Search results:
General Information
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 25876034 | 2015 | Cell line : LoVo, HT 29 Source : ATCC, Tissue from First Affiliated Hospital of Kunming Medical University Sample Type : CRC tumor and normal tissue No. of Sample : 38 Stage : - | PCR,Western blotting,Bisulfite sequencing,Cell invasion | Up-regulation | - | Results demonstrated that the up-regulated expression of PAR4 and�TFF2�frequently occurs in�colorectal cancer�tissues |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfides. They are stable secretory proteins expressed in gastrointestinal mucosa. Their functions are not defined, but they may protect the mucosa from insults, stabilize the mucus layer and affect healing of the epithelium. The encoded protein inhibits gastric acid secretion. This gene and two other related trefoil family member genes are found in a cluster on chromosome 21. [provided by RefSeq, Jul 2008] |
| Chromosome | 21 |
| Location | 21q22.3 |
| Start | 43766466 |
| End | 43771208 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 4743 |
| OMIM ID | 182590 |
| HGNC ID | HGNC:11756 |
| Unigene ID | Hs.2979 |
| Ensembl ID | ENSG00000160181 |
| PharmGKB ID | PA36471 |
mRNA Information
| mRNA ID | ?NM_005423.4 |
|---|---|
| Exon | join(1..221,1070..1219,3468..3614,4554..4743) | mRNA Sequence | Download Select all |
| Length | 717 |
Protein Information
| Protein ID | NP_005414.1 |
|---|---|
| Protein Name | trefoil factor 2 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 129 |
| Uniprot ID | Q9BTL4 |
| Ensembl Protein ID | ENSP00000292433 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| N | Glycosylation | 38 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00111 | 79-122 | Trefoil |
| cl00103 | 79-122 | Trefoil superfamily |
| cd00111 | 36-72 | Trefoil |
| cl00103 | 36-72 | Trefoil superfamily |
| smart00018 | 79-124 | PD |
| pfam00088 | 80-121 | Trefoil |
| smart00018 | 29-75 | PD |
| pfam00088 | 36-72 | Trefoil |
Ontology Information
| HPRD ID | 5591 |
|---|---|
| Molecular Class | Secreted polypeptide |
| Molecular Function | Protein-tyrosine kinase activity (GO:0004713) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.