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General Information
- Evidence
- Gene
- mRNA
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- Protein
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- Enzyme
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 20454457 | 2010 | Cell line : RKO, HCT116, SW480, SW837, Colo205, CaCo2 and DLD1b,CCD841 Source : ATCC Sample Type : - No. of Sample : Mouse model Stage : - | Chromatin immunoprecipitation,CGI microarray,ChIP-Chop analysis,MassARRAY analysis,Western blotting | Methylation | - | Analysis of tumor suppressor properties of two aberrantly methylated transcription factors, HOXB13 and TBX18, revealed that both inhibited growth and clonogenic survival of colon cancer cells in vitro. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Basic helix-loop-helix proteins |
| Description | TCF21 encodes a transcription factor of the basic helix-loop-helix family. The TCF21 product is mesoderm specific, and expressed in embryonic epicardium, mesenchyme-derived tissues of lung, gut, gonad, and both mesenchymal and glomerular epithelial cells in the kidney. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008] |
| Chromosome | 6 |
| Location | 6q23.2 |
| Start | 134210259 |
| End | 134216675 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 6417 |
| OMIM ID | 603306 |
| HGNC ID | HGNC:11632 |
| Unigene ID | Hs.78061 |
| Ensembl ID | ENSG00000118526 |
| PharmGKB ID | PA36387 |
mRNA Information
| mRNA ID | ?NM_003206.3 |
|---|---|
| Exon | join(1..727,2593..2690,4035..6417) | mRNA Sequence | Download Select all |
| Length | 3249 |
Protein Information
| Protein ID | NP_003197.2 |
|---|---|
| Protein Name | transcription factor 21 |
| Molecular Wt. (Da) | 41220 |
| Protein Sequence | Download Select all |
| Length | 179 |
| Uniprot ID | Q99988 |
| Ensembl Protein ID | ENSP00000252809 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 6929 | TCF3 | 918 | NP_003191.1 | in vitro;in vivo;yeast 2-hybrid | 11591653 |
| 8543 | LMO4 | 9122 | NP_006760.1 | yeast 2-hybrid | 15231748 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00083 | 77-136 | HLH |
| cl00081 | 77-136 | HLH superfamily |
| smart00353 | 85-136 | HLH |
| pfam00010 | 80-132 | HLH |
Ontology Information
| HPRD ID | 4860 |
|---|---|
| Molecular Class | Transcription factor |
| Molecular Function | Receptor signaling complex scaffold activity (GO:0030159) |
| Biological Process | Apoptosis (GO:0006915) |
Drug Information
No matching records could be found.