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General Information
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 22733436 | 2012 | Cell line : - Source : - Sample Type : Population-based case-control study No. of Sample : 395 cases and 393 cancer-free controls. Stage : - | SNPshot assay, Multiple logistic regression models. | Polymorhpism | - | 5 polymorphisms: rs2072100 (TAC1), rs10198644 (TACR1), rs2193409 (TACR1), rs3771810 (TACR1), and rs4644560 (TACR2). |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | GPCR / Class A : Tachykinin receptors |
| Description | This gene belongs to a gene family of tachykinin receptors. These tachykinin receptors are characterized by interactions with G proteins and contain seven hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin substance P, also referred to as neurokinin 1. The encoded protein is also involved in the mediation of phosphatidylinositol metabolism of substance P. [provided by RefSeq, Sep 2008] |
| Chromosome | 2 |
| Location | 2p13.1-p12 |
| Start | 75273590 |
| End | 75426645 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 153056 |
| OMIM ID | 162323 |
| HGNC ID | HGNC:11526 |
| Unigene ID | Hs.633301 |
| Ensembl ID | ENSG00000115353 |
| PharmGKB ID | PA36302 |
mRNA Information
| mRNA ID | ?NM_001058.3 |
|---|---|
| Exon | join(1..974,78752..78946,145765..145915,148073..148269, 149797..153057) | mRNA Sequence | Download Select all |
| Length | 4795 |
Protein Information
| Protein ID | NP_001049.1 |
|---|---|
| Protein Name | tachykinin receptor 1 |
| Molecular Wt. (Da) | 77048 |
| Protein Sequence | Download Select all |
| Length | 407 |
| Uniprot ID | O75116 |
| Ensembl Protein ID | ENSP00000317985 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Calcium signaling pathway | hsa04020 |
| Measles | hsa05162 |
| Neuroactive ligand-receptor interaction | hsa04080 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam00001 | 55-305 | 7tm_1 |
| PHA02638 | 56-321 | PHA02638 |
| PHA03087 | 56-331 | PHA03087 |
| PHA02834 | 57-320 | PHA02834 |
Ontology Information
| HPRD ID | 2202 |
|---|---|
| Molecular Class | G protein coupled receptor |
| Molecular Function | Protein binding (GO:0005515) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165); Apoptosis (GO:0006915) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| P25103 | DB00673 | Aprepitant | SmallMoleculeDrug |
| P25103 | DB01221 | Ketamine | SmallMoleculeDrug |
| P25103 | DB04894 | Vapreotide | SmallMoleculeDrug |
| P25103 | DB09048 | Netupitant | SmallMoleculeDrug |