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General Information
- Evidence
- Gene
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- Protein
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- Enzyme
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 23532689 | 2013 | Cell line : - Source : - Sample Type : CRC tumor and Normal tissue No. of Sample : 156 CRCs, the corresponding 42 distant, 96 adjacent normal mucosa, 35 lymph node metastases Stage : TNM Stage III,IV | Immunohistochemistry | Up-regulation | - | BTF3 overexpression may be an early event in CRC development and could be useful biomarker for the early stage of CRCs. BTF3 staining significantly increased from distant or adjacent normal mucosa to primary CRCs (p < 0.0001) or metastases (p = 0.002 and p < 0.0001). |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | |
| Description | This gene encodes the basic transcription factor 3. This protein forms a stable complex with RNA polymerase IIB and is required for transcriptional initiation. Alternative splicing results in multiple transcript variants encoding different isoforms. This gene has multiple pseudogenes. |
| Chromosome | 5 |
| Location | 5q13.3 |
| Start | 73498425 |
| End | 73505623 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 7199 |
| OMIM ID | 602542 |
| HGNC ID | HGNC:1125 |
| Unigene ID | Hs.591768 |
| Ensembl ID | ENSG00000145741 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_001037637.1 |
|---|---|
| Exon | join(1..375,710..778,4064..4177,4492..4693,5923..5979, 6768..7199) | mRNA Sequence | Download Select all |
| Length | 1262 |
CDS Information
| Location | join(244..375,710..778,4064..4177,4492..4693,5923..5979, 6768..6814) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS34185.1 |
Protein Information
| Protein ID | NP_001032726.1 |
|---|---|
| Protein Name | basic transcription factor 3 |
| Molecular Wt. (Da) | 22037 |
| Protein Sequence | Download Select all |
| Length | 206 |
| Uniprot ID | P29992 |
| Ensembl Protein ID | ENSP00000078429 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 30;- |
| S | Phosphorylation | 30;- |
| S | Phosphorylation | 201 |
| S | Phosphorylation | 157 |
| S | Phosphorylation | 201 |
| S | Phosphorylation | 101 |
| S | Phosphorylation | 57 |
| S | Phosphorylation | 101 |
| T | Phosphorylation | 160 |
| T | Phosphorylation | 116 |
| T | Phosphorylation | 160 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 1460 | CSNK2B | 278 | NP_001311.3 | in vitro;yeast 2-hybrid | 10094400 |
| 5431 | POLR2B | 15943 | NP_000929.1 | in vitro | 2320128 |
Pathway Information
No matching records could be found.
Structure Information
| PDB ID | 3LKX |
|---|---|
| Resolution | 2.5 |
| Method | X-RAY DIFFRACTION |
| Chains | A |
| Molecule | Transcription factor BTF3 |
| Model | View |
Ontology Information
| HPRD ID | 2936 |
|---|---|
| Molecular Class | Transcription factor |
| Molecular Function | G-protein coupled receptor activity (GO:0004930) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.