Search results:
General Information
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 18803050 | 2008 | Cell line : - Source : Department of Gastrointestinal surgery sun yat-sen University. Sample Type : CRC tumor and normal tissue No. of Sample : 120 Stage : Dukes stage A-D | Methylation-specific PCR, RT-PCR | Hypermethylation | - | Hypermethylation leads to silence of Syk gene involved in the initiation of colorectal cancer. |
| 23609194 | 2013 | Cell line : - Source : Department of Gastrointestinal surgery sun yat-sen University. Sample Type : CRC tumor and normal tissue No. of Sample : 210 Stage : - | - | Hypermethylation | - | Syk is identified as a potential tumor suppressor in CRC progression. |
| 25921550 | 2015 | Cell line : - Source : NCBI SNP database (gene ID: 6850), Sixth affiliated Hospital of sun yat-sen University, the sun yat - sen university cancer center,Han Chinese in Southern China. Sample Type : Population-based case-control study No. of Sample : - Stage : - | TaqMan-MGB probe analyses, In silico analysis tools, linkage disequilibrium analysis, SNP Genotyping | Polymorhpism | - | The SYK -803 A>T genotypes TA and TT are independent risk factors for CRC development in Han Chinese in Southern China.The frequencies of the TA and TT genotypes and the T allele of the -803A>T SNP were found to be significantly higher in the CRC patients |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | SH2 domain containing |
| Description | This gene encodes a member of the family of non-receptor type Tyr protein kinases. This protein is widely expressed in hematopoietic cells and is involved in coupling activated immunoreceptors to downstream signaling events that mediate diverse cellular responses, including proliferation, differentiation, and phagocytosis. It is thought to be a modulator of epithelial cell growth and a potential tumour suppressor in human breast carcinomas. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010] |
| Chromosome | 9 |
| Location | 9q22 |
| Start | 93564012 |
| End | 93660842 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 96831 |
| OMIM ID | 600085 |
| HGNC ID | HGNC:11491 |
| Unigene ID | Hs.371720 |
| Ensembl ID | ENSG00000165025 |
| PharmGKB ID | PA36273 |
mRNA Information
| mRNA ID | ?NM_001135052.3 |
|---|---|
| Exon | join(1..214,42179..42636,43755..43915,60527..60665, 62910..62988,63369..63418,65452..65520,72525..72612, 72993..73170,75892..76101,77085..77274,86070..86210, 86836..86948,93849..96881) | mRNA Sequence | Download Select all |
| Length | 5129 |
Protein Information
| Protein ID | NP_001128524.1 |
|---|---|
| Protein Name | spleen tyrosine kinase |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 635 |
| Uniprot ID | O95819 |
| Ensembl Protein ID | ENSP00000314363 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| Y | Phosphorylation | 131 |
| Y | Phosphorylation | 131 |
| Y | Phosphorylation | 323 |
| Y | Phosphorylation | 348 |
| Y | Phosphorylation | 352 |
| Y | Phosphorylation | 525 |
| Y | Phosphorylation | 526 |
| Y | Phosphorylation | 296;- |
| Y | Phosphorylation | 568;- |
| S | Phosphorylation | 297 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 695 | BTK | 2248 | NP_000052.1 | in vitro;in vivo | 112 262 821 159 801 000 000 000 000 000 |
| 867 | CBL | 1320 | NP_005179.2 | in vitro;in vivo | 86 217 191 113 383 000 000 000 000 000 000 000 000 |
| 868 | CBLB | 5136 | NP_733762.2 | in vitro | 1 002 212 012 771 180 |
| 930 | CD19 | 113 | NP_001761.3 | in vivo | 9120258 |
| 933 | CD22 | 114 | NP_001762.2 | in vitro | 8627166 |
| 973 | CD79A | 203 | NP_001774.1 | in vitro;in vivo | 7500027 |
| 1441 | CSF3R | 737 | NP_724781.1 | in vitro | 8197119 |
| 1845 | DUSP3 | 2553 | NP_004081.1 | in vitro;in vivo | 12447358 |
| 2017 | CTTN | 1268 | NP_005222.2 | in vivo | 8636079 |
| 2057 | EPOR | 587 | NP_000112.1 | in vitro;in vivo | 9852052 |
| 2206 | MS4A2 | 915 | NP_000130.1 | in vitro;in vivo | 8071371 |
| 2207 | FCER1G | 916 | NP_004097.1 | in vitro;in vivo | 8071371 |
| 2209 | FCGR1A | 904 | NP_000557.1 | in vivo | 11141335 |
| 2212 | FCGR2A | 906 | NP_001129691.1 | in vitro;in vivo | 875 663 192 952 889 000 000 |
| 2268 | FGR | 1288 | NP_005239.1 | in vitro;in vivo | 11672534 |
| 2534 | FYN | 655 | NP_002028.1 | in vitro;in vivo | 9535867 |
| 2885 | GRB2 | 150 | NP_002077.1 | in vitro;in vivo | 11964172 |
| 3059 | HCLS1 | 3199 | NP_005326.2 | in vitro | 9104825 |
| 3601 | IL15RA | 3045 | NP_002180.1 | in vitro | 11714793 |
| 3689 | ITGB2 | 2506 | NP_000202.2 | in vivo | 12885943 |
| 3716 | JAK1 | 992 | NP_002218.2 | in vitro | 10825200 |
| 3932 | LCK | 1080 | NP_005347.3 | in vivo | 75 390 358 798 764 |
| 5335 | PLCG1 | 1398 | NP_002651.2 | in vitro;in vivo | 888 586 886 571 031 000 000 000 000 000 000 000 |
| 5336 | PLCG2 | 2570 | AAH11772.1 | in vitro | 124 703 021 277 118 000 000 000 |
| 5450 | POU2AF1 | 3126 | NP_006226.2 | in vivo | 16713566 |
| 5578 | PRKCA | 1498 | NP_002728.1 | in vitro | 12881490 |
| 5587 | PRKD1 | 5668 | NP_002733.2 | in vitro;in vivo | 8885868 |
| 5595 | MAPK3 | 3479 | NP_002737.2 | in vitro | 9218456 |
| 5777 | PTPN6 | 1475 | NP_536859.1 | in vivo | 1 007 251 611 356 830 |
| 6195 | RPS6KA1 | 3402 | NP_001006666.1 | in vitro | 9218456 |
| 6452 | SH3BP2 | 3657 | NP_003014.3 | in vitro;in vivo;yeast 2-hybrid | 98 464 811 139 047 000 000 000 |
| 6464 | SHC1 | 2780 | NP_001123512.1 | in vivo | 10 482 988 971 020 400 000 000 000 000 |
| 6521 | SLC4A1 | 175 | NP_000333.1 | in vitro;in vivo | 199 869 720 650 701 000 000 000 000 000 |
| 6622 | SNCA | 1227 | NP_000336.1 | in vitro;in vivo | 120 967 131 174 462 000 000 000 |
| 6714 | SRC | 1819 | NP_005408.1 | in vivo | 7513017 |
| 6774 | STAT3 | 26 | NP_644805.1 | in vivo | 10825200 |
| 7099 | TLR4 | 4325 | NP_612564.1 | in vivo | 14699155 |
| 7277 | TUBA4A | 1851 | NP_005991.1 | in vitro | 8617742 |
| 7305 | TYROBP | 4996 | NP_003323.1 | in vitro;in vivo | 9490415 |
| 7314 | UBB | 6771 | NP_061828.1 | in vitro | 11046148 |
| 7409 | VAV1 | 1284 | NP_005419.2 | in vitro;in vivo;yeast 2-hybrid | 8986718 |
| 7410 | VAV2 | 2694 | NP_001127870.1 | in vitro | 15345594 |
| 11184 | MAP4K1 | 3583 | NP_009112.1 | in vitro | 11514608 |
| 28988 | DBNL | 6588 | NP_001116428.1 | in vivo | 9891087 |
| 54900 | LAX1 | 8312 | NP_060243.2 | in vivo | 12359715 |
| 118788 | PIK3AP1 | 6401 | NP_689522.2 | in vitro | 11163197 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| B cell receptor signaling pathway | hsa04662 |
| Epstein-Barr virus infection | hsa05169 |
| Fc epsilon RI signaling pathway | hsa04664 |
| Fc gamma R-mediated phagocytosis | hsa04666 |
| Natural killer cell mediated cytotoxicity | hsa04650 |
| NF-kappa B signaling pathway | hsa04064 |
| Osteoclast differentiation | hsa04380 |
| Phospholipase D signaling pathway | hsa04072 |
| PI3K-Akt signaling pathway | hsa04151 |
| Platelet activation | hsa04611 |
| Tuberculosis | hsa05152 |
| Viral carcinogenesis | hsa05203 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd05116 | 375-631 | PTKc_Syk |
| cl21453 | 375-631 | PKc_like superfamily |
| cd09938 | 13-116 | SH2_N-SH2_Zap70_Syk_like |
| cl15255 | 13-116 | SH2 superfamily |
| cd10401 | 164-262 | SH2_C-SH2_Syk_like |
| cl15255 | 164-262 | SH2 superfamily |
| cd05060 | 375-631 | PTKc_Syk_like |
| cd05115 | 367-633 | PTKc_Zap-70 |
| cd00192 | 375-627 | PTKc |
| cd05056 | 365-631 | PTKc_FAK |
| cd05057 | 375-619 | PTKc_EGFR_like |
| cd05040 | 375-622 | PTKc_Ack_like |
| cd05034 | 375-626 | PTKc_Src_like |
| cd05039 | 377-628 | PTKc_Csk_like |
| cd05068 | 365-630 | PTKc_Frk_like |
| cd05038 | 375-626 | PTKc_Jak_rpt2 |
| cd05041 | 377-622 | PTKc_Fes_like |
| cd05033 | 365-629 | PTKc_EphR |
| cd05059 | 365-620 | PTKc_Tec_like |
| cd05108 | 373-619 | PTKc_EGFR |
| cd05052 | 365-630 | PTKc_Abl |
| cd05067 | 367-630 | PTKc_Lck_Blk |
| cd05085 | 377-626 | PTKc_Fer |
| cd05084 | 375-622 | PTKc_Fes |
| cd05112 | 375-620 | PTKc_Itk |
| cd05032 | 365-628 | PTKc_InsR_like |
| cd05109 | 377-619 | PTKc_HER2 |
| cd05044 | 375-628 | PTKc_c-ros |
| cd05148 | 359-629 | PTKc_Srm_Brk |
| cd05082 | 365-628 | PTKc_Csk |
| cd05110 | 375-619 | PTKc_HER4 |
| cd05036 | 367-626 | PTKc_ALK_LTK |
| cd05048 | 375-627 | PTKc_Ror |
| cd05050 | 403-622 | PTKc_Musk |
| cd05063 | 373-622 | PTKc_EphR_A2 |
| cd05051 | 403-619 | PTKc_DDR |
| cd05053 | 365-620 | PTKc_FGFR |
| cd05066 | 374-622 | PTKc_EphR_A |
| cd05072 | 375-630 | PTKc_Lyn |
| cd05046 | 373-619 | PTK_CCK4 |
| cd05111 | 375-619 | PTK_HER3 |
| cd05045 | 374-620 | PTKc_RET |
| cd05065 | 377-622 | PTKc_EphR_B |
| cd05099 | 367-627 | PTKc_FGFR4 |
| cd05049 | 375-628 | PTKc_Trk |
| cd05083 | 365-626 | PTKc_Chk |
| cd05114 | 375-620 | PTKc_Tec_Rlk |
| cd05081 | 377-626 | PTKc_Jak3_rpt2 |
| cd05113 | 365-622 | PTKc_Btk_Bmx |
| cd14203 | 375-619 | PTKc_Src_Fyn_like |
| cd05073 | 374-629 | PTKc_Hck |
| cd05090 | 375-629 | PTKc_Ror1 |
| cd14205 | 375-626 | PTKc_Jak2_rpt2 |
| cd13999 | 377-619 | STKc_MAP3K-like |
| cd05035 | 375-628 | PTKc_TAM |
| cd14204 | 362-626 | PTKc_Mer |
| cd05069 | 367-630 | PTKc_Yes |
| cd05058 | 377-619 | PTKc_Met_Ron |
| cd05075 | 375-628 | PTKc_Axl |
| cd05079 | 375-619 | PTKc_Jak1_rpt2 |
| cd05074 | 361-628 | PTKc_Tyro3 |
| cd05080 | 375-630 | PTKc_Tyk2_rpt2 |
| cd05091 | 375-629 | PTKc_Ror2 |
| cd05047 | 377-626 | PTKc_Tie |
| cd05064 | 365-622 | PTKc_EphR_A10 |
| cd05070 | 367-630 | PTKc_Fyn |
| cd05055 | 375-619 | PTKc_PDGFR |
| cd05061 | 375-622 | PTKc_InsR |
| cd05071 | 367-630 | PTKc_Src |
| cd05089 | 370-626 | PTKc_Tie1 |
| cd05101 | 342-619 | PTKc_FGFR2 |
| cd05098 | 355-619 | PTKc_FGFR1 |
| cd05100 | 365-619 | PTKc_FGFR3 |
| cd05092 | 376-627 | PTKc_TrkA |
| cd10402 | 157-259 | SH2_C-SH2_Zap70 |
| cd05097 | 367-627 | PTKc_DDR_like |
| cd05096 | 403-622 | PTKc_DDR1 |
| cd05095 | 367-626 | PTKc_DDR2 |
| cd05062 | 375-622 | PTKc_IGF-1R |
| cd05043 | 380-633 | PTK_Ryk |
| cd00180 | 377-622 | PKc |
| cd05093 | 375-628 | PTKc_TrkB |
| cd05094 | 364-616 | PTKc_TrkC |
| cd05088 | 377-626 | PTKc_Tie2 |
| cd05054 | 432-620 | PTKc_VEGFR |
| cd05106 | 470-622 | PTKc_CSF-1R |
| cd05104 | 469-622 | PTKc_Kit |
| cd05105 | 470-619 | PTKc_PDGFR_alpha |
| cd14061 | 377-628 | STKc_MLK |
| cd14207 | 469-628 | PTKc_VEGFR1 |
| cd05103 | 469-628 | PTKc_VEGFR2 |
| cd14146 | 377-622 | STKc_MLK4 |
| cd13978 | 377-626 | STKc_RIP |
| cd14059 | 424-626 | STKc_MAP3K12_13 |
| cd05107 | 470-628 | PTKc_PDGFR_beta |
| cd05102 | 477-622 | PTKc_VEGFR3 |
| cd14058 | 377-630 | STKc_TAK1 |
| cd14145 | 365-626 | STKc_MLK1 |
| cd14060 | 378-619 | STKc_MLTK |
| cd14206 | 375-626 | PTKc_Aatyk3 |
| cd14148 | 377-626 | STKc_MLK2 |
| cd05037 | 377-626 | PTK_Jak_rpt1 |
| cd14147 | 370-626 | STKc_MLK3 |
| cd06606 | 375-624 | STKc_MAPKKK |
| cd05042 | 375-626 | PTKc_Aatyk |
| cd14014 | 374-617 | STKc_PknB_like |
| cd05087 | 375-626 | PTKc_Aatyk1 |
| cd14027 | 417-631 | STKc_RIP1 |
| cd10345 | 167-259 | SH2_C-SH2_Zap70_Syk_like |
| pfam00017 | 168-244 | SH2 |
| cd08215 | 375-617 | STKc_Nek |
| cd05122 | 375-617 | PKc_STE |
| cd05078 | 421-622 | PTK_Jak2_rpt1 |
| smart00252 | 166-250 | SH2 |
| cd09935 | 164-258 | SH2_ABL |
| cd09937 | 165-263 | SH2_csk_like |
| cd05086 | 375-609 | PTKc_Aatyk2 |
| pfam00017 | 15-92 | SH2 |
| cd14062 | 377-627 | STKc_Raf |
| cd14064 | 377-622 | PKc_TNNI3K |
| cd05117 | 375-562 | STKc_CAMK |
| cd06627 | 415-617 | STKc_Cdc7_like |
| smart00252 | 14-98 | SH2 |
| cd05076 | 410-622 | PTK_Tyk2_rpt1 |
| cd14121 | 377-573 | STKc_ULK3 |
| cd14009 | 377-608 | STKc_ATG1_ULK_like |
| cd14003 | 375-587 | STKc_AMPK-like |
| cd14000 | 377-617 | STKc_LRRK |
| cd14066 | 377-626 | STKc_IRAK |
| cd08529 | 375-617 | STKc_FA2-like |
| cd06612 | 377-624 | STKc_MST1_2 |
| cd14073 | 375-575 | STKc_NUAK |
| cd13990 | 420-617 | STKc_TLK |
| cd14208 | 415-622 | PTK_Jak3_rpt1 |
| cd14025 | 416-624 | STKc_RIP4_like |
| cd06623 | 375-624 | PKc_MAPKK_plant_like |
| cd08222 | 375-630 | STKc_Nek11 |
| cd14221 | 410-626 | STKc_LIMK1 |
| cd05123 | 418-623 | STKc_AGC |
| cd06629 | 405-625 | STKc_Bck1_like |
| cd05077 | 410-622 | PTK_Jak1_rpt1 |
| cd06628 | 377-617 | STKc_Byr2_like |
| cd05578 | 378-619 | STKc_Yank1 |
| cd14084 | 355-617 | STKc_Chk2 |
| cd14150 | 375-622 | STKc_A-Raf |
| cd14222 | 410-623 | STKc_LIMK2 |
| cd08528 | 377-617 | STKc_Nek10 |
| cd14072 | 375-589 | STKc_MARK |
| cd14076 | 377-573 | STKc_Kin4 |
| cd14151 | 375-628 | STKc_B-Raf |
| cd14008 | 377-616 | STKc_LKB1_CaMKK |
| cd14080 | 375-562 | STKc_TSSK-like |
| cd06611 | 376-617 | STKc_SLK_like |
| cd14105 | 375-583 | STKc_DAPK |
| cd00173 | 167-244 | SH2 |
| cd14065 | 377-626 | PKc_LIMK_like |
| cd14162 | 375-573 | STKc_TSSK4-like |
| cd06605 | 375-621 | PKc_MAPKK |
| cd14190 | 371-575 | STKc_MLCK2 |
| cd08220 | 377-564 | STKc_Nek8 |
| cd14192 | 377-614 | STKc_MLCK3 |
| cd08217 | 375-617 | STKc_Nek2 |
| cd09933 | 167-258 | SH2_Src_family |
| cd13992 | 418-629 | PK_GC |
| cd14075 | 375-575 | STKc_NIM1 |
| cd14193 | 373-580 | STKc_MLCK4 |
| cd14113 | 373-573 | STKc_Trio_C |
| cd06609 | 375-576 | STKc_MST3_like |
| cd14165 | 377-597 | STKc_TSSK1_2-like |
| cd14071 | 374-563 | STKc_SIK |
| cd14149 | 357-622 | STKc_C-Raf |
| cd06642 | 354-617 | STKc_STK25 |
| cd05581 | 375-576 | STKc_PDK1 |
| cd14202 | 377-600 | STKc_ULK1 |
| cd14067 | 416-617 | STKc_LRRK1 |
| cd06620 | 369-617 | PKc_Byr1_like |
| cd14161 | 377-575 | STKc_NUAK2 |
| cd06640 | 354-617 | STKc_MST4 |
| cd13979 | 376-624 | STKc_Mos |
| cd14063 | 372-622 | PK_KSR |
| cd14070 | 375-563 | STKc_HUNK |
| cd10347 | 166-244 | SH2_Nterm_shark_like |
| cd14106 | 371-575 | STKc_DRAK |
| cd06614 | 414-624 | STKc_PAK |
| cd14068 | 377-635 | STKc_LRRK2 |
| cd14154 | 377-623 | STKc_LIMK |
| cd06641 | 354-617 | STKc_MST3 |
| cd10402 | 13-106 | SH2_C-SH2_Zap70 |
| cd14156 | 417-626 | PKc_LIMK_like_unk |
| cd14164 | 417-575 | STKc_TSSK6-like |
| cd14103 | 377-560 | STKc_MLCK |
| cd05118 | 377-567 | STKc_CMGC |
| cd14120 | 377-605 | STKc_ULK1_2-like |
| cd06632 | 377-624 | STKc_MEKK1_plant |
| cd14093 | 407-563 | STKc_PhKG |
| cd08530 | 375-575 | STKc_CNK2-like |
| cd14006 | 377-561 | STKc_MLCK-like |
| cd06917 | 377-575 | STKc_NAK1_like |
| cd14196 | 375-575 | STKc_DAPK2 |
| cd14197 | 375-575 | STKc_DRAK1 |
| cd06638 | 410-617 | STKc_myosinIIIA_N |
| cd06644 | 376-624 | STKc_STK10 |
| cd06643 | 376-616 | STKc_SLK |
| cd14201 | 377-591 | STKc_ULK2 |
| cd05616 | 377-581 | STKc_cPKC_beta |
| cd14186 | 366-573 | STKc_PLK4 |
| cd14041 | 420-573 | STKc_TLK2 |
| cd10363 | 164-259 | SH2_Src_HCK |
| cd00173 | 14-92 | SH2 |
| cd05615 | 377-581 | STKc_cPKC_alpha |
| cd14191 | 372-583 | STKc_MLCK1 |
| cd09937 | 11-106 | SH2_csk_like |
| cd08228 | 374-622 | STKc_Nek6 |
| cd09933 | 14-106 | SH2_Src_family |
| cd06622 | 376-622 | PKc_PBS2_like |
| cd14026 | 377-619 | STKc_RIP2 |
| cd06631 | 377-624 | STKc_YSK4 |
| cd05579 | 403-564 | STKc_MAST_like |
| cd14098 | 377-563 | STKc_Rad53_Cds1 |
| cd06621 | 377-564 | PKc_Pek1_like |
| cd13998 | 440-626 | STKc_TGFbR-like |
| cd06633 | 338-560 | STKc_TAO3 |
| cd14007 | 375-617 | STKc_Aurora |
| cd14194 | 375-583 | STKc_DAPK1 |
| cd09932 | 163-245 | SH2_C-SH2_PLC_gamma_like |
| cd14155 | 411-626 | PKc_TESK |
| cd14047 | 373-567 | STKc_EIF2AK2_PKR |
| cd10348 | 168-251 | SH2_Cterm_shark_like |
| cd09935 | 14-106 | SH2_ABL |
| cd10370 | 14-106 | SH2_Src_Src42 |
| cd08224 | 374-617 | STKc_Nek6_7 |
| cd14012 | 425-624 | PK_eIF2AK_GCN2_rpt1 |
| cd14198 | 369-580 | STKc_DRAK2 |
| cd06616 | 372-621 | PKc_MKK4 |
| cd05592 | 375-575 | STKc_nPKC_theta_like |
| cd14195 | 375-580 | STKc_DAPK3 |
| cd10370 | 164-258 | SH2_Src_Src42 |
| cd14040 | 420-573 | STKc_TLK1 |
| cd14209 | 375-573 | STKc_PKA |
| cd14079 | 375-563 | STKc_AMPK_alpha |
| cd14158 | 377-567 | STKc_IRAK4 |
| cd06610 | 415-617 | STKc_OSR1_SPAK |
| cd09941 | 167-244 | SH2_Grb2_like |
| cd14096 | 377-563 | STKc_RCK1-like |
| cd09944 | 163-262 | SH2_Grb7_family |
| cd07838 | 376-567 | STKc_CDK4_6_like |
| cd14054 | 377-626 | STKc_BMPR2_AMHR2 |
| cd14116 | 371-622 | STKc_Aurora-A |
| cd14099 | 375-562 | STKc_PLK |
| cd14002 | 378-573 | STKc_STK36 |
| cd14097 | 375-589 | STKc_STK33 |
| cd05580 | 375-564 | STKc_PKA_like |
| cd14038 | 377-573 | STKc_IKK_beta |
| cd14044 | 403-623 | PK_GC-C |
| cd10368 | 168-258 | SH2_Src_Fyn |
| cd06613 | 375-560 | STKc_MAP4K3_like |
| cd10343 | 167-261 | SH2_SHIP |
| cd10361 | 162-244 | SH2_Fps_family |
| cd05611 | 417-618 | STKc_Rim15_like |
| cd06655 | 414-616 | STKc_PAK2 |
| cd08229 | 374-622 | STKc_Nek7 |
| cd13994 | 414-566 | STKc_HAL4_like |
| cd06639 | 410-617 | STKc_myosinIIIB_N |
| cd06650 | 376-624 | PKc_MEK1 |
| cd10360 | 167-244 | SH2_Srm |
| cd10365 | 168-256 | SH2_Src_Src |
| cd14131 | 410-617 | PKc_Mps1 |
| cd06608 | 409-617 | STKc_myosinIII_N_like |
| cd05620 | 375-575 | STKc_nPKC_delta |
| cd14042 | 416-628 | PK_GC-A_B |
| cd06630 | 415-564 | STKc_MEKK1 |
| cd06647 | 366-616 | STKc_PAK_I |
| cd13996 | 377-567 | STKc_EIF2AK |
| cd14663 | 375-563 | STKc_SnRK3 |
| cd10369 | 14-106 | SH2_Src_Frk |
| cd14166 | 377-589 | STKc_CaMKI_gamma |
| cd10418 | 168-258 | SH2_Src_Fyn_isoform_a_like |
| cd10369 | 164-258 | SH2_Src_Frk |
| cd14077 | 420-563 | STKc_Kin1_2 |
| cd05570 | 375-575 | STKc_PKC |
| cd08225 | 420-622 | STKc_Nek5 |
| cd06649 | 376-585 | PKc_MEK2 |
| cd06626 | 375-625 | STKc_MEKK4 |
| cd06617 | 376-573 | PKc_MKK3_6 |
| cd06654 | 375-616 | STKc_PAK1 |
| cd13989 | 377-573 | STKc_IKK |
| cd06648 | 416-573 | STKc_PAK_II |
| cd14048 | 367-564 | STKc_EIF2AK3_PERK |
| cd14039 | 377-573 | STKc_IKK_alpha |
| cd05595 | 375-573 | STKc_PKB_beta |
| cd07829 | 420-564 | STKc_CDK_like |
| cd13982 | 370-617 | STKc_IRE1 |
| cd07840 | 420-567 | STKc_CDK9_like |
| cd14179 | 370-589 | STKc_MSK1_C |
| cd10367 | 168-258 | SH2_Src_Fgr |
| cd14137 | 375-559 | STKc_GSK3 |
| cd08223 | 420-564 | STKc_Nek4 |
| cd05582 | 420-621 | STKc_RSK_N |
| cd07836 | 375-575 | STKc_Pho85 |
| cd06619 | 377-584 | PKc_MKK5 |
| cd10364 | 15-106 | SH2_Src_Lyn |
| cd05619 | 370-581 | STKc_nPKC_theta |
| cd06656 | 414-616 | STKc_PAK3 |
| cd14095 | 420-580 | STKc_DCKL |
| cd14200 | 415-573 | STKc_CaMKK1 |
| cd10419 | 168-257 | SH2_Src_Fyn_isoform_b_like |
| cd08219 | 420-617 | STKc_Nek3 |
| cd07870 | 375-600 | STKc_PFTAIRE2 |
| cd10371 | 168-258 | SH2_Src_Blk |
| cd14081 | 420-563 | STKc_BRSK1_2 |
| cd10344 | 168-251 | SH2_SLAP |
| cd14052 | 377-565 | PTKc_Wee1_fungi |
| cd10362 | 14-106 | SH2_Src_Lck |
| cd07865 | 377-564 | STKc_CDK9 |
| cd14078 | 375-563 | STKc_MELK |
| cd14083 | 414-561 | STKc_CaMKI |
| cd10341 | 163-244 | SH2_N-SH2_PLC_gamma_like |
| cd14153 | 377-619 | PK_KSR2 |
| cd14133 | 374-617 | PKc_DYRK_like |
| cd06618 | 376-617 | PKc_MKK7 |
| cd14082 | 374-567 | STKc_PKD |
| cd06659 | 414-584 | STKc_PAK6 |
| cd07863 | 376-572 | STKc_CDK4 |
| cd05585 | 415-633 | STKc_YPK1_like |
| cd07832 | 416-564 | STKc_CCRK |
| cd10345 | 14-105 | SH2_C-SH2_Zap70_Syk_like |
| cd14181 | 413-573 | STKc_PhKG2 |
| cd13983 | 374-573 | STKc_WNK |
| cd14172 | 430-592 | STKc_MAPKAPK3 |
| cd14010 | 414-573 | STKc_ULK4 |
| cd13987 | 430-574 | STKc_SBK1 |
| cd07834 | 424-564 | STKc_MAPK |
| cd14118 | 415-573 | STKc_CAMKK |
| cd14664 | 377-572 | STK_BAK1_like |
| cd05618 | 405-573 | STKc_aPKC_iota |
| cd05572 | 377-564 | STKc_cGK |
| cd14114 | 375-575 | STKc_Twitchin_like |
| cd06625 | 375-624 | STKc_MEKK3_like |
| cd10362 | 164-258 | SH2_Src_Lck |
| cd14069 | 375-562 | STKc_Chk1 |
| cd05612 | 420-575 | STKc_PRKX_like |
| cd14004 | 375-617 | STKc_PASK |
| cd14167 | 420-563 | STKc_CaMKI_alpha |
| cd14053 | 427-567 | STKc_ACVR2 |
| cd08218 | 411-617 | STKc_Nek1 |
| cd10415 | 163-263 | SH2_Grb10 |
| cd06634 | 375-560 | STKc_TAO2 |
| cd05587 | 447-575 | STKc_cPKC |
| cd07862 | 376-575 | STKc_CDK6 |
| cd06635 | 375-560 | STKc_TAO1 |
| cd14087 | 420-573 | STKc_PSKH1 |
| cd14187 | 411-589 | STKc_PLK1 |
| cd14176 | 375-573 | STKc_RSK2_C |
| cd07857 | 446-572 | STKc_MPK1 |
| cd10352 | 169-251 | SH2_a2chimerin_b2chimerin |
| cd05603 | 375-631 | STKc_SGK2 |
| cd10414 | 163-244 | SH2_Grb14 |
| cd10413 | 14-104 | SH2_Grb7 |
| cd14117 | 368-580 | STKc_Aurora-B_like |
| cd07833 | 405-564 | STKc_CDKL |
| cd09940 | 167-244 | SH2_Vav_family |
| cd13985 | 375-627 | STKc_GAK_like |
| cd10344 | 17-102 | SH2_SLAP |
| cd05632 | 377-577 | STKc_GRK5 |
| cd09944 | 14-66 | SH2_Grb7_family |
| cd10400 | 164-227 | SH2_SAP1a |
| cd14175 | 375-573 | STKc_RSK1_C |
| cd06658 | 414-573 | STKc_PAK5 |
| cd09931 | 168-245 | SH2_C-SH2_SHP_like |
| cd08221 | 442-617 | STKc_Nek9 |
| cd14163 | 375-622 | STKc_TSSK3-like |
| cd07871 | 376-564 | STKc_PCTAIRE3 |
| cd13993 | 377-562 | STKc_Pat1_like |
| cd07852 | 423-563 | STKc_MAPK15-like |
| cd13975 | 478-630 | PKc_Dusty |
| cd14178 | 375-573 | STKc_RSK3_C |
| cd10413 | 163-244 | SH2_Grb7 |
| cd07880 | 456-575 | STKc_p38gamma |
| cd07873 | 376-564 | STKc_PCTAIRE1 |
| cd07878 | 468-564 | STKc_p38beta |
| cd05607 | 373-577 | STKc_GRK7 |
| cd14089 | 430-563 | STKc_MAPKAPK |
| cd06607 | 416-560 | STKc_TAO |
| cd10367 | 15-106 | SH2_Src_Fgr |
| cd06624 | 477-588 | STKc_ASK |
| cd10366 | 168-256 | SH2_Src_Yes |
| cd05617 | 415-573 | STKc_aPKC_zeta |
| cd10348 | 15-99 | SH2_Cterm_shark_like |
| cd07864 | 420-607 | STKc_CDK12 |
| cd14043 | 481-619 | PK_GC-2D |
| cd14091 | 376-573 | STKc_RSK_C |
| cd07877 | 468-564 | STKc_p38alpha |
| cd07879 | 465-575 | STKc_p38delta |
| cd14056 | 375-564 | STKc_TGFbR_I |
| cd14199 | 415-573 | STKc_CaMKK2 |
| cd14119 | 420-617 | STKc_LKB1 |
| cd14170 | 430-592 | STKc_MAPKAPK2 |
| cd10418 | 15-106 | SH2_Src_Fyn_isoform_a_like |
| cd05613 | 420-573 | STKc_MSK1_N |
| cd14115 | 414-573 | STKc_Kalirin_C |
| cd14184 | 375-574 | STKc_DCKL2 |
| cd05609 | 403-575 | STKc_MAST |
| cd09930 | 163-246 | SH2_cSH2_p85_like |
| cd05614 | 420-573 | STKc_MSK2_N |
| cd05574 | 375-575 | STKc_phototropin_like |
| cd10358 | 167-261 | SH2_PTK6_Brk |
| cd05631 | 377-577 | STKc_GRK4 |
| cd07835 | 420-564 | STKc_CDK1_CdkB_like |
| cd14174 | 369-580 | STKc_Mnk1 |
| cd09941 | 14-76 | SH2_Grb2_like |
| cd07849 | 465-567 | STKc_ERK1_2_like |
| cd14049 | 377-566 | STKc_EIF2AK1_HRI |
| cd14169 | 420-561 | STKc_CaMKI_beta |
| cd14140 | 440-567 | STKc_ACVR2b |
| cd06615 | 375-564 | PKc_MEK |
| cd07856 | 411-564 | STKc_Sty1_Hog1 |
| cd14152 | 473-620 | STKc_KSR1 |
| cd09934 | 164-260 | SH2_Tec_family |
| cd05630 | 377-601 | STKc_GRK6 |
| cd09931 | 16-109 | SH2_C-SH2_SHP_like |
| cd05593 | 375-573 | STKc_PKB_gamma |
| cd07845 | 418-586 | STKc_CDK10 |
| cd10347 | 13-68 | SH2_Nterm_shark_like |
| cd05577 | 377-577 | STKc_GRK |
| cd07841 | 374-564 | STKc_CDK7 |
| cd14107 | 375-563 | STKc_obscurin_rpt1 |
| cd06657 | 414-573 | STKc_PAK4 |
| cd07847 | 410-564 | STKc_CDKL1_4 |
| cd05604 | 417-573 | STKc_SGK3 |
| cd14177 | 403-573 | STKc_RSK4_C |
| cd14085 | 420-563 | STKc_CaMKIV |
| cd14104 | 465-614 | STKc_Titin |
| cd10354 | 167-244 | SH2_Cterm_RasGAP |
| cd14109 | 412-588 | PK_Unc-89_rpt1 |
| cd07851 | 446-564 | STKc_p38 |
| cd07858 | 474-572 | STKc_TEY_MAPK |
| cd14001 | 405-564 | PKc_TOPK |
| cd07872 | 375-567 | STKc_PCTAIRE2 |
| cd07869 | 375-600 | STKc_PFTAIRE1 |
| cd14182 | 413-594 | STKc_PhKG1 |
| cd14173 | 440-595 | STKc_Mnk2 |
| cd07830 | 375-567 | STKc_MAK_like |
| cd14189 | 411-563 | STKc_PLK3 |
| cd05594 | 367-573 | STKc_PKB_alpha |
| cd05602 | 375-581 | STKc_SGK1 |
| cd05583 | 418-564 | STKc_MSK_N |
| cd10364 | 164-258 | SH2_Src_Lyn |
| cd10411 | 167-244 | SH2_SH2B2 |
| cd14183 | 420-575 | STKc_DCKL1 |
| cd10398 | 164-258 | SH2_Tec_Txk |
| cd14050 | 418-617 | PKc_Myt1 |
| cd13968 | 403-514 | PKc_like |
| cd10368 | 15-106 | SH2_Src_Fyn |
| cd07854 | 410-564 | STKc_MAPK4_6 |
| cd14188 | 411-617 | STKc_PLK2 |
| cd10406 | 163-244 | SH2_Vav2 |
| cd05589 | 478-581 | STKc_PKN |
| cd14229 | 377-593 | STKc_HIPK3 |
| cd05591 | 375-573 | STKc_nPKC_epsilon |
| cd05605 | 477-577 | STKc_GRK4_like |
| cd05571 | 375-564 | STKc_PKB |
| cd07861 | 375-564 | STKc_CDK1_euk |
| cd13991 | 427-557 | STKc_NIK |
| cd09943 | 167-244 | SH2_Nck_family |
| cd10414 | 14-66 | SH2_Grb14 |
| cd14031 | 374-573 | STKc_WNK3 |
| cd10417 | 167-261 | SH2_SH2D7 |
| cd09934 | 16-106 | SH2_Tec_family |
| cd14180 | 446-578 | STKc_MSK2_C |
| cd07860 | 420-564 | STKc_CDK2_3 |
| cd14074 | 374-593 | STKc_SNRK |
| cd07853 | 456-567 | STKc_NLK |
| cd06637 | 446-564 | STKc_TNIK |
| cd10340 | 15-108 | SH2_N-SH2_SHP_like |
| cd10365 | 15-99 | SH2_Src_Src |
| cd14011 | 416-574 | PK_SCY1_like |
| cd07859 | 417-564 | STKc_TDY_MAPK |
| cd05633 | 377-577 | STKc_GRK3 |
| cd14088 | 420-573 | STKc_CaMK_like |
| cd10354 | 14-92 | SH2_Cterm_RasGAP |
| cd05573 | 419-573 | STKc_ROCK_NDR_like |
| cd07839 | 376-570 | STKc_CDK5 |
| cd05598 | 375-573 | STKc_LATS |
| cd13988 | 420-578 | STKc_TBK1 |
| cd14141 | 440-564 | STKc_ACVR2a |
| cd13986 | 416-617 | STKc_16 |
| cd14086 | 374-563 | STKc_CaMKII |
| cd13977 | 434-563 | STKc_PDIK1L |
| cd10343 | 14-109 | SH2_SHIP |
| cd10363 | 15-106 | SH2_Src_HCK |
| cd14142 | 444-564 | STKc_ACVR1_ALK1 |
| cd07875 | 474-621 | STKc_JNK1 |
| cd14185 | 375-574 | STKc_DCKL3 |
| cd10371 | 15-106 | SH2_Src_Blk |
| cd05627 | 419-623 | STKc_NDR2 |
| cd14045 | 420-623 | PK_GC_unk |
| cd05610 | 375-517 | STKc_MASTL |
| cd10360 | 14-92 | SH2_Srm |
| cd06653 | 417-572 | STKc_MEKK3_like_u1 |
| cd06636 | 446-564 | STKc_MAP4K4_6_N |
| cd05590 | 446-573 | STKc_nPKC_eta |
| cd09925 | 167-215 | SH2_SHC |
| cd14032 | 374-573 | STKc_WNK2_like |
| cd06652 | 417-572 | STKc_MEKK2 |
| cd05584 | 419-618 | STKc_p70S6K |
| cd07874 | 474-622 | STKc_JNK3 |
| cd14108 | 375-575 | STKc_SPEG_rpt1 |
| cd05606 | 423-633 | STKc_beta_ARK |
| cd13997 | 448-617 | PKc_Wee1_like |
| cd10350 | 167-219 | SH2_SH2D4A |
| cd10399 | 168-252 | SH2_Tec_Bmx |
| cd14046 | 373-569 | STKc_EIF2AK4_GCN2_rpt2 |
| cd07831 | 418-564 | STKc_MOK |
| cd14168 | 420-563 | STKc_CaMKI_delta |
| cd14090 | 429-580 | STKc_Mnk |
| cd10351 | 167-219 | SH2_SH2D4B |
| cd07876 | 474-622 | STKc_JNK2 |
| cd06651 | 417-572 | STKc_MEKK3 |
| cd10349 | 167-244 | SH2_SH2D2A_SH2D7 |
| cd10417 | 14-94 | SH2_SH2D7 |
| cd10419 | 15-99 | SH2_Src_Fyn_isoform_b_like |
| cd10415 | 15-109 | SH2_Grb10 |
| cd10349 | 14-92 | SH2_SH2D2A_SH2D7 |
| cd10340 | 168-253 | SH2_N-SH2_SHP_like |
| cd10398 | 19-106 | SH2_Tec_Txk |
| cd09940 | 12-107 | SH2_Vav_family |
| cd09943 | 14-91 | SH2_Nck_family |
| cd10366 | 15-99 | SH2_Src_Yes |
| cd10361 | Aug-92 | SH2_Fps_family |
| cd10400 | 13-75 | SH2_SAP1a |
| cd10350 | 14-95 | SH2_SH2D4A |
| cd10358 | 14-96 | SH2_PTK6_Brk |
| cd10341 | 14-73 | SH2_N-SH2_PLC_gamma_like |
| cd10351 | 14-95 | SH2_SH2D4B |
| cd09932 | 14-94 | SH2_C-SH2_PLC_gamma_like |
| cd10399 | 13-106 | SH2_Tec_Bmx |
| cd10352 | 16-64 | SH2_a2chimerin_b2chimerin |
| cd10411 | 14-94 | SH2_SH2B2 |
| pfam07714 | 374-626 | Pkinase_Tyr |
| smart00219 | 370-626 | TyrKc |
| smart00221 | 370-626 | STYKc |
| smart00220 | 375-620 | S_TKc |
| pfam00069 | 375-622 | Pkinase |
| COG0515 | 375-625 | SPS1 |
| PTZ00267 | 445-617 | PTZ00267 |
| PTZ00263 | 368-573 | PTZ00263 |
| PTZ00024 | 374-572 | PTZ00024 |
| PTZ00426 | 375-564 | PTZ00426 |
| PTZ00283 | 429-617 | PTZ00283 |
| PTZ00266 | 414-617 | PTZ00266 |
| PLN00034 | 410-617 | PLN00034 |
| PHA03209 | 414-568 | PHA03209 |
| TIGR03903 | 419-587 | TOMM_kin_cyc |
Ontology Information
| HPRD ID | 16051 |
|---|---|
| Molecular Class | Tyrosine kinase |
| Molecular Function | Structural constituent of cytoskeleton (GO:0005200) |
| Biological Process | Apoptosis (GO:0006915) |
Drug Information
No matching records could be found.