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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| TERT | 7015 | telomerase reverse transcriptase | 5 | TRT, TP2, TCS1, hEST2, EST2 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 23613397 | 2013 | Cell line : - Source : - Sample Type : Paraffin embedded primary colon adenocarcinomas No. of Sample : 60 Stage : - | Microarray, Immunohistochemistry | Up-regulation | - | c-MYC overexpression is correlated with progressive disease - due to colon adenocarcinoma dedifferentiation - inhibition of its activity combined with h-TERT regulated expression is a new target for novel therapeutic regimens. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | |
| Description | Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. Alternatively spliced variants encoding different isoforms of telomerase reverse transcriptase have been identified; the full-length sequence of some variants has not been determined. Alternative splicing at this locus is thought to be one mechanism of regulation of telomerase activity. |
| Chromosome | 5 |
| Location | 5p15.33 |
| Start | 1253167 |
| End | 1295047 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 41881 |
| OMIM ID | 187270 |
| HGNC ID | HGNC:11730 |
| Unigene ID | Hs.492203 |
| Ensembl ID | ENSG00000164362 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_001193376.1 |
|---|---|
| Exon | join(1..277,382..1735,12424..12619,14710..14890, 15578..15757,16252..16407,22768..22863,23844..23929, 26415..26528,28513..28584,34448..34574,36389..36450, 39637..39761,40543..40680,41217..41881) | mRNA Sequence | Download Select all |
| Length | 3829 |
CDS Information
| Location | join(59..277,382..1735,12424..12619,14710..14890, 15578..15757,16252..16407,22768..22863,23844..23929, 26415..26528,28513..28584,34448..34574,36389..36450, 39637..39761,40543..40680,41217..41320) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS54831.1 |
Protein Information
| Protein ID | NP_001180305.1 |
|---|---|
| Protein Name | telomerase reverse transcriptase |
| Molecular Wt. (Da) | 119917 |
| Protein Sequence | Download Select all |
| Length | 1069 |
| Uniprot ID | P08069 |
| Ensembl Protein ID | ENSP00000268035 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| Y | Phosphorylation | 707 |
| Y | Phosphorylation | 707 |
| S | Phosphorylation | 227 |
| S | Phosphorylation | 227 |
| S | Phosphorylation | 812 |
| T | Phosphorylation | 1101 |
| S | Phosphorylation | 1113 |
Enzyme Information
| EC | 2.7.7.49 |
|---|---|
| Name | RNA-directed DNA polymerase DNA nucleotidyltransferase (RNA-directed) reverse transcriptase revertase RNA-dependent deoxyribonucleate nucleotidyltransferase RNA revertase RNA-dependent DNA polymerase RNA-instructed DNA polymerase RT |
| Class | Transferases; Transferring phosphorus-containing groups; Nucleotidyltransferases |
| Sysname | deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (RNA-directed) |
| Substrate | deoxynucleoside triphosphate [CPD:C00677]; DNAn [CPD:C00039] |
| Product | diphosphate [CPD:C00013]; DNAn+1 [CPD:C00039] |
| Reaction (IUBMB) |  |
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 2475 | MTOR | 3134 | NP_004949.1 | in vivo | 15843522 |
| 2547 | XRCC6 | 1071 | NP_001460.1 | in vitro;in vivo | 12377759 |
| 3320 | HSP90AA1 | 777 | NP_001017963.2 | in vivo | 12586360 |
| 4691 | NCL | 1245 | NP_005372.2 | in vivo | 15371412 |
| 5578 | PRKCA | 1498 | NP_002728.1 | in vitro;in vivo | 9837921 |
| 5970 | RELA | 1241 | NP_068810.3 | in vitro;in vivo | 12517770 |
| 6198 | RPS6KB1 | 10202 | NP_003152.1 | in vivo | 15843522 |
| 10971 | YWHAQ | 886 | NP_006817.1 | in vitro;in vivo;yeast 2-hybrid | 10835362 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| HTLV-I infection | hsa05166 |
Structure Information
| PDB ID | 2BCK |
|---|---|
| Resolution | 2.8 |
| Method | X-RAY DIFFRACTION |
| Chains | C, F |
| Molecule | Telomerase reverse transcriptase |
| Model | View |
Domain Information
| ID | Location | Description |
|---|---|---|
| cd01648 | 825-936 | TERT |
| cl02808 | 825-936 | RT_like superfamily |
| smart00975 | 460-594 | Telomerase_RBD |
| cl13446 | 460-594 | Telomerase_RBD superfamily |
| pfam12009 | 459-594 | Telomerase_RBD |
| cd01651 | 830-910 | RT_G2_intron |
| cd01646 | 830-908 | RT_Bac_retron_I |
| cd01650 | 618-729 | RT_nLTR_like |
| cl02808 | 618-729 | RT_like superfamily |
| cd03487 | 832-905 | RT_Bac_retron_II |
| pfam00078 | 811-905 | RVT_1 |
Ontology Information
| HPRD ID | 897 |
|---|---|
| Molecular Class | Reverse transcriptase |
| Molecular Function | Cell adhesion molecule activity (GO:0005194) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| O14746 | DB00495 | Zidovudine | SmallMoleculeDrug |