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General Information
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 24925595 | 2014 | Cell line : - Source : - Sample Type : CRC tumor and Blood sample No. of Sample : 150 CRC stage I-III, 3 blood sample Stage : TNM Stage I-III | methylation-specific PCR | Methylation | - | Levels of TAC1 and SEPT9 methylation detected in postoperative sera of patients with CRC appear to be novel promising prognostic markers and may probably be considered for monitoring of CRC recurrence. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Endogenous ligands |
| Description | This gene encodes four products of the tachykinin peptide hormone family, substance P and neurokinin A, as well as the related peptides, neuropeptide K and neuropeptide gamma. These hormones are thought to function as neurotransmitters which interact with nerve receptors and smooth muscle cells. They are known to induce behavioral responses and function as vasodilators and secretagogues. Substance P is an antimicrobial peptide with antibacterial and antifungal properties. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2014] |
| Chromosome | 7 |
| Location | 7q21-q22 |
| Start | 97361271 |
| End | 97369784 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 8514 |
| OMIM ID | 162320 |
| HGNC ID | HGNC:11517 |
| Unigene ID | Hs.2563 |
| Ensembl ID | ENSG00000006128 |
| PharmGKB ID | PA36297 |
mRNA Information
| mRNA ID | ?NM_003182.2 |
|---|---|
| Exon | join(1..237,646..777,1765..1861,2290..2334,2868..2891, 4341..4394,7916..8514) | mRNA Sequence | Download Select all |
| Length | 1188 |
Protein Information
| Protein ID | NP_003173.1 |
|---|---|
| Protein Name | tachykinin, precursor 1 |
| Molecular Wt. (Da) | 44311 |
| Protein Sequence | Download Select all |
| Length | 129 |
| Uniprot ID | Q9NSB8 |
| Ensembl Protein ID | ENSP00000305632 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| Q | Proteolytic Cleavage | 63 |
| F | Proteolytic Cleavage | 64 |
| F | Proteolytic Cleavage | 65 |
| G | Proteolytic Cleavage | 66 |
| Q | Proteolytic Cleavage | 63 |
| F | Proteolytic Cleavage | 64 |
| F | Proteolytic Cleavage | 65 |
| G | Proteolytic Cleavage | 66 |
| Q | Proteolytic Cleavage | 63 |
| F | Proteolytic Cleavage | 64 |
| F | Proteolytic Cleavage | 65 |
| G | Proteolytic Cleavage | 66 |
| Q | Proteolytic Cleavage | 63 |
| F | Proteolytic Cleavage | 64 |
| F | Proteolytic Cleavage | 65 |
| G | Proteolytic Cleavage | 66 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 2335 | FN1 | 626 | NP_997647.1 | in vitro | 11342427 |
| 6865 | TACR2 | 1207 | NP_001048.2 | in vivo | 796 163 610 189 055 |
| 6869 | TACR1 | 1208 | NP_001049.1 | in vivo | 12548712 |
| 6870 | TACR3 | 1209 | NP_001050.1 | in vivo | 9272936 |
| 7917 | BAT3 | 808 | NP_004630.3 | yeast 2-hybrid | 16169070 |
| 55701 | - | 13335 | NP_060541.3 | yeast 2-hybrid | 16169070 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
No matching records could be found.
Ontology Information
| HPRD ID | 4922 |
|---|---|
| Molecular Class | Unclassified |
| Molecular Function | Protein serine/threonine kinase activity (GO:0004674) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.