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General Information
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
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- Domain
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 23959449 | 2013 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | - | Up-regulation | - | TBX2 could serve as a potential target of cancer drug therapy. TBX2 was up-regulated in CRC in comparison with the corresponding normal mucosa at transcriptional and protein level. Up-expression of TBX2 was significantly associated with depth of tumor invasion (P = 0.006), distant metastasis (P = 0.038), advanced AJCC stage (P = 0.008), and relapse (P = 0.003). |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | T-boxes |
| Description | This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene product is the human homolog of mouse Tbx2, and shares strong sequence similarity with Drosophila omb protein. Expression studies indicate that this gene may have a potential role in tumorigenesis as an immortalizing agent. Transcript heterogeneity due to alternative polyadenylation has been noted for this gene. |
| Chromosome | 17 |
| Location | 17q23.2 |
| Start | 61394698 |
| End | 61409466 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 14769 |
| OMIM ID | 600747 |
| HGNC ID | HGNC:11597 |
| Unigene ID | Hs.531085 |
| Ensembl ID | ENSG00000121068 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | XM_011525158.1 |
|---|---|
| Exon | join(1..792,3828..5874,6987..7254,8364..8510,9724..9800, 9909..10072,10505..11139,13357..14769) | mRNA Sequence | Download Select all |
| Length | 3396 |
CDS Information
| Location | join(5480..5874,6987..7254,8364..8510,9724..9800, 9909..10072,10505..11139,13357..13809) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS11627.2 |
Protein Information
| Protein ID | NP_005985.3 |
|---|---|
| Protein Name | T-box 2 |
| Molecular Wt. (Da) | 74935 |
| Protein Sequence | Download Select all |
| Length | 712 |
| Uniprot ID | P17181 |
| Ensembl Protein ID | ENSP00000270139 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 1482 | NKX2-5 | 2787 | NP_004378.1 | in vitro | 12023302 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00182 | 104-289 | TBOX |
| cl00145 | 104-289 | TBOX superfamily |
| pfam00907 | 106-287 | T-box |
| smart00425 | 105-292 | TBOX |
| pfam12598 | 305-382 | TBX |
| cl13973 | 305-382 | TBX superfamily |
| pfam04094 | 282-441 | DUF390 |
| PHA03307 | 300-467 | PHA03307 |
| pfam05466 | 287-411 | BASP1 |
| pfam11600 | 355-445 | CAF-1_p150 |
| PHA03375 | 306-409 | PHA03375 |
| PRK07003 | 313-389 | PRK07003 |
| PRK12323 | 313-476 | PRK12323 |
| PLN02543 | 299-416 | PLN02543 |
| PHA03307 | 292-435 | PHA03307 |
| pfam08648 | 348-449 | DUF1777 |
Ontology Information
| HPRD ID | 932 |
|---|---|
| Molecular Class | Transcription regulatory protein |
| Molecular Function | Transmembrane receptor protein tyrosine kinase activity (GO:0004714) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.