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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
BSG 682 basigin (Ok blood group)  19EMMPRIN, CD147 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
22782346   2012Cell line : -

Source : -

Sample Type : CRC tumor and Normal tissue

No. of Sample : 277

Stage : TNM Stage III

immunohistochemistry and western blottingUp-regulation-EMMPRIN is a promising prognostic biomarker in colorectal cancer.

It could be used in the selection of stage III patients for adjuvant therapy.

EMMPRIN expression was associated with shorter metastasis-free, disease-specific and overall survival in both univariate and multivariate analyses.


Gene Details



Chromosome 19 - NC_000019.10 (571277..583493)

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Gene Type protein coding
Gene Family CD molecules, "Blood group antigens", "Immunoglobulin superfamily / I-set domain containing", "Immunoglobulin superfamily / Immunoglobulin-like domain containing"
Description The protein encoded by this gene is a plasma membrane protein that is important in spermatogenesis, embryo implantation, neural network formation, and tumor progression. The encoded protein is also a member of the immunoglobulin superfamily. Multiple transcript variants encoding different isoforms have been found for this gene.  
Chromosome 19
Location 19p13.3
Start 571277  
End 583493  
Strand +  
Gene Sequence

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Length 12217  
OMIM ID 109480   
HGNC ID HGNC:1116   
Unigene ID Hs.501293   
Ensembl ID ENSG00000172270   
PharmGKB ID -   

mRNA Information


mRNA ID NM_198590.2
Exon join(1..303,8224..8380,9103..9185,9370..9506,10039..10315, 11030..11054,11238..11306,11474..12217)  
mRNA Sequence

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Length 2107  



CDS Information


   
Location join(272..303,9103..9185,9370..9506,10039..10315, 11030..11054,11238..11301)
CDS Sequence

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CCDS ID CCDS12032.1



Protein Information


      
Protein IDNP_001719.2
Protein Namebasigin (Ok blood group)
Molecular Wt. (Da)40201
Protein Sequence

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Length 385  
Uniprot IDP43220
Ensembl Protein ID ENSP00000362353  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation362;-
SPhosphorylation246;-
SPhosphorylation153;-
SPhosphorylation182;-
SPhosphorylation368;-
SPhosphorylation252;-
SPhosphorylation159;-
SPhosphorylation188;-
NGlycosylation160
NGlycosylation44
NGlycosylation268
NGlycosylation152
NGlycosylation59
NGlycosylation88
SPhosphorylation367
SPhosphorylation251
SPhosphorylation158
SPhosphorylation187
SPhosphorylation279
SPhosphorylation163
SPhosphorylation70
SPhosphorylation99

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                              
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
857CAV13028NP_001744.2in vivo15201341   
9260PDLIM710436NP_005442.2yeast 2-hybrid16189514   


Pathway Information


No matching records could be found.

Structure Information


PDB ID3B5H
Resolution2.8
MethodX-RAY DIFFRACTION
Chains A, B  
Molecule Cervical EMMPRIN  
Model View



Domain Information




ID Location Description
cd0009640-114  Ig
cl1196040-114  Ig superfamily
cd05758219-317  Ig5_KIRREL3-like
cl11960219-317  Ig superfamily
cd0572936-112  Ig2_FGFR_like
pfam0004737-110  ig
pfam13895228-318  Ig_2
cd0585634-112  Ig2_FGFRL1-like
pfam1392729-112  Ig_3
cd0496836-117  Ig3_Contactin_like
cd05732234-318  Ig5_NCAM-1_like
cd00096238-315  Ig
cd0572540-112  Ig3_Robo
cd05870234-311  Ig5_NCAM-2
cd0576341-112  Ig_1
pfam1389535-114  Ig_2
cd0572237-125  Ig1_Neogenin
cd0574537-112  Ig3_Peroxidasin
cd05898219-317  Ig5_KIRREL3
cd0573237-112  Ig5_NCAM-1_like
cd0587037-112  Ig5_NCAM-2
cd0497837-112  Ig4_L1-NrCAM_like
cd0586940-112  Ig5_NCAM-1
cd05866235-318  Ig1_NCAM-2
cd0572836-112  Ig4_Contactin-2-like
cd0573937-56  Ig3_RPTP_IIa_LAR_like
cd05895239-312  Ig_Pro_neuregulin-1
cd00099232-301  IgV
cd0576437-112  Ig_2
cd0574839-113  Ig_Titin_like
cd04977222-311  Ig1_NCAM-1_like
cd0574337-112  Ig_Perlecan_D2_like
smart00410228-318  IG_like
smart0040837-112  IGc2
smart00409228-318  IG
smart0041029-113  IG_like
smart0040929-113  IG
pfam0767925-112  I-set
pfam07679232-318  I-set
smart00408234-308  IGc2


Ontology Information


   
HPRD ID714
Molecular ClassCell surface receptor
Molecular FunctionCatalytic activity (GO:0003824)
Biological ProcessMetabolism (GO:0008152); Energy pathways (GO:0006091)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO