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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
NR2F2 7026 nuclear receptor subfamily 2, group F, member 2  15COUP-TFII, COUPTFB, SVP40, NF-E3 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
25032732   2014Cell line : -

Source : -

Sample Type : -

No. of Sample : -

Stage : -

Immunostaining, immunoblotting and real time RT-PCRUp-regulation-Chicken ovalbumin upstream promoter-transcription factor II was found to be a biomarker associated with patient survival and colorectal cancer metastasis.

Overexpression of COUP-TFII was required for cancer cells to metastasise in vivo.

19082449   2009Cell line : -

Source : Dong-A University Hospital

Sample Type : CRC tumor and normal tissue

No. of Sample : 95

Stage : -

ImmunohistochemistryUp-regulation-COUP-TFII may represent a biomarker for good prognosis in colorectal cancer.

ositive COUP-TFII protein expression was detected in 57.89% of colorectal cancers.


Gene Details



Chromosome 15 - NC_000015.1096325928..96340263)

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Gene Type protein coding
Gene Family Nuclear hormone receptors
Description This gene encodes a member of the steroid thyroid hormone superfamily of nuclear receptors. The encoded protein is a ligand inducible transcription factor that is involved in the regulation of many different genes. Alternate splicing results in multiple transcript variants.  
Chromosome 15
Location 15q26
Start 96325928  
End 96340263  
Strand +  
Gene Sequence

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Length 14336  
OMIM ID 107773   
HGNC ID HGNC:7976   
Unigene ID Hs.347991   
Ensembl ID ENSG00000185551   
PharmGKB ID -   

mRNA Information


mRNA ID NM_001145155.1
Exon join(1..425,8149..8676,11421..14336)  
mRNA Sequence

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Length 3869  



CDS Information


   
Locationjoin(383..425,8149..8676,11421..11695)
CDS Sequence

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CCDS ID CCDS45358.1



Protein Information


      
Protein IDNP_066285.1
Protein Namenuclear receptor subfamily 2, group F, member 2
Molecular Wt. (Da)45440
Protein Sequence

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Length 414  
Uniprot IDP01344
Ensembl Protein ID ENSP00000370796  



Post-translational Modification Information (Source : HPRD)


No matching records could be found.

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                             
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
2033EP3004078NP_001420.2in vitro;in vivo9826778   
10114HIPK35111NP_005725.3yeast 2-hybrid15231748   
55603FAM46A13311NP_060103.2yeast 2-hybrid15231748   


Pathway Information


No matching records could be found.

Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd06948177-411  NR_LBD_COUP-TF
cl11397177-411  NR_LBD superfamily
cd0695879-151  NR_DBD_COUP_TF
cl0259679-151  NR_DBD_like superfamily
cd06950210-388  NR_LBD_Tlx_PNR_like
cd06930209-373  NR_LBD_F2
cd06943182-385  NR_LBD_RXR_like
cd06952212-396  NR_LBD_TR2_like
cd06157210-373  NR_LBD
cd06931182-399  NR_LBD_HNF4_like
cd0691679-150  NR_DBD_like
pfam00104198-387  Hormone_recep
cd06944212-400  NR_LBD_Ftz-F1_like
pfam0010577-146  zf-C4
smart00430216-373  HOLI
cd0696779-155  NR_DBD_TR2_like
cd07069212-400  NR_LBD_Lrh-1
cd0696079-153  NR_DBD_HNF4A
cd0716479-155  NR_DBD_PNR_like_1
cd0695679-153  NR_DBD_RXR
cd0696178-161  NR_DBD_TR
cd0696873-159  NR_DBD_ROR
cd0716376-155  NR_DBD_TLX
cd0696979-151  NR_DBD_NGFI-B
cd0715479-150  NR_DBD_PNR_like
cd07068182-400  NR_LBD_ER_like
cd0716779-154  NR_DBD_Lrh-1_like
smart0039979-147  ZnF_C4
cd0697076-155  NR_DBD_PNR
cd0696479-153  NR_DBD_RAR
cd0716879-155  NR_DBD_DHR4_like
cd0695779-155  NR_DBD_PNR_like_2
cd0716579-155  NR_DBD_DmE78_like
cd0716979-155  NR_DBD_GCNF_like
cd0716679-158  NR_DBD_REV_ERB
cd06946212-400  NR_LBD_ERR
cd07070212-400  NR_LBD_SF-1
cd0696578-155  NR_DBD_Ppar
cd0717979-152  2DBD_NR_DBD2
cd0716179-149  NR_DBD_EcR
cd0717179-153  NR_DBD_ER
cd0695979-149  NR_DBD_EcR_like
cd06951190-398  NR_LBD_Dax1_like
cd0715679-149  NR_DBD_VDR_like
cd0715579-153  NR_DBD_ER_like
cd06945182-402  NR_LBD_Nurr1_like
cd0715879-150  NR_DBD_Ppar_like
cd0717079-154  NR_DBD_ERR
cd0716079-149  NR_DBD_LXR
cd0696279-147  NR_DBD_FXR
cd0695579-153  NR_DBD_VDR
cd06953210-389  NR_LBD_DHR4_like
cd06929209-381  NR_LBD_F1
cd07350213-401  NR_LBD_Dax1
cd07349213-400  NR_LBD_SHP
cd0716279-149  NR_DBD_PXR
cd06949182-400  NR_LBD_ER
cd06937210-400  NR_LBD_RAR
cd0696679-147  NR_DBD_CAR
cd0717379-144  NR_DBD_AR
cd06940224-386  NR_LBD_REV_ERB
cd0717279-148  NR_DBD_GR_PR
cd0696379-148  NR_DBD_GR_like
cd06954212-399  NR_LBD_LXR
cd0715779-144  2DBD_NR_DBD1
cd07348225-386  NR_LBD_NGFI-B
cd06936224-381  NR_LBD_Fxr
cd06935224-386  NR_LBD_TR
cd06938224-386  NR_LBD_EcR
cd07072219-406  NR_LBD_DHR38_like
cd07071226-406  NR_LBD_Nurr1
cd06941224-413  NR_LBD_DmE78_like
cd06932209-381  NR_LBD_PPAR
cd06933203-374  NR_LBD_VDR
cd06934212-381  NR_LBD_PXR_like
cd07074214-353  NR_LBD_PR
cd07076215-323  NR_LBD_GR
cd06939224-381  NR_LBD_ROR_like
cd06947203-353  NR_LBD_GR_Like
cd07073214-322  NR_LBD_AR
cd07075214-249  NR_LBD_MR


Ontology Information


   
HPRD ID898
Molecular ClassNuclear receptor
Molecular FunctionGrowth factor activity (GO:0008083)
Biological ProcessCell communication (GO:0007154); Signal transduction (GO:0007165)  



SNP Information


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Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO