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General Information
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 11166150 | 2001 | Cell line : - Source : - Sample Type : CRC tumor and adjecent normal tissue No. of Sample : - Stage : - | - | Up-regulation | - | TGF-beta3 expression was detected in normal colonic mucosa and, at slightly higher levels, in tumour tissues. Gene knock-out mice were used. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Endogenous ligands |
| Description | This gene encodes a member of the TGF-beta family of proteins. The encoded protein is secreted and is involved in embryogenesis and cell differentiation. Defects in this gene are a cause of familial arrhythmogenic right ventricular dysplasia 1. [provided by RefSeq, Mar 2009] |
| Chromosome | 14 |
| Location | 14q24 |
| Start | 76424440 |
| End | 76449334 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 24895 |
| OMIM ID | 190230 |
| HGNC ID | HGNC:11769 |
| Unigene ID | Hs.592317 |
| Ensembl ID | - |
| PharmGKB ID | PA36483 |
mRNA Information
| mRNA ID | ?NM_003239.3 |
|---|---|
| Exon | join(1..199,1233..2450,11274..11437,11737..11866, 17297..17404,19505..19676,21916..22069,23647..24895) | mRNA Sequence | Download Select all |
| Length | 3394 |
Protein Information
| Protein ID | NP_003230.1 |
|---|---|
| Protein Name | transforming growth factor, beta 3 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 412 |
| Uniprot ID | Q99689 |
| Ensembl Protein ID | ENSP00000278919 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 1490 | CTGF | 412 | NP_001892.1 | in vivo | 10457363 |
| 2022 | ENG | 565 | NP_001108225.1 | in vivo | 9872992 |
| 7042 | TGFB2 | 1828 | AAA50404.1 | in vivo | 11157754 |
| 7046 | TGFBR1 | 1822 | NP_004603.1 | in vivo | 118 506 371 206 005 000 000 000 |
| 7048 | TGFBR2 | 1823 | NP_001020018.1 | in vivo | 1 185 063 711 382 740 000 000 000 000 000 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| AGE-RAGE signaling pathway in diabetic complications | hsa04933 |
| Amoebiasis | hsa05146 |
| Cell cycle | hsa04110 |
| Chagas disease (American trypanosomiasis) | hsa05142 |
| Chronic myeloid leukemia | hsa05220 |
| Colorectal cancer | hsa05210 |
| Cytokine-cytokine receptor interaction | hsa04060 |
| Dilated cardiomyopathy | hsa05414 |
| Endocytosis | hsa04144 |
| FoxO signaling pathway | hsa04068 |
| Hepatitis B | hsa05161 |
| Hippo signaling pathway | hsa04390 |
| HTLV-I infection | hsa05166 |
| Hypertrophic cardiomyopathy (HCM) | hsa05410 |
| Inflammatory bowel disease (IBD) | hsa05321 |
| Leishmaniasis | hsa05140 |
| Malaria | hsa05144 |
| MAPK signaling pathway | hsa04010 |
| Pancreatic cancer | hsa05212 |
| Pathways in cancer | hsa05200 |
| Renal cell carcinoma | hsa05211 |
| Rheumatoid arthritis | hsa05323 |
| TGF-beta signaling pathway | hsa04350 |
| Toxoplasmosis | hsa05145 |
| Tuberculosis | hsa05152 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam00019 | 314-412 | TGF_beta |
| cl02510 | 314-412 | TGF_beta superfamily |
| pfam00688 | 23-226 | TGFb_propeptide |
| cl02928 | 23-226 | TGFb_propeptide superfamily |
| smart00204 | 315-412 | TGFB |
| PHA02913 | 308-411 | PHA02913 |
Ontology Information
| HPRD ID | 11532 |
|---|---|
| Molecular Class | Growth factor |
| Molecular Function | RNA binding (GO:0003723) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
No matching records could be found.