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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| TCF3 | 6929 | transcription factor 3 | 19 | E2A, ITF1, MGC129647, MGC129648, bHLHb21, VDIR, E47 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 25375219 | 2014 | Cell line : - Source : Fudan University Shanghai Cancer Center (Shanghai, China). Sample Type : CRC tumor and normal tissue No. of Sample : 64 Stage : TNM Stage II,III | real time RT-PCR, immunohistochemistry,Kaplan-Meier analyses,Bisulfite genomic sequencing ,Methylation specific PCR | Up-regulation/ hypomethylated | - | The up-regulation of TCF3, which is mainly caused by promoter hypomethylation, is one of the molecular mechanisms involved in the development and progression of CRC. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Basic helix-loop-helix proteins |
| Description | This gene encodes a member of the E protein (class I) family of helix-loop-helix transcription factors. E proteins activate transcription by binding to regulatory E-box sequences on target genes as heterodimers or homodimers, and are inhibited by heterodimerization with inhibitor of DNA-binding (class IV) helix-loop-helix proteins. E proteins play a critical role in lymphopoiesis, and the encoded protein is required for B and T lymphocyte development. Deletion of this gene or diminished activity of the encoded protein may play a role in lymphoid malignancies. This gene is also involved in several chromosomal translocations that are associated with lymphoid malignancies including pre-B-cell acute lymphoblastic leukemia (t(1;19), with PBX1), childhood leukemia (t(19;19), with TFPT) and acute leukemia (t(12;19), with ZNF384). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 9. [provided by RefSeq, Sep 2011] |
| Chromosome | 19 |
| Location | 19p13.3 |
| Start | 1609289 |
| End | 1652328 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 43040 |
| OMIM ID | 147141 |
| HGNC ID | HGNC:11633 |
| Unigene ID | Hs.371282 |
| Ensembl ID | ENSG00000071564 |
| PharmGKB ID | PA164742580 |
mRNA Information
| mRNA ID | ?NM_001136139.2 |
|---|---|
| Exon | join(98..127,2140..2250,6000..6072,20022..20095, 20311..20389,25001..25068,26719..26851,28427..28476, 30012..30114,30204..30373,30457..30589,31236..31294, 31381..31459,32574..32647,32953..33111,33193..33316, 36606..36741,36907..37142,40578..43137) | mRNA Sequence | Download Select all |
| Length | 4451 |
Protein Information
| Protein ID | NP_001129611.1 |
|---|---|
| Protein Name | transcription factor 3 |
| Molecular Wt. (Da) | 42826 |
| Protein Sequence | Download Select all |
| Length | 654 |
| Uniprot ID | Q9Y5V3 |
| Ensembl Protein ID | ENSP00000325333 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| T | Phosphorylation | 355 |
| T | Phosphorylation | 355 |
| S | Phosphorylation | 379 |
| S | Phosphorylation | 381 |
| Y | Phosphorylation | 382 |
| S | Phosphorylation | 514 |
| S | Phosphorylation | 134 |
| S | Phosphorylation | 139 |
| S | Phosphorylation | 306 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 801 | CALM1 | 241 | NP_008819.1 | in vitro;in vivo | 10757985 |
| 808 | CALM3 | 243 | NP_005175.2 | in vitro;in vivo | 10757985 |
| 1387 | CREBBP | 2534 | NP_004371.2 | in vitro;in vivo;yeast 2-hybrid | 1 243 573 915 507 440 |
| 1499 | CTNNB1 | 286 | NP_001895.1 | in vivo | 1 210 726 315 327 760 |
| 56676 | ASCL3 | 18523 | NP_065697.1 | yeast 2-hybrid | 11784080 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| HTLV-I infection | hsa05166 |
| Signaling pathways regulating pluripotency of stem cells | hsa04550 |
| Transcriptional misregulation in cancer | hsa05202 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00083 | 547-607 | HLH |
| cl00081 | 547-607 | HLH superfamily |
| smart00353 | 555-608 | HLH |
| pfam00010 | 550-603 | HLH |
| pfam10243 | 486-564 | MIP-T3 |
| TIGR01622 | 474-574 | SF-CC1 |
Ontology Information
| HPRD ID | 5530 |
|---|---|
| Molecular Class | Transcription factor |
| Molecular Function | Metallopeptidase activity (GO:0008237) |
| Biological Process | Protein metabolism (GO:0019538) |
Drug Information
No matching records could be found.