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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| KLF5 | 688 | Kruppel-like factor 5 (intestinal) | 13 | IKLF, CKLF |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 21885866 | 2011 | Cell line : DLD 1, IEC 6 Source : ATCC Sample Type : - No. of Sample : - Stage : - | Ultrahigh-Throughput Screen ,Western Blotting,Cell Viability Assay | Up-regulation | - | - |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Kruppel-like transcription factors, "Zinc fingers, C2H2-type" |
| Description | This gene encodes a member of the Kruppel-like factor subfamily of zinc finger proteins. The encoded protein is a transcriptional activator that binds directly to a specific recognition motif in the promoters of target genes. This protein acts downstream of multiple different signaling pathways and is regulated by post-translational modification. It may participate in both promoting and suppressing cell proliferation. Expression of this gene may be changed in a variety of different cancers and in cardiovascular disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013] |
| Chromosome | 13 |
| Location | 13q21.3 |
| Start | 73629114 |
| End | 73651676 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 22563 |
| OMIM ID | 602903 |
| HGNC ID | HGNC:6349 |
| Unigene ID | Hs.508234 |
| Ensembl ID | ENSG00000102554 |
| PharmGKB ID | PA30139 |
mRNA Information
| mRNA ID | NM_001286818.1 |
|---|---|
| Exon | join(1..183,6886..7759,8849..8908,20733..22567) | mRNA Sequence | Download Select all |
| Length | 2969 |
Protein Information
| Protein ID | NP_001273747.1 |
|---|---|
| Protein Name | Kruppel-like factor 5 (intestinal) |
| Molecular Wt. (Da) | 41049 |
| Protein Sequence | Download Select all |
| Length | 366 |
| Uniprot ID | P26927 |
| Ensembl Protein ID | ENSP00000373234 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 153 |
| K | Acetylation | 369 |
| S | Phosphorylation | 116 |
| S | Phosphorylation | 441 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 1387 | CREBBP | 2534 | NP_004371.2 | in vitro | 12682370 |
| 2961 | GTF2E2 | 1800 | NP_002086.1 | in vitro | 9089417 |
| 2963 | GTF2F2 | 1804 | NP_004119.1 | in vitro | 9089417 |
| 4790 | NFKB1 | 1238 | NP_003989.2 | in vitro;in vivo | 14573617 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam13465 | 419-444 | zf-H2C2_2 |
| cl22375 | 419-444 | zf-H2C2_2 superfamily |
| pfam00096 | 433-455 | zf-C2H2 |
| cl23491 | 433-455 | zf-C2H2 superfamily |
| pfam13465 | 389-406 | zf-H2C2_2 |
| cl22375 | 389-406 | zf-H2C2_2 superfamily |
| COG5048 | 359-433 | COG5048 |
| COG5048 | 155-451 | COG5048 |
| COG5189 | 360-453 | SFP1 |
Ontology Information
| HPRD ID | 11827 |
|---|---|
| Molecular Class | Transcription factor |
| Molecular Function | Molecular function unknown (GO:0005554) |
| Biological Process | Biological_process unknown (GO:0000004) |
Drug Information
No matching records could be found.