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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
TFRC 7037 Transferrin receptor (p90, CD71)  3T9; TR; TFR; p90; CD71; TFR1; TRFR 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
15668490   2005Cell line : -

Source : Department of Pathology of Wrocaw Medical University.

Sample Type : -

No. of Sample : -

Stage : -

GenotypingPolymorhpism-G142S polymorphism were identified in the transferrin receptor gene (TFRC).

22968445   2012Cell line : -

Source : -

Sample Type : Prostate, Lung, Colorectal and Ovarian Cancer

No. of Sample : 679 persons with advanced distal adenoma and 697 control

Stage : -

Laser capture microdissection,FFPE-FASP,SAX fractionation,LC-MSMS,Label-free quantitation.Up-regulation3.5-


Gene Details



Chromosome: 3; NC_000003.11 (195776155..195809032, complement)

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Gene Type protein coding
Gene Family CD molecules
Description -  
Chromosome 3
Location 3q29
Start 196049284  
End 196082161  
Strand +  
Gene Sequence

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Length 32878  
OMIM ID 190010   
HGNC ID HGNC:11763   
Unigene ID Hs.529618    
Ensembl ID ENSG00000072274   
PharmGKB ID -   

mRNA Information


mRNA ID NM_001128148.1
Exon join(1..119,5040..5098,6802..7003,8037..8232,10010..10159, 10664..10766,12594..12707,14032..14130,14505..14644, 16562..16719,17734..17853,19223..19308,19517..19580, 21915..21982,23530..23588,23797..23878,26861..27082, 28604..28744,29978..32878)  
mRNA Sequence

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Length 5100  



CDS Information


   
Locationjoin(5063..5098,6802..7003,8037..8232,10010..10159, 10664..10766,12594..12707,14032..14130,14505..14644, 16562..16719,17734..17853,19223..19308,19517..19580, 21915..21982,23530..23588,23797..23878,26861..27082, 28604..28744,29978..30220)
CDS Sequence

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CCDS ID CCDS3312.1



Protein Information


      
Protein IDNP_003225.2
Protein NameTransferrin receptor (p90, CD71)
Molecular Wt. (Da)84741
Protein Sequence

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Length 760  
Uniprot IDO60610
Ensembl Protein ID ENSP00000373706  



Post-translational Modification Information (Source : HPRD)


Residue Type site
TGlycosylation104
NGlycosylation251
NGlycosylation317
CDisulfide Bridge556;558
CPalmitoylation62
CPalmitoylation67
NGlycosylation727
CDisulfide Bridge89;98
SPhosphorylation24
YPhosphorylation20
TPhosphorylation658;-
SPhosphorylation19
TPhosphorylation21
NGlycosylation250
NGlycosylation722
NGlycosylation726
YPhosphorylation19
SPhosphorylation34
SPhosphorylation499
YPhosphorylation503

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                             
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
919CD2471729NP_932170.1in vitro;in vivo9448136   
5869RAB5B1544NP_002859.1in vivo7789520   
7018TF1811NP_001054.1in vivo12   210   842   626   863   200   000   000   


Pathway Information


                        
Pathway Name Pathway ID
Endocytosis hsa04144
Hematopoietic cell lineage hsa04640
HIF-1 signaling pathway hsa04066
Phagosome hsa04145


Structure Information


PDB ID1CX8
Resolution3.2
MethodX-RAY DIFFRACTION
Chains A,B,C  
Molecule TRANSFERRIN RECEPTOR PROTEIN  
Model View



Domain Information




ID Location Description
cd09848385-610  M28_TfR
cl14876385-610  Zinc_peptidase_like superfamily
cd02128201-377  PA_TfR
cl10459201-377  Peptidases_S8_S53 superfamily
cd03874365-607  M28_PMSA_TfR_like
cd08022385-609  M28_PSMA_like
cd02690339-601  M28
pfam04253636-752  TFR_dimer
cl07854636-752  TFR_dimer superfamily
cd02121197-358  PA_GCPII_like
pfam04389401-576  Peptidase_M28
cd00538207-352  PA
cd03877383-563  M28_like_PA
cd02133232-282  PA_C5a_like
cd08015387-595  M28_like_4
pfam02225223-284  PA
cd02131219-353  PA_hNAALADL2_like
cd02130216-352  PA_ScAPY_like
cd05660373-455  M28_like_PA_1
cd08021382-576  M28_like_5
cd05663388-485  M28_like_PA_PDZ_associated
cd03883388-463  M28_Pgcp_like
cd05662388-551  M28_like_2
cd05642380-460  M28_AAP_like
cd04818250-282  PA_subtilisin_1
cd02122254-307  PA_GRAIL_like
cd04819214-285  PA_2
cd03876399-494  M28_SGAP_like
cd02124252-299  PA_PoS1_like
cd05661388-464  M28_like_PA_2
COG2234153-576  Iap


Ontology Information


   
HPRD ID532
Molecular ClassMembrane transport protein
Molecular FunctionDNA-methyltransferase activity (GO:0009008)
Biological ProcessRegulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219)  



SNP Information


View SNP Geneview Report   

Drug Information


Uniprot ID DrugBank ID Name Type
P02786DB05260Gallium nitrateSmallMoleculeDrug

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO