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General Information
- Evidence
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 22399500 | 2012 | Cell line : HCT116 Source : - Sample Type : - No. of Sample : - Stage : - | 2D gel electrophoresis, Peptide mass fingerprinting,SDS-PAGE and western blotting,Immunofluorescent staining and confocal microscopy | Unknown | - | - |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Heat Shock Proteins / Chaperonins |
| Description | The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants of this gene, encoding different isoforms, have been characterized. In addition, three pseudogenes that appear to be derived from this gene have been found. [provided by RefSeq, Jun 2010] |
| Chromosome | 6 |
| Location | 6q25-q27 |
| Start | 160199530 |
| End | 160212135 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 12606 |
| OMIM ID | 186980 |
| HGNC ID | HGNC:11655 |
| Unigene ID | Hs.363137 |
| Ensembl ID | ENSG00000120438 |
| PharmGKB ID | PA36406 |
mRNA Information
| mRNA ID | ?NM_030752.2 |
|---|---|
| Exon | complement(<10649..11045) | mRNA Sequence | Download Select all |
| Length | 1567 |
Protein Information
| Protein ID | NP_110379.2 |
|---|---|
| Protein Name | t-complex 1 |
| Molecular Wt. (Da) | 42813 |
| Protein Sequence | Download Select all |
| Length | 556 |
| Uniprot ID | P62380 |
| Ensembl Protein ID | ENSP00000237264 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 544;- |
| S | Phosphorylation | 389;- |
| K | Acetylation | 400 |
| K | Acetylation | 245 |
| K | Acetylation | 199 |
| K | Acetylation | 44 |
| K | Acetylation | 532 |
| K | Acetylation | 377 |
| S | Phosphorylation | 551 |
| S | Phosphorylation | 396 |
| C | S-Nitrosylation | 357 |
| C | S-Nitrosylation | 202 |
| S | Phosphorylation | 27 |
| S | Phosphorylation | 119 |
| Y | Phosphorylation | 121 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd03335 | 9-535 | TCP1_alpha |
| cl02777 | 9-535 | chaperonin_like superfamily |
| TIGR02340 | 5-540 | chap_CCT_alpha |
| cd00309 | 9-532 | chaperonin_type_I_II |
| cd03343 | 11-532 | cpn60 |
| pfam00118 | 28-532 | Cpn60_TCP1 |
| COG0459 | 9-541 | GroEL |
| cd03340 | 21-537 | TCP1_eta |
| TIGR02345 | 10-533 | chap_CCT_eta |
| cd03336 | 14-535 | TCP1_beta |
| PTZ00212 | 14-535 | PTZ00212 |
| cd03338 | 10-531 | TCP1_delta |
| cd03339 | 11-532 | TCP1_epsilon |
| TIGR02343 | 9-532 | chap_CCT_epsi |
| TIGR02342 | 8-531 | chap_CCT_delta |
| cd03337 | 11-531 | TCP1_gamma |
| TIGR02344 | 5-531 | chap_CCT_gamma |
| TIGR02341 | 9-538 | chap_CCT_beta |
| cd03341 | 21-531 | TCP1_theta |
| TIGR02346 | 20-535 | chap_CCT_theta |
| TIGR02347 | 21-532 | chap_CCT_zeta |
| cd03342 | 21-532 | TCP1_zeta |
| cd03333 | 145-405 | chaperonin_like |
| cd03334 | 169-424 | Fab1_TCP |
| cd03344 | 28-135 | GroEL |
| TIGR02348 | 28-135 | GroEL |
| PTZ00114 | 28-155 | PTZ00114 |
| PRK12849 | 29-97 | groEL |
| PLN03167 | 28-120 | PLN03167 |
| PRK00013 | 28-103 | groEL |
| CHL00093 | 18-525 | groEL |
| TIGR02339 | 11-531 | thermosome_arch |
| PRK12850 | 28-135 | groEL |
| PRK14104 | 28-536 | PRK14104 |
| PRK12851 | 18-130 | groEL |
| PRK12852 | 28-135 | groEL |
Ontology Information
| HPRD ID | 16049 |
|---|---|
| Molecular Class | Chaperone |
| Molecular Function | Chemokine activity (GO:0008009) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.