Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| HNF1B | 6928 | HNF1 homeobox B | 17 | FJHN; HNF2; LFB3; TCF2; HPC11; LF-B3; MODY5; TCF-2; VHNF1; HNF-1B; HNF1beta |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 21922590 | 2012 | Cell line : - Source : Helsinki and Turku University Central Hospital. Sample Type : CRC tumor and normal tissue No. of Sample : 60 patients with metastatic CRC Stage : TNM Stage IV | Agilent's miRNA microarrays, real time RT-PCR | Down-regulation | - | Potential target genes of Upregulated miR-92a include RGS3, HNF1B, TMF, and MIA3 which involved in apoptosis. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Homeoboxes / HNF class |
| Description | This gene encodes a member of the homeodomain-containing superfamily of transcription factors. The protein binds to DNA as either a homodimer, or a heterodimer with the related protein hepatocyte nuclear factor 1-alpha. The gene has been shown to function in nephron development, and regulates development of the embryonic pancreas. Mutations in this gene result in renal cysts and diabetes syndrome and noninsulin-dependent diabetes mellitus, and expression of this gene is altered in some types of cancer. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009] |
| Chromosome | 17 |
| Location | 17q12 |
| Start | 37686431 |
| End | 37745078 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 58648 |
| OMIM ID | 189907 |
| HGNC ID | HGNC:11630 |
| Unigene ID | Hs.191144 |
| Ensembl ID | ENSG00000108753 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_001304286.1 |
|---|---|
| Exon | join(1..538,5440..5639,11336..11522,13249..13484, 34416..34576,40030..40162,57687..58648) | mRNA Sequence | Download Select all |
| Length | 2432 |
CDS Information
| Location | join(195..538,5440..5639,11336..11522,13249..13484, 34416..34576,40030..40162,57687..57799) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | - |
Protein Information
| Protein ID | NP_000449.1 |
|---|---|
| Protein Name | HNF1 homeobox B |
| Molecular Wt. (Da) | 61193 |
| Protein Sequence | Download Select all |
| Length | 557 |
| Uniprot ID | Q08211 |
| Ensembl Protein ID | ENSP00000356520 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 466 | ATF1 | 440 | NP_005162.1 | in vitro | 9671480 |
| 6927 | HNF1A | 800 | NP_000536.5 | in vitro | 2044952 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Maturity onset diabetes of the young | hsa04950 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00086 | 232-305 | homeodomain |
| cl00084 | 232-305 | homeodomain superfamily |
| pfam04812 | 314-551 | HNF-1B_C |
| cl04770 | 314-551 | HNF-1B_C superfamily |
| smart00389 | 231-305 | HOX |
| pfam00046 | 232-304 | Homeobox |
| pfam04814 | 1-182 | HNF-1_N |
| pfam09770 | 410-519 | PAT1 |
| pfam09770 | 382-532 | PAT1 |
Ontology Information
| HPRD ID | 3670 |
|---|---|
| Molecular Class | Transcription factor |
| Molecular Function | Cytoskeletal protein binding (GO:0008092) |
| Biological Process | Cell growth and/or maintenance (GO:0008151) |
Drug Information
No matching records could be found.