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General Information
- Evidence
- Gene
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- Protein
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- Enzyme
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 25628943 | 2014 | Cell line : - Source : Department of General surgery, Shanghai Sixth Peoples Hospital Affiliated to Shanghai Jiaotong University. Sample Type : CRC tumor and normal tissue No. of Sample : 30 Stage : - | Immunohistochemistry,real time RT-PCR and western blotting | Up-regulation | - | Tbx3 may promote CRC progression by involving EMT program. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | T-boxes |
| Description | This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This protein is a transcriptional repressor and is thought to play a role in the anterior/posterior axis of the tetrapod forelimb. Mutations in this gene cause ulnar-mammary syndrome, affecting limb, apocrine gland, tooth, hair, and genital development. Alternative splicing of this gene results in three transcript variants encoding different isoforms; however, the full length nature of one variant has not been determined. [provided by RefSeq, Jul 2008] |
| Chromosome | 12 |
| Location | 12q24.21 |
| Start | 115108059 |
| End | 115121969 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 13911 |
| OMIM ID | 601621 |
| HGNC ID | HGNC:11602 |
| Unigene ID | Hs.744016 |
| Ensembl ID | ENSG00000135111 |
| PharmGKB ID | PA36365 |
mRNA Information
| mRNA ID | ?NM_005996.3 |
|---|---|
| Exon | join(1..1353,3019..3286,4514..4660,6509..6585,7695..7852, 9330..10000,11863..13911) | mRNA Sequence | Download Select all |
| Length | 4754 |
Protein Information
| Protein ID | NP_005987.3 |
|---|---|
| Protein Name | T-box 3 |
| Molecular Wt. (Da) | 67469 |
| Protein Sequence | Download Select all |
| Length | 743 |
| Uniprot ID | O43529 |
| Ensembl Protein ID | ENSP00000264249 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 707;- |
| S | Phosphorylation | 687;- |
| S | Phosphorylation | 456;- |
| S | Phosphorylation | 436;- |
| S | Phosphorylation | 371 |
| S | Phosphorylation | 381 |
| S | Phosphorylation | 351 |
| S | Phosphorylation | 361 |
| S | Phosphorylation | 738 |
| S | Phosphorylation | 740 |
| S | Phosphorylation | 742 |
| S | Phosphorylation | 718 |
| S | Phosphorylation | 720 |
| S | Phosphorylation | 722 |
| S | Phosphorylation | 375 |
| S | Phosphorylation | 355 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Signaling pathways regulating pluripotency of stem cells | hsa04550 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00182 | 104-307 | TBOX |
| cl00145 | 104-307 | TBOX superfamily |
| pfam00907 | 104-305 | T-box |
| smart00425 | 104-310 | TBOX |
| pfam12598 | 323-411 | TBX |
| cl13973 | 323-411 | TBX superfamily |
| pfam05466 | 324-491 | BASP1 |
Ontology Information
| HPRD ID | 2239 |
|---|---|
| Molecular Class | Transcription regulatory protein |
| Molecular Function | MHC class I receptor activity (GO:0030106); MHC class II receptor activity (GO:0045012) |
| Biological Process | Immune response (GO:0006955) |
Drug Information
No matching records could be found.