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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 24125969 | 2013 | Cell line : - Source : - Sample Type : CRC tumor and adjacent normal tissue No. of Sample : 56 Stage : TNM Stage I-IV | RT-PCR, immunohistochemistry,ELISA | Mutation | - | TFF3 expression may play a role in promoting lymph node metastases of CRCs and serum TFF3 may be a potential useful marker for patients with CRCs and their metastases. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfides. They are stable secretory proteins expressed in gastrointestinal mucosa. Their functions are not defined, but they may protect the mucosa from insults, stabilize the mucus layer and affect healing of the epithelium. This gene is expressed in goblet cells of the intestines and colon. This gene and two other related trefoil family member genes are found in a cluster on chromosome 21. [provided by RefSeq, Jul 2008] |
| Chromosome | 21 |
| Location | 21q22.3 |
| Start | 43731777 |
| End | 43735706 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 3930 |
| OMIM ID | 600633 |
| HGNC ID | HGNC:11757 |
| Unigene ID | Hs.82961 |
| Ensembl ID | ENSG00000160180 |
| PharmGKB ID | PA36472 |
mRNA Information
| mRNA ID | ?NM_003226.3 |
|---|---|
| Exon | join(1..304,1966..2112,3328..3930) | mRNA Sequence | Download Select all |
| Length | 1054 |
Protein Information
| Protein ID | NP_003217.3 |
|---|---|
| Protein Name | trefoil factor 3 (intestinal) |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 80 |
| Uniprot ID | Q13671 |
| Ensembl Protein ID | ENSP00000310406 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| C | Disulfide Bridge | 102;119 |
| C | Disulfide Bridge | 82;108 |
| C | Disulfide Bridge | 92;107 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00111 | 30-72 | Trefoil |
| cl00103 | 30-72 | Trefoil superfamily |
| smart00018 | 30-75 | PD |
| pfam00088 | 31-72 | Trefoil |
Ontology Information
| HPRD ID | 4923 |
|---|---|
| Molecular Class | Secreted polypeptide |
| Molecular Function | Auxiliary transport protein activity (GO:0015457) |
| Biological Process | Transport (GO:0006810) |
Drug Information
No matching records could be found.