Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| TFAP2A | 7020 | transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) | 6 | AP-2 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 11429425 | 2001 | Cell line : - Source : Kuopio University Hospital Sample Type : CRC tumor and normal tissue No. of Sample : CRC 30 and normal tissue 13 Stage : - | RT-PCR,in situ hybridisation,immunohistochemistry | Up-regulation | - | - |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | The protein encoded by this gene is a transcription factor that binds the consensus sequence 5'-GCCNNNGGC-3'. The encoded protein functions as either a homodimer or as a heterodimer with similar family members. This protein activates the transcription of some genes while inhibiting the transcription of others. Defects in this gene are a cause of branchiooculofacial syndrome (BOFS). Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Dec 2009] |
| Chromosome | 6 |
| Location | 6p24.3 |
| Start | 10393419 |
| End | 10419797 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 26379 |
| OMIM ID | 107580 |
| HGNC ID | HGNC:11742 |
| Unigene ID | Hs.519880 |
| Ensembl ID | ENSG00000137203 |
| PharmGKB ID | PA36459 |
mRNA Information
| mRNA ID | ?NM_001032280.2 |
|---|---|
| Exon | join(1..53,9290..9343,9487..9724,12781..12832, 14886..15117,17015..17133,19036..19177,20920..22948) | mRNA Sequence | Download Select all |
| Length | 2919 |
Protein Information
| Protein ID | NP_001027451.1 |
|---|---|
| Protein Name | transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 437 |
| Uniprot ID | Q15007 |
| Ensembl Protein ID | ENSP00000336911 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| D | Proteolytic Cleavage | 19 |
| D | Proteolytic Cleavage | 19 |
| D | Proteolytic Cleavage | 19 |
| D | Proteolytic Cleavage | 13 |
| D | Proteolytic Cleavage | 13 |
| D | Proteolytic Cleavage | 13 |
| S | Phosphorylation | 185 |
| S | Phosphorylation | 179 |
| S | Phosphorylation | 181 |
| S | Phosphorylation | 187 |
| S | Phosphorylation | 181 |
| S | Phosphorylation | 183 |
| S | Phosphorylation | 225 |
| S | Phosphorylation | 219 |
| S | Phosphorylation | 221 |
| S | Phosphorylation | 239 |
| S | Phosphorylation | 233 |
| S | Phosphorylation | 235 |
| S | Phosphorylation | 222 |
| S | Phosphorylation | 216 |
| S | Phosphorylation | 218 |
| S | Phosphorylation | 223 |
| S | Phosphorylation | 217 |
| S | Phosphorylation | 219 |
| T | Phosphorylation | 224 |
| T | Phosphorylation | 218 |
| T | Phosphorylation | 220 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 324 | APC | 1439 | NP_000029.2 | in vitro;in vivo | 15331612 |
| 1499 | CTNNB1 | 286 | NP_001895.1 | in vivo | 15331612 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam03299 | 209-414 | TF_AP-2 |
| cl03992 | 209-414 | TF_AP-2 superfamily |
Ontology Information
| HPRD ID | 9997 |
|---|---|
| Molecular Class | Transcription factor |
| Molecular Function | Transcription factor activity (GO:0003700) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
No matching records could be found.