACCCTGGGCTG CCAAAAATAACTGTTTGCACCGGCTTATCAGTCAGCAGGAGGGAAACGTAGCCTTTCCTCATTTGCCAGG GATGTGACGCTGGAAGCATCCCTGGCCCCCGGGGCTGGAAGCCCTGCCCGAGGGGGACTGTGCCTCCCTC CCGAATTGCATCCGGAAGACCTTACTTTTCCAACTGACTTCTTCAGGCACGGGGCTGCCGCTGGGCATCC CGGACGCCTCTGCATCTGTGCGCGGAGAAGCTCCTACCTAGGGCAGCACTGGCCGGCCTGAGCCTCTCCC AGCTGGTGGGGGTGGCCGGGGGTGTCCCTGCCTTATCGCAGCCAGACACGCTGCACCTGCCGCCGCCTGG CGGGCCCTGCCCAGGCCCTGCTCCTTTCCCAGCCTTCTTAACTTTCAAAACTTTGCCTCCTGTTTCCAAG AAAGGACCTTATCTGCTGGGCTAGGCCTCGAGGGACTGGCAAGGACACCCTGCGCAGGGCACCATGACCT TGGAAGGAGGTCCGGGGAGGGGCTGCTGCGGTGTCTGCTCTCACCTTCCTCCTGCTCAGGGGCCCTGGGG CTCCTGCCGTGTCTGCTCTCACCTCTCTCCTGCTCAGGGGCCCTGGGGCTCACGTACATTTTTTTTTTTT TTTTTTTGAGACGGAGTCTCGCTCTGTTCCCCAGGCTGGAGTGCAGTGGCGCGAACTGGGCTCACTGCAA GCTCCGCCTCCCGGGTTCATGCCATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACAGGCACCCGC CACCACGCCCGGCCAATTTTTTGTATTTTTCAGTAGAGACGGGGTTTCACCGTGTTAGCCAGGATGGTCT CAATCTCCTGACCTCGTGATCCGCCCGCCTCGGCCTCCCAAAGTGCTGGTACTACAGGCGTGAGTCAACG CGTGCGGCCTTTTTTTTTTTTTTTTTTTTTTTTTTTGAGACGGAGTTTCACTCTTGTTGCTCAGGCTGGA GTGCAGTGGAGTGGTCTTGGCTCACTGCAATCTCCGCCCCCTGGGTTCAAGTGATTCTCGTGCCTCAGCC TCCCGAGTAGCTGGGATTACAGGTGCCTGCCACAGTGCCCAGCTAATTTTTTTTTTTTTTTTTTAGTAGA GACGGGGTTTCACCATCTTGGCCAGGTTGGTCTTGAACTTCTGACCTCGTGATCCACCTGCCTCAGCCTC CCAAAGTGCTGGGATTAAAGGCGTGAGCCACCGCGCCCGGCCAGCACGCTTCTTAATCAGCATGCAGGCT GTGACATGCGGAAACCAGGGGCACAGGCTCTGAAGTTTGTACTCTGGAGCTGGAGCAGTCAGGGTTAAAT GGGAGCGGCTGGGAAGGGTGTGTTTCCACGAGGCCTTTCTGATGTCTCAGTGCCCAGTCTGGACCCGGGT AGAAGGTGTGGCCAGTGCCTTGAGTCAGTGGAGCAGTTGCCTGTGCCTGGTCTCTGTGAGATGGGTTGGT CAGGGGCTAGGCAGAGCCTGTGCCTGGTCTCTGTGAGATGGGTTGGTCAGGGGCTAGGCAGAGCCTGTGC TGGGGGTAGCAGGTGCCCTCTAAAGGGGCCAGTGACAGTCTCTCTCCCAGCAGTGAGAAACCCACGCTTA GGGGCCGGGCGCGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGTGGGTGGATCGCCTGA GGTCAGGAGTTCGAGACCAGCCTGGCCAACATGGTGAAACCCCATCTCTACTAAAAATACAAAAGTTAGC CGAGTGTGGTGGCGTGTGCCTGTAATCCCAGCTACTCGGGAGGCTGAGGCAGAACATTGCTGGAGCCTGG GAGGCGGAGCTTGCGGTGACCCGAGATCGCACCATTGCGCTCCAGCCTGGGCGACACAGCGAGACTCTGT CTCAAAAATAAATAAATAAATAAATAAATAAATAAATAAATAAATAAATCTGGCTTGAGTTTTGACAAAT GTATATGCAGGGTCAATGGGAAGACAGACGCTGGAGGGTGGAAGCCTGACTGTGAGAGTGAGCCCCCTGC TTTCCTGAACAGTCAGTGGAGGAGGTCCTGGGAGCTCAGGTGAGCACCTGAACGGTAGGGCAGAGCCTGA GGGTCTTGGTGGAGACAGGCAAGAAGGTTGCAGGAACCTAGTCTGGCCCAGTGCCTGGGAGAACGGGAGG GAACACGGAGGCAGGGAGGCAGAGGGGTTGGCAGGACCTGGACTGGACTGTGCGTCGCAGCTACCCACAG CTTGACCCCACTGCCTTGAAGTGAGTGATGCACCCTCACTAGTGTTCAGCGTCCAATTTCATCCTGGCCC TGAGTGTGTAACGGCTTTGCCCTTGCGGGGCCCCCTGGGATGAGGGGTGAGCCCTGTCCCTTCCTGGTCA CTGTCTGCCATCAGGAGCTGCCCCGCTTACAGCTGTGATTCAGGAGCCACTGCATTTCCTCCAGCCCCCT GGGTGCTGCCAGGGGGTCCTCCTATTCTGGGAGCTGGTGTGTTCTGACTGGAGGCTGCCATGTGCAGAGT GCTGTCAAGGAGAAGGGGTGTCCACTGCCCAGCCCTGAGGCCCAAGGCCTTGGCCAGCCTTGCTGCCAGC GCTGCAGGGAAAAAGCCTCCTTTGTGTGTGGGAAGTTTAATAAACTCCGCTCAGATTGTGTCTCGCAGCG AGTGTCTGGAACCTTCCAGACAAGCCTCAGGCGTCCGGTCCTCCAGTTGGTGTGGAAAGCGTGGGCGATC ACCAAGGGGGGTGGGTTGGGGCAGATGGAGCCGGCGTGAGTCCCGTCTCTTCCCTTCCTTCCCAGAAAGG CAGCCCTGGAGTCCATGCCTTGTCCCGCTCTCACCGGCAAAAAGTATAATCTTATTAGAAATAGGAAAGT TCCAAAAAGCATCAATGAGTTAAAAAGAGGGCTGGGCATGTTCGGTCATGCCTGTAATCCCAGCACTTTG GGAGGCCAAGGCGGGTGGATCACCCGAGGTTGGGAGTTAGCCTGACCAACATGGTGAAACCCTGTCTCTA CTAAAAATACAAAATTAGCTGAGTGTGGTGGCGCACGCCTGTAATCCCAGCTACTCTGGAGGCTGAGGCA GGAGAATCACTTGAACCCGGGAAGCAGAGGTTGCGGTGAGCCAAGACCATGCCATTGCACTCCAGCCTGG GTAACAAGAGTGAAACTCCGTCTCGAAAAAAAAAAGGGCTGGGGCCGGGCGTGGTGGCTCACGCCTGTAA TCCCAGCACTTTGGGAGGCCGAGGCGGTTTGATCACAAGGTCAGAAGTTTGAGACCAGCGTGGCCAACAT GGTGAAACCCTCTCTCTACTAAAAATAGAAAAACTAGCCAGGTGTGGTGGCACATGCCAATAATCCCAGC TACTTCATCTGAGGTCAGGAGTTCAAGACCAGCCTGGCCAATATGGCGAAACTCCGTCTCTACTACAAAT ACAAAAATTAGCCAGGCGTGGTGGCGCGCGCCTGTAGTCCAGCTACTGGGGAAGCTGAAGCAAGGAGAAT CGCTTGAACCTGGGAGGCGGAGGTTGCGGTGAGCCGAGATCGCATCATTGCATTCCAGGCTGGGCAAGCC TAGGAGAGAAGAGCGAAATTGTGTCTCAAAAAAACAATTAATTAAAATAAAATCAGTGCCATAGGCTGTT TCTGGTAGGCAGTGGGTTCCTAGGGTGGAGCAGGGAAGGGCTGGAAAGGGTCGCCTGTGCCCAGCCCGAC TCCCCGTGCTTCTCGGGGGACAGCACGGCTAGCTGCTGCTGCGGAGCCCACAGTGGGGTTCTGGGGGGGG GGGTGCAGGCAGAAGGCCGCCATGCCTCCCTCCCCCTTTCCACCCCAGTGAGAGTGGGCTCGAAGGCAGG GAGTCTGCCCGCCTTGTGGAGCCTCCGCAGAGGCACCCAGGGCTGCCGTGAGCGCACAGCCTGGCGGTGT CCCACGGCCCTGCCCTTTCCTGTCACTTCCACCTGTTGCAAAACACTGTGCTTTCGTATCTTTTCTTTCT ACCTGTTTGGAAATGTGAAAATCACTGCTGCCGTAGGAAACGGGCCCAGATCCGGGCTGTGGCTCTCCCA TCCGCACCGCCCCCGCGGTGTCCAGCCAGGAGGTGGGAGGTGGGCGGCACTCAGTGTGCCTGGTTGCGGC GATGATTGGCAGATGCTTGGACCTATGGTAAAGAGGATTTTCGCGAGCTGGGAGTCAGTCCTGGACTTTG TAGGTCTTTACATCCCAGGCGGCCTTTATGGGGTTCCAGCATCTGCTGAGGCCCCTGCGCCAGCCATGTG AGGCCTGGGTGTCCTCGAGGCCTCTGTTTGTGCCCCTCTCTGGGCAGCGGGAGGGAGAGCTCTGAGACCC AGAGGGAGCTCAGGGGCTGGGCAGCCGCAGAACAGCGGGGGTAATGGGTCCACTGGGGGTTCTGGGCTGT GCACACAGTGGGCTTCCGGTGCCCAGCCAGCTGGGGCAGGCCTGGAATGTTGGTTCCTCTCTCAGGATCT GGGGCGCTGCTGTAGCTGTCGGGGAATCAGTGAGGCGGCTGGACGGCCCGTATATCCCACAAACGCCACC GTATTGCTCAAACTGGACTCAATTTTCTTAACACCTTTTTTTTTTTTTTTTTTTTTTTTTTTGGAGACAG GGTCTCACTGTATCGCCGAGGCTGGAGTGCAGTGGCGCAATCATAGCTCTGGGCTCAGGTGACCCTCCTG CCCCCAAGGTAGCTGGGACTGCAGATGTGCACCACCACACCCGACTAGTTTTTTGTAGAGATGGGGTTTC GCCATGTTGTCCAGGCTGGTCTCAAACTCCTAGACTCAAGCTATCCGCCTGCCTGGGCCTCCCAGAGTGC TGGGATTACAGGTATGAGCCACTGCTTCGCCACGTTCACCTTTATTTACTTATTTATTTATTTTTGAGAC GGAGTCTCGCTCTGTCCCCCAGGCTGGAGTGCTGTGGCACGATCTTGGCTCACTGCAAGCTCCGCTTCAG CCTCCCAAGTAAGCTGGAACTACAGGTGCCTGCCACCAAGCCTGGCTAATTTTGTTTTTGTATTTTTAGT AGAGACGGGGTTTCACCGTGTTAGCCAGTATGGTCTCGATCTCCTGACCTTGTGATCCGCCCGCCTCGGC CTCCCAAAGTCCTGGGATTACAGGCTTGAGTCACTGTGCCCGGCCCACCTTTTTATTTTTTATTTTATAG AGACAAGGGCTTGCTGTGTTGCCCAGGCTGGTCTTGAACCCCTGACCTTAAGTAATCCTCTCTGGCCTCC CAAAGTGCTGGGATTACAGGTGTAAGCCATAGTACTGGGCCTAAAGTTCACCTTTTTTTTTTTTTTTTTT TTTTTTGAGATGGAGTCTCGCTCTGTCACCCAGGCTGGAGTGCAGTGGCGTGATCTTGGCTCACTGCAAG CTCTGCCTCCCGGGTTCACACCATTCTCCTGCCTCAGCCTCCCGAATAGCTGGGACTACAGGCGCCTGCC ACCATGCCCGGCTAATTTTTTTGTATTTTTAGTAGAGATGGGGTTTCACTGTGTTAGCCAGGATGGTCTC GATCTCCTGACCTCGTGATCTGCCTGCCTCGGCCTCCCAAAGTGCTGGGGTTACAGGTGTGAGCCACCGC ACCCGGCAAAGTTCACCTTTTTAAAGTGTGTAATTCAGTGGCATATAGTACATTGACAGAGTTGCACAAC TATCACCTCTATCAGCTTCCAGAACATTCTTGTTACCCCAGAAGGAAACCCCGTCTCTGTCAGCCATCAC TCCCCATTCCCTCCCCAGTCCCGGCACCCACGCATTCCCTTCCTGCCTCTGGATTGGCCTGTCCTGAACA TTTCACACGAGTGGTGTCACACACCGCGTGGCCTTTTGCGTCCGGCTTGTCTCACGGAGTGTGCTGTCCT CAAGGGGCATCCGCGCCGTGGCCTGGGTCCGAACCTCTCTGCTGTTCACGGCTGCGTCACTTTCCAGTGT GTGGAGGGCCACGCTGCGTTTGACTGCTCATCTGTGGCTGGACACTTGGGCTGCTCCCGCCTCTGCCTGT GAATTGTGGCTGCTTTGGTGCACGTGTGCTCAGCCGGCGTCCCTCTAGAATCCTTGAGGGCCTTGTTTCA GCCACATCAGGAGGGATTCAGGGACCAGGGCACGCGGGTCTGGAGCTGGGTGTTCCTGGGTCTCCATGTG CCTCCCAGTCCTGCTCTGAGCCGTGGGAGGCCGGGGCGAGGGCCAGGCCCATCTCTTCCCTGTATGATCT GTTTCTAGGCAGACGGAGGCTCCTAGCCCCACCTCTCTGTGAGCTTGAGTGGCGTTTATGACTCTCCTTC CTATTTCCTGTCCTGCTAATCAACAAGTCAGCTAAACAGTCCATGCTGCCTGGGCAAGCCCAGTAGGCCC CTAACGTGGCACCTCGGAGCGGCTGGCGATGCCCCAAGAGCCGGGCTTCCCCCTCCTGGAGGCTCTTCCT GTTCCTCGCCAAGCTCTTAGGTTTCGCTGGGCCTCCTCTTCTGCTCTTTTTCTGGCTGGAGACGTCAGAG GAAGCCTGGCGATCTAGAGAAGCTGATGTGCACCCATCATCCCGGAGGTGACTGCCACCAGGCGGGGGTG GCTCCACCCCCACTCCTCCCCTGGCATAAATCGGGGGACGCACGTGCCTGCGCAGAATGCCTTGGTCCCT TTTAATTAAACAGACAACCCAGTGTCCCTTGGTCTATGCTGACCTGCTCAGGAGTGCCTGGGCTCTTCCA CGTTTCAGCTGCTGTGTGTCCTGCTGCTGTGAAGTGTCCCCGTTGAGGTGGAGGCAGGGCAGGGCGCCTT CGGTGAGGGCGAGTCCTCCTGTGCCCGTTTCCCCATCTGTAGAATGATGGCTCATGGAGGAGACATGGTG TCGGCAGGTGGTGGCCGGCGCAGGGAGGTTTCCAGGAGGGAGTCCTCCACCCTCATTTGCTTTTAGGGCC GTGCAGCCTCCCGAGCGGCCCCCACGAGGCTCTGAGGCTGCATGCAGGTTGAGCTCCTGGCCTCACTGCC CCTCCTCAGGGTTAGGACTGTGCTGGAGCCTGGGTGGGTGTGGGGTGGTCCCTGCACAGGCAGCAGGAGG TGGGCCAGAGCGGTGCTGGACCTGAAGGCCCGTGGCTCCCTCAGCTCCACTGAGGAGGCTGGAATAGTGT CCTGGGCCACCTTCCCTGCCGGTAGCCGGCTCCTGCTGAGGGAGGGGGTGCTTTCGCCTCCTGGTGGAGC ATCAGGCTCTTGGGGCCTGTGCGTCCGAGCATCTGGCCTCTGCTGTCTGAAAACAGCACCTTCCCCGCCC CCCGGCCACCGCATCTCCTCTGAATAGAAGGCAAGTCTTGCCTCCCAGGAATGGCCTGTGACCTTCATCA GCGGGGGAGGTTAGGGGCACACAGAGCCCTGGGGAACAAGGGGATCTGGGGCTGAGCCGGGCCTCTCGGG CCCACCCCGAGCTCTCCTGAGCAGCCTGGCAGGCAGGAAGGCGCTGGGCCCCGGGGCCTTTGCCGAGCCC AGCCTCACCCTCAGCGTCCCCCTCAATGCCCTGGGTGCCTGCCAGGCTGTGGACACAGGCCCTGGCCAGT TCTATAAATAACCTTGCCGGGCCCTGCTGGGAATTGGTGCCACCACCACATAGCCCAGAGAGAACGGAAA CACAGGGCTTCTCAGCGAGCAGACCAGGCCTGCGGTGACCAGTGGAAGTGGGGGACGCTTTCAGGGCTGG GCAGCCCGACAGGGCACCGGGCACAGCCAGGGGCCGGAACCAGTTGCTCACTGGCTCCGCTTCTGGGGGA CTGTGTCCCTCTGTGCCCCGTCCCCATCACACCTTGCTTTCCCTTCATCCTGCTCTCCTAGCCCCTCCCC AGACTGGCGGCCCCTTGTCCAGGCCCAGCCCCAGCACAGCCTGCAGCCCTGGCAGAGCTCAGGCCTTGGC CTTCTGAGGTTGCCCTGAGGGCAGTGAGCAATGAGCCCTGGGACTGGTGCACTGGGAGGGAAAGGTGAGC CAAGGCTTCCTGCAAGAGGCAGCCCTGAGCTGGGGGTGGGGAAGGCTGGGTCGTGGGATACCCCTGACAC CCCAAGTTTTTTTTTTGAGATGGAGTCTTGCTCTGTCACCCAGGCTGGAGTGCAGTGGTGAGATCTCGAC TCTCTGCAACCTCCGCCTCCCAGGTTCAAGCGATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGATTACA GGCGCCCATCACCACGCCCGGCTAATTTTTGTATTTTTAGTAGAGACAAGGTTTCACCATGTTGGCCAGG CTGGTTTCGAACTCCTGACCTCAGGTGATCCACCTCGGCCTCCCATAGTGTCGGGATTACAGGCGTGAGT CACCGCGCCTGGCCCCCCAGCTGTTTTTTATGCTCCATGCTTGGGCTTCCTGTTAAGAATTAAAAAAGAA AAAAAAAACTATGGAGATGGAATTTACATACTGTACAACTCATTCGTTCACAGTGTACAATTCAGTGGCA TTAAGTACATTCACACGGCTGTGCAACCACTACTTCTAATTCCAGAACGTTCGGTCACCCCAAAAGCAAG CCCCATTCCCATTGTGTCACTCTCCATCCCCTCCACCAGCTCCTGGCCACTCTGAATCCACTTCCTGGCT CTGGATTGGCTTGTCCTGGATATTGCATAGAAATGGGATCCTGTCGGCCGGGCGCGGTGACTCACGAGAG CAAGAGATCCAGACCATCCTGGCCAACATGGTGAAACCCCATCTCTACTAAAAATACAAAAATTAGCTGG GCGTGGTTGCGGGCACCTGTAGTCCCAGCGACTCAGGGGCTGAGTCAGGAGAAATCGCTTGAACCCGGGA GGCAGAGGTTGCAGTGAGCTGAGATCATGCCATTGCACTCTGGCCTGGCGACAGAGTGAGACTCCGTCTC CAAAAAAAAAAAAACAAGAAATGGGATCCTGTCATCCCAGCGTTTTCCGAGGCCGAGGTGGGCAGATGAC TTGAGCCTAGTAGTTCAAACGAGACCAGCCTGGGCAGCACGGTGAAACTGTCTCTACTAAAATACAAAAA TTAGCTGGGCATGGTAGCACACGTCTGTAGTCCCAGCTACTTGCGGGGCTGAGATGGGAGGATCGCTTGA GCCTGGGAGGTGCACTCCAGCCTGGGCGACAGGGAAACCCTGTCTCAAAAAAAAAAAAAAAAGTGCATCA CACACTGTGTGTCCTTTAGTGTCTCACTGTGACATCCTCAAGGTGCAGCTAGGCTGTGGCTCGAGTCAGA GCCTCACTGGTTTTTGTGGCTGAGTCTTGTTGAGTGCGTGGATGGGCTGTGCTGATCCTCGTCTGTGGAA GGGCCCCTGGGTGGTTCCACATCTCGGCTGCTGTGCGTCCTGCTGCTGTGAGCATCTCGTGCTCCGTTTC TGCGTGGCGTGTACTGTTCCTCAGGGTGTGTACCTGGGAGTGGAGCTGCTGGCTCACAGGGTAACAGACC TTTGGAGAAGCTGCAGACGCTTCCACGCCCACCCACTGGGTGTGAGGACCTTGCTCCTCGTCATTTTTGT TTTTGTTTAATTTTTTCTTTTATGAGACAGGGTCTTATTCTGTTGTCCAGGCTGGAGTGCAGTAGCACGA TCACAGGTAACTACAGGCTCAAGTGATCCTCCCACCTGAGCCTCCCGAGTAGCTAGGACTTGAGGCACGT ACCTCCACACCTGGCTAATTTTTGTATTTTTAGTAGAGACAGGGTTTCGCCGTGTTGCTCAGGCTGGTCT CGAACTCCTGAGCTCAGGTGATCCACCCGCCTCGGCCTCCTATAGTGCTGGGAGAAATGAAGTGTCTGCG ACAGGGCGGCAGCTGCAGAGGGGGCTGTGCTCTCTGGCCTGTTGTGCCCCACCCTTGTGACAGGCAGGTG GGCGTGGCCAACTGGGCGGCAGCTGCAGAGGGGGCAGTGACAGGCGGGTGGGTGTGGCAGGACCCCACAA TGTCTCTTTCTGTGGCGTCTCCTTCTTCGCCTGCCCCTTCCTATGGGCCATCCTTCCAGCTCACCTGCGG CCCACCCTCCAAGGAGTGGGACCCTCGGAGTTGGGAGCCCTTGGCTGCGTGGGACTGTACTGTGTGACGG AGCCATCACCAGGGCTCCAACTCACCCTGGCTCCTGCCACAGTCTGGGCTCCATCTGTGCTACCATTGCA GTAGTCTGGTTTCTAGGAAGCAAAACTGTTACTGAGTTACAAAGCTCAATTAAGAGTGTCCTTTGGGAGG CCGAGGCGGGCGGATCACAAGGTCAGGAGATCGAGACCATCCTGGCCAACATGGTGAAACCCTGTCTGTA CTAAAATACAAAAAAATTAGCCGGCTGTGGTGACACGTGCCTGTAGTCCCAGCTACTCGGGAGGCTGAGG CAGGGAAATCACTTGAACCTGGGAGGCAGAGGTTGCAGTGAGCTGAGATCGGGCCACCGTGCTCCAGCCT AGGGACAGAGCAAGACTCTGTCTCAGAAAAAAAAAAAAGTGTCCTAACTGTGTCCTCCAAAGCCCTCGCC GGCCGATGACAGACTAGAGGGCGCTGTGCTCCCACCCCCTACCGCCCTGAGCCTGGACGCGTGGCCCCTG CAGGGCCCTTTCCCACAGCACTGTGAACTCACAGCTTCTCTCTAGGGAAGGGAGGAGGTACGCCACTTCC ACAGGGAGATGGGGAGGCCGACTCCAGGGATCCAGGCCATCATCCTGACGTTGGGTCGGCTGATACACCC CTGTCCTCTCTGTCCCAGGGAAATTCAACTACTGAGGAGGTTACGGCACAAAAATGTCATCCAGCTGGTG GATGTGTTATACAACGAAGAGAAGCAGAAAATATATCCTTTCCGGTGTTGGGACCGCGGGGCCTCCGTGG GAGGGGCTGGGGCCCTGGGTCCGCCTGCCTCGAGGCCTGCTCCTCTTCCCGTCTCCTTGAAGGAGACTGG CACACGAGGGCCGTGGCCTTCCCTGGTTCCCCGGAAGTCAGCCATTGTGGCAATGGCTGCGCAGCTTGCT GAAAGGGGCCCTGAGCCCTGGCCCCTGTGTCTTGGGCCCGTGGGGTGTCAAGTCCCTTTTTTCTCAGAGT CTCCTCCCAGGCTAACCAGGGGTGTAGCCACGGTCTGCCTGAGACAGGCCACGCGGGCTGACCGTTGTGG GCCATTTTGGTCGTGGCTGGGCGTGTCCTCGTGTCATCTGTGGACACCCCCATGGGTCTTACGGGCACAG CCTCCCTACGGGGACTTTGCTTCCTAAGGCCCTGTGCCCAGAGCAAGAGCCAGAAGTGGTCCTGAGGCTG GGGCTGTGTTCCCTGAGCCACGCGGTCAGGGGCCCTGGGACCGTCCTGCATGGGCCCGAGCCTGCTTGGG GGGGCGTCCAGGAGGCACCATCCCCCGCCCATGGGCAGGGTGGGGGACGTGAGCCCCGCAGGAACGCTGC CCCAAGAGTCAGCCCTGTCCTCCCCTTCCCCGTAGGCTCCTTCCTCCTGGGACGCTGGGGCCCCTGGGCC TTTTCAGAGGGGTGGCTGAGGGCAGGGTGGGCCCTGGTCCCGAGGAGGGGCAAGGTGGGTGCAGAGGGTC CCTCCAGAGCCCCTTTTCTGGCCCCCGTGCTCCCTGGGCCTGTGAGTGGGGCCGCCCCCTGAGCTGTGTG TCCTTAGCGCCCCACGTATATGGTGATGGAGTACTGCGTGTGTGGCATGCAGGAAATGCTGGACAGCGTG CCGGAGAAGCGTTTCCCAGTGTGCCAGGCCCACGGGTGCGTGCGCGGGGCAGGGGCCAGGGTGGGGCGGG GGCCGGGGGCCAGGCAGGGCAGGCTCCTTTCCGTGAGGCCACACTGCTTGTCCTGATATTCATTGACATG AAGGCCCAAGTTTTTTTGTTTTTTTGTTTTTTTGTGTTTTTTTTCGAGATGGAGTCTCACTCTGTCGCCC AGGCTGGAGTGCAATGGTGCGATCTCGGCTCACTGCAAGCTCCGCCTCCGAGGTTCACGCCATTCTTCTG CCTCAGCTTCCCGAGTAGCTGGGATTACAGGCGCCCGCCACCACGCCCGGCTAATTTTTTGTATTTTTAG TAGAGACGGGGTTTCACCGTGTTAGCCAGGATGGTCTCAAACTCCTGACCTCGTGATCCGCCTGCCTCAG CCTCCCAAAGTGCTGGGATTACAGGCATGAGCTACCACGCCCGGCCTTGTAAAGGCCCAAGTTTTTAAAA ACAGTTTTGGGGTCCCCCATGTGTGGCATCCACAGGCAGGGCTGCTGCCAACCTCCCGCCTCCATCTTTG CTGGGCCTGCTGCCTGAGGCCAGTGGCCTGCTTCCAGCCCATCGCTGGCAGCCGCCTGCCCTGACCAGAT CTCCTGGATGCAGGTCTGTGGCCTCAGAGTCAGGGCCCCTTGCTGCTGCAGGACCACAGGGGCAGGGAGG GGCCTGCTGTTCCAGCAAGACTTTGGGGTGCAGCCGGCCTGTGGCCCACAGGAAAATGAGACCTGTGGAC ATCCGGGGCCCTGCCAGACGTGGCTCGGCCGGACGAGGGTGGCCACTGCAGGCGCAGGTGTGGCTCCCTG CTGGACCTAGCCTTTCCTCTGTCCTGTGTGCCTGGACTTCTGTGACTTCCCAGCTGGGCCTGTGGTGTTT GGGAGGCTCCCAGGCAGCTGCAAAGGGGACCCCTGTGAGGGGCAGGGAGGCCTCGGCCCCAGGACGGGTG TGTGCTGCCCGCAGGTACTTCTGTCAGCTGATTGACGGCCTGGAGTACCTGCATAGCCAGGGCATTGTGC ACAAGGACATCAAGCCGGGGAACCTGCTGCTCACCACCGGTGGCACCCTCAAAATCTCCGACCTGGGCGT GGCCGAGGTAGGCACGTGCTAGGGGGGGCCCTGGGGCGCCCCCTCCCGGGCACTCCCTGAGGGCTGCACG GCACCGCCACAGGCACTGCACCCGTTCGCGGCGGACGACACCTGCCGGACCAGCCAGGGCTCCCCGGCTT TCCAGCCGCCCGAGATTGCCAACGGCCTGGACACCTTCTCCGGCTTCAAGGTGGACATCTGGTCGGCTGG GGTCACCCTGTAAGTGCCCCGCCCCCCCGGGCACTCACCACACGCACACTCCGAGGGGCCTCTGCGTCTT GGGCAGCTGCCGGCCTGTGGGCGCAGGGCGTGGCCACCGGCCCAGACCCTCTCTGGCCACAGCCGCTAGG GGGTGCTTACTTTATGGAAATGTAACTCATACGGCAGATGGTGGTTCACCCGTGTGAAGTGCAGCCTGGC CCGTCAGGGATCTTCACAGAGTGGCACGGCCGACCCTCCTCCCAGAGCCCCACAGGGAAGCTGGGCGGGT GACAGCAGCTCCAGGCCCCTTCCCCGGGTGGGTCCAGAGGACACTCCCCTCCTACCCCGTAGCCTCCACT AGTGGAAGGTGGTGAAGACAGAGGTGTCCTTGAGTCCACAGGGCCTCTGGTCCAGCAGCCACGGGACGCC TCTGTCCCTGGGGTAGAGCTGGGGCTCCTAGGGCGTCAACCACCTTGACTGACCACGCCTTTCTTCCCTC CCCTCGAAATGAAGCTACAACATCACCACGGGTCTGTACCCCTTCGAAGGGGACAACATCTACAAGTTGT TTGAGAACATCGGGAAGGGGAGCTACGCCATCCCGGGCGACTGTGGCCCCCCGCTCTCTGACCTGCTGAA AGGTGGGAGCCTCATCCCTCTGCCCGCAGCCCCAGGGAGGCGGGGCTTTTGTGCAGAAATGTAGGGTTGG GGGTGTCAGGTGGGGGGCTATTGGCCCCGAGACCCCAGCAGGCATTGAGAGGACTGAGTGGAGAGGCCGA CCTCCCCGCAGGGCCTGGTTTGCCAGGTCCCTCAGCTCCACCCTGCTTCTGGGCCCTGTTCACCCTCCGA ACTCCCACCCCAGAGGGCAGTGCTGCCCTGCGCCTCCCCCAGCCCCACCCTCGGGGGCTCCCTGGCTTGC AGGGTCTGTCAGGGTTGTCCTGCTGCACTTCCTACGCATGGCAGCAGGTGGCACTGGCCGTCCGTCCATC TGCCCAGTGGCCTTGGGAGAACGGAACCGCCCTGGCCGTCCAGCCCAGCCCTGTCTCCCTGCCAGCCGCG CACAGGCTGTCCCCGGCATGTCCCAGGAGTGGAGTGGCCTCTGTCAGGGAGACCGCCTGTGCGCGGGGTC CCCCTTAGGAGCGTCCAGGTATCACCCAGGGCCTGACAACAGAGGCTGGGCAGGCGGGGACGGTTGGTGG GGTCTCAGGCCTGTGCCCAGCTGACAGGCTCCTCGCCGGCTTCTCCTCAGGGATGCTTGAGTACGAACCG GCCAAGAGGTTCTCCATCCGGCAGATCCGGCAGCACAGGTGAGCGGCCCCTGGGGGCAGTGGGGCCGAGG CTGCAGGGAGGCCGGCCATGTGGGCAGCTGGTTGAGCGGGCGCTAGAGCAGGGCGTGGTGGGGGTGCCAG GCTGGGCTGGGGCCAGACCCCGTGCAGCGCCCGCAGTTCTCGGGGCCCGAGTGGGGTCTCTGGGCAGTGT CCTGTTACCGGCCAGACCCAGGCGCCTTGTCCGAACTGGGGTCTGAGTGAGGACATGCGTCCGTCCCTGC CCTAGGCATGGAGATGCGCCAGGAAGGGCACAGCTGGTCCCAAACACTGGCGAGAGCCTCTCTTTTTCCC CTCCTCCTGGGGCTCCCAGCAGCAGGGTGTGGCTGGGATCCAGCCCAGGGCCCCCAGCTCCATGACAGGG AAGACAGAGCAGCGGACGGGGTCAGCAGGCCCCACAGTGCCGCCTCCCTCACTTCGTGGGCTCTGCTCCT CTGCACCAGCCCCTGGAGGCCCTTGAGCCGTCTGCTGGAGCCCCTCCGAGCCCCGAGGCCACCCACTGAG ACCGGCTCTGGGAGTGGGAGTGTCCGGACCCCTGAGGCGCTGGTGCTGATTGTGCCTTGGGGGTCTCTGC ACAGCTCGGGTCATCTGGGCGCCTGGCGGGGACTGGGGCTGCCCCCCGATAGCCTCCTGGGCTGGGATGT GCTCAGGGCCCCCCAGACCCCCTTCTGGCCTTTGCTGGCTTTGCAGCCAGCATCCATCTGGTGGGTGCTG GCTTCTGAGTGCCACCTGGGACACAGGCCTCAGGGTGGAGGGGACATCTGTCAGGCTTGGAGTCAGGTCA GCCTGCCTGCTCCTAGAGGACATGGCTGAGCTTCTGTGGTCACAGCCACCCCTTGCACGGCCTGGTCCCA GCTCCTGAGTGTGTGGCAGGTACCCTGGGCCCAGAGGAGCTGGGTCGGAAAACTGGACCGCCCTGGTGCC AGCCTGACAGGCGCCACTGCTTCTGGGCGTTTGCAGCTGGTTCCGGAAGAAACATCCTCCGGCTGAAGCA CCAGTGCCCATCCCACCGAGCCCAGACACCAAGGACCGGTGGCGCAGCATGACTGTGGTGCCGTACTTGG AGGACCTGCACGGCGCGGACGAGGACGAGGACCTCTTCGACATCGAGGATGACATCATCTACACTCAGGA CTTCACGGTGCCCGGTGAGTCTGGCGGGGGCCCCTGCCCGGCTCTGCTGACTCGGCCAGGATGTCCCACG GGAGCAGGGTGCCTGCCTGTCTGCAACAAGGACAGCTTCTGCCCTCTGGTGGCCAATCCCACGTCCCCAA AGCCTCCAGCCCACCTGCAGGCTGCCTCCGCCCTGCGGGCCGCTGGGACATGGCTGAAAGGTGTGGGGTC AGCGGGGGCACCAGCCCAGGCCTGTCTGGCCAGGAGGGTTCCTCAGGCGTCTCTCCGGGTGCTGCCCAGC CAGGCACCACCCACCGGCCTTGGCCTGAGTCCCAGCAGGAGCAGGCGGGGGAGCCCCAGGGTCGGGGGAG GGTAGGTGAGAGTCAGGGTGCAGGGTGGCCCCTCAGACAGCTGGCATGAGAGAGGGTCCAGTGGCCCTCC CTCCCGTCGTCCCTGAGGCCTGCCCGCTGGCCCTGATGCCGGCCGCCCTTCTTCCCTAGGTGGCGAGGAG GCGTCTGAGGCAGGGCTTAGAGCGGAGCGCGGCTTGCAGAAGAGCGAGGGCTCAGACCTTTCAGGAGAGG AAGCCTCTCGGCCGGCGCCGCAGTAGTGCCTGAGGAGGAGCTCAGGGCCTTAGCGTAGGGGCGGCCCACA TTGGCAGCCAGCCCCTCCCCGCCATGCTCCCGGCTTGGCTGTGTTCGGCCCAGGGCTGGGCCGTGTCATA AAGAGTTTTGCAGTGTATCTGCAGGGTGGATGCTTGCTGCGCTCGGGCTGGAGCCTGAGGGGGCTTTCTG CTTTACTGTTTCAGCGGGAAGTGGTGGGCAGGGGCCGGCCTGAGAAGGGGGGTACGCCAGGCAGGTTGGG ATGTGAGGACCCAGTGCACAGGGTCCACCCCCGGGCCCGAGGGTCCCAGAATAGTGGGGGCCCTGCAGAG AGCCCCCCATTAGGTCCCTCAGCACTCCTGGGCCCCTCATCAAACCCCTAGGCTCAGCTCAGTAGCTGGT CCCCAGGAGAGTACAGTGTGGGGGCCCCCGAGAGCACAGTGTATGGGGGTCCCCGGGGGGTACAGTGTCT GGGGGCCCCCCAGGAGGATGCAGCATGTGGGGGCCCCCCAGGAGGGTACAGCGTGTGTGGGGCCCCCAGG ATCACAGGGTCTCAGCTCCTGGGCTCTTGGATTTGCAGCACCACGACCATCGCGTCTGGTCTGTTGGAAC GGGAGGTGCTGCTGGGTACCCTGGTCACTAGGGTGTGCTGGGAGGTGGGGGCCCCTCATGGTGCCCATCC TTGGGGCCTGGCTGCAATTTGACCCCAGGCCCAGGGTCTTCTGCCTTTCAGAGCCCTGGTGCCCTGAGAC GGGCAGCCAGGCAAATCCCAGGCAGGAGGGCCAGTTAGGGCAGGGCCAGCCCAGGCAGGTTGCGAGAGTC CCTACTGGGACGTGGACCACACGCTGACCCCCACGGCCGCCCCTGCAGGCCAGGATCCCTGAGCCAGGAC CCGGCACTGGCTTCCCTCCTGGGGACCCTCAGGCCTGTGTGAGACCTGGGCTGCCCTGGGGTGAGGTGCC TGGGAGGAGAGCAGGGGCTGGGCCACCTTTTTCATGACCCTGCTAAGCCCACTGTGGGTGGTGAGGAGGA GTACCCAGCAGGGGGAAGGGCCGCCAGACCACTCGGCATGGCTGAGGCCTCAGTACTCAGTACTGGGTAC TCAGGTGGACGCCCCTCCCACTGCTCAGATGCTGGGGACAGGCTCAACTTCAGGCTTCAGCGTGAGCCCC GTCCCTGACCTGCAGAGCCCCCTTGCGTTGGGGCAGGACAGCCCGGCGCCCTCGGGTCAGGCCATCCTCT GCGCTCTGCCGGGGCTGCTGCATCGGCCTCTGCGTGCCTCCACTTTGGCCTCACGTGTCCCTACCCAGGA TGCGGGTCCTGCTGCCAACACCCAGATCCCAGGGAAGGGGCTTGGGCTAGATCCTGGGCACCAGTGCAGA CAGGAGTGTGGGGTGGGGCAAGGGCCCAGTGGCGGCTGTGCCCGCTGATGCAGAGCTGGGGCACCTTGTC CACAGGGTCTGCCCCACCAGAGACGGGCTGGGCCCAAGCTCAGACCTATGGGTGCAATTGGTGCCTCCTC ACCAAGGTCTTTTTTATCTTTTTTTTTTTTTGGAGACAGAGTCTTGCTCTGTCGCCCAGGCTGGAGTGCT GTGGTGCGATCTCGGCTCACTGCAACCTCCACCTCCCGGATTCAAGCAATTCTGCCTCAGCCTCCTGAGT AGCTGGGATTACAAGTGCGCGCCAGCATGCCCGGCTAATTTTTGTATGTTTAGTAGAGACGGGGGTTTCA CCATGTTGGTCAGGCTGGTCTCAAACTCCTAACCTCATGATCTGCCCACCTCGGCCTCCCAAAGTGCTGG GATTACAAGCGTGAGCCACCGCGACCGGCCCAAGGTGCTTTTTTAAAGCTAGTGACTTCCTGTGCACATG GGGTGGGTGTGTGGCAAGTTCTGGAAGCTGCTGAGTCAGCCACTGGTCCATTCTCGGAGCTGGGGCTCTG CACTGGGCACATGAGCTCTGGGGCAGCCCGGGGCGGCCTCCCACTGACTTCGCCCGGGAGGGGCCTCGGG GATGGCTCGGCAGCCAGTGTGTTCGCGGAGTCCTCGCCAACCACCACGGCTCCTCGCAGGGACAGTACGT GGGCAGCTTCCTGCACTTTCCCCTGCCATTGTGAGAACAGTGTCCACCTGGGCAGGGTGGGCAGCCCCAG GCCTGTGGGTTTCACCAGGGTGCTGGTGATGGTTGGTGGCTAGCAGGGACTGGGGGCAGCTGGGGGCCCT GGCAGGCTGAGCTCTGCTCCCCGCGTGGTTCTGTGCTGGCATTTCGCGTGCCTGGCCTGAGCCTGGCCCG AGCCTGGCCCTCCTGTGTCCTCACAGATGAGCATGTGGCGGCTCCTGGGCCTCTAGAACCAACCATGGGC CAGGGTGCCCCAGGGGAGCACGGGAGGGTCCTGCCTTGTCAGCTTGCCTCCTACTCGTGAGGTTCCTGCA GTCAGTACCTGGGTGGGGTCCCACCTGCGGCCATGGCAGGTGCAACAGACGTGGTGGAGGGGACACTCCT GCCCAGGCCATCTGCGGGAGGCTCAGCCCCGGGGGGTGCCTCCCAGAGCTGCTGGGGGGCAGCATTTCAG GCTGGATACACCTGGGCCTGACCCGGGGGCGGGCATGGCCTGGGCAGCAGCTGTAAGTGCGTCCCCGTGG TGGGGGCCAGCCAGGTCCCTGTGGCTCTGGGGTTGCGCCCCTCAGCTCAGGCCACACTTGCCGTCTCCCT CCCAGGACAGGTCCCAGAAGAGGAGGCCAGTCACAATGGACAGCGCCGGGGCCTCCCCAAGGCCGTGTGT ATGAACGGCACAGAGGCGGCGCAGCTGAGCACCAAATCCAGGGCGGAGGGCCGGGCCCCCAACCCTGCCC GCAAGGCCTGCTCCGCCAGCAGCAAGATCCGCCGGCTGTCGGCCTGCAAGCAGCAGTGAGGCTGGCCGCC TGCAGGTGGGGCGCGGCGGGGCCCGGGTGGGGCATGTGGGGACAACGCCTGGATGCCACAGCCAGCCGTG AGCATAGCCCGCGCTAGTCAGTCATGGTGACCGTCACGTGGCTGCGCGTGGTTGCCATGTGGCCTTTGGG TGGCTTGGCCACGTAGCGATCCCCGTGGAGGGTGCCGTCTCGGGGCCTGGTGTCTGGCCAGCGTGCTGGT CATGGAGGCCTACGTGTGGCGGGGCTCTGGGGGGGCGTGCCGTCCTCACAGCCACCTCTCAGAGTGGGTG CATTCCGAGGACCCTGCCCTGGGCCTGGCGCCCCCTCCCCATGCCCGCGCCGCTTCCAGGAAAGGCTTAT GCTGGGCTCAGCCCAGAGGCTTTTGAGCACCAGTGGGTGGTGGGTGGTGGGGAGGGGCCGCGGCCTCCAT GGCTCTGCCGGGGTGCCGCAGGCTCTGAGCCAGCTGCCAAGTATGGCTGAGGCTGAGTCGTGCCGGACGC TGCCCTGTCTCTCCCTGTGTGCCTGCCTCCTCTCCCAGCCCCAGCCCCAGCCCCGGGTGGGAGACGGAGT CCCAGAGGTGTCAGAGACCCTTAAGTCACCTGCCGAGGATGCGGGGTGGATGGGGGCCCGAGGCTGAAGC CCCTGCCTTGCCACAGCCCCTCTCCCAGGTTTTGGGGGCCACCGCCTGAGTTACATGTCTGTCCCCCAAA TGGGTGCCCACAGCCCATCCACCAGCGTCAGAGCCCGCCAGGCCCCACTGCAAAAGGCCACACAATGTAC CCCGGGAGTGACTCAAGGGTGGCCTTCCCTGGCCTCCCCTGCTGCCCCCCAGGAGTCCGGTAGCCCCATG ACTGTACCTCAGCTTCTCCATCCTCCCAGGGGCCCGCGGGAGGCGGAGAACCGGTGCCCAGGCTGACCTC TTCCGTCTTCCTTCCACCCTGCAGCCCGTGTCCAGGAGCCCCGCCAGGTGCCCGCGCCAGGCCCTCAGTC TTCCTGCCGGTTCCGCCCGCCCTCCCGGAGAGGTGGCCGCCATGCTTCTGTGCCGACCACGCCCCAGGAC CTCCGGAGCGCCCTGCAGGGCCGGGCAGGGGGACAGCAGGGACCGGGCGCAGCCCTCCCCCCTCGGCCGC CCGGCAGTGCACGCGGCTTGTTGACTTCGCAGCCCCGGGCGGAGCCTTCCCGGGCGGGCGTGGGAGGAGG GAGGCGGCCTCCATGCACTTTATGTGGAGACTACTGGCCCCGCCCGTGGCCTCGTGCTCCGCAGGGCGCC CAGCGCCGTCCGGCGGCCCCGCCGCAGACCAGCTGGCGGGTGTGGAGACCAGGCTCCTGACCCCGCCATG CATGCAGCGCCACCTGGAAGCCGCGCGGCCGCTTTGGTTTTTTGTTTGGTTGGTTCCATTTTCTTTTTTT CTTTTTTTTTTTAAGAAAAAATAAAAGGTGGATTTGAGCTGTGGCTGTGAGGGGTGTTTGGGAGCTGCTG GGTGGCAGGGGGGCTGTGGGGTCGGGCTCACGTCGCGGCCGCCTTTGCGCTCTCGGGTCACCCTGCTTTG GCGGCCCGGCCGGAGGGCAGGACCCTCACCTCTCCCCCAAGGCCACTGCGCTCTTGGGACCCCAGAGAAA ACCCGGAGCAAGCAGGAGTGTGCGGTCAATATTTATATCATCCAGAAAAGAAAAACACGAGAAACGCCAT CGCGGGATGGTGCAGACGCGGCGGGGACTCGGAGGGTGCCGTGCGGGCGAGGCCGCCCAAATTTGGCAAT AAATAAAGCTTGGGAAGCTTGGACCTG Download Select all
Length	22637
OMIM ID	602216
HGNC ID	HGNC:11389
Unigene ID	Hs.515005
Ensembl ID	ENSG00000118046
PharmGKB ID	-

mRNA Information

mRNA ID	NM_000455.4
Exon	join(1..1405,12619..12702,13526..13615,14575..14707, 14783..14919,15415..15542,16151..16208,17187..17374, 20656..20865,21795..22637)
mRNA Sequence	>6794 GCGTGTCGGGCGCGGAAGGGGGAGGCGGCCCGGGGCGCCCGCGAGTGAGGCGCGGGGCGGCGAA GGGAGCGCGGGTGGCGGCACTTGCTGCCGCGGCCTTGGATGGGCTGGGCCCCCCTCGCCGCTCC GCCTCCTCCACACGCGCGGCGGCCGCGGCGAGGGGGACGCGCCGCCCGGGGCCCGGCACCTTCG GGAACCCCCCGGCCCGGAGCCTGCGGCCTGCGCCGCCTCGGCCGCCGGGAGCCCCGTGGAGCCC CCGCCGCCGCGCCGCCCCGCGGACCGGACGCTGAGGGCACTCGGGGCGGGGCGCGCGCTCGGGC AGACGTTTGCGGGGAGGGGGGCGCCTGCCGGGCCCCGGCGACCACCTTGGGGGTCGCGGGCCGG CTCGGGGGGCGCCCAGTGCGGGCCCTCGCGGGCGCCGGGCAGCGACCAGCCCTGAGCGGAGCTG TTGGCCGCGGCGGGAGGCCTCCCGGACGCCCCCAGCCCCCCGAACGCTCGCCCGGGCCGGCGGG AGTCGGCGCCCCCCGGGAGGTCCGCTCGGTCGTCCGCGGCGGAGCGTTTGCTCCTGGGACAGGC GGTGGGACCGGGGCGTCGCCGGAGACGCCCCCAGCGAAGTTGGGCTCTCCAGGTGTGGGGGTCC CGGGGGGTAGCGACGTCGCGGACCCGGCCTGTGGGATGGGCGGCCCGGAGAAGACTGCGCTCGG CCGTGTTCATACTTGTCCGTGGGCCTGAGGTCCCCGGAGGATGACCTAGCACTGAAAAGCCCCG GCCGGCCTCCCCAGGGTCCCCGAGGACGAAGTTGACCCTGACCGGGCCGTCTCCCAGTTCTGAG GCCCGGGTCCCACTGGAACTCGCGTCTGAGCCGCCGTCCCGGACCCCCGGTGCCCGCCGGTCCG CAGACCCTGCACCGGGCTTGGACTCGCAGCCGGGACTGACGTGTAGAACAATCGTTTCTGTTGG AAGAAGGGTTTTTCCCTTCCTTTTGGGGTTTTTGTTGCCTTTTTTTTTTCTTTTTTCTTTGTAA AATTTTGGAGAAGGGAAGTCGGAACACAAGGAAGGACCGCTCACCCGCGGACTCAGGGCTGGCG GCGGGACTCCAGGACCCTGGGTCCAGCATGGAGGTGGTGGACCCGCAGCAGCTGGGCATGTTCA CGGAGGGCGAGCTGATGTCGGTGGGTATGGACACGTTCATCCACCGCATCGACTCCACCGAGGT CATCTACCAGCCGCGCCGCAAGCGGGCCAAGCTCATCGGCAAGTACCTGATGGGGGACCTGCTG GGGGAAGGCTCTTACGGCAAGGTGAAGGAGGTGCTGGACTCGGAGACGCTGTGCAGGAGGGCCG TCAAGATCCTCAAGAAGAAGAAGTTGCGAAGGATCCCCAACGGGGAGGCCAACGTGAAGAAGGA AATTCAACTACTGAGGAGGTTACGGCACAAAAATGTCATCCAGCTGGTGGATGTGTTATACAAC GAAGAGAAGCAGAAAATGTATATGGTGATGGAGTACTGCGTGTGTGGCATGCAGGAAATGCTGG ACAGCGTGCCGGAGAAGCGTTTCCCAGTGTGCCAGGCCCACGGGTACTTCTGTCAGCTGATTGA CGGCCTGGAGTACCTGCATAGCCAGGGCATTGTGCACAAGGACATCAAGCCGGGGAACCTGCTG CTCACCACCGGTGGCACCCTCAAAATCTCCGACCTGGGCGTGGCCGAGGCACTGCACCCGTTCG CGGCGGACGACACCTGCCGGACCAGCCAGGGCTCCCCGGCTTTCCAGCCGCCCGAGATTGCCAA CGGCCTGGACACCTTCTCCGGCTTCAAGGTGGACATCTGGTCGGCTGGGGTCACCCTCTACAAC ATCACCACGGGTCTGTACCCCTTCGAAGGGGACAACATCTACAAGTTGTTTGAGAACATCGGGA AGGGGAGCTACGCCATCCCGGGCGACTGTGGCCCCCCGCTCTCTGACCTGCTGAAAGGGATGCT TGAGTACGAACCGGCCAAGAGGTTCTCCATCCGGCAGATCCGGCAGCACAGCTGGTTCCGGAAG AAACATCCTCCGGCTGAAGCACCAGTGCCCATCCCACCGAGCCCAGACACCAAGGACCGGTGGC GCAGCATGACTGTGGTGCCGTACTTGGAGGACCTGCACGGCGCGGACGAGGACGAGGACCTCTT CGACATCGAGGATGACATCATCTACACTCAGGACTTCACGGTGCCCGGACAGGTCCCAGAAGAG GAGGCCAGTCACAATGGACAGCGCCGGGGCCTCCCCAAGGCCGTGTGTATGAACGGCACAGAGG CGGCGCAGCTGAGCACCAAATCCAGGGCGGAGGGCCGGGCCCCCAACCCTGCCCGCAAGGCCTG CTCCGCCAGCAGCAAGATCCGCCGGCTGTCGGCCTGCAAGCAGCAGTGAGGCTGGCCGCCTGCA GCCCGTGTCCAGGAGCCCCGCCAGGTGCCCGCGCCAGGCCCTCAGTCTTCCTGCCGGTTCCGCC CGCCCTCCCGGAGAGGTGGCCGCCATGCTTCTGTGCCGACCACGCCCCAGGACCTCCGGAGCGC CCTGCAGGGCCGGGCAGGGGGACAGCAGGGACCGGGCGCAGCCCTCCCCCCTCGGCCGCCCGGC AGTGCACGCGGCTTGTTGACTTCGCAGCCCCGGGCGGAGCCTTCCCGGGCGGGCGTGGGAGGAG GGAGGCGGCCTCCATGCACTTTATGTGGAGACTACTGGCCCCGCCCGTGGCCTCGTGCTCCGCA GGGCGCCCAGCGCCGTCCGGCGGCCCCGCCGCAGACCAGCTGGCGGGTGTGGAGACCAGGCTCC TGACCCCGCCATGCATGCAGCGCCACCTGGAAGCCGCGCGGCCGCTTTGGTTTTTTGTTTGGTT GGTTCCATTTTCTTTTTTTCTTTTTTTTTTTAAGAAAAAATAAAAGGTGGATTTGAGCTGTGGC TGTGAGGGGTGTTTGGGAGCTGCTGGGTGGCAGGGGGGCTGTGGGGTCGGGCTCACGTCGCGGC CGCCTTTGCGCTCTCGGGTCACCCTGCTTTGGCGGCCCGGCCGGAGGGCAGGACCCTCACCTCT CCCCCAAGGCCACTGCGCTCTTGGGACCCCAGAGAAAACCCGGAGCAAGCAGGAGTGTGCGGTC AATATTTATATCATCCAGAAAAGAAAAACACGAGAAACGCCATCGCGGGATGGTGCAGACGCGG CGGGGACTCGGAGGGTGCCGTGCGGGCGAGGCCGCCCAAATTTGGCAATAAATAAAGCTTGGGA AGCTTGGACCTGAAAAAAAAAA Download Select all
Length	3286

CDS Information

Location	join(1116..1405,12619..12702,13526..13615,14575..14707, 14783..14919,15415..15542,16151..16208,17187..17374, 20661..20865,21795..22284)
CDS Sequence	>lcl\|NM_000455.4_cds_NP_000446.1_1 [gene=STK11] [protein=serine/threonine-protein kinase STK11] [protein_id=NP_000446.1] [location=1116..2417] ATGGAGGTGGTGGACCCGCAGCAGCTGGGCATGTTCACGGAGGGCGAGCTGATGTCGGTGGGTATGGACA CGTTCATCCACCGCATCGACTCCACCGAGGTCATCTACCAGCCGCGCCGCAAGCGGGCCAAGCTCATCGG CAAGTACCTGATGGGGGACCTGCTGGGGGAAGGCTCTTACGGCAAGGTGAAGGAGGTGCTGGACTCGGAG ACGCTGTGCAGGAGGGCCGTCAAGATCCTCAAGAAGAAGAAGTTGCGAAGGATCCCCAACGGGGAGGCCA ACGTGAAGAAGGAAATTCAACTACTGAGGAGGTTACGGCACAAAAATGTCATCCAGCTGGTGGATGTGTT ATACAACGAAGAGAAGCAGAAAATGTATATGGTGATGGAGTACTGCGTGTGTGGCATGCAGGAAATGCTG GACAGCGTGCCGGAGAAGCGTTTCCCAGTGTGCCAGGCCCACGGGTACTTCTGTCAGCTGATTGACGGCC TGGAGTACCTGCATAGCCAGGGCATTGTGCACAAGGACATCAAGCCGGGGAACCTGCTGCTCACCACCGG TGGCACCCTCAAAATCTCCGACCTGGGCGTGGCCGAGGCACTGCACCCGTTCGCGGCGGACGACACCTGC CGGACCAGCCAGGGCTCCCCGGCTTTCCAGCCGCCCGAGATTGCCAACGGCCTGGACACCTTCTCCGGCT TCAAGGTGGACATCTGGTCGGCTGGGGTCACCCTCTACAACATCACCACGGGTCTGTACCCCTTCGAAGG GGACAACATCTACAAGTTGTTTGAGAACATCGGGAAGGGGAGCTACGCCATCCCGGGCGACTGTGGCCCC CCGCTCTCTGACCTGCTGAAAGGGATGCTTGAGTACGAACCGGCCAAGAGGTTCTCCATCCGGCAGATCC GGCAGCACAGCTGGTTCCGGAAGAAACATCCTCCGGCTGAAGCACCAGTGCCCATCCCACCGAGCCCAGA CACCAAGGACCGGTGGCGCAGCATGACTGTGGTGCCGTACTTGGAGGACCTGCACGGCGCGGACGAGGAC GAGGACCTCTTCGACATCGAGGATGACATCATCTACACTCAGGACTTCACGGTGCCCGGACAGGTCCCAG AAGAGGAGGCCAGTCACAATGGACAGCGCCGGGGCCTCCCCAAGGCCGTGTGTATGAACGGCACAGAGGC GGCGCAGCTGAGCACCAAATCCAGGGCGGAGGGCCGGGCCCCCAACCCTGCCCGCAAGGCCTGCTCCGCC AGCAGCAAGATCCGCCGGCTGTCGGCCTGCAAGCAGCAGTGA Download Select all
CCDS ID	-

Protein Information

Protein ID	NP_000446.1
Protein Name	Serine/threonine kinase 11
Molecular Wt. (Da)	48505
Protein Sequence	>6794 MEVVDPQQLGMFTEGELMSVGMDTFIHRIDSTEVIYQPRRKRAKLIGKYLMGDLLGEGSYGKVK EVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRLRHKNVIQLVDVLYNEEKQKMYMV MEYCVCGMQEMLDSVPEKRFPVCQAHGYFCQLIDGLEYLHSQGIVHKDIKPGNLLLTTGGTLKI SDLGVAEALHPFAADDTCRTSQGSPAFQPPEIANGLDTFSGFKVDIWSAGVTLYNITTGLYPFE GDNIYKLFENIGKGSYAIPGDCGPPLSDLLKGMLEYEPAKRFSIRQIRQHSWFRKKHPPAEAPV PIPPSPDTKDRWRSMTVVPYLEDLHGADEDEDLFDIEDDIIYTQDFTVPGQVPEEEASHNGQRR GLPKAVCMNGTEAAQLSTKSRAEGRAPNPARKACSASSKIRRLSACKQQ Download Select all
Length	433
Uniprot ID	Q92466
Ensembl Protein ID	ENSP00000256996

Post-translational Modification Information (Source : HPRD)

Residue	Type	site
S	Phosphorylation	31
S	Phosphorylation	325
T	Phosphorylation	336
C	Prenylation	430
S	Phosphorylation	428
S	Phosphorylation	428
T	Phosphorylation	189
T	Phosphorylation	363
S	Phosphorylation	428
S	Phosphorylation	428
T	Phosphorylation	32

Enzyme Information

EC	2.7.11.1
Name	non-specific serine/threonine protein kinase A-kinase AP50 kinase ATP-protein transphosphorylase calcium-dependent protein kinase C calcium/phospholipid-dependent protein kinase cAMP-dependent protein kinase cAMP-dependent protein kinase A casein kinase casein kinase (phosphorylating) casein kinase 2 casein kinase I casein kinase II cGMP-dependent protein kinase CK-2 CKI CKII cyclic AMP-dependent protein kinase cyclic AMP-dependent protein kinase A cyclic monophosphate-dependent protein kinase cyclic nucleotide-dependent protein kinase cyclin-dependent kinase cytidine 3',5'-cyclic monophosphate-responsive protein kinase dsk1 glycogen synthase a kinase glycogen synthase kinase HIPK2 Hpr kinase hydroxyalkyl-protein kinase hydroxyalkyl-protein kinase M phase-specific cdc2 kinase mitogen-activated S6 kinase p82 kinase phosphorylase b kinase kinase PKA protein glutamyl kinase protein kinase (phosphorylating) protein kinase A protein kinase CK2 protein kinase p58 protein phosphokinase protein serine kinase protein serine-threonine kinase protein-aspartyl kinase protein-cysteine kinase protein-serine kinase Prp4 protein kinase Raf kinase Raf-1 ribosomal protein S6 kinase II ribosomal S6 protein kinase serine kinase serine protein kinase serine-specific protein kinase serine(threonine) protein kinase serine/threonine protein kinase STK32 T-antigen kinase threonine-specific protein kinase twitchin kinase type-2 casein kinase betaIIPKC epsilon PKC Wee 1-like kinase Wee-kinase WEE1Hu
Class	Transferases; Transferring phosphorus-containing groups; Protein-serine/threonine kinases
Sysname	ATP:protein phosphotransferase (non-specific)
Substrate	ATP [CPD:C00002]; protein
Product	ADP [CPD:C00008]; phosphoprotein
Reaction (IUBMB)

PPi Information

(Click to view network : Source STRING) View

Interactant Gene ID (Source: HPRD)	Gene Symbol	HPRD ID	Ref Seq ID	Technique	References
2011	MARK2	2753	NP_001034558.2	in vitro	14976552
4139	MARK1	7353	NP_061120.3	in vitro;in vivo	1 497 655 214 517 240
5563	PRKAA2	2735	NP_006243.2	in vitro	10642499
7157	TP53	1859	NP_000537.3	in vivo	11430832
25843	MOBKL3	10165	NP_056202.2	yeast 2-hybrid	16169070
54861	SNRK	18082	NP_060189.3	in vitro;in vivo	15733851
92335	STRADA	14332	NP_001003787.1	in vitro;in vivo;yeast 2-hybrid	12805220

Pathway Information

Pathway Name	Pathway ID
Adipocytokine signaling pathway	hsa04920
AMPK signaling pathway	hsa04152
FoxO signaling pathway	hsa04068
Longevity regulating pathway - mammal	hsa04211
mTOR signaling pathway	hsa04150
PI3K-Akt signaling pathway	hsa04151

Structure Information

No matching records could be found.

Domain Information

ID	Location	Description
cd14119	55-309	STKc_LKB1
cl21453	55-309	PKc_like superfamily
cd14008	55-309	STKc_LKB1_CaMKK
cd14003	48-308	STKc_AMPK-like
cd05117	48-308	STKc_CAMK
cd14081	47-309	STKc_BRSK1_2
cd14663	48-308	STKc_SnRK3
cd14079	46-309	STKc_AMPK_alpha
cd14118	55-308	STKc_CAMKK
cd00180	55-307	PKc
cd14080	49-309	STKc_TSSK-like
cd14069	49-309	STKc_Chk1
cd14007	51-310	STKc_Aurora
cd14014	48-305	STKc_PknB_like
cd14078	45-308	STKc_MELK
cd05123	55-309	STKc_AGC
cd08215	48-303	STKc_Nek
cd06606	48-309	STKc_MAPKKK
cd14099	48-309	STKc_PLK
cd14162	49-309	STKc_TSSK4-like
cd14073	55-308	STKc_NUAK
cd14199	46-308	STKc_CaMKK2
cd14098	48-308	STKc_Rad53_Cds1
cd13994	55-309	STKc_HAL4_like
cd14071	92-309	STKc_SIK
cd14084	45-308	STKc_Chk2
cd14009	94-308	STKc_ATG1_ULK_like
cd14075	97-308	STKc_NIM1
cd07829	49-309	STKc_CDK_like
cd14095	48-308	STKc_DCKL
cd05581	49-309	STKc_PDK1
cd14072	48-308	STKc_MARK
cd05122	55-309	PKc_STE
cd14076	47-308	STKc_Kin4
cd05118	55-309	STKc_CMGC
cd14070	46-308	STKc_HUNK
cd14161	48-308	STKc_NUAK2
cd14006	89-308	STKc_MLCK-like
cd14200	95-308	STKc_CaMKK1
cd07841	48-325	STKc_CDK7
cd08530	53-307	STKc_CNK2-like
cd07840	98-309	STKc_CDK9_like
cd14002	48-306	STKc_STK36
cd13985	54-303	STKc_GAK_like
cd14087	48-308	STKc_PSKH1
cd14103	55-308	STKc_MLCK
cd13999	55-303	STKc_MAP3K-like
cd14163	49-309	STKc_TSSK3-like
cd06627	48-309	STKc_Cdc7_like
cd05579	122-309	STKc_MAST_like
cd13993	48-305	STKc_Pat1_like
cd08224	97-305	STKc_Nek6_7
cd14188	48-309	STKc_PLK2
cd08529	49-305	STKc_FA2-like
cd13997	54-307	PKc_Wee1_like
cd07835	55-309	STKc_CDK1_CdkB_like
cd07834	54-345	STKc_MAPK
cd06632	51-306	STKc_MEKK1_plant
cd14167	49-308	STKc_CaMKI_alpha
cd14083	48-308	STKc_CaMKI
cd14121	94-308	STKc_ULK3
cd07838	49-309	STKc_CDK4_6_like
cd14074	97-308	STKc_SNRK
cd06623	55-311	PKc_MAPKK_plant_like
cd14189	49-309	STKc_PLK3
cd14091	49-325	STKc_RSK_C
cd07845	97-324	STKc_CDK10
cd08217	53-307	STKc_Nek2
cd07833	47-309	STKc_CDKL
cd07860	55-309	STKc_CDK2_3
cd14096	44-308	STKc_RCK1-like
cd14077	47-308	STKc_Kin1_2
cd00192	53-306	PTKc
cd14131	49-306	PKc_Mps1
cd05580	49-310	STKc_PKA_like
cd14185	49-308	STKc_DCKL3
cd14169	49-308	STKc_CaMKI_beta
cd14164	49-308	STKc_TSSK6-like
cd14114	95-309	STKc_Twitchin_like
cd14665	92-308	STKc_SnRK2-3
cd08218	48-303	STKc_Nek1
cd14092	94-337	STKc_MSK_C
cd14662	92-308	STKc_SnRK2
cd14010	95-308	STKc_ULK4
cd05578	93-309	STKc_Yank1
cd14183	43-308	STKc_DCKL1
cd14184	48-308	STKc_DCKL2
cd05572	55-309	STKc_cGK
cd14165	49-309	STKc_TSSK1_2-like
cd14097	49-308	STKc_STK33
cd14191	49-309	STKc_MLCK1
cd08225	48-303	STKc_Nek5
cd14093	48-309	STKc_PhKG
cd07830	49-309	STKc_MAK_like
cd06626	52-308	STKc_MEKK4
cd14050	53-306	PKc_Myt1
cd14192	94-309	STKc_MLCK3
cd14166	92-308	STKc_CaMKI_gamma
cd14175	49-312	STKc_RSK1_C
cd05570	122-310	STKc_PKC
cd14209	55-310	STKc_PKA
cd14116	92-308	STKc_Aurora-A
cd06628	48-308	STKc_Byr2_like
cd06612	53-309	STKc_MST1_2
cd14195	49-310	STKc_DAPK3
cd14086	95-316	STKc_CaMKII
cd06625	52-309	STKc_MEKK3_like
cd08219	48-303	STKc_Nek3
cd14190	53-309	STKc_MLCK2
cd14187	38-309	STKc_PLK1
cd07866	46-309	STKc_BUR1
cd14104	48-312	STKc_Titin
cd06611	55-309	STKc_SLK_like
cd07839	48-309	STKc_CDK5
cd14194	49-308	STKc_DAPK1
cd14178	49-308	STKc_RSK3_C
cd14168	92-308	STKc_CaMKI_delta
cd07831	92-309	STKc_MOK
cd13982	97-309	STKc_IRE1
cd14105	49-308	STKc_DAPK
cd07832	42-309	STKc_CCRK
cd06614	55-306	STKc_PAK
cd14090	49-308	STKc_Mnk
cd06610	94-309	STKc_OSR1_SPAK
cd14012	93-307	PK_eIF2AK_GCN2_rpt1
cd14186	49-306	STKc_PLK4
cd05612	92-311	STKc_PRKX_like
cd14004	95-309	STKc_PASK
cd14106	107-309	STKc_DRAK
cd07836	55-309	STKc_Pho85
cd06643	55-306	STKc_SLK
cd14094	53-312	STKc_CASK
cd14193	53-308	STKc_MLCK4
cd07855	55-324	STKc_ERK5
cd14120	97-299	STKc_ULK1_2-like
cd05609	54-310	STKc_MAST
cd05611	120-310	STKc_Rim15_like
cd05574	98-327	STKc_phototropin_like
cd14137	48-309	STKc_GSK3
cd06629	48-308	STKc_Bck1_like
cd14117	92-310	STKc_Aurora-B_like
cd14196	49-308	STKc_DAPK2
cd14022	107-309	PK_TRB2
cd14180	50-323	STKc_MSK2_C
cd05620	54-331	STKc_nPKC_delta
cd14023	107-309	PK_TRB1
cd14202	97-309	STKc_ULK1
cd14085	95-319	STKc_CaMKIV
cd14176	29-308	STKc_RSK2_C
cd07863	55-309	STKc_CDK4
cd07857	55-320	STKc_MPK1
cd05595	54-339	STKc_PKB_beta
cd14101	49-310	STKc_PIM2
cd13986	49-306	STKc_16
cd08223	49-308	STKc_Nek4
cd14061	92-303	STKc_MLK
cd08222	48-306	STKc_Nek11
cd08228	97-307	STKc_Nek6
cd06633	55-340	STKc_TAO3
cd05619	120-311	STKc_nPKC_theta
cd07861	97-309	STKc_CDK1_euk
cd14109	97-309	PK_Unc-89_rpt1
cd07837	55-309	STKc_CdkB_plant
cd06647	48-310	STKc_PAK_I
cd13979	55-270	STKc_Mos
cd06644	55-311	STKc_STK10
cd14082	89-308	STKc_PKD
cd14181	48-309	STKc_PhKG2
cd06613	55-306	STKc_MAP4K3_like
cd14058	94-303	STKc_TAK1
cd14005	48-309	STKc_PIM
cd14201	97-309	STKc_ULK2
cd13983	53-309	STKc_WNK
cd05584	54-310	STKc_p70S6K
cd14133	49-309	PKc_DYRK_like
cd07852	98-329	STKc_MAPK15-like
cd14177	49-314	STKc_RSK4_C
cd14059	95-306	STKc_MAP3K12_13
cd14179	55-323	STKc_MSK1_C
cd08220	48-303	STKc_Nek8
cd07843	97-309	STKc_CDC2L1
cd07847	55-309	STKc_CDKL1_4
cd07878	55-336	STKc_p38beta
cd07864	46-308	STKc_CDK12
cd14024	103-308	PK_TRB3
cd05571	98-319	STKc_PKB
cd05592	122-310	STKc_nPKC_theta_like
cd07849	49-330	STKc_ERK1_2_like
cd06652	51-255	STKc_MEKK2
cd07858	48-327	STKc_TEY_MAPK
cd06917	53-307	STKc_NAK1_like
cd14108	92-267	STKc_SPEG_rpt1
cd06605	55-311	PKc_MAPKK
cd06621	47-314	PKc_Pek1_like
cd07856	55-320	STKc_Sty1_Hog1
cd14111	89-308	STKc_SPEG_rpt2
cd07877	55-336	STKc_p38alpha
cd05587	124-311	STKc_cPKC
cd05585	54-311	STKc_YPK1_like
cd14100	49-308	STKc_PIM1
cd07842	97-309	STKc_CDK8_like
cd05621	120-369	STKc_ROCK2
cd05596	120-369	STKc_ROCK
cd14173	50-308	STKc_Mnk2
cd05616	124-310	STKc_cPKC_beta
cd06653	51-255	STKc_MEKK3_like_u1
cd06607	97-244	STKc_TAO
cd05603	47-309	STKc_SGK2
cd06630	49-310	STKc_MEKK1
cd14107	93-309	STKc_obscurin_rpt1
cd07870	97-344	STKc_PFTAIRE2
cd07871	49-309	STKc_PCTAIRE3
cd14046	54-306	STKc_EIF2AK4_GCN2_rpt2
cd07846	48-309	STKc_CDKL2_3
cd13996	54-303	STKc_EIF2AK
cd05613	54-326	STKc_MSK1_N
cd05575	55-310	STKc_SGK
cd06609	95-311	STKc_MST3_like
cd07873	49-309	STKc_PCTAIRE1
cd05591	122-311	STKc_nPKC_epsilon
cd05604	54-340	STKc_SGK3
cd05590	54-310	STKc_nPKC_eta
cd14174	50-310	STKc_Mnk1
cd07848	48-309	STKc_CDKL5
cd05601	120-327	STKc_CRIK
cd05593	54-309	STKc_PKB_gamma
cd05615	124-311	STKc_cPKC_alpha
cd05622	22-369	STKc_ROCK1
cd13988	96-302	STKc_TBK1
cd05608	148-327	STKc_GRK1
cd14027	97-303	STKc_RIP1
cd14036	94-303	STKc_GAK
cd14182	97-311	STKc_PhKG1
cd14019	48-309	STKc_Cdc7
cd05148	55-305	PTKc_Srm_Brk
cd13976	107-309	PK_TRB
cd06631	52-308	STKc_YSK4
cd06651	52-255	STKc_MEKK3
cd06624	55-307	STKc_ASK
cd08221	49-303	STKc_Nek9
cd14147	94-306	STKc_MLK3
cd05577	91-311	STKc_GRK
cd07879	48-331	STKc_p38delta
cd07865	97-242	STKc_CDK9
cd07844	97-309	STKc_PCTAIRE_like
cd14102	49-308	STKc_PIM3
cd05573	120-311	STKc_ROCK_NDR_like
cd08528	49-272	STKc_Nek10
cd06655	98-314	STKc_PAK2
cd07880	55-336	STKc_p38gamma
cd05583	55-310	STKc_MSK_N
cd08229	93-297	STKc_Nek7
cd07851	55-336	STKc_p38
cd14197	110-309	STKc_DRAK1
cd07862	55-309	STKc_CDK6
cd13990	48-306	STKc_TLK
cd06659	98-322	STKc_PAK6
cd06634	50-315	STKc_TAO2
cd14037	95-303	STKc_NAK_like
cd14146	94-303	STKc_MLK4
cd06654	48-314	STKc_PAK1
cd06635	50-244	STKc_TAO1
cd05038	54-303	PTKc_Jak_rpt2
cd07876	97-342	STKc_JNK2
cd05594	54-309	STKc_PKB_alpha
cd14148	54-297	STKc_MLK2
cd14048	55-306	STKc_EIF2AK3_PERK
cd14110	89-308	STKc_obscurin_rpt2
cd06656	48-314	STKc_PAK3
cd05617	120-310	STKc_aPKC_zeta
cd14065	55-306	PKc_LIMK_like
cd07872	49-310	STKc_PCTAIRE2
cd14089	55-308	STKc_MAPKAPK
cd05614	54-330	STKc_MSK2_N
cd14145	94-303	STKc_MLK1
cd05079	55-303	PTKc_Jak1_rpt2
cd05586	125-319	STKc_Sck1_like
cd05034	97-297	PTKc_Src_like
cd05083	51-305	PTKc_Chk
cd05040	53-305	PTKc_Ack_like
cd06648	98-310	STKc_PAK_II
cd14052	54-307	PTKc_Wee1_fungi
cd07853	95-242	STKc_NLK
cd14150	96-303	STKc_A-Raf
cd05588	124-310	STKc_aPKC
cd06622	53-311	PKc_PBS2_like
cd14031	47-309	STKc_WNK3
cd07875	97-342	STKc_JNK1
cd14112	47-308	STKc_Unc-89_rpt2
cd07850	97-327	STKc_JNK
cd14170	54-335	STKc_MAPKAPK2
cd07874	97-342	STKc_JNK3
cd05624	120-381	STKc_MRCK_beta
cd14132	95-309	STKc_CK2_alpha
cd05080	55-303	PTKc_Tyk2_rpt2
cd13974	145-307	STKc_SHIK
cd05618	120-310	STKc_aPKC_iota
cd14158	52-256	STKc_IRAK4
cd14066	55-306	STKc_IRAK
cd14047	53-306	STKc_EIF2AK2_PKR
cd06620	55-260	PKc_Byr1_like
cd14113	95-309	STKc_Trio_C
cd06608	47-244	STKc_myosinIII_N_like
cd13987	55-306	STKc_SBK1
cd07854	55-259	STKc_MAPK4_6
cd14171	98-308	STKc_MAPKAPK5
cd14210	49-309	PKc_DYRK
cd06638	53-308	STKc_myosinIIIA_N
cd05582	55-309	STKc_RSK_N
cd06617	160-313	PKc_MKK3_6
cd05602	54-328	STKc_SGK1
cd14088	96-308	STKc_CaMK_like
cd13978	55-270	STKc_RIP
cd07869	97-268	STKc_PFTAIRE1
cd14033	48-309	STKc_WNK4
cd05589	128-267	STKc_PKN
cd14060	95-303	STKc_MLTK
cd05600	113-313	STKc_Sid2p_like
cd13995	44-306	STKc_MAP3K8
cd06658	98-316	STKc_PAK5
cd14062	96-303	STKc_Raf
cd05056	36-303	PTKc_FAK
cd14000	159-297	STKc_LRRK
cd05039	97-305	PTKc_Csk_like
cd06646	95-244	STKc_MAP4K5
cd05099	48-303	PTKc_FGFR4
cd14198	93-309	STKc_DRAK2
cd13989	96-255	STKc_IKK
cd06657	98-316	STKc_PAK4
cd05082	98-305	PTKc_Csk
cd06642	53-308	STKc_STK25
cd14203	97-297	PTKc_Src_Fyn_like
cd05630	91-311	STKc_GRK6
cd14151	47-303	STKc_B-Raf
cd14149	96-275	STKc_C-Raf
cd14068	95-251	STKc_LRRK2
cd05597	120-373	STKc_DMPK_like
cd05605	90-311	STKc_GRK4_like
cd05599	125-378	STKc_NDR_like
cd06641	55-311	STKc_MST3
cd06639	53-265	STKc_myosinIIIB_N
cd14205	94-250	PTKc_Jak2_rpt2
cd14154	55-248	STKc_LIMK
cd06618	161-321	PKc_MKK7
cd06640	53-311	STKc_MST4
cd14051	121-307	PTKc_Wee1
cd05098	48-303	PTKc_FGFR1
cd05610	124-327	STKc_MASTL
cd05623	120-269	STKc_MRCK_alpha
cd05068	40-297	PTKc_Frk_like
cd14172	109-308	STKc_MAPKAPK3
cd06637	47-255	STKc_TNIK
cd05072	97-297	PTKc_Lyn
cd05606	142-324	STKc_beta_ARK
cd05090	96-308	PTKc_Ror1
cd14039	55-255	STKc_IKK_alpha
cd06636	47-255	STKc_MAP4K4_6_N
cd13991	142-305	STKc_NIK
cd05101	48-303	PTKc_FGFR2
cd07859	48-260	STKc_TDY_MAPK
cd14222	92-297	STKc_LIMK2
cd05059	98-297	PTKc_Tec_like
cd14030	47-312	STKc_WNK1
cd05048	55-308	PTKc_Ror
cd14018	121-301	STKc_PINK1
cd05081	48-250	PTKc_Jak3_rpt2
cd05060	89-297	PTKc_Syk_like
cd05041	97-305	PTKc_Fes_like
cd06645	95-244	STKc_MAP4K3
cd05045	48-303	PTKc_RET
cd14040	48-303	STKc_TLK1
cd05085	52-305	PTKc_Fer
cd14136	98-309	STKc_SRPK
cd05100	48-303	PTKc_FGFR3
cd05114	92-270	PTKc_Tec_Rlk
cd05053	51-303	PTKc_FGFR
cd14038	55-255	STKc_IKK_beta
cd14032	48-309	STKc_WNK2_like
cd05067	98-297	PTKc_Lck_Blk
cd14011	95-310	PK_SCY1_like
cd05632	91-329	STKc_GRK5
cd14041	48-255	STKc_TLK2
cd05055	51-303	PTKc_PDGFR
cd05071	97-314	PTKc_Src
cd05032	51-303	PTKc_InsR_like
cd05070	97-314	PTKc_Fyn
cd14221	97-248	STKc_LIMK1
cd05633	156-324	STKc_GRK3
cd14049	53-305	STKc_EIF2AK1_HRI
cd07867	97-268	STKc_CDC2L6
cd05116	55-309	PTKc_Syk
cd05091	96-308	PTKc_Ror2
cd06616	161-304	PKc_MKK4
cd14115	55-308	STKc_Kalirin_C
cd14016	48-198	STKc_CK1
cd07868	97-250	STKc_CDK8
cd05069	97-314	PTKc_Yes
cd05084	89-305	PTKc_Fes
cd05051	90-303	PTKc_DDR
cd14155	89-306	PKc_TESK
cd05112	92-312	PTKc_Itk
cd14063	96-305	PK_KSR
cd05631	91-255	STKc_GRK4
cd14664	55-256	STK_BAK1_like
cd05052	97-305	PTKc_Abl
cd06619	53-255	PKc_MKK5
cd14134	44-309	PKc_CLK
cd05046	96-303	PTK_CCK4
cd05113	97-270	PTKc_Btk_Bmx
cd05049	55-304	PTKc_Trk
cd05115	90-305	PTKc_Zap-70
cd14223	156-324	STKc_GRK2
cd13992	95-303	PK_GC
cd14001	95-254	PKc_TOPK
cd06650	97-254	PKc_MEK1
cd05073	97-297	PTKc_Hck
cd14204	51-306	PTKc_Mer
cd05037	99-303	PTK_Jak_rpt1
cd05629	93-310	STKc_NDR_like_fungal
cd05061	55-303	PTKc_InsR
cd05607	156-327	STKc_GRK7
cd05092	55-303	PTKc_TrkA
cd05074	48-305	PTKc_Tyro3
cd06615	130-254	PKc_MEK
cd14135	97-313	STKc_PRP4
cd05093	55-303	PTKc_TrkB
cd14013	159-309	STKc_SNT7_plant
cd05105	159-303	PTKc_PDGFR_alpha
cd05075	48-305	PTKc_Axl
cd05097	97-286	PTKc_DDR_like
cd05104	159-305	PTKc_Kit
cd05628	54-255	STKc_NDR1
cd05108	54-257	PTKc_EGFR
cd05625	90-255	STKc_LATS1
cd05626	90-197	STKc_LATS2
cd05047	53-303	PTKc_Tie
cd05627	113-330	STKc_NDR2
cd14156	97-248	PKc_LIMK_like_unk
cd05096	90-303	PTKc_DDR1
cd14214	50-309	PKc_CLK3
cd05107	155-301	PTKc_PDGFR_beta
cd14159	98-258	STKc_IRAK1
cd05089	53-303	PTKc_Tie1
cd06649	160-254	PKc_MEK2
cd14064	97-304	PKc_TNNI3K
cd14067	159-270	STKc_LRRK1
cd14025	122-303	STKc_RIP4_like
cd13977	48-297	STKc_PDIK1L
cd13975	160-251	PKc_Dusty
cd05598	120-310	STKc_LATS
cd05094	55-305	PTKc_TrkC
cd08216	97-255	PK_STRAD
cd14152	51-270	STKc_KSR1
cd14226	44-311	PKc_DYRK1
cd14216	98-309	STKc_SRPK1
cd05057	159-257	PTKc_EGFR_like
cd14218	98-309	STKc_SRPK3
cd14153	51-297	PK_KSR2
cd13998	163-249	STKc_TGFbR-like
cd05043	159-278	PTK_Ryk
cd14144	105-249	STKc_BMPR1
cd05063	98-297	PTKc_EphR_A2
cd14207	156-260	PTKc_VEGFR1
cd05095	55-305	PTKc_DDR2
cd05062	48-303	PTKc_IGF-1R
cd14055	94-250	STKc_TGFbR2_like
cd14215	48-309	PKc_CLK2
cd14015	126-184	STKc_VRK
cd14056	97-248	STKc_TGFbR_I
cd05066	98-303	PTKc_EphR_A
cd14139	121-306	PTKc_Wee1b
cd05035	51-305	PTKc_TAM
cd05050	55-306	PTKc_Musk
smart00220	49-309	S_TKc
pfam00069	49-309	Pkinase
COG0515	48-335	SPS1
smart00221	51-305	STYKc
smart00219	51-305	TyrKc
pfam07714	51-306	Pkinase_Tyr
PTZ00263	51-329	PTZ00263
PLN00009	48-310	PLN00009
PLN00034	97-325	PLN00034
PTZ00024	41-325	PTZ00024
PTZ00426	94-355	PTZ00426
PTZ00283	119-299	PTZ00283
PTZ00266	55-318	PTZ00266
PTZ00267	93-305	PTZ00267
PTZ00036	49-299	PTZ00036
PHA03207	91-257	PHA03207
PHA03209	98-254	PHA03209
TIGR03903	93-297	TOMM_kin_cyc
PTZ00284	54-333	PTZ00284
PHA03210	30-250	PHA03210
PHA03212	98-251	PHA03212
PRK13184	157-311	pknD
PLN03225	159-314	PLN03225
PLN03224	130-223	PLN03224
PHA03211	93-246	PHA03211
PHA03390	107-309	pk1
pfam14531	138-297	Kinase-like
PHA02988	97-304	PHA02988

Ontology Information

HPRD ID	1615
Molecular Class	Serine/threonine kinase
Molecular Function	RNA binding (GO:0003723)
Biological Process	Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219)

SNP Information

View SNP Geneview Report

Drug Information

No matching records could be found.

External Links

ArrayExpress GO
ICGC GO
Cancer3D GO
COSMIC GO
NCG GO
TSGene GO
Tumor Gene Family of Databases GO
CCDB GO
G2SBC GO
Osteosarcoma Database GO
RCDB GO

ArrayExpress	GO
ICGC	GO
Cancer3D	GO
COSMIC	GO
NCG	GO
TSGene	GO
Tumor Gene Family of Databases	GO
CCDB	GO
G2SBC	GO
Osteosarcoma Database	GO
RCDB	GO